Research graph
References from Metabolite-driven dysfunction of intratumoral tertiary lymphoid structures: single-cell and spatial omics perspectives on cancer immune escape. Local targets link to admitted publications; unresolved targets remain external evidence.
Oncology meets immunology: the cancer-immunity cycle
10.1016/j.immuni.2013.07.012 · 2013 · External reference
Critical role for CD103(+)/CD141(+) dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma
10.1016/j.ccell.2016.06.003 · 2016 · External reference
Tumor-draining lymph nodes: at the crossroads of metastasis and immunity
10.1126/sciimmunol.abg3551 · 2021 · External reference
Tertiary lymphoid structures in the era of cancer immunotherapy
10.1038/s41568-019-0144-6 · 2019 · External reference
Tertiary lymphoid structures in cancer
10.1126/science.abf9419 · 2022 · External reference
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
10.1158/0008-5472.can-11-0431 · 2011 · External reference
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer
10.1016/j.immuni.2022.02.001 · 2022 · External reference
Tertiary lymphoid structures in cancer: Immune mechanisms and clinical implications
10.1002/mco2.489 · 2024 · External reference
B cells and tertiary lymphoid structures in tumors: Immunity cycle, clinical impact, and therapeutic applications
10.7150/thno.105423 · 2025 · External reference
Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures
10.1200/jco.2007.15.0284 · 2008 · External reference
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
10.1038/s41586-019-1914-8 · 2020 · External reference
B cells and tertiary lymphoid structures promote immunotherapy response
10.1038/s41586-019-1922-8 · 2020 · External reference
B cells are associated with survival and immunotherapy response in sarcoma
10.1038/s41586-019-1906-8 · 2020 · External reference
Tertiary lymphoid structures: new immunotherapy biomarker
10.3389/fimmu.2024.1394505 · 2024 · External reference
Heterogeneity of tertiary lymphoid structures in cancer
10.3389/fimmu.2023.1286850 · 2023 · External reference
Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression
10.1038/s43018-021-00232-6 · 2021 · External reference
T follicular helper and B cell crosstalk in tertiary lymphoid structures and cancer immunotherapy
10.1038/s41467-022-29753-z · 2022 · External reference
Standardized pathology screening of mature tertiary lymphoid structures in cancers
10.1016/j.labinv.2023.100063 · 2023 · External reference
Methods and applications for single-cell and spatial multi-omics
10.1038/s41576-023-00580-2 · 2023 · External reference
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma
10.1038/s41467-024-52153-4 · 2024 · External reference
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer
10.1038/s41467-025-65421-8 · 2025 · External reference
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
10.1038/s41467-021-23355-x · 2021 · External reference
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure
10.1016/j.xcrm.2024.101448 · 2024 · External reference
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures
10.1016/j.ccell.2025.03.011 · 2025 · External reference
Metabolic barriers to cancer immunotherapy
10.1038/s41577-021-00541-y · 2021 · External reference
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
10.1038/s41571-019-0203-7 · 2019 · External reference
Beggars banquet: metabolism in the tumor immune microenvironment and cancer therapy
10.1016/j.cmet.2023.06.003 · 2023 · External reference
The adenosine pathway in immuno-oncology
10.1038/s41571-020-0382-2 · 2020 · External reference
The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy
10.1186/s12916-025-04037-7 · 2025 · External reference
Tertiary lymphoid structure-associated B cells enhance CXCL13(+)CD103(+)CD8(+) tissue-resident memory T-cell response to programmed cell death protein 1 blockade in cancer immunotherapy
10.1053/j.gastro.2023.10.022 · 2024 · External reference
Metabolism of immune cells in cancer
10.1038/s41568-020-0273-y · 2020 · External reference
LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells
10.1016/j.cmet.2016.08.011 · 2016 · External reference
Hypoxia-driven immune escape in the tumor microenvironment
10.3390/cells9040992 · 2020 · External reference
Lipid metabolism in tumor immunology and immunotherapy
10.3389/fonc.2023.1187279 · 2023 · External reference
Lymphoid neogenesis in chronic inflammatory diseases
10.1038/nri1786 · 2006 · External reference
Tertiary lymphoid organs in infection and autoimmunity
10.1016/j.it.2012.04.006 · 2012 · External reference
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
10.1038/nri3700 · 2014 · External reference
The roles of tertiary lymphoid structures in chronic diseases
10.1038/s41581-023-00706-z · 2023 · External reference
Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy
10.1038/cmi.2017.13 · 2017 · External reference
Tertiary lymphoid structures in cancer and beyond
