Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Advances in the role of specialized pro-resolving mediators in periodontitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies
10.1038/s41413-025-00478-1 · 2026 · External reference
Periodontal diseases
10.1038/nrdp.2017.38 · 2017 · External reference
WHO calls to end the global crisis of oral health
10.1016/s0140-6736(22)02322-4 · 2022 · External reference
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
10.1038/s41577-020-00488-6 · 2021 · External reference
Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe)
10.1111/jcpe.13807 · 2023 · External reference
Periodontal disease and rheumatoid arthritis: a systematic review
10.1177/0022034513483142 · 2013 · External reference
Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve
10.1111/prd.12317 · 2020 · External reference
Emerging concepts in the resolution of periodontal inflammation: A role for resolvin E1
10.3389/fimmu.2017.01682 · 2017 · External reference
Specialized pro-resolving mediator network: an update on production and actions
10.1042/ebc20200018 · 2020 · External reference
Pro-resolving mediators in the regulation of periodontal disease
10.1016/j.mam.2017.04.006 · 2017 · External reference
Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review
10.1111/eos.12759 · 2021 · External reference
Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease
10.1038/s41569-023-00984-x · 2024 · External reference
Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution
10.1038/s42255-024-01115-7 · 2024 · External reference
Modulating the sEH/EETs axis restrains specialized proresolving mediator impairment and regulates T cell imbalance in experimental periodontitis
10.4049/jimmunol.2300650 · 2021 · External reference
Immunomodulation of periodontitis with SPMs
10.3389/froh.2023.1288722 · 2023 · External reference
Roles of specialized pro-resolving mediators and omega-3 polyunsaturated fatty acids in periodontal inflammation and impact on oral microbiota
10.3389/froh.2023.1217088 · 2023 · External reference
Specialized pro-resolving lipid mediators in experimental periodontitis: A systematic review
10.1111/odi.12979 · 2019 · External reference
Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology
10.1152/function.087.2025 · 2026 · External reference
Leukocyte-endothelial cell interactions in the inflammatory response
10.1038/labinvest.3780446 · 2002 · External reference
Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases
10.3390/ijms20143394 · 2019 · External reference
Pattern recognition receptors: function, regulation and therapeutic potential
10.1038/s41392-025-02264-1 · 2025 · External reference
Cytokines in sepsis: a critical review of the literature on systemic inflammation and multiple organ dysfunction
10.3389/fimmu.2025.1682306 · 2025 · External reference
Specialized pro-resolving lipid mediators: endogenous roles and pharmacological activities in infections
10.3390/molecules28135032 · 2023 · External reference
Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets
10.3389/fimmu.2024.1435054 · 2024 · External reference
Staging and grading of periodontitis: Framework and proposal of a new classification and case definition
10.1111/jcpe.12945 · 2018 · External reference
Resolution of inflammation in periodontitis
10.1902/jop.2005.76.11-s.2168 · 2005 · External reference
Proresolving lipid mediators and mechanisms in the resolution of acute inflammation
10.1016/j.immuni.2014.02.009 · 2014 · External reference
Regulation of inflammation by lipid mediators in oral diseases
10.1111/odi.12544 · 2017 · External reference
Insight into the role of macrophages in periodontitis restoration and development
10.1080/21505594.2024.2427234 · 2024 · External reference
Distinct profiles of specialized pro-resolving lipid mediators and corresponding receptor gene expression in periodontal inflammation
10.3389/fimmu.2020.01307 · 2020 · External reference
Inflammasomes and their regulation in periodontal disease: a review
10.1111/jre.12733 · 2020 · External reference
The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution
10.1016/j.smim.2015.03.004 · 2015 · External reference
Macrophages in periodontitis: a dynamic shift between tissue destruction and repair
10.1016/j.jdsr.2022.10.002 · 2022 · External reference
The role of inflammasome NLPR3 in the development and therapy of periodontitis
10.7150/ijms.74575 · 2022 · External reference
Specialized pro-resolving lipid mediators: a key player in resolving inflammation in autoimmune diseases
10.1016/j.scib.2024.07.049 · 2025 · External reference
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
10.1172/jci97943 · 2018 · External reference
Subgingival microbiome and specialized pro-resolving lipid mediator pathway profiles are correlated in periodontal inflammation
10.3389/fimmu.2021.691216 · 2021 · External reference
Low-grade chronic inflammation: a shared mechanism for chronic diseases
10.1152/physiol.00021.2024 · 2025 · External reference
Periodontal pathogens and their links to neuroinflammation and neurodegeneration
10.3390/microorganisms11071832 · 2023 · External reference
The impact of the soluble epoxide hydrolase cascade on periodontal tissues
10.3389/fdmed.2023.1129371 · 2023 · External reference
Mitochondria: an emerging unavoidable link in the pathogenesis of periodontitis caused by Porphyromonas gingivalis
10.3390/ijms25020737 · 2024 · External reference
