Research graph
References from Identification of ion homeostasis-related genes as diagnostic biomarkers for pulmonary arterial hypertension via WGCNA and machine learning. Local targets link to admitted publications; unresolved targets remain external evidence.
Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment
10.1186/s12964-019-0478-4 · 2019 · External reference
Evaluation and management of pulmonary arterial hypertension in congenital heart disease
10.14797/ufej2329 · 2021 · External reference
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca(2+) signaling
10.1152/physrev.00030.2021 · 2023 · External reference
Unresolved reference
2008 · External reference
Pro-survival lipid Sphingosine-1-Phosphate metabolically programs T cells to limit anti-tumor activity
10.1016/j.celrep.2019.07.044 · 2019 · External reference
Ion channels and transporters in muscle cell differentiation
10.3390/ijms222413615 · 2021 · External reference
Zinc promotes cell proliferation via regulating metal-regulatory transcription factor 1 expression and transcriptional activity in pulmonary arterial hypertension
10.1080/15384101.2023.2205209 · 2023 · External reference
PIEZO ion channels in cardiovascular functions and diseases
10.1161/circresaha.123.322798 · 2024 · External reference
Ion channels and their role in chemo-resistance
10.1016/bs.ctm.2023.09.008 · 2023 · External reference
The role of ABCG2 in health and disease: linking cancer therapy resistance and other disorders
10.1016/j.lfs.2024.123245 · 2025 · External reference
1,5-Diaryl-1,2,4-triazole ureas as new SLC-0111 analogues endowed with dual carbonic anhydrase and VEGFR-2 inhibitory activities
10.1021/acs.jmedchem.3c00721 · 2023 · External reference
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
10.1183/13993003.03957-2020 · 2021 · External reference
Regularization paths for generalized linear models via coordinate descent
10.18637/jss.v033.i01 · 2010 · External reference
Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease
10.1086/688314 · 2016 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2016 · External reference
Mechanisms and treatment of pulmonary arterial hypertension
10.1038/s41569-024-01064-4 · 2025 · External reference
Autoimmunity to Sphingosine-1-Phosphate-Receptors in systemic sclerosis and pulmonary arterial hypertension
10.3389/fimmu.2022.935787 · 2022 · External reference
Unresolved reference
2024 · External reference
Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension
10.1540/jsmr.58.50 · 2022 · External reference
Medically important alterations in transport function and trafficking of ABCG2
10.3390/ijms22062786 · 2021 · External reference
Treatment of pulmonary arterial hypertension: recent progress and a look to the future
10.1016/s2213-2600(23)00264-3 · 2023 · External reference
Translational potential of targeting Anoctamin-1-Encoded calcium-activated chloride channels in hypertension
10.1016/j.bcp.2022.115320 · 2022 · External reference
The roles of proton-sensing G-Protein-Coupled receptors in inflammation and cancer
10.3390/genes15091151 · 2024 · External reference
Unresolved reference
2025 · External reference
Expression of hypoxia-related tissue factors in astrocytic gliomas. A multivariate survival study with emphasis upon carbonic anhydrase IX
10.1016/j.humpath.2006.07.020 · 2007 · External reference
Multidrug efflux transporter ABCG2: expression and regulation
10.1007/s00018-021-03901-y · 2021 · External reference
Feature selection with the boruta package
2010 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Vascular smooth muscle cells mechanosensitive regulators and vascular remodeling
10.1159/000519845 · 2022 · External reference
The physiological basis of pulmonary arterial hypertension
10.1183/13993003.02334-2021 · 2022 · External reference
Unresolved reference
2019 · External reference
Pulmonary hypertension associated with lung disease: new insights into pathomechanisms, diagnosis, and management
10.1016/s2213-2600(23)00259-x · 2023 · External reference
Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
10.1038/s41598-021-95196-z · 2021 · External reference
Activated protein C drives beta-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5
10.1016/j.jbc.2026.111190 · 2026 · External reference
