Research graph
References from Exploring type 2 inflammation and disease complexity: perspectives of a clinical immunologist. Local targets link to admitted publications; unresolved targets remain external evidence.
Type 2 inflammation in asthma and other airway diseases
10.1183/23120541.00576-2021 · 2022 · External reference
The role of airway epithelial cell alarmins in asthma
10.3390/cells11071105 · 2022 · External reference
Role of thymic stromal lymphopoietin in allergy and beyond
10.1038/s41577-022-00735-y · 2023 · External reference
The biology of thymic stromal lymphopoietin (TSLP)
10.1016/b978-0-12-404717-4.00004-4 · 2013 · External reference
Revaccination of adults against diphtheria. I: Responses and reactions to different doses of diphtheria toxoid in 30-70-year-old persons with low serum antitoxin levels
10.1111/j.1699-0463.1986.tb02114.x · 1986 · External reference
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
10.1038/ni1247 · 2005 · External reference
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
10.1084/jem.20051135 · 2005 · External reference
TSLP enhances the function of helper type 2 cells
10.1002/eji.201041195 · 2011 · External reference
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development
10.1038/ni1452 · 2007 · External reference
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
10.4049/jimmunol.190.supp.114.21 · 2013 · External reference
Innate type 2 cells and asthma
10.1016/j.coph.2012.06.001 · 2012 · External reference
TSLP shapes the pathogenic responses of memory CD4(+) T cells in eosinophilic esophagitis
10.1126/scisignal.adg6360 · 2023 · External reference
Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics
10.1183/13993003.00260-2020 · 2020 · External reference
Hypoxia induces the production of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis with nasal polyps
10.1016/j.intimp.2023.110559 · 2023 · External reference
FDA approves first-in-class TSLP-targeted antibody for severe asthma
10.1038/d41573-022-00013-5 · 2022 · External reference
Anti-cytokine biologics for asthma in adults
10.1016/s0140-6736(25)01625-3 · 2025 · External reference
Efficacy of Tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials
10.1164/rccm.202210-2005oc · 2023 · External reference
Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes
10.1016/j.jdermsci.2012.03.007 · 2012 · External reference
Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis
10.1016/j.jaci.2024.10.031 · 2024 · External reference
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
10.1038/ni805 · 2002 · External reference
Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells
10.1165/rcmb.2008-0041oc · 2009 · External reference
The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide
10.1038/mi.2014.41 · 2015 · External reference
Epithelial cell-derived cytokines: more than just signaling the alarm
10.1172/jci124606 · 2019 · External reference
Thymic stromal lymphopoietin (TSLP), its isoforms and the interplay with the epithelium in allergy and asthma
10.3390/ijms241612725 · 2023 · External reference
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin
10.21203/rs.3.rs-628045/v1 · 2022 · External reference
Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin
10.1016/j.jaci.2015.04.011 · 2015 · External reference
Thymic stromal lymphopoietin: To cut a long story short
10.1016/j.jcmgh.2017.01.005 · 2017 · External reference
Tezepelumab in adults and adolescents with severe, uncontrolled asthma
10.1056/nejmoa2034975 · 2021 · External reference
Cytokine antibody array-based analysis of IL-37 treatment effects in asthma
10.18632/aging.203515 · 2021 · External reference
Skewed inflammation is associated with aberrant interleukin-37 signaling pathway in atopic dermatitis
10.1111/all.14769 · 2021 · External reference
Allergic-like disorders and asthma in patients with common variable immunodeficiency: a multi-center experience
10.1080/02770903.2020.1862185 · 2022 · External reference
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation
10.1038/ncomms3675 · 2013 · External reference
Context-dependent function of TSLP and IL-1beta in skin allergic sensitization and atopic march
10.1038/s41467-022-32196-1 · 2022 · External reference
IL-1beta enhances inflammatory TH2 differentiation
10.1016/j.jaci.2016.02.033 · 2016 · External reference
The interleukin-1 family: back to the future
10.1016/j.immuni.2013.11.010 · 2013 · External reference
IL-33 exacerbates antigen-induced arthritis by activating mast cells
10.1073/pnas.0801898105 · 2008 · External reference
The pleiotropic immunomodulatory functions of IL-33 and its implications in tumor immunity
10.3389/fimmu.2018.02601 · 2018 · External reference
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