10.1016/j.it.2014.09.006 · 2014 · External reference
Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances
10.1038/s41392-024-01947-5 · 2024 · External reference
Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · 2024 · External reference
Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
10.1093/annonc/mdx727 · 2017 · External reference
The tumor-draining lymph node as a reservoir for systemic immune surveillance
10.1016/j.trecan.2023.09.006 · 2024 · External reference
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells
10.1158/0008-5472.can-13-1342 · 2014 · External reference
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer
10.1158/0008-5472.can-11-0952 · 2011 · External reference
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
10.1164/rccm.201309-1611oc · 2014 · External reference
Tertiary lymphoid structures and B cells: an intratumoral immunity cycle
10.1016/j.immuni.2023.08.009 · 2023 · External reference
High endothelial venules in cancer: regulation, function, and therapeutic implication
10.1016/j.ccell.2023.02.002 · 2023 · External reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · 2022 · External reference
High endothelial venules (HEVs) in immunity, inflammation and cancer
10.1007/s10456-021-09792-8 · 2021 · External reference
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
10.1038/s41467-022-29040-x · 2022 · External reference
CXCL9 and CXCL13 shape endometrial cancer immune-activated microenvironment via tertiary lymphoid structure formation
10.1111/cas.16371 · 2025 · External reference
Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma
10.1158/0008-5472.can-17-1987 · 2018 · External reference
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer
10.1080/2162402x.2021.1900635 · 2021 · External reference
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
10.1038/ni.3290 · 2015 · External reference
Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring
10.3389/fimmu.2024.1422206 · 2024 · External reference
Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer
10.1136/jitc-2022-005539 · 2023 · External reference
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
10.1186/s12943-024-01980-6 · 2024 · External reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · 2025 · External reference
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
10.1136/jitc-2024-009243 · 2024 · External reference
The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma
10.1002/ctm2.1074 · 2022 · External reference
Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4(+) T cells in head and neck cancer
10.1038/s41467-025-59341-w · 2025 · External reference
Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structures
10.1016/j.xcrm.2025.101934 · 2025 · External reference
Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside
10.1016/j.medj.2024.10.023 · 2025 · External reference
Activation of B cells in tertiary lymphoid structures in cancer: Anti-tumor or anti-self
10.1016/j.smim.2022.101703 · 2023 · External reference
Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses
10.1158/2326-6066.cir-22-0110 · 2022 · External reference
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
10.1016/j.cell.2018.12.034 · 2018 · External reference
A blueprint for tumor-infiltrating B cells across human cancers
10.1126/science.adj4857 · 2024 · External reference
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells
10.2139/ssrn.4663949 · 2024 · External reference
B cells and tertiary lymphoid structures: Friends or foes in cancer immunotherapy
10.1158/1078-0432.ccr-21-1130 · 2022 · External reference
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
10.1016/j.ccell.2025.12.011 · 2026 · External reference
CD86(+) antigen-presenting B cells are increased in cancer, localize in tertiary lymphoid structures, and induce specific T-cell responses
10.1158/2326-6066.cir-20-0949 · 2021 · External reference
Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer
10.1038/s41467-024-46873-w · 2024 · External reference
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
10.1038/s41590-024-01792-2 · 2024 · External reference
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1(+) T lymphocyte niches through a feed-forward loop
10.1016/j.ccell.2022.12.006 · 2022 · External reference
Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses
10.1016/j.immuni.2015.08.006 · 2015 · External reference
Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
10.2139/ssrn.3575119 · 2021 · External reference
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
10.1016/j.ccell.2024.07.006 · 2024 · External reference
Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patients
10.1186/s12935-025-03635-y · 2025 · External reference
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma
10.1016/j.ccell.2021.02.013 · 2021 · External reference
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
