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References from Macrophage-linked lipid metabolic signatures for HCC prognosis identified through integrated bulk and single-cell transcriptomics. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
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Predictors of early and late hepatocellular carcinoma recurrence
10.3748/wjg.v29.i8.1243 · 2023 · External reference
EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
10.1016/j.jhep.2024.08.028 · 2025 · External reference
China liver cancer guidelines for the diagnosis and treatment of hepatocellular carcinoma (2024 edition)
10.1159/000546574 · 2025 · External reference
Milestones in the treatment of hepatocellular carcinoma: A systematic review
10.1016/j.critrevonc.2020.103179 · 2021 · External reference
Hepatocellular carcinoma
10.1016/s0140-6736(22)01200-4 · 2022 · External reference
Tumor-associated macrophages in liver cancer: From mechanisms to therapy
10.1002/cac2.12345 · 2022 · External reference
Tumor‐associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
10.1053/j.gastro.2014.08.039 · 2014 · External reference
Tumor-associated macrophages in hepatocellular carcinoma: friend or foe
10.5009/gnl20223 · 2021 · External reference
Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC
10.1016/j.cell.2018.09.053 · 2018 · External reference
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
10.1016/j.apsb.2021.09.019 · 2022 · External reference
Drilling for oil: tumor-surrounding adipocytes fueling cancer
10.1016/j.trecan.2020.03.001 · 2020 · External reference
Hepatocellular carcinoma and lipid metabolism: Novel targets and therapeutic strategies
10.1016/j.canlet.2024.217061 · 2024 · External reference
Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation
10.1186/s12943-018-0838-5 · 2018 · External reference
Landscape and dynamics of single immune cells in hepatocellular carcinoma
10.1016/j.cell.2019.10.003 · 2019 · External reference
The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
10.1002/hep.32740 · 2023 · External reference
CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor
10.1038/s41421-023-00529-z · 2023 · External reference
Lipid metabolism-related gene signature predicts prognosis and indicates immune microenvironment infiltration in advanced gastric cancer
10.1155/2024/6639205 · 2024 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
ReactomeGSA: new features to simplify public data reuse
10.1093/bioinformatics/btae338 · 2024 · External reference
Translation and Adaptation of the Adult Developmental Coordination Disorder/Dyspraxia Checklist (ADC) into Asian Uzbekistan
10.3390/sports11070135 · 2023 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2
10.1093/bioinformatics/btac409 · 2022 · External reference
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
10.1093/bioinformatics/btw313 · 2016 · External reference
UpSetR: an R package for the visualization of intersecting sets and their properties
10.1093/bioinformatics/btx364 · 2017 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Clinicopathological characteristics of pheochromocytoma/paraganglioma and screening of prognostic markers
10.1002/jso.27358 · 2023 · External reference
Applying logistic LASSO regression for the diagnosis of atypical Crohn's disease
10.1038/s41598-022-15609-5 · 2022 · External reference
Time-dependent ROC curve analysis in medical research: current methods and applications
10.1186/s12874-017-0332-6 · 2017 · External reference
Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
10.1016/j.immuni.2025.05.006 · 2025 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Unveiling cuproptosis-driven molecular clusters and immune dysregulation in ankylosing spondylitis
10.2147/jir.s502520 · 2025 · External reference
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
10.1016/j.celrep.2016.12.019 · 2017 · External reference
Inferring tumour purity and stromal and immune cell admixture from expression data
10.1038/ncomms3612 · 2013 · External reference
Classification of triple-negative breast cancers based on Immunogenomic profiling
10.1186/s13046-018-1002-1 · 2018 · External reference
An immune-related signature based on molecular subtypes for predicting the prognosis and immunotherapy efficacy of hepatocellular carcinoma
10.3389/fimmu.2025.1481366 · 2025 · External reference
Epigenetics in hepatocellular carcinoma
10.1016/j.semcancer.2021.07.017 · 2022 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer
10.3389/fonc.2024.1480028 · 2024 · External reference
Correlation analysis of mitochondrial DNA maintenance-related genes with HCC prognosis, tumor mutation burden and tumor microenvironment features
10.1371/journal.pone.0325033 · 2025 · External reference
Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer
10.1002/ctm2.70335 · 2025 · External reference
Implications of genetic heterogeneity in hepatocellular cancer
10.1016/bs.acr.2022.01.007 · 2022 · External reference
A novel immune-related genes prognosis biomarker for hepatocellular carcinoma
10.18632/aging.202173 · 2020 · External reference
Predictive models for HCC prognosis, recurrence risk, and immune infiltration based on two exosomal genes: MYL6B and THOC2
10.2147/jir.s315957 · 2021 · External reference
Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma
10.1136/jitc-2019-000501 · 2020 · External reference
Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells
10.1038/s42003-020-01367-5 · 2020 · External reference
Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring
10.1038/s42255-024-01019-6 · 2024 · External reference
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
