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References from PLA2G2F/lysoplasmalogen axis links epidermal lipid metabolism to type 2 inflammation and itch in atopic dermatitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers
10.1093/intimm/dxy015 · 2018 · External reference
Atopic dermatitis
10.1038/s41572-018-0001-z · 2018 · External reference
Reconciling innate and acquired immunity in atopic dermatitis
10.1016/j.jaci.2020.02.008 · 2020 · External reference
Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch
10.1016/j.cell.2017.08.006 · 2017 · External reference
Skin microbiota-host interactions
10.1038/nature25177 · 2018 · External reference
The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis
10.1038/s41590-018-0256-2 · 2018 · External reference
Prostanoids and leukotrienes in the pathophysiology of atopic dermatitis and psoriasis
10.1093/intimm/dxy087 · 2019 · External reference
The immunological anatomy of the skin
10.1038/s41577-018-0084-5 · 2019 · External reference
Current insights into skin lipids and their roles in cutaneous health and disease
10.1097/mco.0000000000000902 · 2023 · External reference
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches
10.1111/imr.13193 · 2023 · External reference
COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization
10.1016/j.jaci.2005.03.042 · 2005 · External reference
Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling
10.1016/j.jaci.2012.01.063 · 2012 · External reference
Prostaglandin E2 (PGE2)-EP2 signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression
10.1016/j.jaci.2019.06.036 · 2019 · External reference
Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis
10.1016/j.jaci.2017.04.045 · 2018 · External reference
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
10.1016/j.jaci.2017.04.045 · 2001 · External reference
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation
10.1016/j.immuni.2012.06.018 · 2012 · External reference
Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction
10.1038/srep27995 · 2016 · External reference
Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice
10.1111/j.1600-0625.2006.00438.x · 2006 · External reference
Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins
10.1096/fj.15-279653 · 2016 · External reference
Involvement of leukotriene B4 released from keratinocytes in itch-associated response to intradermal interleukin-31 in mice
10.2340/00015555-2697 · 2017 · External reference
Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice
10.1038/sj.jid.5700810 · 2007 · External reference
A basophil-neuronal axis promotes itch
10.1016/j.cell.2020.12.033 · 2021 · External reference
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch
10.1073/pnas.2022087118 · 2021 · External reference
Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration
10.1016/j.prostaglandins.2023.106718 · 2023 · External reference
Specialized pro-resolving lipid mediators and dietary omega-3/6 fatty acids in selected inflammatory skin diseases: a systematic review
10.3390/antiox15010009 · 2025 · External reference
LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis
10.1016/j.jid.2018.10.034 · 2019 · External reference
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond
10.1016/j.pharmthera.2023.108382 · 2023 · External reference
The roles of sPLA2s in skin homeostasis and disease
10.3390/biom13040668 · 2023 · External reference
Secreted phospholipase A2 regulates intercellular communications by coordinating extracellular phospholipid metabolism
10.1093/intimm/dxaf027 · 2025 · External reference
Modulation of immunity by the secreted phospholipase A2 family
10.1111/imr.13205 · 2023 · External reference
Extracellular vesicles as a hydrolytic platform of secreted phospholipase A2
10.1016/j.bbalip.2024.159536 · 2024 · External reference
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia
10.1084/jem.20141904 · 2015 · External reference
Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2
10.1016/j.biochi.2023.09.027 · 2023 · External reference
Secreted phospholipase A2 specificity on natural membrane phospholipids
10.1016/bs.mie.2016.09.007 · 2017 · External reference
A rapid method of total lipid extraction and purification
10.1139/o59-099 · 1959 · External reference
Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin
10.1038/jid.2008.232 · 2009 · External reference
Molecular cloning, heterologous expression, and enzymatic characterization of lysoplasmalogen-specific phospholipase D from Thermocrispum sp
10.1002/2211-5463.12131 · 2016 · External reference
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
10.1021/jm800422v · 2008 · External reference
Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis
10.1074/jbc.m109083200 · 2002 · External reference
Design of bispecific antibody Fc region employing a shark-human chimeric and asymmetric format
10.1016/j.jbiosc.2025.09.001 · 2025 · External reference
Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape
10.1016/j.anai.2017.10.039 · 2018 · External reference
Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial
10.1016/s0140-6736(17)31191-1 · 2017 · External reference
Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders
10.3389/fimmu.2025.1694066 · 2025 · External reference
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma
10.1016/j.cmet.2022.02.011 · 2022 · External reference
Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts
10.1016/j.immuni.2024.06.012 · 2024 · External reference
PLA2G12A-driven extracellular vesicle–lipid signaling amplifies pathogenic T cell responses in inflammatory diseases
10.1016/j.celrep.2026.117391 · 2026 · External reference
Pruritus in allergy and immunology
10.1016/j.jaci.2019.06.016 · 2019 · External reference
Neuro-immune interactions in urticaria:a pruritus-centric dissection
10.3389/fimmu.2026.1782901 · 2026 · External reference
Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics
10.1186/s41232-018-0089-2 · 2018 · External reference
Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA
10.1046/j.1523-1747.2001.00179.x · 2001 · External reference
Hair follicular expression and function of group X secreted phopholipase A2 in mouse skin
10.1074/jbc.m110.206714 · 2011 · External reference
Plasmalogens as biomarkers and therapeutic targets
10.1016/j.jlr.2025.100925 · 2025 · External reference
Plasmalogens in innate immune cells: from arachidonate signaling to ferroptosis
10.3390/biom14111461 · 2024 · External reference
Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism
10.1038/s41467-022-31805-3 · 2022 · External reference
Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice
10.1016/j.jlr.2025.100808 · 2025 · External reference
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
10.1038/ni.2245 · 2012 · External reference