10.1016/j.ccell.2021.03.007 · 2021 · External reference
Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
10.1016/j.immuni.2020.04.014 · 2020 · External reference
Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma
10.1158/2159-8290.cd-24-0991 · 2025 · External reference
A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging
10.1016/j.cell.2018.08.039 · 2018 · External reference
Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
10.1016/j.cell.2020.07.005 · 2020 · External reference
Spatially organized multicellular immune hubs in human colorectal cancer
10.1016/j.cell.2021.08.003 · 2021 · External reference
Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma
10.1038/s41698-024-00752-1 · 2024 · External reference
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures
10.1016/j.immuni.2025.09.018 · 2025 · External reference
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
10.1038/s41571-022-00619-z · 2022 · External reference
Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures
10.1016/j.celrep.2025.116250 · 2025 · External reference
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
10.1038/s41586-024-08426-5 · 2025 · External reference
Regulatory B cells in cancer
10.1111/imr.12939 · 2021 · External reference
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression
10.1126/sciimmunol.adi4191 · 2024 · External reference
CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes
10.4049/jimmunol.180.9.6288 · 2008 · External reference
Hypoxia-adenosinergic regulation of B cell responses
10.3389/fimmu.2024.1478506 · 2024 · External reference
Metabolic dialogs between B cells and the tumor microenvironment: Implications for anticancer immunity
10.1016/j.canlet.2023.216076 · 2023 · External reference
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
10.1038/nri3298 · 2012 · External reference
High endothelial venules: A vascular perspective on tertiary lymphoid structures in cancer
10.3389/fimmu.2021.736670 · 2021 · External reference
Fighting in a wasteland: deleterious metabolites and antitumor immunity
10.1172/jci148549 · 2022 · External reference
Cell-programmed nutrient partitioning in the tumour microenvironment
10.1038/s41586-021-03442-1 · 2021 · External reference
Tumor microenvironmental nutrients, cellular responses, and cancer
10.1016/j.chembiol.2023.08.011 · 2023 · External reference
Lactic acid and an acidic tumor microenvironment suppress anticancer immunity
10.3390/ijms21218363 · 2020 · External reference
Inhibition of the adenosine pathway to potentiate cancer immunotherapy: Potential for combinatorial approaches
10.1146/annurev-med-060619-023155 · 2021 · External reference
Improving immune-vascular crosstalk for cancer immunotherapy
10.1038/nri.2017.145 · 2018 · External reference
Hypoxia and the phenomenon of immune exclusion
10.1186/s12967-020-02667-4 · 2021 · External reference
Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation
10.3389/fimmu.2025.1702402 · 2025 · External reference
Accomplices of the hypoxic tumor microenvironment compromising antitumor immunity: Adenosine, lactate, acidosis, vascular endothelial growth factor, potassium ions, and phosphatidylserine
10.3389/fimmu.2017.01887 · 2017 · External reference
From metabolic byproduct to immune modulator: The role of lactate in tumor immune escape
10.3389/fimmu.2024.1492050 · 2024 · External reference
Involvement of tumor immune microenvironment metabolic reprogramming in colorectal cancer progression, immune escape, and response to immunotherapy
10.3389/fimmu.2024.1353787 · 2024 · External reference
Metabolism in the tumor microenvironment
10.1146/annurev-cancerbio-030419-033333 · 2020 · External reference
MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma
10.1038/s41467-025-56392-x · 2025 · External reference
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
10.4049/jimmunol.212.supp.1394.5643 · 2024 · External reference
Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade
10.1038/s41590-019-0312-6 · 2019 · External reference
Regulatory role of CD39 and CD73 in tumor immunity
10.2217/fon-2023-0871 · 2024 · External reference
Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy
10.20892/j.issn.2095-3941.2024.0228 · 2024 · External reference
Adenosine-A2A receptor pathway in cancer immunotherapy
10.3389/fimmu.2022.837230 · 2022 · External reference
Upregulation of indoleamine 2,3-dioxygenase 1 in tumor cells and tertiary lymphoid structures is a hallmark of inflamed non-small cell lung cancer
10.1158/1078-0432.ccr-23-1928 · 2023 · External reference
Hypoxia--a key regulatory factor in tumour growth
10.1038/nrc704 · 2002 · External reference
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
10.1007/s00109-014-1189-3 · 2014 · External reference
Targeting hypoxia-A2A adenosinergic immunosuppression of antitumor T cells during cancer immunotherapy
10.3389/fimmu.2020.570041 · 2020 · External reference