10.1126/sciimmunol.add8945 · 2023 · External reference
Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation
10.7150/ijbs.96831 · 2024 · External reference
FABP5+ lipid-loaded macrophages process tumour-derived unsaturated fatty acid signal to suppress T-cell antitumour immunity
10.1016/j.jhep.2024.09.029 · 2025 · External reference
Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function
10.1016/j.cmet.2019.11.021 · 2020 · External reference
CRISPR/Cas9 screens reveal that hexokinase 2 enhances cancer stemness and tumorigenicity by activating the ACSL4-fatty acid β-oxidation pathway
10.1002/advs.202105126 · 2022 · External reference
Knockdown of ECHS1 protein expression inhibits hepatocellular carcinoma cell proliferation via suppression of Akt activity
10.1615/critreveukaryotgeneexpr.2013007531 · 2013 · External reference
Comprehensive analysis of chronic hepatitis B concurrent with non-alcoholic fatty liver disease: a proteomics report based on clinical liver samples
10.1186/s12014-024-09523-3 · 2025 · External reference
Silencing ECHS1 attenuates the proliferation and induces the autophagy of hepatocellular carcinoma via impairing cell metabolism and activating AMPK
10.4149/neo_2015_106 · 2015 · External reference
ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells
10.1016/j.canlet.2012.11.030 · 2013 · External reference
The role of PPARs in disease
10.3390/cells9112367 · 2020 · External reference
Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of hepatocellular carcinoma (HCC)
10.1016/j.biopha.2024.117089 · 2024 · External reference
The role of PPAR alpha in the modulation of innate immunity
10.3390/ijms221910545 · 2021 · External reference
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
10.1136/gutjnl-2022-328364 · 2023 · External reference
Fatty acid metabolism affects hepatocellular carcinoma progression via the PPAR-γ signaling pathway and fatty acid β-oxidation
10.1016/j.intimp.2024.112917 · 2024 · External reference
Hepatocarcinogenesis prevention by Pirfenidone is PPARγ mediated and involves modification of nuclear NF-kB p65/p50 ratio
10.3390/ijms222111360 · 2021 · External reference
Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy
10.1172/jci.insight.163624 · 2023 · External reference
CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
10.1186/s13046-025-03329-3 · 2025 · External reference
Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway
10.1016/j.phymed.2023.155285 · 2024 · External reference
Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
10.1016/j.phrs.2023.106786 · 2023 · External reference
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways
10.1016/j.jhep.2015.07.039 · 2015 · External reference
MARCH8 suppresses hepatocellular carcinoma by promoting SREBP1 degradation and modulating fatty acid de novo synthesis
10.1038/s41419-025-07707-9 · 2025 · External reference
TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation
10.1038/s41388-024-03056-7 · 2024 · External reference
Sodium butyrate increases USP5-mediated ubiquitination degradation of GPX4 and enhances anti-cancer efficacy of anti-PD-1 antibody
10.1016/j.bcp.2025.116927 · 2025 · External reference
AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC
10.1016/j.jhep.2025.12.029 · 2026 · External reference
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells
10.1016/j.bbalip.2015.12.001 · 2016 · External reference
Understanding the tumor immune microenvironment (TIME) for effective therapy
10.1038/s41591-018-0014-x · 2018 · External reference
Cold and hot tumors: from molecular mechanisms to targeted therapy
10.1038/s41392-024-01979-x · 2024 · External reference
Dendritic cells in the cancer microenvironment
10.7150/jca.5046 · 2013 · External reference
Molecular and cellular insights into T cell exhaustion
10.1038/nri3862 · 2015 · External reference
The role of fibroblasts in pancreatic cancer: Extracellular matrix versus paracrine factors
10.1016/j.tranon.2017.04.009 · 2017 · External reference
Cancer-associated fibroblasts suppress CD8+ T-cell infiltration and confer resistance to immune-checkpoint blockade
10.1158/0008-5472.can-21-4141 · 2022 · External reference
Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis
10.1002/hep.22698 · 2009 · External reference
miR-10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 (CSMD1)
10.1186/s12885-016-2801-4 · 2016 · External reference
Combined identification of ARID1A, CSMD1, and SENP3 as effective prognostic biomarkers for hepatocellular carcinoma
10.18632/aging.202586 · 2021 · External reference
Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis
10.1016/j.isci.2023.108495 · 2023 · External reference
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2
10.1038/42523 · 1997 · External reference
Single-cell RNA-seq reveals the immune cell landscape and cell-cell communications in childhood Sjögren’s disease
10.1038/s42003-024-06123-x · 2024 · External reference
Deciphering the role of tryptophan metabolism-associated genes ECHS1 and ALDH2 in gastric cancer: implications for tumor immunity and personalized therapy
10.3389/fimmu.2024.1460308 · 2024 · External reference
Tumor-infiltrating CD8+ T-cell numbers and serum C-reactive protein levels as a prognostic biomarker in hepatocellular carcinoma patients receiving atezolizumab plus bevacizumab
10.1111/hepr.14100 · 2025 · External reference
From genes to therapy: a lipid metabolism-related genetic risk model predicts HCC outcomes and enhances immunotherapy
10.1186/s12885-025-14306-6 · 2025 · External reference
Development of a novel CD8+ T cell-associated signature for prognostic assessment in hepatocellular carcinoma
10.1177/10732748241270583 · 2024 · External reference