pH-Dependent structure and dynamics of the catalytic domains of human carbonic anhydrase II and IX
10.1021/acs.jpcb.3c04721 · 2023 · External reference
The pathobiology of pulmonary arterial hypertension
10.1016/j.ccl.2021.08.001 · 2022 · External reference
Energetics and dynamics of the proton shuttle of carbonic anhydrase II
10.1007/s00018-023-04936-z · 2023 · External reference
Potassium channels as therapeutic targets in pulmonary arterial hypertension
10.3390/biom12101341 · 2022 · External reference
Unresolved reference
2015 · External reference
Diagnosis and treatment of pulmonary arterial hypertension: a review
10.1001/jama.2022.4402 · 2022 · External reference
Endogenous peroxynitrite modulates PGHS-1-dependent thromboxane A2 formation and aggregation in human platelets
10.1016/j.freeradbiomed.2008.04.042 · 2008 · External reference
New drugs and therapies in pulmonary arterial hypertension
10.3390/ijms24065850 · 2023 · External reference
Panorama of artery endothelial cell dysfunction in pulmonary arterial hypertension
10.1016/j.yjmcc.2024.10.004 · 2024 · External reference
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance
10.1158/0008-5472.can-10-3820 · 2011 · External reference
Calcium-sensing receptor (CaSR), its impact on inflammation and the consequences on cardiovascular health
10.3390/ijms22052478 · 2021 · External reference
Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension
10.1186/s12890-022-01939-7 · 2022 · External reference
Echocardiography in pulmonary arterial hypertension: comprehensive evaluation and technical considerations
10.3390/jcm10153229 · 2021 · External reference
Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels
10.1002/cbin.11682 · 2021 · External reference
A lifelike guided journey through the pathophysiology of pulmonary hypertension-from measured metabolites to the mechanism of action of drugs
10.3389/fcvm.2024.1341145 · 2024 · External reference
clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
10.1016/j.xinn.2021.100141 · 2021 · External reference
Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells
10.1152/ajpcell.00313.2022 · 2022 · External reference
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications
10.1016/j.tcb.2022.07.004 · 2023 · External reference
Diagnosis and treatment of pulmonary arterial hypertension: a review
10.1001/jama.2022.4402 · ExternalCitation · doi-reference
Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels
10.1002/cbin.11682 · ExternalCitation · doi-reference
Multidrug efflux transporter ABCG2: expression and regulation
10.1007/s00018-021-03901-y · ExternalCitation · doi-reference
Energetics and dynamics of the proton shuttle of carbonic anhydrase II
10.1007/s00018-023-04936-z · ExternalCitation · doi-reference
Ion channels and their role in chemo-resistance
10.1016/bs.ctm.2023.09.008 · ExternalCitation · doi-reference
Translational potential of targeting Anoctamin-1-Encoded calcium-activated chloride channels in hypertension
10.1016/j.bcp.2022.115320 · ExternalCitation · doi-reference
The pathobiology of pulmonary arterial hypertension
10.1016/j.ccl.2021.08.001 · ExternalCitation · doi-reference
Pro-survival lipid Sphingosine-1-Phosphate metabolically programs T cells to limit anti-tumor activity
10.1016/j.celrep.2019.07.044 · ExternalCitation · doi-reference
Endogenous peroxynitrite modulates PGHS-1-dependent thromboxane A2 formation and aggregation in human platelets
10.1016/j.freeradbiomed.2008.04.042 · ExternalCitation · doi-reference
Expression of hypoxia-related tissue factors in astrocytic gliomas. A multivariate survival study with emphasis upon carbonic anhydrase IX
10.1016/j.humpath.2006.07.020 · ExternalCitation · doi-reference
Activated protein C drives beta-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5
10.1016/j.jbc.2026.111190 · ExternalCitation · doi-reference
The role of ABCG2 in health and disease: linking cancer therapy resistance and other disorders
10.1016/j.lfs.2024.123245 · ExternalCitation · doi-reference
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications
10.1016/j.tcb.2022.07.004 · ExternalCitation · doi-reference
clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
10.1016/j.xinn.2021.100141 · ExternalCitation · doi-reference
