Research graph
References from Semaglutide and pioglitazone restore airway mucosal homeostasis by resolving Pseudomonas aeruginosa pyocyanin-induced mucus hypersecretion, ciliostasis, and type 2 airway inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials
10.1186/s12890-025-03823-6 · 2025 · External reference
Sexually dimorphic response to tobacco exposure in COPD: a systematic review and meta-analysis
10.1186/s12890-025-04079-w · 2026 · External reference
Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers
10.1164/rccm.201002-0222oc · 2010 · External reference
Impact of Fev1 and acute exacerbation rate (aer) on the Gold 2011 grading of COPD in a community based respirology practice
2013 · External reference
The role of pyocyanin in Pseudomonas aeruginosa infection
10.1016/j.molmed.2004.10.002 · 2004 · External reference
Modulation of pulmonary immune functions by the Pseudomonas aeruginosa secondary metabolite pyocyanin
10.3389/fimmu.2025.1550724 · 2025 · External reference
Pseudomonas aeruginosa-derived metabolites and volatile organic compounds: impact on lung epithelial homeostasis and mucosal immune response
10.3389/fimmu.2025.1553013 · 2025 · External reference
Effects of hypoglycemic agents on pulmonary diseases: a comprehensive narrative review
10.2147/jir.s556790 · 2025 · External reference
Respiratory ciliary beat frequency in COPD: balancing oxidative stress and pharmacological treatment
10.3390/antiox14111340 · 2025 · External reference
Barrier function of airway tract epithelium
10.4161/tisb.24997 · 2013 · External reference
Respiratory tract mucin genes and mucin glycoproteins in health and disease
10.1152/physrev.00010.2005 · 2006 · External reference
Airway mucus function and dysfunction
10.1056/nejmra0910061 · 2010 · External reference
Foxa2 regulates alveolarization and goblet cell hyperplasia
10.1242/dev.00966 · 2004 · External reference
Inactivation of FOXA2 by respiratory bacterial pathogens and dysregulation of pulmonary mucus homeostasis
10.3389/fimmu.2020.00515 · 2020 · External reference
Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor
10.1183/09031936.02.00001402 · 2002 · External reference
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
10.1172/jci39731 · 2009 · External reference
Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways
10.1038/mi.2012.81 · 2013 · External reference
Pyocyanin-induced mucin production is associated with redox modification of FOXA2
10.1186/1465-9921-14-82 · 2013 · External reference
Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARgamma-FOXA2-phosphatase signaling
10.1038/s41385-020-0262-1 · 2020 · External reference
FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases
10.1111/cmi.12957 · 2019 · External reference
Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2
10.1111/j.1462-5822.2011.01727.x · 2012 · External reference
Diabetes mellitus in patients with chronic obstructive pulmonary disease-the impact on mortality
10.1371/journal.pone.0175794 · 2017 · External reference
Incidence of type II diabetes in chronic obstructive pulmonary disease: a nested case-control study
10.1038/s41533-019-0138-6 · 2019 · External reference
Diabetes as a risk factor for severe exacerbation and death in patients with COPD: a prospective cohort study
10.1093/eurpub/ckz219 · 2020 · External reference
Development of therapeutic options on type 2 diabetes in years: Glucagon-like peptide-1 receptor agonist's role intreatment; from the past to future
10.4239/wjd.v10.i8.446 · 2019 · External reference
GLP-1 receptor agonists for type 2 diabetes mellitus: recent developments and emerging agents
10.1002/phar.1507 · 2014 · External reference
Structural and functional insights into PPAR-γ: review of its potential and drug design innovations for the development of antidiabetic agents
10.1016/j.ejmech.2025.118264 · 2026 · External reference
Effects of rosiglitazone and metformin on pancreatic beta cell gene expression
10.1007/s00125-006-0155-1 · 2006 · External reference
Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells
10.1152/ajplung.00388.2005 · 2006 · External reference
Glucagon-like peptide-1 receptor agonists in the prevention of ischemic stroke: therapeutic potential and mechanisms
10.5853/jos.2025.00584 · 2025 · External reference
Benefits of glucagon-like peptide-1 receptor agonists versus pioglitazone for cardio-hepatic outcomes: a territory-wide target trial emulation
10.1186/s12933-025-02973-5 · 2025 · External reference
Designing next-generation cardiometabolic outcome trials for obesity medicines
10.1016/j.jacc.2026.01.013 · 2026 · External reference
Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells:: involvement of PDX-1 and HNF3β transcription factors
10.1002/jcp.10143 · 2002 · External reference
Recent advances in the design, development and therapeutic applications of PPARγ agonists
10.1080/17568919.2025.2571022 · 2025 · External reference
Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
10.1136/bmj.l7078 · 2020 · External reference
Cardiovascular disease and diabetes: a new challenge in the treatment and management
10.3390/ijms27010354 · 2025 · External reference
