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References from α7nAChR alleviates cognitive impairment by promoting autophagy in astrocytes via CaMKK2/AMPK/mTOR pathway in sepsis-associated encephalopathy. Local targets link to admitted publications; unresolved targets remain external evidence.
Sepsis-associated encephalopathy: mechanisms, diagnosis, and treatments update
10.7150/ijbs.102234 · 2025 · External reference
Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database
10.1097/cm9.0000000000000392 · 2019 · External reference
Long-term cognitive impairment and functional disability among survivors of severe sepsis
10.1001/jama.2010.1553 · 2010 · External reference
Neurofilament light chains to assess sepsis-associated encephalopathy: are we on the track toward clinical implementation
10.1186/s13054-023-04497-4 · 2023 · External reference
Cerebral dysfunctions caused by sepsis during ageing
10.1038/s41577-021-00643-7 · 2022 · External reference
Sepsis-associated encephalopathy: a vicious cycle of immunosuppression
10.1186/s12974-020-1701-3 · 2020 · External reference
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor
10.1016/j.bbi.2020.10.008 · 2021 · External reference
Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy
2021 · External reference
Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches
10.1007/s12640-020-00270-5 · 2021 · External reference
Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis
10.1016/j.bbi.2019.05.038 · 2019 · External reference
Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy
10.1186/s12974-019-1689-8 · 2020 · External reference
Experimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to blood-brain barrier breakdown
10.1016/j.bbi.2019.10.012 · 2020 · External reference
AQP4 aggravates cognitive impairment in sepsis-associated encephalopathy through inhibiting Nav1.6-mediated astrocyte autophagy
10.1002/advs.202306241 · 2023 · External reference
Cell biology of astrocyte-synapse interactions
10.1016/j.neuron.2017.09.056 · 2017 · External reference
Cytokines as emerging regulators of central nervous system synapses
10.1016/j.immuni.2023.04.011 · 2023 · External reference
Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes
10.1002/glia.23697 · 2020 · External reference
Astrocyte autophagy flux protects neurons against oxygen-glucose deprivation and ischemic/reperfusion injury
10.1089/rej.2017.1999 · 2018 · External reference
Nobiletin regulates intracellular Ca(2+) levels via IP(3)R and ameliorates neuroinflammation in Aβ42-induced astrocytes
10.1016/j.redox.2024.103197 · 2024 · External reference
Beyond acetylcholinesterase inhibitors for treating Alzheimer's disease: α7-nAChR agonists in human clinical trials
10.2174/1381612820666140316130720 · 2014 · External reference
Astrocytic α7-nicotinic acetylcholine receptors mediate pain information processing and perception
10.1016/j.nbd.2025.107245 · 2026 · External reference
Activation of α7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses
10.1111/jnc.12436 · 2013 · External reference
Astrocytes mediate the pro-cognitive value of α7nAChRs and of α7nAChR-targeting therapeutics
10.64898/2026.04.16.719027 · 2026 · External reference
Usefulness of α7 nicotinic receptor messenger RNA levels in peripheral blood mononuclear cells as a marker for cholinergic antiinflammatory pathway activity in septic patients: results of a pilot study
10.1093/infdis/jiu425 · 2015 · External reference
Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis
10.5847/wjem.j.1920-8642.2025.099 · 2025 · External reference
Autophagy plays an important role in anti-inflammatory mechanisms stimulated by alpha7 nicotinic acetylcholine receptor
10.3389/fimmu.2017.00553 · 2017 · External reference
Melatonin regulates the autophagic flux via activation of alpha-7 nicotinic acetylcholine receptors
10.1111/jpi.12235 · 2015 · External reference
α7nAChR deletion aggravates myocardial infarction and enhances systemic inflammatory reaction via mTOR-signaling-related autophagy
10.1007/s10753-019-00979-2 · 2019 · External reference
Immunodesign of experimental sepsis by cecal ligation and puncture
10.1038/nprot.2008.214 · 2009 · External reference
Activating α7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway
10.1007/s00011-023-01714-2 · 2023 · External reference
High-fat diet enhances working memory in the Y-maze test in male C57BL/6J mice with less anxiety in the elevated plus maze test
10.3390/nu12072036 · 2020 · External reference
Scorpion venom heat-resistant peptide is neuroprotective against cerebral ischemia-reperfusion injury in association with the NMDA-MAPK pathway
10.1007/s12264-019-00425-1 · 2020 · External reference
Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice
10.1186/s13195-020-00616-3 · 2020 · External reference
TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain
10.1186/s12974-019-1618-x · 2019 · External reference
TRIM32 deficiency impairs synaptic plasticity by excitatory-inhibitory imbalance via Notch pathway