Enhancing cancer immunotherapy using antiangiogenics: Opportunities and challenges
10.1038/nrclinonc.2018.29 · 2018 · External reference
Reprogramming of lipid metabolism in the tumor microenvironment: A strategy for tumor immunotherapy
10.1186/s12944-024-02024-0 · 2024 · External reference
Lipid accumulation and dendritic cell dysfunction in cancer
10.1038/nm.2172 · 2010 · External reference
CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability
10.1016/j.cmet.2021.02.015 · 2021 · External reference
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors
10.1016/j.immuni.2021.05.003 · 2021 · External reference
Blocking antibodies targeting the CD39/CD73 immunosuppressive pathway unleash immune responses in combination cancer therapies
10.1016/j.celrep.2019.04.091 · 2019 · External reference
Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma
10.1016/j.jhep.2018.09.003 · 2019 · External reference
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma
10.1038/s41590-024-01992-w · 2024 · External reference
Tumor-infiltrating plasma cells are associated with tertiary lymphoid structures, cytolytic T-cell responses, and superior prognosis in ovarian cancer
10.1158/1078-0432.ccr-15-2762 · 2016 · External reference
Lactate in the tumour microenvironment: From immune modulation to therapy
10.1016/j.ebiom.2021.103627 · 2021 · External reference
Targeting adenosine for cancer immunotherapy
10.1186/s40425-018-0360-8 · 2018 · External reference
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
10.1182/blood-2005-05-1795 · 2006 · External reference
MCT4 blockade increases the efficacy of immune checkpoint blockade
10.1136/jitc-2023-007349 · 2023 · External reference
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
10.1126/science.adf8486 · 2023 · External reference
Multiplex imaging in immuno-oncology
10.1136/jitc-2023-006923 · 2023 · External reference
Spatial transcriptomics: Technical aspects of recent developments and their applications in neuroscience and cancer research
10.1002/advs.202206939 · 2023 · External reference
Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing
10.1186/s12885-023-10977-1 · 2023 · External reference
Spatial transcriptomics: Technical aspects of recent developments and their applications in neuroscience and cancer research
10.1002/advs.202206939 · ExternalCitation · doi-reference
The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma
10.1002/ctm2.1074 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: Immune mechanisms and clinical implications
10.1002/mco2.489 · ExternalCitation · doi-reference
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
10.1007/s00109-014-1189-3 · ExternalCitation · doi-reference
High endothelial venules (HEVs) in immunity, inflammation and cancer
10.1007/s10456-021-09792-8 · ExternalCitation · doi-reference
Metabolic dialogs between B cells and the tumor microenvironment: Implications for anticancer immunity
10.1016/j.canlet.2023.216076 · ExternalCitation · doi-reference
Critical role for CD103(+)/CD141(+) dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma
10.1016/j.ccell.2016.06.003 · ExternalCitation · doi-reference
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma
10.1016/j.ccell.2021.02.013 · ExternalCitation · doi-reference
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
10.1016/j.ccell.2021.03.007 · ExternalCitation · doi-reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · ExternalCitation · doi-reference
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1(+) T lymphocyte niches through a feed-forward loop
10.1016/j.ccell.2022.12.006 · ExternalCitation · doi-reference
High endothelial venules in cancer: regulation, function, and therapeutic implication
10.1016/j.ccell.2023.02.002 · ExternalCitation · doi-reference
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
10.1016/j.ccell.2024.07.006 · ExternalCitation · doi-reference
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures
10.1016/j.ccell.2025.03.011 · ExternalCitation · doi-reference
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
10.1016/j.ccell.2025.12.011 · ExternalCitation · doi-reference
A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging
10.1016/j.cell.2018.08.039 · ExternalCitation · doi-reference
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
10.1016/j.cell.2018.12.034 · ExternalCitation · doi-reference
Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
10.1016/j.cell.2020.07.005 · ExternalCitation · doi-reference
Spatially organized multicellular immune hubs in human colorectal cancer
10.1016/j.cell.2021.08.003 · ExternalCitation · doi-reference
Blocking antibodies targeting the CD39/CD73 immunosuppressive pathway unleash immune responses in combination cancer therapies
10.1016/j.celrep.2019.04.091 · ExternalCitation · doi-reference
Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures
10.1016/j.celrep.2025.116250 · ExternalCitation · doi-reference
