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References from Mechanisms of acquired resistance to osimertinib in EGFR T790M-Positive lung adenocarcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
10.1073/pnas.0710370104 · 2007 · External reference
The role of early changes in routine coagulation tests in predicting the occurrence and prognosis of sepsis
10.5847/wjem.j.1920-8642.2025.036 · 2025 · External reference
Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
10.1038/ncomms11815 · 2016 · External reference
Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer
10.1038/s41467-023-35961-y · 2023 · External reference
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
10.1158/2159-8290.cd-14-0337 · 2014 · External reference
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
10.1126/science.1141478 · 2007 · External reference
Non-Small cell lung cancer, version 3.2022, NCCN Clinical Practice Guidelines in oncology
10.6004/jnccn.2022.0025 · 2022 · External reference
Exon 16-skipping HER2 as a novel mechanism of osimertinib resistance in EGFR L858R/T790M-positive non-small cell lung cancer
10.1016/j.jtho.2019.09.006 · 2020 · External reference
Performance of a novel medical artificial intelligence large language model on supporting decision-making for emergency patients with suspected sepsis
10.5847/wjem.j.1920-8642.2025.095 · 2025 · External reference
EGFR-mutant adenocarcinomas that transform to small cell lung cancer and other neuroendocrine carcinomas: clinical outcomes
10.1200/jco.18.01585 · 2019 · External reference
EGFR mutation incidence in non-small cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII)
2015 · External reference
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
10.1056/nejmoa0810699 · 2009 · External reference
Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer
10.1056/nejmoa1612674 · 2017 · External reference
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small cell lung cancer
10.1038/ncomms7377 · 2015 · External reference
Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes
10.1016/j.jtho.2019.06.002 · 2019 · External reference
Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation
10.1158/1078-0432.ccr-10-2692 · 2011 · External reference
Assessment of resistance mechanisms and clinical implications in patients with EGFR T790M-positive lung cancer and acquired resistance to osimertinib
10.1001/jamaoncol.2018.2969 · 2018 · External reference
Osimertinib versus platinum-pemetrexed for patients with EGFR T790M advanced NSCLC and progression on a prior EGFR-tyrosine kinase inhibitor: AURA3 overall survival analysis
10.1016/j.annonc.2020.08.2100 · 2020 · External reference
Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial
10.1016/s1470-2045(16)30033-x · 2016 · External reference
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial
10.1016/s1470-2045(16)30146-2 · 2016 · External reference
Mechanisms of acquired resistance to first-line osimertinib: preliminary data from the phase III FLAURA study
10.1093/annonc/mdy424.063 · 2018 · External reference
Overall survival with osimertinib in untreated, EGFR-mutated advanced NSCLC (FLAURA)
10.1056/nejmoa1913662 · 2020 · External reference
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
10.1126/scitranslmed.3002003 · 2011 · External reference
A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small cell lung cancer of adenocarcinoma histology (PIONEER)
10.1097/jto.0000000000000033 · 2014 · External reference
Osimertinib in untreated EGFR-mutated advanced non-small cell lung cancer
10.1056/nejmoa1713137 · 2018 · External reference
Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21660 · 2021 · External reference
HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
10.1158/2159-8290.cd-12-0108 · 2012 · External reference
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
10.1038/nm.3854 · 2015 · External reference
Phase Ib/II study of capmatinib (INC280) plus gefitinib after failure of epidermal growth factor receptor (EGFR) inhibitor therapy in patients with EGFR-mutated, MET factor-dysregulated non-small cell lung cancer
10.1200/jco.2018.77.7326 · 2018 · External reference
Analysis of tumor specimens at the time of acquired resistance to EGFR TKI therapy in 155 patients with EGFR-mutant lung cancers
10.1158/1078-0432.ccr-12-2246 · 2013 · External reference
Concurrent alterations in EGFR-mutant lung cancers associated with resistance to EGFR kinase inhibitors and characterization of mTOR as a mediator of resistance
10.1158/1078-0432.ccr-17-2961 · 2018 · External reference
The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis
10.18632/oncotarget.12587 · 2016 · External reference
A predictive model for intracranial hemorrhage in adult patients receiving extracorporeal membrane oxygenation
10.5847/wjem.j.1920-8642.2025.037 · 2025 · External reference