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References from Minocycline ameliorates CNS autoimmunity through restraint of CD4+CD11bc+ cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Minocycline for the management of multiple sclerosis: repositioning potential, opportunities, and challenges
10.1080/14737175.2020.1838276 · 2021 · External reference
Inhibition of autoimmune encephalomyelitis by a tetracycline
10.1002/ana.10092 · 2002 · External reference
Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: application to drug discovery
10.1002/jnr.21389 · 2007 · External reference
High salt diet intake promotes the induction of experimental autoimmune encephalomyelitis by exacerbating neutrophil infiltration and microglial activation
10.1016/j.ejphar.2025.177982 · 2025 · External reference
Minocycline inhibits LPS-induced retinal microglia activation
10.1016/j.neuint.2005.04.018 · 2005 · External reference
Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition
10.1016/j.bbagen.2012.01.011 · 2012 · External reference
Anti-inflammatory effects of minocycline are mediated by retinoid signaling
10.1186/s12868-018-0460-x · 2018 · External reference
Cypermethrin induces the activation of rat primary microglia and expression of inflammatory proteins
10.1007/s12031-020-01753-y · 2021 · External reference
Central nervous system macrophages in health and disease
10.1146/annurev-immunol-082423-041334 · 2025 · External reference
Immunology of multiple sclerosis
10.1055/s-0036-1579739 · 2016 · External reference
Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus
10.1016/j.brainresbull.2021.05.028 · 2021 · External reference
Minocycline ameliorates chronic unpredictable mild stress-induced neuroinflammation and abnormal mPFC-HIPP oscillations in mice
10.1007/s12035-022-03018-8 · 2022 · External reference
Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy
10.1038/srep34228 · 2016 · External reference
Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2
10.3892/ijmm.2017.2908 · 2017 · External reference
CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model
10.1016/j.jneuroim.2009.01.026 · 2009 · External reference
Characterization of CD8-positive macrophages infiltrating the central nervous system of rats with chronic autoimmune encephalomyelitis
10.1002/jnr.21924 · 2009 · External reference
CD8+ phagocyte recruitment in rat experimental autoimmune encephalomyelitis: association with inflammatory tissue destruction
10.1016/s0002-9440(10)63508-0 · 2003 · External reference
Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies
10.1016/j.jneuroim.2021.577547 · 2021 · External reference
Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity
10.1186/s12974-024-03017-7 · 2024 · External reference
Anti-neuroinflammatory effects of a novel bile acid derivative
10.3390/ijms25137136 · 2024 · External reference
A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate
10.4049/jimmunol.1402302 · 2015 · External reference
Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord
10.1016/j.jneuroim.2009.11.009 · 2010 · External reference
Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases
10.1111/neup.12039 · 2013 · External reference
Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis
10.1093/brain/awf133 · 2002 · External reference
Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis
10.1016/j.ejphar.2012.04.043 · 2012 · External reference
Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis
10.1111/j.1471-4159.2008.05238.x · 2008 · External reference
Minocycline attenuates neonatal germinal-matrix-hemorrhage-induced neuroinflammation and brain edema by activating cannabinoid receptor 2
10.1007/s12035-015-9154-x · 2016 · External reference
Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota
10.1186/s12974-021-02123-0 · 2021 · External reference
The lung microbiome regulates brain autoimmunity
10.1038/s41586-022-04427-4 · 2022 · External reference
Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs
10.1128/aac.8.6.713 · 1975 · External reference
Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity
10.3389/fmed.2022.1033980 · 2022 · External reference
Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo
10.1111/j.1471-4159.2005.03503.x · 2005 · External reference
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration
10.1016/j.exer.2022.108953 · 2022 · External reference
Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury
10.1007/s00011-024-01927-z · 2024 · External reference
INPP5D upregulation by minocycline mitigates sepsis-associated neuroinflammation and neuronal dysfunction via microglial autophagy and antioxidant pathways
10.1007/s10753-025-02413-2 · 2026 · External reference
Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
10.1074/jbc.m611907200 · 2007 · External reference
Proteomic analysis of the anti-inflammatory action of minocycline
10.1002/pmic.201000273 · 2011 · External reference
Minocycline modulates cytokine and chemokine production in lipopolysaccharide-stimulated THP-1 monocytic cells by inhibiting IκB kinase α/β phosphorylation
10.1016/j.trsl.2012.10.001 · 2013 · External reference
Minocycline hydrochloride nanoliposomes inhibit the production of TNF-α in LPS-stimulated macrophages
10.2147/ijn.s34036 · 2012 · External reference
Infiltrating macrophages are key to the development of seizures following virus infection
10.1128/jvi.02747-12 · 2013 · External reference
Multiple sclerosis: molecular mechanisms and therapeutic opportunities
10.1089/ars.2012.5068 · 2013 · External reference
Distinct role of nitric oxide and peroxynitrite in mediating oligodendrocyte toxicity in culture and in experimental autoimmune encephalomyelitis
10.1016/j.neuroscience.2011.04.007 · 2011 · External reference
Peroxynitrite reduces Treg cell expansion and function by mediating IL-2R nitration and aggravates multiple sclerosis pathogenesis
10.1016/j.redox.2024.103240 · 2024 · External reference
Minocycline-preconditioned neural stem cells enhance neuroprotection after ischemic stroke in rats
10.1523/jneurosci.5686-11.2012 · 2012 · External reference
Impact of minocycline on extracellular matrix metalloproteinase inducer, a factor implicated in multiple sclerosis immunopathogenesis
10.4049/jimmunol.1600436 · 2016 · External reference