Tumor microenvironmental nutrients, cellular responses, and cancer
10.1016/j.chembiol.2023.08.011 · ExternalCitation · doi-reference
LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells
10.1016/j.cmet.2016.08.011 · ExternalCitation · doi-reference
CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability
10.1016/j.cmet.2021.02.015 · ExternalCitation · doi-reference
Beggars banquet: metabolism in the tumor immune microenvironment and cancer therapy
10.1016/j.cmet.2023.06.003 · ExternalCitation · doi-reference
Lactate in the tumour microenvironment: From immune modulation to therapy
10.1016/j.ebiom.2021.103627 · ExternalCitation · doi-reference
Oncology meets immunology: the cancer-immunity cycle
10.1016/j.immuni.2013.07.012 · ExternalCitation · doi-reference
Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses
10.1016/j.immuni.2015.08.006 · ExternalCitation · doi-reference
Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
10.1016/j.immuni.2020.04.014 · ExternalCitation · doi-reference
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors
10.1016/j.immuni.2021.05.003 · ExternalCitation · doi-reference
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer
10.1016/j.immuni.2022.02.001 · ExternalCitation · doi-reference
Tertiary lymphoid structures and B cells: an intratumoral immunity cycle
10.1016/j.immuni.2023.08.009 · ExternalCitation · doi-reference
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures
10.1016/j.immuni.2025.09.018 · ExternalCitation · doi-reference
Tertiary lymphoid organs in infection and autoimmunity
10.1016/j.it.2012.04.006 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer and beyond
10.1016/j.it.2014.09.006 · ExternalCitation · doi-reference
Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma
10.1016/j.jhep.2018.09.003 · ExternalCitation · doi-reference
Standardized pathology screening of mature tertiary lymphoid structures in cancers
10.1016/j.labinv.2023.100063 · ExternalCitation · doi-reference
Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside
10.1016/j.medj.2024.10.023 · ExternalCitation · doi-reference
Activation of B cells in tertiary lymphoid structures in cancer: Anti-tumor or anti-self
10.1016/j.smim.2022.101703 · ExternalCitation · doi-reference
The tumor-draining lymph node as a reservoir for systemic immune surveillance
10.1016/j.trecan.2023.09.006 · ExternalCitation · doi-reference
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure
10.1016/j.xcrm.2024.101448 · ExternalCitation · doi-reference
Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structures
10.1016/j.xcrm.2025.101934 · ExternalCitation · doi-reference
Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy
10.1038/cmi.2017.13 · ExternalCitation · doi-reference
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
10.1038/ni.3290 · ExternalCitation · doi-reference
Lipid accumulation and dendritic cell dysfunction in cancer
10.1038/nm.2172 · ExternalCitation · doi-reference
Hypoxia--a key regulatory factor in tumour growth
10.1038/nrc704 · ExternalCitation · doi-reference
Enhancing cancer immunotherapy using antiangiogenics: Opportunities and challenges
10.1038/nrclinonc.2018.29 · ExternalCitation · doi-reference
Improving immune-vascular crosstalk for cancer immunotherapy
10.1038/nri.2017.145 · ExternalCitation · doi-reference
Lymphoid neogenesis in chronic inflammatory diseases
10.1038/nri1786 · ExternalCitation · doi-reference
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
10.1038/nri3298 · ExternalCitation · doi-reference
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
10.1038/nri3700 · ExternalCitation · doi-reference
Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances
10.1038/s41392-024-01947-5 · ExternalCitation · doi-reference
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
10.1038/s41467-021-23355-x · ExternalCitation · doi-reference
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
10.1038/s41467-022-29040-x · ExternalCitation · doi-reference
T follicular helper and B cell crosstalk in tertiary lymphoid structures and cancer immunotherapy
10.1038/s41467-022-29753-z · ExternalCitation · doi-reference
Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer
10.1038/s41467-024-46873-w · ExternalCitation · doi-reference
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma
10.1038/s41467-024-52153-4 · ExternalCitation · doi-reference
MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma
10.1038/s41467-025-56392-x · ExternalCitation · doi-reference
Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4(+) T cells in head and neck cancer
10.1038/s41467-025-59341-w · ExternalCitation · doi-reference
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer
10.1038/s41467-025-65421-8 · ExternalCitation · doi-reference
Tertiary lymphoid structures in the era of cancer immunotherapy
10.1038/s41568-019-0144-6 · ExternalCitation · doi-reference
Metabolism of immune cells in cancer
