Research graph
References from Reframing ATR: from the immunologic/nonimmunologic dichotomy to adaptive, innate, and physicochemical drivers within the allergy–inflammation–coagulation axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2026 · External reference
Time to revisit the definition and clinical criteria for anaphylaxis
10.1016/j.waojou.2019.100066 · 2019 · External reference
Unresolved reference
2025 · External reference
Transfusion-related adverse reactions reported to the National Healthcare Safety Network Hemovigilance Module, United States, 2010 to 2012
10.1111/trf.12918 · 2015 · External reference
Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
10.1016/j.jaci.2003.12.591 · 2004 · External reference
Epinephrine: the drug of choice for anaphylaxis-a statement of the world allergy organization
10.1097/wox.0b013e31817c9338 · 2008 · External reference
Anaphylactic transfusion reactions associated with anti-IgA antibody
10.1056/nejm196901232800404 · 1969 · External reference
Serologic specificity of human anti-IgA and its significance in transfusion
10.1182/blood.v34.5.573.573 · 1969 · External reference
Non-allergic hypersensitivity reactions to immunoglobulin preparations in antibody deficiencies: What role for anti-IgA IgG and complement activation
10.1007/s12016-024-09007-0 · 2024 · External reference
Allergic transfusion reactions from blood components donated by IgA-deficient donors with and without anti-IgA: a comparative retrospective study
10.1111/j.1423-0410.2010.01326.x · 2010 · External reference
The role of anti-IgA antibodies in causing adverse reactions to gamma globulin infusion in immunodeficient patients: a comprehensive review of the literature
10.1016/j.jaci.2011.06.047 · 2012 · External reference
Unresolved reference
External reference
Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
10.1172/jci119255 · 1997 · External reference
Human IgE-independent systemic anaphylaxis
10.1016/j.jaci.2016.02.015 · 2016 · External reference
Food allergy: transfused and transplanted
10.1007/s11882-010-0110-6 · 2010 · External reference
Anaphylaxis from passive transfer of peanut allergen in a blood product
10.1056/nejmc1101692 · 2011 · External reference
Peanut and fish allergy due to platelet transfusion in a child
10.1503/cmaj.141407 · 2015 · External reference
Passive transfer of peanut hypersensitivity by fresh frozen plasma
10.1001/archinte.167.8.853 · 2007 · External reference
Thrombosis as an intravascular effector of innate immunity
10.1038/nri3345 · 2013 · External reference
The interactions between inflammation and coagulation
10.1111/j.1365-2141.2005.05753.x · 2005 · External reference
Coagulation and sepsis
10.1016/j.thromres.2016.11.007 · 2017 · External reference
Clinical effects and possible mechanisms of transfusion-related immunomodulation
2022 · External reference
Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum
10.1016/j.jaci.2005.12.1343 · 2006 · External reference
Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria
10.1111/j.1398-9995.2009.02222.x · 2010 · External reference
Increase of coagulation potential in chronic spontaneous urticaria
10.1111/j.1398-9995.2010.02506.x · 2011 · External reference
Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1beta
10.1111/1346-8138.15516 · 2020 · External reference
Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria
10.1111/all.14110 · 2020 · External reference
Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor
10.1016/j.jaci.2020.08.018 · 2021 · External reference
Increased thrombin generation potential in patients with chronic spontaneous urticaria
10.1016/j.alit.2014.07.006 · 2015 · External reference
Molecular intercommunication between the complement and coagulation systems
10.4049/jimmunol.0903678 · 2010 · External reference
Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions
10.1007/s00281-017-0646-9 · 2018 · External reference
Complement activation in arterial and venous thrombosis is mediated by plasmin
10.1016/j.ebiom.2016.02.011 · 2016 · External reference
Complement and coagulation: so close, yet so far
10.1182/blood-2017-10-811943 · 2017 · External reference
Coagulation and complement: Key innate defense participants in a seamless web
10.3389/fimmu.2022.918775 · 2022 · External reference
Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a
10.1016/j.imlet.2009.10.007 · 2010 · External reference
Function, structure and therapeutic potential of complement C5a receptors
10.1038/sj.bjp.0707332 · 2007 · External reference
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
10.1073/pnas.97.10.5255 · 2000 · External reference
Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor
10.1111/j.1538-7836.2009.03682.x · 2010 · External reference
Thrombin signalling and protease-activated receptors
10.1038/35025229 · 2000 · External reference
Proteinase-activated receptors
10.1016/s0031-6997(24)01493-5 · 2001 · External reference
PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology
10.1124/mol.109.062018 · 2010 · External reference
Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2
10.1038/s41467-025-59138-x · 2025 · External reference
Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis
10.1016/j.intimp.2015.04.047 · 2015 · External reference
Localization of protease-activated receptors-1 and -2 in human mast cells: indications for an amplified mast cell degranulation cascade
10.3109/10520290009064152 · 2000 · External reference
The role of coagulation and complement factors for mast cell activation in the pathogenesis of chronic spontaneous urticaria
10.3390/cells10071759 · 2021 · External reference
Activation of coagulation, anti-coagulation, fibrinolysis and the complement system in patients with urticaria
2012 · External reference
Evaluation of dysfunction in blood coagulation in children with urticaria
2016 · External reference
Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper
10.1111/all.15889 · 2023 · External reference
Anaphylactic reaction after methylene blue-treated plasma transfusion
10.1093/bja/aer009 · 2011 · External reference
Methylene blue-treated plasma: an increased allergy risk
10.1016/j.jaci.2012.03.050 · 2012 · External reference
