Research graph
References from CFEM proteins: unique to fungi with essential roles in plant host interactions. Local targets link to admitted publications; unresolved targets remain external evidence.
A candidate effector protein PstCFEM1 contributes to virulence of stripe rust fungus and impairs wheat immunity
10.1007/s44154-022-00042-5 · 2022 · External reference
Improving transient protein expression in agroinfiltrated Nicotiana benthamiana
10.1111/nph.19894 · 2024 · External reference
AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage
10.1093/nar/gkaf1226 · 2025 · External reference
Formation of disulfide bonds in proteins and peptides
10.1016/j.biotechadv.2004.09.002 · 2005 · External reference
Bioinformatics analysis and functional characterization of the CFEM proteins of Metarhizium anisopliae
10.3390/jof8070661 · 2022 · External reference
The conserved cysteine-rich secretory protein MaCFEM85 interacts with MsWAK16 to activate plant defenses
10.3390/ijms24044037 · 2023 · External reference
Stress-induced reactive oxygen species compartmentalization, perception and signalling
10.1038/s41477-021-00887-0 · 2021 · External reference
Bioinformatics and transcriptome analysis of CFEM proteins in Fusarium graminearum
10.3390/jof7100871 · 2021 · External reference
Advances in the control of phytopathogenic fungi that infect crops through their root system
2020 · External reference
Genome-wide identification and characterization of effector candidates with conserved motif in Falciphora oryzae
10.3390/ijms25010650 · 2024 · External reference
A comparative study of the pathogenicity of Fusarium circinatum and other Fusarium species in Polish provenances of P. sylvestris L
10.3390/f9090560 · 2018 · External reference
Characterization of adenylate cyclase interacting protein ACI1 in the rice blast fungus, Magnaporthe oryzae
10.2174/1874437000802010074 · 2008 · External reference
Magnaporthe grisea Pth11p is a novel plasma membrane protein that mediates appressorium differentiation in response to inductive substrate cues
10.1105/tpc.11.10.2013 · 1999 · External reference
Fusarium spp. diversity associated with symptomatic Acacia koa in Hawai'i
10.1111/efp.12713 · 2021 · External reference
Protein disulfide engineering
10.1016/j.febslet.2013.11.024 · 2014 · External reference
Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines
10.1039/c6mb00861e · 2017 · External reference
Diversity of GPI-anchored fungal adhesins
10.1515/hsz-2020-0199 · 2020 · External reference
Biotrophic fungal pathogens: a critical overview
10.1007/s12010-022-04087-0 · 2023 · External reference
Seeking the roles for fungal small-secreted proteins in affecting saprophytic lifestyles
10.3389/fmicb.2020.00455 · 2020 · External reference
CgCFEM1 is required for the full virulence of Colletotrichum gloeosporioides
10.3390/ijms25052937 · 2024 · External reference
CLANS: a Java application for visualizing protein families based on pairwise similarity
10.1093/bioinformatics/bth444 · 2004 · External reference
GPI-anchor remodeling: Potential functions of GPI-anchors in intracellular trafficking and membrane dynamics
10.1016/j.bbalip.2012.01.004 · 2012 · External reference
Cerato-platanins: a fungal protein family with intriguing properties and application potential
10.1007/s00253-014-5690-y · 2014 · External reference
Bioinformatic analysis and functional characterization of the CFEM proteins in maize anthracnose fungus Colletotrichum graminicola
10.1016/s2095-3119(19)62675-4 · 2020 · External reference
Dothideomycetes: plant pathogens, saprobes, and extremophiles
10.1002/9781118735893.ch6 · 2013 · External reference
Fungal diversity revisited: 2.2 to 3.8 million species
10.1128/microbiolspec.funk-0052-2016 · 2017 · External reference
Fusarium sacchari CFEM proteins suppress host immunity and differentially contribute to virulence
10.3390/ijms252312805 · 2024 · External reference
Identification of common fungal extracellular membrane (CFEM) proteins in Fusarium sacchari that inhibit plant immunity and contribute to virulence
10.1128/spectrum.01452-23 · 2023 · External reference
Glycosylphosphatidylinositol (GPI)-anchored proteins
10.1248/bpb.25.409 · 2002 · External reference
Sensing host and environmental cues by fungal GPCRs
10.1016/j.pbi.2024.102667 · 2024 · External reference
The plant immune system
10.1038/nature05286 · 2006 · External reference
Effectors of plants pathogenic fungi and fungal like microbes: a comprehensive review on mechanisms, roles, and host interactions
10.3389/fpls.2025.1626960 · 2025 · External reference
Biosynthesis and biology of mammalian GPI-anchored proteins
10.1098/rsob.190290 · 2020 · External reference
Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling
10.1194/jlr.r063313 · 2016 · External reference
Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence
10.1111/j.1567-1364.2009.00541.x · 2009 · External reference
Pathways of heme utilization in fungi
10.1016/j.bbamcr.2020.118817 · 2020 · External reference
