Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Single-cell profiling reveals context-dependent immune regulation shared by sepsis and systemic lupus erythematosus. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting sepsis: Disease tolerance, immune resilience, and compartmentalized immunity
10.3390/biomedicines12112420 · 2024 · External reference
Severe COVID-19 and sepsis: Immune pathogenesis and laboratory markers
10.3390/microorganisms9010159 · 2021 · External reference
Advances in mechanisms of systemic lupus erythematosus
2014 · External reference
Immunometabolism in systemic lupus erythematosus: Relevant pathogenetic mechanisms and potential clinical applications
10.1016/j.jfma.2021.03.019 · 2021 · External reference
Immunosenescence: A critical factor associated with organ injury after sepsis
10.3389/fimmu.2022.917293 · 2022 · External reference
An update on pathogenesis of systemic lupus erythematosus
2014 · External reference
Clinical and immunological biomarkers for systemic lupus erythematosus
10.3390/biom11070928 · 2021 · External reference
RIPK1/RIPK3/MLKL necrosome contributes to the sepsis-induced cardiorenal necroptotic inflammatory injury and mortality
10.2174/0118761429374574250415114715 · 2024 · External reference
Stimulation of soluble guanylyl cyclase (sGC) by cinaciguat attenuates sepsisinduced cardiac injury
10.2174/0118761429387280250506114040 · 2024 · External reference
Oral hydroxychloroquine mitigates lipopolysaccharide-induced lung injury by inhibiting pyroptosis in mice
10.2174/1874467215666220822110855 · 2023 · External reference
Mendelian randomization and infection: Pitfalls and promises
10.1093/infdis/jiaf251 · 2025 · External reference
Investigation of genes associated with atherosclerosis in patients with systemic lupus erythematosus
10.46497/archrheumatol.2021.8024 · 2021 · External reference
Endogenous retroviruses transcriptional modulation after severe infection, trauma and burn
10.3389/fimmu.2018.03091 · 2018 · External reference
Limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
KEGG for taxonomy-based analysis of pathways and genomes
10.1093/nar/gkac963 · 2023 · External reference
KEGG: Kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
KEGG: Kyoto encyclopedia of genes and genomes
10.1093/nar/27.1.29 · 1999 · External reference
A novel immune-related gene signature to identify the tumor microenvironment and prognose disease among patients with oral squamous cell carcinoma patients using ssGSEA: A bioinformatics and biological validation study
10.3389/fimmu.2022.922195 · 2022 · External reference
Genomic atlas of the human plasma proteome
10.1038/s41586-018-0175-2 · 2018 · External reference
pROC: An open-source package for R and S+ to analyze and compare ROC curves
10.1186/1471-2105-12-77 · 2011 · External reference
Combining machine learning and single-cell sequencing to identify key immune genes in sepsis
10.1038/s41598-025-85799-1 · 2025 · External reference
Modulation of the itaconate pathway attenuates murine lupus
10.1002/art.42284 · 2022 · External reference
4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages
10.4049/jimmunol.2100488 · 2021 · External reference
Dataset on the differentiation of THP-1 monocytes to LPS inducible adherent macrophages and their capacity for NO/iNOS signaling
10.1016/j.dib.2021.106786 · 2021 · External reference
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
10.1038/s41467-019-13078-5 · 2019 · External reference
Myeloid CD169/Siglec1: An immunoregulatory biomarker in viral disease
10.3389/fmed.2022.979373 · 2022 · External reference
SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies
10.1136/rmdopen-2021-001934 · 2022 · External reference
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
10.1007/s15010-021-01606-9 · 2021 · External reference
SIGLEC1 (CD169): A marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients
10.1038/s41598-021-89786-0 · 2021 · External reference
Knockdown of SIGLEC1 inhibits osteogenic differentiation to alleviate ankylosing spondylitis progression by suppressing the TGF-β1/SMAD signaling pathway
10.1007/s00210-024-03456-2 · 2024 · External reference
Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: A key component of antiviral signalling
10.1042/bj20121425 · 2013 · External reference
TRIM25 and DEAD-Box RNA helicase DDX3X cooperate to regulate RIG-I-mediated antiviral immunity
10.3390/ijms22169094 · 2021 · External reference
The role of TRIM25 in the occurrence and development of cancers and inflammatory diseases
10.1016/j.bbcan.2023.188954 · 2023 · External reference
TRIM25 dictates selective miRNA loading into extracellular vesicles during inflammation
10.1038/s41598-023-50336-5 · 2023 · External reference
TRIM25 inhibits HBV replication by promoting HBx degradation and the RIG-I-mediated pgRNA recognition
10.1097/cm9.0000000000002617 · 2023 · External reference
TRIMmunity: The roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity
10.1016/j.jmb.2013.12.005 · 2014 · External reference
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
10.1038/s41467-019-14190-2 · 2020 · External reference