Research graph
References from Tonsillar Tfh cells contribute to the pathogenesis of IgA nephropathy in collaboration with memory B cells. Local targets link to admitted publications; unresolved targets remain external evidence.
IgA nephropathy
10.1038/s41572-023-00476-9 · 2023 · External reference
The pathogenesis of IgA nephropathy and implications for treatment
10.1038/s41581-024-00885-3 · 2025 · External reference
Executive summary of the KDIGO 2021 guideline for the management of glomerular diseases
10.1016/j.kint.2021.05.015 · 2021 · External reference
Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy
10.1046/j.1523-1755.2001.0590031077.x · 2001 · External reference
Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region
10.1016/j.carres.2010.07.022 · 2010 · External reference
Glomerular immunodeposits of patients with IgA Nephropathy are enriched for IgG autoantibodies specific for galactose-deficient IgA1
10.1681/asn.2018111156 · 2019 · External reference
Identification and characterization of circulating immune complexes in IgA nephropathy
10.1126/sciadv.abm8783 · 2022 · External reference
A phase 2 trial of sibeprenlimab in patients with IgA nephropathy
10.1056/nejmoa2305635 · 2024 · External reference
The selective endothelin receptor antagonist SC0062 in IgA nephropathy: a randomized double-blind placebo-controlled clinical trial
10.1681/asn.0000000538 · 2025 · External reference
Long-term results from an open-label extension study of atacicept for the treatment of IgA nephropathy
10.1681/asn.0000000541 · 2025 · External reference
Alternative complement pathway inhibition with iptacopan in IgA nephropathy
10.1056/nejmoa2410316 · 2025 · External reference
Normal structure, function, and histology of mucosa-associated lymphoid tissue
10.1080/01926230600865531 · 2006 · External reference
Function of mucosa-associated lymphoid tissue in antibody formation
10.3109/08820131003680369 · 2010 · External reference
Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy
10.1111/j.1523-1755.2004.00486.x · 2004 · External reference
A comparison of the clinical efficacy of tonsillectomy with steroid pulse therapy and tonsillectomy therapy alone for patients with immunoglobulin A nephropathy: a retrospective observational study
10.1007/s10157-024-02527-1 · 2024 · External reference
Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial
10.1016/s0140-6736(23)01554-4 · 2023 · External reference
Therapy of IgA nephropathy: time for a paradigm change
10.3389/fmed.2024.1461879 · 2024 · External reference
Association between galactose-deficient IgA1 derived from the tonsils and recurrence of IgA nephropathy in patients who underwent kidney transplantation
10.3389/fimmu.2020.02068 · 2020 · External reference
A higher frequency of CD4+CXCR5+ T follicular helper cells in patients with newly diagnosed IgA nephropathy
10.1016/j.imlet.2013.12.004 · 2014 · External reference
T cells in IgA nephropathy: role in pathogenesis, clinical significance and potential therapeutic target
10.1007/s10157-018-1665-0 · 2019 · External reference
Increased proportion of follicular helper T cells is associated with B cell activation and disease severity in IgA nephropathy
10.3389/fimmu.2022.901465 · 2022 · External reference
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers
10.1073/pnas.1100898108 · 2011 · External reference
Affinity maturation of antibody responses is mediated by differential plasma cell proliferation
10.1126/science.adr6896 · 2025 · External reference
Revised equations for estimated GFR from serum creatinine in Japan
10.1053/j.ajkd.2008.12.034 · 2009 · External reference
An atlas of cells in the human tonsil
10.1016/j.immuni.2024.01.006 · 2024 · External reference
Human extrafollicular CD4+ Th cells help memory B cells produce Igs
10.4049/jimmunol.1701217 · 2018 · External reference
The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes
10.1084/jem.20190301 · 2019 · External reference
Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
10.1016/j.immuni.2011.01.009 · 2011 · External reference
Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells
10.1073/pnas.1404671111 · 2014 · External reference
Long-term outcomes in IgA nephropathy
10.2215/cjn.0000000000000135 · 2023 · External reference
Challenges and opportunities for consistent classification of human B cell and plasma cell populations
10.3389/fimmu.2019.02458 · 2019 · External reference
Implication of TIGIT+ human memory B cells in immune regulation
10.1038/s41467-021-21413-y · 2021 · External reference
Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection
10.3389/fimmu.2023.1213344 · 2023 · External reference
IgD-CD27- double-negative (DN) B cells: origins and functions in health and disease
10.1016/j.imlet.2023.03.003 · 2023 · External reference
Clinical manifestations and pathogenesis of tonsillar focal diseases: IgA nephropathy and palmoplantar pustulosis
10.1159/000324583 · 2011 · External reference
CEACAM6 as a machine learning-derived immune biomarker for predicting neoadjuvant chemotherapy response in HR+/HER2- breast cancer
10.3389/fimmu.2025.1662004 · 2025 · External reference
Patients with immunoglobulin A nephropathy show abnormal frequencies of B cell subsets, unconventional T cells, and high levels of galactose-deficient IgA1–coated gut bacteria
10.1016/j.ekir.2024.11.007 · 2024 · External reference
Bcl6-expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
10.4049/jimmunol.1202963 · 2013 · External reference
Human T follicular helper clones seed the germinal center-resident regulatory pool
10.1126/sciimmunol.ade8162 · 2023 · External reference
Diagnostic and prognostic value of galactose-deficient IgA1 in patients with IgA nephropathy: an updated systematic review with meta-analysis
10.3389/fimmu.2023.1209394 · 2023 · External reference
Memory B cells and plasma cells: the differentiative continuum of humoral immunity
10.1111/imr.13016 · 2021 · External reference
Memory B cells
10.1038/s41577-023-00897-3 · 2024 · External reference
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory
10.1126/sciimmunol.abm2084 · 2022 · External reference
A guide to adaptive immune memory
10.1038/s41577-024-01040-6 · 2024 · External reference
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
10.1146/annurev-immunol-103019-085803 · 2020 · External reference
Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases
10.1016/j.xgen.2023.100473 · 2024 · External reference
Identifying potential biomarkers for the diagnosis and treatment of IgA nephropathy based on bioinformatics analysis
10.1186/s12920-023-01494-y · 2023 · External reference
Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions
10.1073/pnas.1416276112 · 2015 · External reference