10.1093/cercor/bhaa064 · 2020 · External reference
Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: likely role of Na(v) 1.6 inhibition in microglia
10.1111/bph.15502 · 2021 · External reference
The astrocyte: metabolic hub of the brain
10.1101/cshperspect.a041355 · 2024 · External reference
Astrocyte biomarkers in Alzheimer's disease
10.1016/j.molmed.2018.11.006 · 2019 · External reference
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases
10.1007/s00018-010-0525-1 · 2011 · External reference
Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze
10.1016/s0091-3057(01)00643-8 · 2001 · External reference
Molecular function of α7 nicotinic receptors as drug targets
10.1113/jp275101 · 2018 · External reference
The alpha7 nicotinic acetylcholine receptor in neuronal plasticity
10.1007/bf02741361 · 1999 · External reference
Regulators of cholinergic signaling in disorders of the central nervous system
10.1111/jnc.15332 · 2021 · External reference
Cholinergic modulation of glial function during aging and chronic neuroinflammation
10.3389/fncel.2020.577912 · 2020 · External reference
Cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nAChR) and the proportion of M1/M2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy
2021 · External reference
Autophagy in astrocytes and its implications in neurodegeneration
10.1016/j.jmb.2019.12.041 · 2020 · External reference
3-Methyladenine attenuates neuroinflammation and improves cognitive function in sepsis-associated encephalopathy by inhibiting autophagy
10.1016/j.intimp.2024.112744 · 2024 · External reference
Pyrrolidine dithiocarbamate ameliorates sepsis-associated encephalopathy by inhibiting autophagy and inflammation in the brain
10.1007/s11064-025-04355-5 · 2025 · External reference
Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model
10.1042/cs20190351 · 2019 · External reference
Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis-associated encephalopathy by immunity-related GTPase M1
10.1111/cns.13229 · 2020 · External reference
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway
10.1016/j.intimp.2020.106287 · 2020 · External reference
Sepsis-associated encephalopathy: Autophagy and miRNAs regulate microglial activation
10.14814/phy2.15964 · 2024 · External reference
CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: Potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway
10.1186/s12974-021-02300-1 · 2021 · External reference
Locus coeruleus-hippocampus noradrenergic activation alleviates sepsis-associated encephalopathy by promoting astrocytic AQP4-related autophagy via α(2)A-AR
10.1016/j.jare.2026.03.024 · 2026 · External reference
Sestrin 2 attenuates sepsis-associated encephalopathy through the promotion of autophagy in hippocampal neurons
10.1111/jcmm.15313 · 2020 · External reference
Selective activation of cholinergic neurotransmission from the medial septal nucleus to hippocampal pyramidal neurones improves sepsis-induced cognitive deficits in mice
10.1016/j.bja.2023.01.019 · 2023 · External reference
The absence of Gasdermin D reduces nuclear autophagy in a cecal ligation and puncture-induced sepsis-associated encephalopathy mouse model
10.3390/brainsci13030478 · 2023 · External reference
Ca2+ in quality control: An unresolved riddle critical to autophagy and mitophagy
10.4161/auto.25367 · 2013 · External reference
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
10.1016/j.molcel.2006.12.009 · 2007 · External reference
The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3
10.1007/s10059-009-0101-4 · 2019 · External reference
Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury
10.1186/s10020-018-0054-1 · 2018 · External reference
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
10.1073/pnas.160589697 · 2005 · External reference
The Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy
10.1016/j.bbrc.2013.11.044 · 2014 · External reference
Pretreatment with Kahweol attenuates sepsis-induced acute lung injury via improving mitochondrial homeostasis in a CaMKKII/AMPK-dependent pathway
10.1002/mnfr.202300083 · 2023 · External reference
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor model
10.1371/journal.pone.0059597 · 2013 · External reference
Extracellular cardiolipin modulates select immune functions of astrocytes in Toll-like receptor (TLR) 4-dependent manner
10.1155/2022/9946439 · 2022 · External reference
L-type voltage-gated calcium channel modulators inhibit glutamate-induced morphology changes in U118-MG astrocytoma cells
10.1007/s10571-020-00828-z · 2020 · External reference
Design of an imaging probe to monitor real-time redistribution of L-type voltage-gated calcium channels in astrocytic glutamate signaling
10.1007/s11307-020-01573-x · 2021 · External reference
Regulation of the phagocytic activity of astrocytes by neuroimmune mediators endogenous to the central nervous system
10.1371/journal.pone.0289169 · 2023 · External reference