Panorama of artery endothelial cell dysfunction in pulmonary arterial hypertension
10.1016/j.yjmcc.2024.10.004 · ExternalCitation · doi-reference
Pulmonary hypertension associated with lung disease: new insights into pathomechanisms, diagnosis, and management
10.1016/s2213-2600(23)00259-x · ExternalCitation · doi-reference
Treatment of pulmonary arterial hypertension: recent progress and a look to the future
10.1016/s2213-2600(23)00264-3 · ExternalCitation · doi-reference
1,5-Diaryl-1,2,4-triazole ureas as new SLC-0111 analogues endowed with dual carbonic anhydrase and VEGFR-2 inhibitory activities
10.1021/acs.jmedchem.3c00721 · ExternalCitation · doi-reference
pH-Dependent structure and dynamics of the catalytic domains of human carbonic anhydrase II and IX
10.1021/acs.jpcb.3c04721 · ExternalCitation · doi-reference
Mechanisms and treatment of pulmonary arterial hypertension
10.1038/s41569-024-01064-4 · ExternalCitation · doi-reference
Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
10.1038/s41598-021-95196-z · ExternalCitation · doi-reference
Zinc promotes cell proliferation via regulating metal-regulatory transcription factor 1 expression and transcriptional activity in pulmonary arterial hypertension
10.1080/15384101.2023.2205209 · ExternalCitation · doi-reference
Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease
10.1086/688314 · ExternalCitation · doi-reference
Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells
10.1152/ajpcell.00313.2022 · ExternalCitation · doi-reference
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca(2+) signaling
10.1152/physrev.00030.2021 · ExternalCitation · doi-reference
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance
10.1158/0008-5472.can-10-3820 · ExternalCitation · doi-reference
Vascular smooth muscle cells mechanosensitive regulators and vascular remodeling
10.1159/000519845 · ExternalCitation · doi-reference
PIEZO ion channels in cardiovascular functions and diseases
10.1161/circresaha.123.322798 · ExternalCitation · doi-reference
The physiological basis of pulmonary arterial hypertension
10.1183/13993003.02334-2021 · ExternalCitation · doi-reference
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
10.1183/13993003.03957-2020 · ExternalCitation · doi-reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · ExternalCitation · doi-reference
Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension
10.1186/s12890-022-01939-7 · ExternalCitation · doi-reference
Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment
10.1186/s12964-019-0478-4 · ExternalCitation · doi-reference
Evaluation and management of pulmonary arterial hypertension in congenital heart disease
10.14797/ufej2329 · ExternalCitation · doi-reference
Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension
10.1540/jsmr.58.50 · ExternalCitation · doi-reference
Regularization paths for generalized linear models via coordinate descent
10.18637/jss.v033.i01 · ExternalCitation · doi-reference
A lifelike guided journey through the pathophysiology of pulmonary hypertension-from measured metabolites to the mechanism of action of drugs
10.3389/fcvm.2024.1341145 · ExternalCitation · doi-reference
Autoimmunity to Sphingosine-1-Phosphate-Receptors in systemic sclerosis and pulmonary arterial hypertension
10.3389/fimmu.2022.935787 · ExternalCitation · doi-reference
Potassium channels as therapeutic targets in pulmonary arterial hypertension
10.3390/biom12101341 · ExternalCitation · doi-reference
The roles of proton-sensing G-Protein-Coupled receptors in inflammation and cancer
10.3390/genes15091151 · ExternalCitation · doi-reference
Calcium-sensing receptor (CaSR), its impact on inflammation and the consequences on cardiovascular health
10.3390/ijms22052478 · ExternalCitation · doi-reference
Medically important alterations in transport function and trafficking of ABCG2
10.3390/ijms22062786 · ExternalCitation · doi-reference
Ion channels and transporters in muscle cell differentiation
10.3390/ijms222413615 · ExternalCitation · doi-reference
New drugs and therapies in pulmonary arterial hypertension
10.3390/ijms24065850 · ExternalCitation · doi-reference
Echocardiography in pulmonary arterial hypertension: comprehensive evaluation and technical considerations
10.3390/jcm10153229 · ExternalCitation · doi-reference