10.1073/pnas.1410700111 · 2014 · External reference
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance
10.1016/j.immuni.2013.02.003 · 2013 · External reference
Interleukin-33 in tissue homeostasis, injury, and inflammation
10.1016/j.immuni.2015.06.006 · 2015 · External reference
Interleukin-33 in health and disease
10.1038/nri.2016.95 · 2016 · External reference
Tissue eosinophils express the IL-33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis
10.1111/all.15127 · 2022 · External reference
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice
10.1073/pnas.1307321110 · 2013 · External reference
G proteins
10.1016/0968-0004(92)90005-t · 1992 · External reference
Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13
10.1016/j.jaci.2024.01.017 · 2024 · External reference
IL-33-dependent induction of allergic lung inflammation by FcgammaRIII signaling
10.1172/jci63802 · 2013 · External reference
IL-33 antagonism does not improve chronic atopic dermatitis: What can we learn
10.1016/j.jaci.2022.10.009 · 2022 · External reference
Research progress in atopic march
10.3389/fimmu.2020.01907 · 2020 · External reference
Relationship between asthma and rhinitis: epidemiologic, pathophysiologic, and therapeutic aspects
10.2310/7480.2005.00016 · 2005 · External reference
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity
10.1084/jem.20080452 · 2008 · External reference
Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis
10.1073/pnas.0802465105 · 2008 · External reference
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
10.1038/nm1332 · 2006 · External reference
X-SCID B cell responses to interleukin-4 and interleukin-13 are mediated by a receptor complex that includes the interleukin-4 receptor alpha chain (p140) but not the gamma c chain
10.1016/b978-012498340-3/50014-2 · 1997 · External reference
Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex
10.1016/s0165-2478(97)85416-8 · 1997 · External reference
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung
10.4049/jimmunol.180.1.522 · 2008 · External reference
Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy
10.1016/j.jaci.2006.09.039 · 2007 · External reference
IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis
10.1053/j.gastro.2008.08.055 · 2008 · External reference
IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung
10.4049/jimmunol.167.3.1683 · 2001 · External reference
Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids
10.1016/j.jaci.2013.03.051 · 2013 · External reference
Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis
10.1056/nejmoa2206714 · 2023 · External reference
IL-13 receptor alpha1 differentially regulates aeroallergen-induced lung responses
10.4049/jimmunol.1004159 · 2011 · External reference
A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis
10.1126/sciimmunol.aaw2938 · 2020 · External reference
Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis
10.1111/all.15510 · 2023 · External reference
Eosinophil depletion with benralizumab for eosinophilic esophagitis
10.1056/nejmoa2313318 · 2024 · External reference
Age-related increase of collagen/fibrin deposition and high PAI-1 production in human nasal polyps
10.3389/fphar.2022.845324 · 2022 · External reference
Emerging endotypes of chronic rhinosinusitis and its application to precision medicine
10.4168/aair.2017.9.4.299 · 2017 · External reference
Type 2 inflammation in asthma--present in most, absent in many
10.1038/nri3786 · 2015 · External reference
Eosinophils in health and disease: the LIAR hypothesis
10.1002/9781444346688.ch8 · 2010 · External reference
Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment
10.1172/jci69404 · 2014 · External reference
Racial disparity in Covid-19 mortality rates - a plausible explanation
10.1016/j.clim.2020.108481 · 2020 · External reference
Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: a single center experience
10.3389/fimmu.2022.1044933 · 2022 · External reference
Dupilumab in real-life settings: a review of adverse events and their pathogenesis
10.1080/14740338.2024.2326480 · 2024 · External reference
Remission of eczema and recovery of Th1 polarization following treatment with dupilumab in STAT3 hyper IgE syndrome
10.1111/pai.13770 · 2022 · External reference
Combination of biological therapy in severe asthma: where we are
10.3390/jpm13111594 · 2023 · External reference
Combining omalizumab with another biotherapy
10.2340/00015555-3140 · 2019 · External reference
A first-in-human, single and multiple dose study of lunsekimig, a novel anti-TSLP/anti-IL-13 NANOBODY(R) compound, in healthy volunteers
10.1111/cts.13864 · 2024 · External reference
Phase 2b randomized trial of OX40 inhibitor telazorlimab for moderate-to-severe atopic dermatitis
10.1016/j.jacig.2023.100195 · 2024 · External reference
