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References from Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges. Local targets link to admitted publications; unresolved targets remain external evidence.
Editorial: Aging and chronic disease: public health challenge and education reform
10.3389/fpubh.2023.1175898 · 2023 · External reference
2024 Alzheimer's disease facts and figures
10.1002/alz.13809 · 2024 · External reference
From geroscience to precision geromedicine: Understanding and managing aging
10.1016/j.cell.2025.03.011 · 2025 · External reference
Geroscience: Linking Aging to Chronic Disease
10.1016/j.cell.2014.10.039 · 2014 · External reference
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
10.1038/nature03260 · 2005 · External reference
Rejuvenation of regeneration in the aging central nervous system
10.1016/j.stem.2011.11.019 · 2012 · External reference
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
10.1126/science.1251141 · 2014 · External reference
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
10.1038/nm.3569 · 2014 · External reference
Safety, tolerability, and feasibility of young plasma infusion in the Plasma for Alzheimer Symptom Amelioration Study: A randomized clinical trial
10.1001/jamaneurol.2018.3288 · 2019 · External reference
Safety of plasma infusions in Parkinson's disease
10.1002/mds.28198 · 2020 · External reference
Platelet factors attenuate inflammation and rescue cognition in ageing
10.1038/s41586-023-06436-3 · 2023 · External reference
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
10.1038/s43587-023-00468-0 · 2023 · External reference
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
10.1038/s41467-023-39873-9 · 2023 · External reference
Blood platelet factor 4: the elixir of brain rejuvenation
10.1186/s13024-023-00681-w · 2024 · External reference
Platelet factor 4: a chemokine enigma
10.1016/j.biocel.2004.12.003 · 2005 · External reference
Platelet factor 4(PF4) and its multiple roles in diseases
10.1016/j.blre.2023.101155 · 2024 · External reference
Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site
10.1371/journal.pone.0024837 · 2011 · External reference
Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
10.1111/j.1538-7836.2010.04154.x · 2011 · External reference
ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp
10.1074/jbc.ra118.006321 · 2019 · External reference
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
10.1084/jem.20021897 · 2003 · External reference
CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3
10.1189/jlb.1006645 · 2008 · External reference
PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway
10.17305/bb.2024.11415 · 2025 · External reference
Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface
10.1182/blood.v99.10.3613 · 2002 · External reference
Platelet factor 4 (PF4) regulates hematopoietic stem cell aging
10.1182/blood-2024-205355 · 2025 · External reference
Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes
10.1182/blood-2009-04-216473 · 2009 · External reference
Leukocyte integrin Mac-1 (CD11b/CD18, αMβ2, CR3) acts as a functional receptor for platelet factor 4
10.1074/jbc.ra117.000515 · 2018 · External reference
CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration
10.1038/s41598-018-27710-9 · 2018 · External reference
Platelet factor 4 impairs the anticoagulant activity of activated protein C
10.1074/jbc.m804703200 · 2009 · External reference
PF4 activates the c-Mpl-Jak2 pathway in platelets
10.1182/blood.2023020872 · 2024 · External reference
Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25- (nonregulatory) T cells
10.4049/jimmunol.174.5.2680 · 2005 · External reference
Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis
10.1111/jth.15005 · 2020 · External reference
Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8
10.1189/jlb.72.3.590 · 2002 · External reference
Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia
10.1182/blood-2010-08-301424 · 2011 · External reference
Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis
10.1182/blood.2019002329 · 2020 · External reference
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials
10.1016/j.chom.2012.10.017 · 2012 · External reference
Chemokines from a structural perspective
10.3390/ijms18102088 · 2017 · External reference
The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer
10.1016/j.cytogfr.2010.10.011 · 2011 · External reference
Platelet factor-4 variant chemokine CXCL4L1 inhibits melanoma and lung carcinoma growth and metastasis by preventing angiogenesis
10.1158/0008-5472.can-06-4682 · 2007 · External reference
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion
10.1038/nm.3707 · 2014 · External reference
Research progress on platelet factor 4 in improving cognition
10.1016/j.expneurol.2025.115403 · 2025 · External reference
Target anesthesia and surgery induced senescent cell via composite microsphere hydrogels as nose-to-brain amplifiers of platelet factor 4 delivery for neurocognitive dysfunction repair
10.1016/j.biomaterials.2025.123863 · 2026 · External reference
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
10.1093/gerona/glu057 · 2014 · External reference
The ageing cortical synapse: hallmarks and implications for cognitive decline
10.1038/nrn3200 · 2012 · External reference
Exercise enhances learning and hippocampal neurogenesis in aged mice
10.1523/jneurosci.1731-05.2005 · 2005 · External reference
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
10.1046/j.1460-9568.2003.02647.x · 2003 · External reference
An aged immune system drives senescence and ageing of solid organs
10.1038/s41586-021-03547-7 · 2021 · External reference
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
10.1038/nature10357 · 2011 · External reference
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
10.1038/nm.3898 · 2015 · External reference
The aged hematopoietic system promotes hippocampal-dependent cognitive decline
10.1111/acel.13192 · 2020 · External reference
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
10.1073/pnas.1116110108 · 2011 · External reference
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
10.1038/ncomms11075 · 2016 · External reference
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells
10.1038/nm.3706 · 2014 · External reference
Suppression of aging in mice by the hormone Klotho
10.1126/science.1112766 · 2005 · External reference
Peripheral elevation of a Klotho fragment enhances brain function and resilience in young, aging, and α-synuclein transgenic mice
10.1016/j.celrep.2017.07.024 · 2017 · External reference
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
10.1038/6368 · 1999 · External reference
Exercise-induced activated platelets increase adult hippocampal precursor proliferation and promote neuronal differentiation
10.1016/j.stemcr.2019.02.009 · 2019 · External reference
Decreased serum PF4 levels correlate with cognitive decline and CSF biomarkers in Alzheimer's disease in a Chinese cohort
10.1016/j.exger.2025.112689 · 2025 · External reference
Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia
10.1002/jcsm.13539 · 2024 · External reference
Identification of stroke biomarkers using proteomic profiling of extracellular vesicles derived from human blood: a preliminary study
10.3389/fneur.2025.1587389 · 2025 · External reference
Multidomain biomarkers as predictors of cardiovascular risk in acute coronary syndrome: a prospective evaluation
10.3390/ijms27052476 · 2026 · External reference
A blood-derived factor rescues ALS: Platelet factor 4 activates OPTN-dependent autophagy to clear SOD1 aggregates independently of PINK1
10.1002/advs.76778 · 2026 · External reference
Intermittent hypoxia preconditioning protects against ischemic brain injury in mice via a PF4-dependent paracrine mechanism
10.1161/strokeaha.125.052213 · 2026 · External reference
Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice
10.1039/d4fo03987d · 2025 · External reference
The disparity of platelet factor 4 and platelets in individuals of different ages
10.1016/j.heliyon.2024.e34923 · 2024 · External reference
In platelet single donor apheresis, platelet factor 4 levels correlated with donor's age and decreased during storage
10.1038/s41598-024-56826-4 · 2024 · External reference
CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis
10.1002/hep.23435 · 2010 · External reference
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN
10.1182/blood.2019004095 · 2020 · External reference
CXCL4 drives fibrosis by promoting several key cellular and molecular processes
10.1016/j.celrep.2021.110189 · 2022 · External reference
Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
10.1182/blood.2021014588 · 2022 · External reference
PF4 in rejuvenation therapy: Neuroprotection and cognitive enhancement
10.17305/bb.2025.11960 · 2025 · External reference