Monocytes and macrophages: origin, homing, differentiation, and functionality during inflammation
10.1016/j.heliyon.2024.e29686 · 2024 · External reference
Inducible antibacterial responses in macrophages
10.1038/s41577-024-01080-y · 2025 · External reference
Specialized pro-resolving mediators: biosynthetic pathways, biocatalytic synthesis, and applications
10.1016/j.biotechadv.2025.108682 · 2025 · External reference
Advances in the chemistry and biology of specialised pro-resolving mediators (SPMs)
10.3390/molecules29102233 · 2024 · External reference
Resolvins, protectins, and maresins: DHA-derived specialized pro-resolving mediators, biosynthetic pathways, synthetic approaches, and their role in inflammation
10.3390/molecules27051677 · 2022 · External reference
Biology and total synthesis of n-3 docosapentaenoic acid-derived specialized pro-resolving mediators
10.3390/molecules29122833 · 2024 · External reference
Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond
10.1016/j.phrs.2023.106982 · 2023 · External reference
The role of endogenous specialized proresolving mediators in mast cells and their involvement in inflammation and resolution
10.3390/ijms26041491 · 2025 · External reference
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions
10.1172/jci129448 · 2019 · External reference
Resolvin D1 binds human phagocytes with evidence for proresolving receptors
10.1073/pnas.0907342107 · 2010 · External reference
Identification of resolvin D2 receptor mediating resolution of infections and organ protection
10.1084/jem.20150225 · 2015 · External reference
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation
10.4049/jimmunol.178.6.3912 · 2007 · External reference
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain
10.1172/jci99888 · 2018 · External reference
Effect of lipoxin A4 on the osteogenic differentiation of periodontal ligament stem cells under lipopolysaccharide-induced inflammatory conditions
10.1111/eos.12932 · 2023 · External reference
Lipoxin suppresses inflammation via the TLR4/MyD88/NF-κB pathway in periodontal ligament cells
10.1111/odi.13250 · 2020 · External reference
Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators
10.4049/jimmunol.171.12.6856 · 2003 · External reference
Systemic inhibition of 5-lipoxygenase by MK-886 exacerbates apical periodontitis bone loss in a mouse model
10.1186/s12903-023-02712-w · 2023 · External reference
The effect of low-dose aspirin on aspirin triggered lipoxin, interleukin 1 beta, and prostaglandin E2 levels in periapical fluid: a double-blind randomized clinical trial
10.1186/s12903-023-03243-0 · 2023 · External reference
The effect of lipoxin A4 on E. coli LPS-induced osteoclastogenesis
10.1007/s00784-020-03385-3 · 2021 · External reference
Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo
10.1097/01.asn.0000032417.73640.72 · 2002 · External reference
Lipoxin A4 promotes autophagy and inhibits overactivation of macrophage inflammasome activity induced by Pg LPS
10.1177/0300060520981259 · 2021 · External reference
Safety and preliminary efficacy of a novel host-modulatory therapy for reducing gingival inflammation
10.3389/fimmu.2021.704163 · 2021 · External reference
Resolvin E1 promotes the resolution of dental pulp inflammation and induces autophagy
10.1111/aej.12971 · 2025 · External reference
RvE1 impacts the gingival inflammatory infiltrate by inhibiting the T cell response in experimental periodontitis
10.3389/fimmu.2021.664756 · 2021 · External reference
Resolvin E1 reverses experimental periodontitis and dysbiosis
10.4049/jimmunol.1600859 · 2016 · External reference
Resolvin E1, but not resolvins E2 and E3, promotes fMLF-induced ROS generation in human neutrophils
10.1002/1873-3468.13215 · 2018 · External reference
Rvd1 alleviates periodontitis by promoting M2 macrophage polarization and efferocytosis
10.1016/j.identj.2025.104593 · 2025 · External reference
Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model
10.1111/iej.14103 · 2024 · External reference
Resolvin D1 modulates periodontal ligament fibroblast function
10.1002/jper.22-0462 · 2023 · External reference
Antibacterial periodontal ligament stem cells enhance periodontal regeneration and regulate the oral microbiome
10.1186/s13287-024-03939-2 · 2024 · External reference
Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity
10.1038/s41467-017-02538-5 · 2018 · External reference
Resolvin D1 improves the Treg/Th17 imbalance in systemic lupus erythematosus through miR-30e-5p
10.3389/fimmu.2021.668760 · 2021 · External reference
Differential effects of resolvin D1 and resolvin E1 on cementoblast function
10.1002/jper.22-0510 · 2023 · External reference
Resolvin D1 modulates the inflammatory processes of human periodontal ligament cells via NF-κB and MAPK signaling pathways
10.3390/biomedicines13123038 · 2025 · External reference
Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway
10.1038/ncomms9272 · 2015 · External reference
A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of inflammation-resolution
10.1016/j.bcp.2022.115181 · 2022 · External reference
Protectins: Their biosynthesis, metabolism and structure-functions
10.1016/j.bcp.2022.115330 · 2022 · External reference
Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
10.4049/jimmunol.176.3.1848 · 2006 · External reference
In vitro biosynthetic pathway investigations of neuroprotectin D1 (NPD1) and protectin DX (PDX) by human 12-lipoxygenase, 15-lipoxygenase-1, and 15-lipoxygenase-2
