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References from Multi-omics integration reveals macrophage polarization and ferroptosis as key mechanisms underlying kaempferol’s therapeutic efficacy in peripheral artery disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Lifetime risk of lower extremity peripheral arterial disease: a Danish nationwide longitudinal study
10.1093/eurheartj/ehae867 · 2025 · External reference
Trends in peripheral artery disease, lower-extremity revascularization, and lower-extremity amputation in incident type 2 diabetes: a Danish population-based cohort study
10.2337/dc24-1644 · 2025 · External reference
Biomaterial-based vascularization strategies for enhanced treatment of peripheral arterial disease
10.1186/s12951-025-03140-4 · 2025 · External reference
Sex differences in peripheral vascular disease: a scientific statement from the American Heart Association
10.1161/cir.0000000000001310 · 2025 · External reference
Unilateral hindlimb ischaemia-induced systemic inflammation is associated with non-ischaemic skeletal muscle inflammation
10.1113/ep091901 · 2024 · External reference
FGF23 as a potential pathophysiological factor in peripheral arterial disease associated with chronic kidney disease
10.3390/ijms25105457 · 2024 · External reference
Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction
10.1186/s40360-025-00908-0 · 2025 · External reference
Kaempferol: unveiling its anti-inflammatory properties for therapeutic innovation
10.1016/j.cyto.2024.156846 · 2025 · External reference
Integrative transcriptome-proteome approach reveals key hypoxia-related features involved in the neuroprotective effects of Yang Xue oral liquid on Alzheimer's and Parkinson's disease
10.3389/fphar.2024.1411273 · 2024 · External reference
Myeloid DRP1 deficiency limits revascularization in ischemic muscles via inflammatory macrophage polarization and metabolic reprogramming
10.1172/jci.insight.177334 · 2025 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine
10.1093/nar/gkae1037 · 2025 · External reference
NetInfer: a web server for prediction of targets and therapeutic and adverse effects via network-based inference methods
10.1021/acs.jcim.0c00291 · 2020 · External reference
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis
10.1093/nar/gkz240 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations
10.1093/nar/gkac935 · 2023 · External reference
Kaempferol regulating macrophage foaming and atherosclerosis through Piezo1-mediated MAPK/NF-kappaB and Nrf2/HO-1 signaling pathway
10.1016/j.jare.2024.11.016 · 2024 · External reference
CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting
10.1093/nar/gkac394 · 2022 · External reference
Identification of potential inhibitors for LLM of Staphylococcus aureus: structure-based pharmacophore modeling, molecular dynamics, and binding free energy studies
10.1080/07391102.2021.1936179 · 2022 · External reference
Structural-based virtual screening and identification of novel potent antimicrobial compounds against YsxC of Staphylococcus aureus
10.1016/j.molstruc.2022.132476 · 2022 · External reference
Exploring the therapeutic potential of beetroot juice in patients with peripheral artery disease: a narrative review
10.1016/j.niox.2025.03.003 · 2025 · External reference
The incidence and significance of delayed bleeding events after lower extremity revascularization in patients with advanced peripheral arterial disease
10.1016/j.jvs.2025.03.394 · 2025 · External reference
Epidemiology of peripheral artery disease
10.1016/b978-1-4377-2930-6.00016-1 · 2015 · External reference
Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells
10.1186/s13073-023-01250-y · 2023 · External reference
LncRNA HMGA1P4 promotes cisplatin-resistance in gastric cancer
10.26355/eurrev_202009_22822 · 2020 · External reference
Identification of functional lncRNAs in gastric cancer by integrative analysis of GEO and TCGA data
10.1002/jcb.29058 · 2019 · External reference
MARCKS signaling differentially regulates vascular smooth muscle and endothelial cell proliferation through a KIS-, p27kip1- dependent mechanism
10.1371/journal.pone.0141397 · 2015 · External reference
The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells
10.1074/jbc.m110.196022 · 2011 · External reference
MYOC promotes the differentiation of C2C12 cells by regulation of the TGF-beta signaling pathways via CAV1
10.3390/biology10070686 · 2021 · External reference
Kaempferol and atherosclerosis: from mechanism to medicine
10.1080/10408398.2022.2121261 · 2024 · External reference
Activation of HSPA5 contributes to pazopanib-induced hepatotoxicity through l-ornithine metabolism pathway and endoplasmic reticulum stress
10.1093/jpp/rgae130 · 2025 · External reference
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection
10.1016/j.metabol.2019.153954 · 2019 · External reference
Beyond cholesterol: emerging risk factors in atherosclerosis
10.3390/jcm14072352 · 2025 · External reference
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway
10.1186/s12944-024-02049-5 · 2024 · External reference
Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IkappaBalpha and PPARgamma
10.1007/s10565-024-09973-3 · 2025 · External reference
Is the suppression of CD36 a promising way for atherosclerosis therapy
10.1016/j.bcp.2023.115965 · 2024 · External reference
Macrophage polarisation and inflammatory mechanisms in atherosclerosis: implications for prevention and treatment
10.1016/j.heliyon.2024.e32073 · 2024 · External reference
Micro- and macrovascular effects of inflammation in peripheral artery disease-pathophysiology and translational therapeutic approaches
10.3390/biomedicines11082284 · 2023 · External reference
Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral artery disease in vivo
10.1016/j.clim.2018.06.006 · 2018 · External reference
Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice
10.1016/j.molmet.2024.102092 · 2025 · External reference
Update on the pathophysiology and medical treatment of peripheral artery disease
10.1038/s41569-021-00663-9 · 2022 · External reference
Paclitaxel-coated balloon for the treatment of multilayer in-stent restenosis: AGENT IDE subgroup analysis
10.1016/j.jacc.2025.05.062 · 2025 · External reference
Effects of a diet rich in polyphenols on lipid metabolism: an updated narrative review
10.4103/hm.hm-d-24-00106 · 2025 · External reference
CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis
10.1038/s41467-023-40824-7 · 2023 · External reference
Spleen tyrosine kinase: a novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failure
10.3389/fimmu.2024.1447901 · 2024 · External reference
Inhibition of PARP1 improves cardiac function after myocardial infarction via up-regulated NLRC5
10.1016/j.cbi.2024.111010 · 2024 · External reference