Structure–function analyses of the Pth11 receptor reveal an important role for CFEM motif and redox regulation in rice blast
10.1111/nph.14347 · 2017 · External reference
Identification of proteins that interact with two regulators of appressorium development, adenylate cyclase and cAMP-dependent protein kinase A, in the rice blast fungus Magnaporthe grisea
10.1007/s00438-003-0935-y · 2004 · External reference
An eight-cysteine-containing CFEM domain unique to a group of fungal membrane proteins
10.1016/s0968-0004(03)00025-2 · 2003 · External reference
Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea
10.1186/gb-2005-6-3-r24 · 2005 · External reference
A relay network of extracellular heme-binding proteins drives C. albicans iron acquisition from hemoglobin
10.1371/journal.ppat.1004407 · 2014 · External reference
A novel CFEM effector in Fusarium verticillioides required for virulence involved in plant immunity suppression and fungal cell wall integrity
10.3390/ijms26094369 · 2025 · External reference
A genome-scale phylogeny of the kingdom Fungi
10.1016/j.cub.2021.01.074 · 2021 · External reference
Pathogenic strategies and immune mechanisms to necrotrophs: Differences and similarities to biotrophs and hemibiotrophs
10.1016/j.pbi.2022.102291 · 2022 · External reference
The new CFEM protein CgCsa required for Fe3+ homeostasis regulates the growth, development, and pathogenicity of Colletotrichum gloeosporioides
10.1016/j.ijbiomac.2024.133216 · 2024 · External reference
Identification and classification of fungal GPCR gene families
10.3390/jof12010030 · 2025 · External reference
Re-localization of a repeat-containing fungal effector by apoplastic protein Chitinase-like 1 blocks its toxicity
10.1038/s41467-024-54470-0 · 2024 · External reference
Fungal effectors and plant susceptibility
10.1146/annurev-arplant-043014-114623 · 2015 · External reference
Twenty years of research on cerato-platanin family proteins: clues, conclusions, and unsolved issues
10.1016/j.fbr.2019.10.001 · 2020 · External reference
Families of sordariomycetes
10.1007/s13225-016-0369-6 · 2016 · External reference
10.1007/978-3-662-46011-5
10.1007/978-3-662-46011-5 · 2015 · External reference
Deletion of new covalently linked cell wall glycoproteins alters the electrophoretic mobility of phosphorylated wall components of Saccharomyces cerevisiae
10.1128/jb.181.10.3076-3086.1999 · 1999 · External reference
Structural basis of haem-iron acquisition by fungal pathogens
10.1038/nmicrobiol.2016.156 · 2016 · External reference
Reactive cysteine in proteins: protein folding, antioxidant defense, redox signaling and more
10.1016/j.cbpc.2006.07.014 · 2007 · External reference
Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
10.1038/s41598-019-42344-1 · 2019 · External reference
10.1201/9781315380773
10.1201/9781315380773 · 2016 · External reference
Infection mechanisms and colonization patterns of fungi associated with soybean
10.5772/62305 · 2016 · External reference
Comparative analysis of secretomes from ectomycorrhizal fungi with an emphasis on small-secreted proteins
10.3389/fmicb.2015.01278 · 2015 · External reference
Systematic contributions of CFEM domain‐containing proteins to iron acquisition are essential for interspecies interaction of the filamentous pathogenic fungus Beauveria bassiana
10.1111/1462-2920.16032 · 2022 · External reference
Positive membrane curvature induced by a CFEM-domain protein is essential for fungal invasion of the host
10.1016/j.ijbiomac.2026.151066 · 2026 · External reference
Research progress on phytopathogenic fungi and their role as biocontrol agents
10.3389/fmicb.2021.670135 · 2021 · External reference
Systemic identification and functional characterization of common in fungal extracellular membrane proteins in Lasiodiplodia theobromae
10.3389/fpls.2021.804696 · 2021 · External reference
BbCFEM7 contributes to the virulence of entomopathogenic fungi by competing for iron with Enterococcus mundtii
10.1016/j.pestbp.2025.106666 · 2025 · External reference
Oxidative cysteine post translational modifications drive the redox code underlying neurodegeneration and amyotrophic lateral sclerosis
10.3390/antiox13080883 · 2024 · External reference
Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity
10.1016/j.fgb.2008.08.003 · 2008 · External reference
Stripe rust effector PstGSRE1 disrupts nuclear localization of ROS-promoting transcription factor TaLOL2 to defeat ROS-induced defense in wheat
10.1016/j.molp.2019.09.010 · 2019 · External reference
Systematic identification and functional characterization of the CFEM proteins in poplar fungus Marssonina brunnea
10.3389/fcimb.2022.1045615 · 2022 · External reference
Multifunctionality of AsCFEM6 and AsCFEM12 effectors from the potato early blight pathogen Alternaria solani
10.1016/j.ijbiomac.2023.128575 · 2024 · External reference
Interaction of entomopathogenic fungi with the host immune system
10.1016/j.dci.2018.01.010 · 2018 · External reference