10.1021/acs.biochem.0c00931 · 2021 · External reference
Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid
10.1016/j.bmcl.2017.03.079 · 2017 · External reference
PDX regulates inflammatory cell infiltration via resident macrophage in LPS-induced lung injury
10.1111/jcmm.15679 · 2020 · External reference
Protectin D1/GPR37 signaling enhances macrophage-dependent efferocytosis to attenuate experimental abdominal aortic aneurysm formation
10.1096/fj.202600063r · 2026 · External reference
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis
10.1172/jci190754 · 2026 · External reference
Maresin 1 alleviates diabetic kidney disease via LGR6-mediated cAMP-SOD2-ROS pathway
10.1155/2022/7177889 · 2022 · External reference
Maresin 1 promotes wound healing and socket bone regeneration for alveolar ridge preservation
10.1177/0022034520917903 · 2020 · External reference
Maresin1 promotes M2 macrophage polarization through peroxisome proliferator-activated receptor-γ activation to expedite resolution of acute lung injury
10.1016/j.jss.2020.06.062 · 2020 · External reference
MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation
10.1371/journal.pone.0115855 · 2015 · External reference
Maresin-1 and inflammatory disease
10.3390/ijms23031367 · 2022 · External reference
Maresin1: A multifunctional regulator in inflammatory bone diseases
10.1016/j.intimp.2023.110308 · 2023 · External reference
Maresin 1 biosynthesis and proresolving anti-infective functions with human-localized aggressive periodontitis leukocytes
10.1128/iai.01131-15 · 2015 · External reference
Mechanistic and therapeutic insights into Nrf2-mediated redox regulation in periodontitis
10.3390/antiox15010072 · 2026 · External reference
Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation
10.1186/s10020-024-00877-w · 2024 · External reference
The mechanism of efferocytosis in the pathogenesis of periodontitis and its possible therapeutic strategies
10.1093/jleuko/qiad016 · 2023 · External reference
The role of foreign body response in peri-implantitis: What is the evidence
10.1111/prd.12456 · 2022 · External reference
Resolving inflammation in CKD: The potential of SPMs and omega-3 derivatives as biomarkers and therapeutics
10.3390/biomedicines14030619 · 2026 · External reference
The potential role of n-3 fatty acids and their lipid mediators on asthmatic airway inflammation
10.3389/fimmu.2024.1488570 · 2024 · External reference
Stereoselective synthesis and structural confirmation of the specialized pro-resolving mediator resolvin E4
10.1021/acs.joc.0c02913 · 2021 · External reference
Impact of resolvin-E1 and maresin-1 on bone marrow stem cell osteogenesis under inflammatory stress
10.3390/cells13110932 · 2024 · External reference
Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling
10.1016/j.jlr.2024.100705 · 2023 · External reference
Promising anti-inflammatory tools: Biomedical efficacy of lipoxins and their synthetic pathways
10.3390/ijms241713282 · 2023 · External reference
A signaling network map of lipoxin (LXA4): an anti-inflammatory molecule
10.1007/s00011-024-01885-6 · 2024 · External reference
Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation
10.1186/s11658-025-00756-0 · 2025 · External reference
Resolving lipoxin A4: Endogenous mediator or exogenous anti-inflammatory agent
10.1016/j.jlr.2024.100734 · 2025 · External reference
Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors
10.1084/jem.185.9.1693 · 1997 · External reference
Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils
10.1021/bi00044a041 · 1995 · External reference
Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo
10.1073/pnas.96.14.8247 · 1999 · External reference
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by human 15-lipoxygenase and 12-lipoxygenase and its regulation through negative allosteric modulators
10.1021/acs.biochem.0c00233 · 2020 · External reference
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages
10.1371/journal.pone.0102362 · 2014 · External reference
Optimizing delivery of specialized pro-resolving mediators for oral inflammation via smart hydrogels and biomaterials
10.1080/20415990.2025.2570109 · 2025 · External reference
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition
10.1016/j.smim.2022.101597 · 2022 · External reference
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue
10.1152/ajpcell.00024.2014 · 2014 · External reference
Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial
10.1002/jper.19-0613 · 2020 · External reference
Treatment of periodontal disease: Does drug delivery matter
10.3389/fbioe.2024.1427758 · 2024 · External reference
Hierarchical chitin nanocrystal-based 3D printed dual-layer membranes hydrogels: A dual drug delivery nano-platform for periodontal tissue regeneration
10.1021/acsnano.4c05558 · 2024 · External reference
Proresolving nanomedicines activate bone regeneration in periodontitis
10.1177/0022034514557331 · 2015 · External reference
Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery
10.1016/j.actbio.2020.09.018 · 2020 · External reference
An “anaerobic invisible” genetically engineered bacterium for periodontitis treatment through temporal modulation on microenvironment
2026 · External reference
Salivary large extracellular vesicle associated bacterial DNA reflects periodontal disease status and non-surgical periodontal therapy response
2026 · External reference