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References from Rewriting the genome: harnessing R2 retrotransposons for precise DNA insertion. Local targets link to admitted publications; unresolved targets remain external evidence.
The CRISPR tool kit for genome editing and beyond
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CRISPR-cas immunity, DNA repair and genome stability
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Distinct and overlapping RNA determinants for binding and target-primed reverse transcription by Bombyx mori R2 retrotransposon protein
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Search-and-replace genome editing without double-strand breaks or donor DNA
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Genome editing with CRISPR–cas nucleases, base editors, transposases and prime editors
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Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
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Distinct families of site-specific retrotransposons occupy identical positions in the rRNA genes of Anopheles gambiae
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High processivity of the reverse transcriptase from a non-long terminal repeat retrotransposon
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End-to-end template jumping by the reverse transcriptase encoded by the R2 retrotransposon
10.1074/jbc.m310450200 · 2004 · External reference
Prime editing for precise and highly versatile genome manipulation
10.1038/s41576-022-00541-1 · 2022 · External reference
All-RNA-mediated targeted gene integration in Mammalian cells with rationally engineered R2 retrotransposons
10.1016/j.cell.2024.06.020 · 2024 · External reference
R2 target-primed reverse transcription: ordered cleavage and polymerization steps by protein subunits asymmetrically bound to the target DNA
10.1128/mcb.25.15.6617-6628.2005 · 2005 · External reference
Role of the Bombyx mori R2 element N-terminal domain in the target-primed reverse transcription (TPRT) reaction
10.1093/nar/gki957 · 2005 · External reference
RNA from the 5' end of the R2 retrotransposon controls R2 protein binding to and cleavage of its DNA target site
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Multiplex genome engineering using CRISPR/cas systems
10.1126/science.1231143 · 2013 · External reference
Distribution of hobo transposable elements in the genus Drosophila
2025 · External reference
Nucleotide sequences at the boundaries between gene and insertion regions in the rDNA of Drosophila melanogaster
10.1093/nar/9.19.5011 · 1981 · External reference
Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon
10.1016/j.cell.2023.05.032 · 2023 · External reference
Genome editing. The new frontier of genome engineering with CRISPR‐Cas9
10.1126/science.1258096 · 2014 · External reference
Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons
10.1038/s41467-025-61321-z · 2025 · External reference
R2 and related site-specific non-long terminal repeat retrotransposons
10.1128/9781555817954.ch34 · 2007 · External reference
R2 retrotransposons encode a self-cleaving ribozyme for processing from an rRNA cotranscript
10.1128/mcb.00300-10 · 2010 · External reference
Integration, regulation, and long-term stability of R2 retrotransposons
2015 · External reference
The diversity of retrotransposons and the properties of their reverse transcriptases
10.1016/j.virusres.2007.12.010 · 2008 · External reference
Evolution of the R2 retrotransposon ribozyme and its self-cleavage site
10.1371/journal.pone.0066441 · 2013 · External reference
Reprogramming site-specific retrotransposon activity to new DNA sites
10.1038/s41586-025-08877-4 · 2025 · External reference
Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
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DNA transposons and the evolution of eukaryotic genomes
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Site‐specific non‐LTR retrotransposons
10.1128/microbiolspec.mdna3-0001-2014 · 2015 · External reference
Programmable base editing of AT to GC in genomic DNA without DNA cleavage
10.1038/nature24644 · 2017 · External reference
Silencing and transcriptional regulation of endogenous retroviruses: an overview
10.3390/v12080884 · 2020 · External reference
Non-LTR retrotransposons and microsatellites: partners in genomic variation
10.4161/mge.25674 · 2013 · External reference
Genetic identification of potential RNA-Binding regions in a group II intron-encoded reverse transcriptase
10.1261/rna.2007310 · 2010 · External reference
Break breast cancer addiction by CRISPR/Cas9 genome editing
2018 · External reference
Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
10.1186/1759-8753-1-15 · 2010 · External reference
Sequence‐specific single‐strand RNA binding protein encoded by the human LINE‐1 retrotransposon
10.1093/emboj/16.19.6034 · 2014 · External reference
Development and applications of CRISPR–Cas9 for genome engineering
10.1016/j.cell.2014.05.010 · 2014 · External reference
Retrotransposable elements R1 and R2 interrupt the rRNA genes of Most insects
10.1073/pnas.88.8.3295 · 1991 · External reference
Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase
10.1093/nar/gku514 · 2014 · External reference
10.1126/science.1225829
10.1126/science.1225829 · 2012 · External reference
Simple and fast classification of non-LTR retrotransposons based on phylogeny of their RT domain protein sequences
10.1016/j.gene.2009.07.019 · 2009 · External reference
RNase H as gene modifier, driver of evolution and antiviral defense
10.3389/fmicb.2017.01745 · 2017 · External reference
Cross-genome screening of novel sequence-specific non-LTR retrotransposons: various multicopy RNA genes and microsatellites are selected as targets
10.1093/molbev/msg235 · 2004 · External reference
Long-term inheritance of the 28S rDNA-specific retrotransposon R2
10.1093/molbev/msi210 · 2005 · External reference
Identification of rDNA-Specific Non-LTR retrotransposons in cnidaria
10.1093/molbev/msl067 · 2006 · External reference
