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References from Exercise-induced metabolic remodeling in type 2 diabetes mellitus: insights from metabolomics. Local targets link to admitted publications; unresolved targets remain external evidence.
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The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
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Plasma lactate as a marker for metabolic health
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Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
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Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: marker or maker of the diabetic phenotype
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Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach
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Metabolite profiles and the risk of developing diabetes
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Divergent survival outcomes associated with elevated branched-chain amino acid levels among older adults with or without hypertension and diabetes: a validated, prospective, longitudinal follow-up study
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Metabolomics of type 2 diabetes mellitus in sprague dawley rats-in search of potential metabolic biomarkers
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Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose
10.1007/s00125-018-4599-x · 2018 · External reference
Glycolysis/gluconeogenesis- and tricarboxylic acid cycle-related metabolites, mediterranean diet, and type 2 diabetes
10.1093/ajcn/nqaa016 · 2020 · External reference
Metabolomics and type 2 diabetes risk: an updated systematic review and meta-analysis of prospective cohort studies
10.2337/dc21-1705 · 2022 · External reference
High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: case-cohort study within the predimed trial
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Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults
10.2337/dc12-0895 · 2013 · External reference
The pivotal role of the western diet, hyperinsulinemia, ectopic fat, and diacylglycerol-mediated insulin resistance in type 2 diabetes
10.3390/ijms26189191 · 2025 · External reference
L-carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine
10.3390/metabo11010051 · 2021 · External reference
The glucose fatty-acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
10.1016/s0140-6736(63)91500-9 · 1963 · External reference
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in finnish men
10.2337/dc13-0800 · 2013 · External reference
Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation
10.1186/s12967-025-06341-5 · 2025 · External reference
Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-american women
10.3945/jn.108.103754 · 2009 · External reference
Plasma acylcarnitines and risk of type 2 diabetes in a mediterranean population at high cardiovascular risk
10.1210/jc.2018-01000 · 2019 · External reference
Molecular choreography of acute exercise
10.1016/j.cell.2020.04.043 · 2020 · External reference
Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men
10.1007/s00125-020-05296-0 · 2021 · External reference
Metabolic architecture of acute exercise response in middle-aged adults in the community
10.1161/circulationaha.120.050281 · 2020 · External reference
Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients: a randomized crossover trial
10.1016/j.metabol.2022.155268 · 2022 · External reference
Metabolic impairments associated with type 2 diabetes mellitus and the potential effects of exercise therapy: an exploratory randomized trial based on untargeted metabolomics
10.1371/journal.pone.0300593 · 2024 · External reference
Moderate-intensity combined training induces lipidomic changes in individuals with obesity and type 2 diabetes
10.1210/clinem/dgae177 · 2024 · External reference
Quantitative biological study of exercise intervention on type 2 diabetes mellitus rats based on serum metabonomics
10.16237/j.cnki.cn44-1404/g8.2016.04.018 · 2016 · External reference
Metabolomics studies on db/db diabetic mice in skeletal muscle reveal effective clearance of overloaded intermediates by exercise
10.1016/j.aca.2017.11.082 · 2018 · External reference
The effect of high-intensity interval training on type 2 diabetic muscle: a metabolomics-based study
10.1016/j.heliyon.2024.e34917 · 2024 · External reference
Metabolomic profiling reveals that exercise lowers biomarkers of cardiac dysfunction in rats with type 2 diabetes
10.3390/antiox13101167 · 2024 · External reference
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC-1α: implications for metabolic disease
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Mechanism underlying the effects of exercise against type 2 diabetes: a review on research progress
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Metformin and exercise effects on postprandial insulin sensitivity and glucose kinetics in pre-diabetic and diabetic adults
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Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes
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10.3390/cells10112832 · 2021 · External reference
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Effect of acute exercise and exercise training on the ability of insulin to clear branched-chain amino acids from plasma in obesity and type 2 diabetes
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Divergent skeletal muscle metabolomic signatures of different exercise training modes independently predict cardiometabolic risk factors
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Pseudotargeted metabolomics method and its application in serum biomarker discovery for hepatocellular carcinoma based on ultra high-performance liquid chromatography/triple quadrupole mass spectrometry
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Establishment and application of a knowledge-directed pseudo-targeted analytical method for diabetic retinopathy
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A roadmap for interpreting 13C metabolite labeling patterns from cells
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Analysis types and quantification methods applied in UPLC-MS metabolomics research: A tutorial
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Metabolomics uncovers the diabetes metabolic network: from pathophysiological mechanisms to clinical applications
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Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs
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Metabolomics and metabolic diseases: where do we stand
10.1016/j.cmet.2016.09.018 · 2017 · External reference
Novel type 2 diabetes prediction score based on traditional risk factors and circulating metabolites: model derivation and validation in two large cohort studies
10.1016/j.eclinm.2024.102971 · 2025 · External reference
Metabolomic biomarkers in vitreous humor: unveiling the molecular landscape of diabetic retinopathy progression
10.1186/s40942-025-00682-5 · 2025 · External reference
β-Hydroxybutyrylation links ketone metabolism to mitochondrial remodeling in diabetic cardiomyopathy
10.2337/db25-0496 · 2026 · External reference
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
10.1038/s41598-018-33507-7 · 2018 · External reference
Increased lipogenesis and impaired β-oxidation predict type 2 diabetic kidney disease progression in american indians
10.1172/jci.insight.130317 · 2019 · External reference
Muscle-saturated bioactive lipids are increased with aging and influenced by high-intensity interval training
10.3390/ijms20051240 · 2019 · External reference
Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity
10.1016/j.cmet.2025.10.013 · 2025 · External reference
Research advances in the application of metabolomics in exercise science
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Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness
10.1007/s00125-014-3343-4 · 2014 · External reference
PLIS: a metabolomic response monitor to a lifestyle intervention study in older adults
10.1096/fj.202201037r · 2022 · External reference
Metabolomic profiling of intensity-dependent responses to acute exercise in healthy humans
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Metabolite concentration changes in humans after a bout of exercise: a systematic review of exercise metabolomics studies
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Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications
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Shared and distinct metabolomics profiles associated with microvascular complications in the diabetes prevention program outcomes study
10.1007/s00125-025-06571-8 · 2026 · External reference
Large-scale association analyses identify host factors influencing human gut microbiome composition
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Altered asparagine and glutamate homeostasis precede coronary artery disease and type 2 diabetes
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