10.1038/s41568-020-0273-y · ExternalCitation · doi-reference
Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · ExternalCitation · doi-reference
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
10.1038/s41571-019-0203-7 · ExternalCitation · doi-reference
The adenosine pathway in immuno-oncology
10.1038/s41571-020-0382-2 · ExternalCitation · doi-reference
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
10.1038/s41571-022-00619-z · ExternalCitation · doi-reference
Methods and applications for single-cell and spatial multi-omics
10.1038/s41576-023-00580-2 · ExternalCitation · doi-reference
Metabolic barriers to cancer immunotherapy
10.1038/s41577-021-00541-y · ExternalCitation · doi-reference
The roles of tertiary lymphoid structures in chronic diseases
10.1038/s41581-023-00706-z · ExternalCitation · doi-reference
B cells are associated with survival and immunotherapy response in sarcoma
10.1038/s41586-019-1906-8 · ExternalCitation · doi-reference
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
10.1038/s41586-019-1914-8 · ExternalCitation · doi-reference
B cells and tertiary lymphoid structures promote immunotherapy response
10.1038/s41586-019-1922-8 · ExternalCitation · doi-reference
Cell-programmed nutrient partitioning in the tumour microenvironment
10.1038/s41586-021-03442-1 · ExternalCitation · doi-reference
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
10.1038/s41586-024-08426-5 · ExternalCitation · doi-reference
Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade
10.1038/s41590-019-0312-6 · ExternalCitation · doi-reference
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
10.1038/s41590-024-01792-2 · ExternalCitation · doi-reference
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma
10.1038/s41590-024-01992-w · ExternalCitation · doi-reference
Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma
10.1038/s41698-024-00752-1 · ExternalCitation · doi-reference
Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression
10.1038/s43018-021-00232-6 · ExternalCitation · doi-reference
Tertiary lymphoid structure-associated B cells enhance CXCL13(+)CD103(+)CD8(+) tissue-resident memory T-cell response to programmed cell death protein 1 blockade in cancer immunotherapy
10.1053/j.gastro.2023.10.022 · ExternalCitation · doi-reference
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer
10.1080/2162402x.2021.1900635 · ExternalCitation · doi-reference
Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
10.1093/annonc/mdx727 · ExternalCitation · doi-reference
CXCL9 and CXCL13 shape endometrial cancer immune-activated microenvironment via tertiary lymphoid structure formation
10.1111/cas.16371 · ExternalCitation · doi-reference
Regulatory B cells in cancer
10.1111/imr.12939 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer
10.1126/science.abf9419 · ExternalCitation · doi-reference
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
10.1126/science.adf8486 · ExternalCitation · doi-reference
A blueprint for tumor-infiltrating B cells across human cancers
10.1126/science.adj4857 · ExternalCitation · doi-reference
Tumor-draining lymph nodes: at the crossroads of metastasis and immunity
10.1126/sciimmunol.abg3551 · ExternalCitation · doi-reference
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression
10.1126/sciimmunol.adi4191 · ExternalCitation · doi-reference
Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer
10.1136/jitc-2022-005539 · ExternalCitation · doi-reference
Multiplex imaging in immuno-oncology
10.1136/jitc-2023-006923 · ExternalCitation · doi-reference
MCT4 blockade increases the efficacy of immune checkpoint blockade
10.1136/jitc-2023-007349 · ExternalCitation · doi-reference
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
10.1136/jitc-2024-009243 · ExternalCitation · doi-reference
Metabolism in the tumor microenvironment
10.1146/annurev-cancerbio-030419-033333 · ExternalCitation · doi-reference
Inhibition of the adenosine pathway to potentiate cancer immunotherapy: Potential for combinatorial approaches
10.1146/annurev-med-060619-023155 · ExternalCitation · doi-reference
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
10.1158/0008-5472.can-11-0431 · ExternalCitation · doi-reference
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer
10.1158/0008-5472.can-11-0952 · ExternalCitation · doi-reference
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells
10.1158/0008-5472.can-13-1342 · ExternalCitation · doi-reference
Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma
10.1158/0008-5472.can-17-1987 · ExternalCitation · doi-reference
Tumor-infiltrating plasma cells are associated with tertiary lymphoid structures, cytolytic T-cell responses, and superior prognosis in ovarian cancer
10.1158/1078-0432.ccr-15-2762 · ExternalCitation · doi-reference
B cells and tertiary lymphoid structures: Friends or foes in cancer immunotherapy
10.1158/1078-0432.ccr-21-1130 · ExternalCitation · doi-reference