Severe anaphylactic reaction after blue dye injection for sentinel lymph node biopsy in breast surgery: Report of two cases and literature review
10.1002/ccr3.3904 · 2021 · External reference
Mast cell degranulation in rat mesenteric venule: effects of L-NAME, methylene blue and ketotifen
10.1006/phrs.1999.0451 · 1999 · External reference
Transfusion-associated adverse reactions (TAARs) and cytokine accumulations in the stored blood components: the impact of prestorage versus poststorage leukoreduction
10.18632/oncotarget.23136 · 2018 · External reference
Kinetics of bradykinin levels during and after leucocyte filtration of platelet concentrates
10.1046/j.1423-0410.1998.7510018.x · 1998 · External reference
Leukocyte filtration fails to limit functional neutrophil activity during cardiac surgery
10.1007/pl00000316 · 2002 · External reference
Long-term leukocyte filtration should be avoided during extracorporeal circulation
10.1155/2013/612848 · 2013 · External reference
Biocompatibility of leukocyte removal filters during bedside leukocyte filtration of red cell concentrates
10.1016/0955-3886(92)90035-f · 1992 · External reference
Effects and side effects of platelet transfusion
10.1055/a-1347-6551 · 2021 · External reference
Pro-inflammatory effects after platelet transfusion: a review
10.1111/vox.12879 · 2020 · External reference
Platelets as cellular effectors of inflammation in vascular diseases
10.1161/circresaha.113.300512 · 2013 · External reference
Expression of complement components and inhibitors on platelet microparticles
10.1080/09537100701777311 · 2008 · External reference
Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment
10.1111/bjh.12150 · 2013 · External reference
Unlocking the non-IgE-mediated pseudo-allergic reaction puzzle with Mas-related G-protein coupled receptor member X2 (MRGPRX2)
10.3390/cells10051033 · 2021 · External reference
MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2- and IgE/FcepsilonRI-mediated events
10.1111/bcp.15845 · 2023 · External reference
Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases
10.1016/j.jaci.2016.04.051 · 2016 · External reference
MRGPRX2 sensing of cationic compounds-a bridge between nociception and skin diseases
10.1111/exd.14222 · 2021 · External reference
The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R>Q154 amino acid substitution
10.1182/blood-2009-11-248336 · 2010 · External reference
Transfusion-associated circulatory overload and transfusion-related acute lung injury
10.1182/blood-2018-10-860809 · 2019 · External reference
Choline transporter-like protein-2: New von Willebrand factor-binding partner involved in antibody-mediated neutrophil activation and transfusion-related acute lung injury
10.1161/atvbaha.115.305259 · 2015 · External reference
Anti-endothelial cell antibodies in vasculitis: A systematic review
10.1016/j.autrev.2016.12.012 · 2017 · External reference
Autoimmune aspects of Kawasaki disease
10.18176/jiaci.0300 · 2019 · External reference
The role of autoantibodies in bridging obesity, aging, and immunosenescence
10.1186/s12979-024-00489-2 · 2024 · External reference
Rethinking the role of older donors in a sustainable blood supply
10.1111/trf.18190 · 2025 · External reference
The multifaceted Mas-related G protein-coupled receptor member X2 in allergic diseases and beyond
10.3390/ijms22094421 · 2021 · External reference
Platelet concentrates in platelet additive solutions generate less complement activation products during storage than platelets stored in plasma
10.2450/2022.0323-21 · 2023 · External reference
PAS or plasma for storage of platelets? A concise review
10.1111/tme.12325 · 2016 · External reference
The impact of platelet additive solution apheresis platelets on allergic transfusion reactions and corrected count increment (CME)
10.1111/trf.12498 · 2014 · External reference
Hemostatic function, immunomodulatory capacity, and effects of lipemia in cold-stored whole blood
10.1111/trf.18065 · 2025 · External reference
Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period
10.3389/fcell.2025.1610009 · 2025 · External reference
Danger in the intensive care unit: Damps in critically ill patients
10.1097/shk.0000000000000506 · 2016 · External reference
The role of danger-associated molecular patterns (DAMPs) in trauma and infections
10.21037/jtd.2016.05.22 · 2016 · External reference
Low-grade chronic inflammation: a shared mechanism for chronic diseases
10.1152/physiol.00021.2024 · 2025 · External reference
Source of chronic inflammation in aging
10.3389/fcvm.2018.00012 · 2018 · External reference
Inflammation in obesity, diabetes, and related disorders
10.1016/j.immuni.2021.12.013 · 2022 · External reference
Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
10.1016/j.mbplus.2022.100107 · 2022 · External reference
Endothelial dysfunction and immunothrombosis in sepsis
10.3389/fimmu.2023.1144229 · 2023 · External reference
Recent advances in laboratory assays for nonhemolytic transfusion reactions
10.1111/j.1537-2995.2009.02388.x · 2010 · External reference
Food and inhaled allergens may play a more prominent role in allergic transfusion reactions than previously recognized
10.1111/trf.18026 · 2024 · External reference
Recent progress in understanding of allergic transfusion reaction
10.1016/j.coi.2025.102644 · 2025 · External reference
The basophil activation test for clinical management of food allergies: Recent advances and future directions
10.2147/jaa.s237759 · 2021 · External reference
Basophil reactivity as biomarker in immediate drug hypersensitivity reactions-potential and limitations
10.3389/fphar.2016.00171 · 2016 · External reference
Clinical utility of a passive immune basophil activation test for the analysis of allergic transfusion reactions
10.1111/trf.14208 · 2017 · External reference
Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice
10.1111/all.14747 · 2021 · External reference
IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
10.1016/j.waojou.2019.100080 · 2020 · External reference
Pilot study on the use of basophil activation tests and skin tests for the prevention of allergic transfusion reactions
10.3389/falgy.2023.1328227 · 2023 · External reference
Point-of-care diagnostics in coagulation management
10.3390/s20154254 · 2020 · External reference