Heme-iron acquisition in fungi
10.1016/j.mib.2019.05.006 · 2019 · External reference
Ferric reductase-related proteins mediate fungal heme acquisition
10.7554/elife.80604 · 2022 · External reference
WISH, a novel CFEM GPCR is indispensable for surface sensing, asexual and pathogenic differentiation in rice blast fungus
10.1016/j.fgb.2017.05.006 · 2017 · External reference
GPI anchored proteins in Aspergillus fumigatus and cell wall morphogenesis
2020 · External reference
A fungal CFEM‐containing effector targets NPR1 regulator NIMIN2 to suppress plant immunity
10.1111/pbi.14166 · 2024 · External reference
Identification of a novel small cysteine-rich protein in the fraction from the biocontrol Fusarium oxysporum strain CS-20 that mitigates Fusarium wilt symptoms and triggers defense responses in tomato
10.3389/fpls.2015.01207 · 2016 · External reference
Iron restriction-induced adaptations in the wall proteome of Candida albicans
10.1099/mic.0.065599-0 · 2013 · External reference
A systematic analysis reveals an essential role for high-affinity iron uptake system, haemolysin and CFEM domain-containing protein in iron homoeostasis and virulence in Candida glabrata
10.1042/bj20140598 · 2014 · External reference
Fungal effector proteins
10.1146/annurev.phyto.112408.132637 · 2009 · External reference
Structural analysis of hydrophobins
10.1016/j.micron.2007.08.003 · 2008 · External reference
Proteomics-based prediction of candidate effectors in the interaction secretome of Trichoderma harzianum and Pseudocercospora Fijiensis
10.3390/microbiolres16080175 · 2025 · External reference
The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence
10.1016/j.fgb.2013.12.005 · 2014 · External reference
Insights of the Neofusicoccum parvum–Liquidambar styraciflua interaction and identification of new cysteine-rich proteins in both species
10.3390/jof7121027 · 2021 · External reference
Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls
10.1073/pnas.2010661117 · 2020 · External reference
Effect of CFEM proteins on pathogenicity, patulin accumulation and host immunity of postharvest apple pathogens Penicillium expansum
10.1016/j.ijfoodmicro.2025.111180 · 2025 · External reference
Regulation and function of defense-related callose deposition in plants
10.3390/ijms22052393 · 2021 · External reference
Cepharanthine inhibits Fusarium solani via oxidative stress and CFEM domain-containing protein targeting
10.3390/microorganisms13061423 · 2025 · External reference
Verticillium dahliae CFEM proteins manipulate host immunity and differentially contribute to virulence
10.1186/s12915-022-01254-x · 2022 · External reference
Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans
10.1111/cmi.13282 · 2021 · External reference
Applications of hydrophobins: current state and perspectives
10.1007/s00253-014-6319-x · 2015 · External reference
Genome-wide comparative analysis of putative Pth11-related G protein-coupled receptors in fungi belonging to Pezizomycotina
10.1186/s12866-017-1076-5 · 2017 · External reference
Protein redox modification as a cellular defense mechanism against tissue ischemic injury
10.1155/2014/343154 · 2014 · External reference
Cross-talk between immunity and behavior: insights from entomopathogenic fungi and their insect hosts
10.1093/femsre/fuae003 · 2024 · External reference
The rust effector PstCFEM2 manipulates TaHA2- and TaCIPK9-mediated apoplastic acidification to promote wheat susceptibility
10.1093/plcell/koag021 · 2026 · External reference
The virulence contribution of the CFEM family genes of Beauveria bassiana is closely influenced by the external iron environment
10.1128/spectrum.03096-24 · 2025 · External reference
Systematic analyses reveal uniqueness and origin of the CFEM domain in fungi
10.1038/srep13032 · 2015 · External reference
Early molecular events in the interaction between Magnaporthe oryzae and rice
10.1186/s42483-024-00226-z · 2024 · External reference
BbCFEM7 plays an important role in the pathogenicity and gut microbial community formation in the co-infection of Beauveria bassiana with Metarhizium rileyi
10.1128/spectrum.02457-25 · 2026 · External reference
At least three families of hyphosphere small secreted cysteine‐rich proteins can optimize surface properties to a moderately hydrophilic state suitable for fungal attachment
10.1111/1462-2920.15413 · 2021 · External reference
Genome-wide identification of effector candidates with conserved motifs from the wheat leaf rust fungus Puccinia triticina
10.3389/fmicb.2020.01188 · 2020 · External reference
BcCFEM1, a CFEM domain-containing protein with putative GPI-anchored site, is involved in pathogenicity, conidial production, and stress tolerance in Botrytis cinerea
10.3389/fmicb.2017.01807 · 2017 · External reference
Fungal CFEM effectors negatively regulate a maize wall-associated kinase by interacting with its alternatively spliced variant to dampen resistance
10.1016/j.celrep.2022.111877 · 2022 · External reference