Upregulation of indoleamine 2,3-dioxygenase 1 in tumor cells and tertiary lymphoid structures is a hallmark of inflamed non-small cell lung cancer
10.1158/1078-0432.ccr-23-1928 · ExternalCitation · doi-reference
Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma
10.1158/2159-8290.cd-24-0991 · ExternalCitation · doi-reference
CD86(+) antigen-presenting B cells are increased in cancer, localize in tertiary lymphoid structures, and induce specific T-cell responses
10.1158/2326-6066.cir-20-0949 · ExternalCitation · doi-reference
Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses
10.1158/2326-6066.cir-22-0110 · ExternalCitation · doi-reference
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
10.1164/rccm.201309-1611oc · ExternalCitation · doi-reference
Fighting in a wasteland: deleterious metabolites and antitumor immunity
10.1172/jci148549 · ExternalCitation · doi-reference
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
10.1182/blood-2005-05-1795 · ExternalCitation · doi-reference
Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing
10.1186/s12885-023-10977-1 · ExternalCitation · doi-reference
The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy
10.1186/s12916-025-04037-7 · ExternalCitation · doi-reference
Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patients
10.1186/s12935-025-03635-y · ExternalCitation · doi-reference
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
10.1186/s12943-024-01980-6 · ExternalCitation · doi-reference
Reprogramming of lipid metabolism in the tumor microenvironment: A strategy for tumor immunotherapy
10.1186/s12944-024-02024-0 · ExternalCitation · doi-reference
Hypoxia and the phenomenon of immune exclusion
10.1186/s12967-020-02667-4 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · ExternalCitation · doi-reference
Targeting adenosine for cancer immunotherapy
10.1186/s40425-018-0360-8 · ExternalCitation · doi-reference
Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures
10.1200/jco.2007.15.0284 · ExternalCitation · doi-reference
Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy
10.20892/j.issn.2095-3941.2024.0228 · ExternalCitation · doi-reference
Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
10.2139/ssrn.3575119 · ExternalCitation · doi-reference
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells
10.2139/ssrn.4663949 · ExternalCitation · doi-reference
Regulatory role of CD39 and CD73 in tumor immunity
10.2217/fon-2023-0871 · ExternalCitation · doi-reference
Accomplices of the hypoxic tumor microenvironment compromising antitumor immunity: Adenosine, lactate, acidosis, vascular endothelial growth factor, potassium ions, and phosphatidylserine
10.3389/fimmu.2017.01887 · ExternalCitation · doi-reference
Targeting hypoxia-A2A adenosinergic immunosuppression of antitumor T cells during cancer immunotherapy
10.3389/fimmu.2020.570041 · ExternalCitation · doi-reference
High endothelial venules: A vascular perspective on tertiary lymphoid structures in cancer
10.3389/fimmu.2021.736670 · ExternalCitation · doi-reference
Adenosine-A2A receptor pathway in cancer immunotherapy
10.3389/fimmu.2022.837230 · ExternalCitation · doi-reference
Heterogeneity of tertiary lymphoid structures in cancer
10.3389/fimmu.2023.1286850 · ExternalCitation · doi-reference
Involvement of tumor immune microenvironment metabolic reprogramming in colorectal cancer progression, immune escape, and response to immunotherapy
10.3389/fimmu.2024.1353787 · ExternalCitation · doi-reference
Tertiary lymphoid structures: new immunotherapy biomarker
10.3389/fimmu.2024.1394505 · ExternalCitation · doi-reference
Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring
10.3389/fimmu.2024.1422206 · ExternalCitation · doi-reference
Hypoxia-adenosinergic regulation of B cell responses
10.3389/fimmu.2024.1478506 · ExternalCitation · doi-reference
From metabolic byproduct to immune modulator: The role of lactate in tumor immune escape
10.3389/fimmu.2024.1492050 · ExternalCitation · doi-reference
Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation
10.3389/fimmu.2025.1702402 · ExternalCitation · doi-reference
Lipid metabolism in tumor immunology and immunotherapy
10.3389/fonc.2023.1187279 · ExternalCitation · doi-reference
Hypoxia-driven immune escape in the tumor microenvironment
10.3390/cells9040992 · ExternalCitation · doi-reference
Lactic acid and an acidic tumor microenvironment suppress anticancer immunity
10.3390/ijms21218363 · ExternalCitation · doi-reference
CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes
10.4049/jimmunol.180.9.6288 · ExternalCitation · doi-reference
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
10.4049/jimmunol.212.supp.1394.5643 · ExternalCitation · doi-reference
B cells and tertiary lymphoid structures in tumors: Immunity cycle, clinical impact, and therapeutic applications
10.7150/thno.105423 · ExternalCitation · doi-reference