Research graph
References from FBXO11 and FBXO32 synergistically activate innate immunity against hepatitis B virus in a NEDD8-dependent manner. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of hepatitis B virus: current status, missed opportunities and a call for action
10.1038/s41575-023-00760-9 · 2023 · External reference
Overview of new targets for hepatitis B virus: immune modulators, interferons, bifunctional peptides, therapeutic vaccines and beyond
10.1016/j.cld.2023.05.003 · 2023 · External reference
Hepatocellular Carcinoma
10.1016/j.cnc.2022.04.004 · 2022 · External reference
Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity
10.3389/fcimb.2023.1206720 · 2023 · External reference
Author Correction: Therapeutic strategies for hepatitis B virus infection: towards a cure
10.1038/s41573-019-0057-9 · 2020 · External reference
Pattern recognition receptors and inflammation
10.1016/j.cell.2010.01.022 · 2010 · External reference
Pattern recognition receptors in health and diseases
10.1038/s41392-021-00687-0 · 2021 · External reference
Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway
10.1007/s00018-020-03671-z · 2021 · External reference
Recent advances in different interactions between toll-like receptors and hepatitis B infection: a review
10.3389/fimmu.2024.1363996 · 2024 · External reference
Perspectives on TLR2 agonist use in the road map to HBV cure
10.1016/j.antiviral.2026.106447 · 2026 · External reference
The crucial roles and research advances of cGAS-STING pathway in liver diseases
10.1080/07853890.2024.2394588 · 2024 · External reference
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3
10.1016/j.cell.2005.08.012 · 2005 · External reference
MAVS: The next STING in cancers and other diseases
10.1016/j.critrevonc.2024.104610 · 2025 · External reference
TBK1, a central kinase in innate immune sensing of nucleic acids and beyond
10.1093/abbs/gmaa051 · 2020 · External reference
Regulation of IRF3 activation in human antiviral signaling pathways
10.1016/j.bcp.2022.115026 · 2022 · External reference
Expanding TRAF function: TRAF3 as a tri-faced immune regulator
10.1038/nri2998 · 2011 · External reference
The roles of TRAF3 in immune responses
10.1155/2023/7787803 · 2023 · External reference
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
10.1038/nature04374 · 2006 · External reference
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
10.1038/nature04369 · 2006 · External reference
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination
10.1084/jem.20192083 · 2020 · External reference
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
10.1038/s41467-021-21456-1 · 2021 · External reference
TBK1 associates with TRIF and TRAF3 related IRF3, IRF7, and type I IFN signaling in large yellow croaker Larimichthys crocea
10.1016/j.fsi.2026.111522 · 2026 · External reference
The ubiquitin code
10.1146/annurev-biochem-060310-170328 · 2012 · External reference
HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathways
10.1016/j.cellin.2025.100294 · 2025 · External reference
10.1371/journal.pone.0307776 · 2024 · Admitted local publication
F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects
10.7150/thno.42735 · 2020 · External reference
FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3-TBK1-IRF3 complex
10.1002/jmv.28655 · 2023 · External reference
Identification of ubiquitin ligases required for skeletal muscle atrophy
10.1126/science.1065874 · 2001 · External reference
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
10.1016/s0092-8674(04)00400-3 · 2004 · External reference
Correction: Zebrafish F-box protein fbxo3 negatively regulates antiviral response through promoting K27-linked polyubiquitination of the transcription factors irf3 and irf7
10.4049/jimmunol.2100441 · 2021 · External reference
Effects of neddylation on viral infection: an overview
10.1007/s00705-023-05930-3 · 2023 · External reference
Blocking neddylation elicits antiviral effect against hepatitis B virus replication
10.1007/s11033-021-06886-w · 2022 · External reference
Nedd8-activating enzyme is a druggable host dependency factor of human and mouse cytomegalovirus
10.3390/v13081610 · 2021 · External reference
Foxo3 knockdown mediates decline of myod1 and myog reducing myoblast conversion to myotubes
10.3390/cells12172167 · 2023 · External reference
MiR-126-5p derived from bone marrow mesenchymal stem cell exosomes promotes skeletal muscle regeneration by regulating FBXO32/MyoD signaling
10.1111/apha.70114 · 2025 · External reference
E3 Ubiquitin Ligase FBXO32 Promotes LPS-Induced Cardiac Injury by Regulating ANXA1/PI3K/AKT Signaling
10.1007/s10753-025-02273-w · 2025 · External reference
METTL3/YTHDF1 drives M1 macrophage polarization and aggravates ulcerative colitis progression by regulating m6A modification of SerpinB5 mRNA and FBXO32-dependent NF-κB pathway
10.1007/s00535-025-02341-w · 2026 · External reference
HBV promotes its replication by up-regulating RAD51C gene expression
10.1038/s41598-024-53047-7 · 2024 · External reference
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages
10.1186/s13020-024-00888-z · 2024 · External reference
Unravelling the broader complexity of IL 6 involvement in health and disease
10.1016/j.cyto.2021.155684 · 2021 · External reference
Interleukin 6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach
10.1016/j.intimp.2022.109130 · 2022 · External reference