Pulmonary mycosis drives Forkhead box protein A2 degradation and mucus hypersecretion through activation of the spleen tyrosine kinase-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling
10.1016/j.ajpath.2020.09.013 · 2021 · External reference
Primary ciliary dyskinesia: evaluation using cilia beat frequency assessment via spectral analysis of digital microscopy images
10.1152/japplphysiol.00629.2010 · 2011 · External reference
Development of a mouse model for chronic cat allergen-induced asthma
10.1159/000369066 · 2014 · External reference
Tregitope-linked refined allergen vaccines for immunotherapy in cockroach allergy
10.1038/s41598-018-33680-9 · 2018 · External reference
Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production
10.1084/jem.186.10.1737 · 1997 · External reference
Targeting TL1A/DR3 signaling offers a therapeutic advantage to neutralizing IL13/IL4Rα in muco-secretory fibrotic disorders
10.3389/fimmu.2021.692127 · 2021 · External reference
Type 2 immunity in the skin and lungs
10.1111/all.14318 · 2020 · External reference
Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis
10.2353/ajpath.2009.090166 · 2009 · External reference
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma
10.1164/rccm.200811-1768oc · 2009 · External reference
Semaglutide: first global approval
10.1007/s40265-018-0871-0 · 2018 · External reference
The discovery and development of liraglutide and semaglutide
10.3389/fendo.2019.00155 · 2019 · External reference
Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide
10.1021/acs.jmedchem.5b00726 · 2015 · External reference
Long-acting GLP-1 receptor agonists semaglutide and liraglutide protect against development of atherosclerosis in animal models independent of body-weight-lowering effects
2017 · External reference
Pioglitazone
10.2165/00003495-200060020-00009 · 2000 · External reference
Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats
10.1007/s001250050901 · 1998 · External reference
Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect
10.1172/jci118041 · 1995 · External reference
The effect of pioglitazone on glucose control and lipid profile in patients with type 2 diabetes
10.1016/s0168-8227(00)81657-5 · 1999 · External reference
Comparing efficacy of Chiglitazar, Pioglitazone, and Semaglutide in type 2 diabetes: A retrospective study
10.1007/s13300-025-01724-9 · 2025 · External reference
Airway epithelial cell peroxisome proliferator-activated receptor gamma regulates inflammation and mucin expression in allergic airway disease
10.4049/jimmunol.1800649 · 2018 · External reference
PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
10.1016/j.cmet.2007.06.010 · 2007 · External reference
Regulation of the mucosal phenotype in dendritic cells by PPARγ: Role of tissue microenvironment
10.1189/jlb.0713408 · 2014 · External reference
PPARs: Key regulators of airway inflammation and potential therapeutic targets in asthma
10.11131/2018/101306 · 2018 · External reference
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue T cells
10.1038/nature11132 · 2012 · External reference
Semaglutide outperforms insulin in restoring neutrophil function against implant-related infection in diabetic and obese mice: Experimental research
10.1097/js9.0000000000001896 · 2025 · External reference
Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro
10.1172/jci112787 · 1987 · External reference
Mechanisms of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro
10.1128/iai.61.7.2848-2853.1993 · 1993 · External reference
How mitochondria produce reactive oxygen species
10.1042/bj20081386 · 2009 · External reference
Human targets of Pseudomonas aeruginosa pyocyanin
10.1073/pnas.2332354100 · 2003 · External reference
Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization
10.1111/j.1462-5822.2006.00696.x · 2006 · External reference
Airway epithelial differentiation and mucociliary clearance
10.1513/annalsats.201802-128aw · 2018 · External reference
Ciliary function and the role of cilia in clearance
10.1089/jam.2006.19.110 · 2006 · External reference
Protein kinase C induced calcium influx and sustained enhancement of ciliary beating by extracellular ATP
10.1016/s0143-4160(97)90034-8 · 1997 · External reference
Ciliary beat co-ordination by calcium
10.1042/bc20100120 · 2011 · External reference
Ca(2+) ](i) modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice
10.1113/ep086681 · 2018 · External reference
Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cϵ-dependent manner
10.1016/j.ajpath.2012.04.022 · 2012 · External reference
Alcohol potentiates RSV-mediated injury to ciliated airway epithelium
10.1016/j.alcohol.2018.07.010 · 2019 · External reference
Zinc protects against swine barn dust-induced cilia slowing
10.3390/biom14070843 · 2024 · External reference
Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase Cepsilon
10.1186/1465-9921-13-49 · 2012 · External reference
Protein kinase C-ϵ (PKC-ϵ):: Its unique structure and function
10.1093/oxfordjournals.jbchem.a003296 · 2002 · External reference
Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment
10.1080/01902140600959630 · 2006 · External reference
The role of connexin and pannexin channels in perinatal brain injury and inflammation
10.3389/fphys.2019.00141 · 2019 · External reference
