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References from Targeting bromodomain and extra-terminal proteins reprograms macrophages and inhibits breast cancer progression. Local targets link to admitted publications; unresolved targets remain external evidence.
Breast cancer-epidemiology, risk factors, classification, prognostic markers, and current treatment strategies-an updated review
10.3390/cancers13174287 · 2021 · External reference
Breast cancer: biology, biomarkers, and treatments
10.1016/j.intimp.2020.106535 · 2020 · External reference
Immunotherapy in triple-negative breast cancer: insights into tumor immune landscape and therapeutic opportunities
10.3389/fmolb.2022.903065 · 2022 · External reference
Macrophages and cancer stem cells: a malevolent alliance
10.1186/s10020-021-00383-3 · 2021 · External reference
Characterization of immunogenicity of Malignant cells with stemness in intrahepatic cholangiocarcinoma by single-cell RNA sequencing
10.1155/2022/3558200 · 2022 · External reference
Prospective identification of tumorigenic breast cancer cells
10.1073/pnas.0530291100 · 2003 · External reference
BET proteins as attractive targets for cancer therapeutics
10.3390/ijms222011102 · 2021 · External reference
An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells
10.1038/s41598-019-53915-7 · 2019 · External reference
The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling
10.1186/s13058-023-01715-3 · 2023 · External reference
The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer
10.1038/onc.2016.184 · 2017 · External reference
Adaptive immune resistance emerges from tumor-initiating stem cells
10.1016/j.cell.2019.03.025 · 2019 · External reference
JQ1, an inhibitor of the epigenetic reader BRD4, suppresses the bidirectional MYC-AP4 axis via multiple mechanisms
10.3892/or.2015.4410 · 2016 · External reference
Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay
10.1186/s13045-016-0362-2 · 2016 · External reference
Targeting CCR2(+) macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer
10.1007/s00432-021-03885-z · 2022 · External reference
Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of Malignant tumors
10.1039/d1bm00724f · 2021 · External reference
Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression
10.1021/acs.jmedchem.6b01816 · 2018 · External reference
BET degrader inhibits tumor progression and stem-like cell growth via Wnt/beta-catenin signaling repression in glioma cells
10.1038/s41419-020-03117-1 · 2020 · External reference
Tumor-associated macrophages: key players in triple-negative breast cancer
10.3389/fonc.2022.772615 · 2022 · External reference
Author correction: hepatic stellate cells suppress NK cell-sustained breast cancer dormancy
10.1038/s41586-021-04104-y · 2021 · External reference
Natural killer cell regulation of breast cancer stem cells mediates metastatic dormancy
10.1158/0008-5472.can-24-0030 · 2024 · External reference
Macrophage polarization
10.1146/annurev-physiol-022516-034339 · 2017 · External reference
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
10.1038/s41392-025-02124-y · 2025 · External reference
Macrophage diversity in human cancers: new insight provided by single-cell resolution and spatial context
10.1016/j.heliyon.2024.e28332 · 2024 · External reference
Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer
10.1186/s13058-024-01887-6 · 2024 · External reference
Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages
10.21203/rs.3.rs-3229780/v1 · 2026 · External reference
A CTL/M2 macrophage-related four-gene signature predicting metastasis-free survival in triple-negative breast cancer treated with adjuvant radiotherapy
10.21203/rs.3.rs-527123/v1 · 2021 · External reference
MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer
10.1186/s12943-019-0988-0 · 2019 · External reference
Macrophages as regulators of tumour immunity and immunotherapy
10.1038/s41577-019-0127-6 · 2019 · External reference
Targeting tumor-associated macrophages: critical players in tumor progression and therapeutic strategies (review)
10.3892/ijo.2024.5648 · 2024 · External reference
M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide
10.1186/s12885-015-1546-9 · 2015 · External reference
Isolation, culture, and polarization of murine bone marrow-derived and peritoneal macrophages
10.1007/978-1-4939-2929-0_6 · 2015 · External reference
Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages
10.1038/s41420-020-00300-3 · 2020 · External reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · 2015 · External reference
Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior
10.1038/s12276-023-01115-9 · 2023 · External reference
The development and improvement of immunodeficient mice and humanized immune system mouse models
10.3389/fimmu.2022.1007579 · 2022 · External reference
Tumor progression and metastasis in murine D2 hyperplastic alveolar nodule mammary tumor cell lines
10.1007/bf00880071 · 1993 · External reference
MMP-9 secreted by tumor associated macrophages promoted gastric cancer metastasis through a PI3K/AKT/Snail pathway
10.1016/j.biopha.2019.109096 · 2019 · External reference
Tumor-associated macrophage clusters linked to immunotherapy in a pan-cancer census
10.1038/s41698-024-00660-4 · 2024 · External reference
Cancer stem cells and immunoresistance: clinical implications and solutions
10.3978/j.issn.2218-6751.2015.12.11 · 2015 · External reference
Elements of cancer immunity and the cancer-immune set point
10.1038/nature21349 · 2017 · External reference
Understanding the tumor immune microenvironment (TIME) for effective therapy
10.1038/s41591-018-0014-x · 2018 · External reference
BET inhibitors drive natural killer activation in non-small cell lung cancer via BRD4 and SMAD3
10.1038/s41467-024-46778-8 · 2024 · External reference
BRD4 inhibition by AZD5153 promotes antitumor immunity via depolarizing M2 macrophages
10.3389/fimmu.2020.00089 · 2020 · External reference
Anatomy of a discovery: m1 and m2 macrophages
10.3389/fimmu.2015.00212 · 2015 · External reference
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
10.1038/s41422-020-0355-0 · 2020 · External reference
Tumor-associated macrophage subtypes on cancer immunity along with prognostic analysis and SPP1-mediated interactions between tumor cells and macrophages
10.1371/journal.pgen.1011235 · 2024 · External reference
CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production
10.1038/s41598-019-51149-1 · 2019 · External reference
CD74 facilitates immunotherapy response by shaping the tumor microenvironment of hepatocellular carcinoma
10.1186/s10020-024-00884-x · 2024 · External reference
Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
10.1016/j.cell.2020.03.048 · 2020 · External reference
Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer
10.1016/j.celrep.2022.110865 · 2022 · External reference
Single-cell and spatial transcriptomics reveal a tumor-associated macrophage subpopulation that mediates prostate cancer progression and metastasis
10.1158/1541-7786.mcr-24-0791 · 2025 · External reference
Distinct migratory properties of M1, M2, and resident macrophages are regulated by alpha(D)beta(2) and alpha(M)beta(2) integrin-mediated adhesion
10.3389/fimmu.2018.02650 · 2018 · External reference
PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6
10.1186/s12865-023-00593-w · 2024 · External reference
GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy
10.3389/fimmu.2023.1127612 · 2023 · External reference
Fibrinogen-like protein 2 promotes proinflammatory macrophage polarization and mitochondrial dysfunction in liver fibrosis
10.1016/j.intimp.2022.109631 · 2023 · External reference
Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche
10.1038/s41467-025-56347-2 · 2025 · External reference
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
10.1038/s41467-020-15129-8 · 2020 · External reference
Fcgamma receptors as regulators of immune responses
10.1038/nri2206 · 2008 · External reference
Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review
10.1136/jitc-2020-001408 · 2020 · External reference
VEGFA/NRP-1/GAPVD1 axis promotes progression and cancer stemness of triple-negative breast cancer by enhancing tumor cell-macrophage crosstalk
10.7150/ijbs.86085 · 2024 · External reference