The wide distribution and change of target specificity of R2 Non-LTR retrotransposons in animals
10.1371/journal.pone.0163496 · 2016 · External reference
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
10.1038/nature17946 · 2016 · External reference
Sleeping beauty transposon insertions into nucleolar DNA by an engineered transposase localized in the nucleolus
10.3390/ijms241914978 · 2023 · External reference
Systematic determination of the packaging limit of lentiviral vectors
10.1089/104303401753153947 · 2001 · External reference
Targeted gene knockin in zebrafish using the 28S rDNA-specific non-LTR-retrotransposon R2Ol
10.1186/s13100-019-0167-2 · 2019 · External reference
DNA-Directed DNA polymerase and strand displacement activity of the reverse transcriptase encoded by the R2 retrotransposon
10.1016/j.jmb.2007.09.047 · 2007 · External reference
Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains
10.1016/j.celrep.2024.114239 · 2024 · External reference
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism
10.1038/s41587-024-02266-4 · 2025 · External reference
Ribosomal DNA integrating rAAV-rDNA vectors allow for stable transgene expression
10.1038/mt.2012.164 · 2012 · External reference
RNA template requirements for target DNA-Primed reverse transcription by the R2 retrotransposable element
10.1128/mcb.15.7.3882 · 1995 · External reference
Downstream 28S gene sequences on the RNA template affect the choice of primer and the accuracy of initiation by the R2 reverse transcriptase
10.1128/mcb.16.9.4726 · 1996 · External reference
Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition
10.1016/0092-8674(93)90078-5 · 1993 · External reference
Non-LTR R2 element evolutionary patterns: phylogenetic incongruences, rapid radiation and the maintenance of multiple lineages
10.1371/journal.pone.0057076 · 2013 · External reference
Globular domain structure and function of restriction-like-endonuclease LINEs: similarities to eukaryotic splicing factor Prp8
10.1186/s13100-017-0097-9 · 2017 · External reference
RNA-guided human genome engineering via Cas9
10.1126/science.1232033 · 2013 · External reference
The age and evolution of non-LTR retrotransposable elements
10.1093/oxfordjournals.molbev.a026164 · 1999 · External reference
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein
10.1126/science.adz3121 · 2025 · External reference
Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA
10.1038/nsmb.1777 · 2010 · External reference
Dual AAV vectors for efficient delivery of large transgenes
10.1038/s41596-025-01243-8 · 2026 · External reference
Endonuclease domain of the Drosophila melanogaster R2 non-LTR retrotransposon and related retroelements: a new model for transposition
10.3389/fgene.2013.00063 · 2013 · External reference
10.1007/s40259-017-0234-5
10.1007/s40259-017-0234-5 · 2017 · External reference
Mobilizing diversity: transposable element insertions in genetic variation and disease
10.1186/1759-8753-1-21 · 2010 · External reference
Transcription activator like effector (TALE)-directed piggyBac transposition in human cells
10.1093/nar/gkt677 · 2013 · External reference
Past, present, and future of CRISPR genome editing technologies
10.1016/j.cell.2024.01.042 · 2024 · External reference
Structure and sequence at an RNA template 5' end influence insertion of transgenes by an R2 retrotransposon protein
10.1261/rna.080031.124 · 2024 · External reference
The next generation of CRISPR–cas technologies and applications
10.1038/s41580-019-0131-5 · 2019 · External reference
Separable structural requirements for cDNA synthesis, nontemplated extension, and template jumping by a non-LTR retroelement reverse transcriptase
10.1016/j.jbc.2022.101624 · 2022 · External reference
Arrangements and rearrangements of sequences flanking the two types of rDNA insertion in D. melanogaster
10.1038/290749a0 · 1981 · External reference
Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding
10.1016/j.str.2007.09.007 · 2007 · External reference
A tale of an A-tail: the lifeline of a SINE
10.4161/mge.23204 · 2012 · External reference
Processing of insect retrotransposons by self-cleaving ribozymes
10.1038/npre.2010.4333.1 · 2010 · External reference
10.1146/annurev-virology-031413-085355
10.1146/annurev-virology-031413-085355 · 2014 · External reference
HIV-1 integration in the human genome favors active genes and local hotspots
10.1016/s0092-8674(02)00864-4 · 2002 · External reference
High‐throughput functional genomics using CRISPR‐Cas9
10.1038/nrg3899 · 2015 · External reference
Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome
10.1186/s13100-019-0148-5 · 2019 · External reference
Sequence-specific retrotransposition of 28S rDNA-specific LINE R2Ol in human cells
10.1261/rna.072512.119 · 2019 · External reference
Template and target-site recognition by human LINE-1 in retrotransposition
10.1038/s41586-023-06933-5 · 2023 · External reference
Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking
10.1126/sciadv.adu5533 · 2025 · External reference
CRISPR technology: a decade of genome editing is only the beginning
10.1126/science.add8643 · 2023 · External reference
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10.1073/pnas.0607612103 · 2006 · External reference
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription
10.1126/science.adg7883 · 2023 · External reference
Genome editing by natural and engineered CRISPR-Associated nucleases
10.1038/s41589-018-0080-x · 2018 · External reference
Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements
1999 · External reference
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
10.1038/s41587-022-01527-4 · 2023 · External reference
Efficient nuclease-directed integration of lentivirus vectors into the human ribosomal DNA locus
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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci
10.1038/s41587-024-02137-y · 2024 · External reference
LINE-1 vectors mediate recombinant antibody gene transfer by retrotransposition in Chinese hamster ovary cells
10.1002/biot.202000620 · 2021 · External reference
