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References from Integrated analysis of isorhamnetin-associated targets in chronic pancreatitis and pancreatic cancer: immune-infiltration associations and antitumor effects in pancreatic cancer cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic pancreatitis
10.1097/mog.0b013e3282ba5736 · 2020 · External reference
Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study
10.3748/wjg.v29.i30.4671 · 2023 · External reference
Effectiveness and safety of central pancreatectomy in benign or low-grade Malignant pancreatic body lesions: a systematic review and meta-analysis
10.1097/js9.0000000000000326 · 2023 · External reference
Tailoring the use of central pancreatectomy through prediction models for major morbidity and postoperative diabetes: International retrospective multicenter study
10.1097/sla.0000000000006157 · 2023 · External reference
Pancreatic cancer precursor lesions - Can immunotherapy prevent progression into pancreatic ductal adenocarcinoma
10.1016/j.canlet.2025.217662 · 2025 · External reference
Pancreatic cancer: Advances and challenges
10.1016/j.cell.2023.02.014 · 2023 · External reference
Therapeutic developments in pancreatic cancer
10.1038/s41575-023-00840-w · 2023 · External reference
Comparative study of the mechanism of natural compounds with similar structures using docking and transcriptome data for improving in silico herbal medicine experimentations
10.1101/2023.04.23.538005 · 2023 · External reference
Systematic pharmacology and experimental validation to elucidate the inflammation-associated mechanism of Huanglian Wendan (HLWD) decoction in the treatment of MAFLD associated with atherosclerosis
10.1016/j.jep.2024.118841 · 2024 · External reference
Editorial: Network pharmacology and traditional medicine
10.3389/fphar.2020.01194 · 2020 · External reference
Lean-Docking: Exploiting ligands' predicted docking scores to accelerate molecular docking
10.1021/acs.jcim.0c01452 · 2021 · External reference
Application of molecular dynamics simulation in biomedicine
10.1111/cbdd.14038 · 2022 · External reference
Mendelian randomization
10.1101/cshperspect.a038984 · 2022 · External reference
Isorhamnetin: A review of pharmacological effects
10.1016/j.biopha.2020.110301 · 2020 · External reference
Progress in the antitumor molecular mechanisms of Isorhamnetin
10.1007/s12672-025-03265-w · 2025 · External reference
Isorhamnetin: Reviewing recent developments in anticancer mechanisms and nanoformulation-driven delivery
10.3390/ijms26157381 · 2025 · External reference
Isorhamnetin suppresses PANC-1 pancreatic cancer cell proliferation through S phase arrest
10.1016/j.biopha.2018.09.105 · 2018 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
NCAPG2 could be an immunological and prognostic biomarker: From pan-cancer analysis to pancreatic cancer validation
10.3389/fimmu.2023.1097403 · 2023 · External reference
Comprehensively prognostic and immunological analysis of snail family transcriptional repressor 2 in pan-cancer and identification in pancreatic carcinoma
10.3389/fimmu.2023.1117585 · 2023 · External reference
Open Babel: An open chemical toolbox
10.1186/1758-2946-3-33 · 2011 · External reference
Ligand docking and binding site analysis with PyMOL and Autodock/Vina
10.1007/s10822-010-9352-6 · 2010 · External reference
In silico evaluation of potential NDM-1 inhibitors: An integrated docking and molecular dynamics approach
10.3390/ph17121715 · 2025 · External reference
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2009 · External reference
Exploratory study on the role of emodin in alleviating MPTP-induced neurotoxicity: A focus on p53-ferroptosis signaling
10.2147/dddt.s522381 · 2025 · External reference
Genomic atlas of the human plasma proteome
10.1038/s41586-018-0175-2 · 2018 · External reference
FinnGen provides genetic insights from a well-phenotyped isolated population
10.1038/s41586-022-05473-8 · 2023 · External reference
A cross-population atlas of genetic associations for 220 human phenotypes
10.1038/s41588-021-00931-x · 2021 · External reference
Nanoceria ameliorates fibrosis, inflammation, and cellular stress in experimental chronic pancreatitis
10.1021/acsbiomaterials.2c00933 · 2023 · External reference
The role of a cholecystokinin receptor antagonist in the management of chronic pancreatitis: A phase 1 trial
10.3390/pharmaceutics16050611 · 2024 · External reference
DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma
10.1136/gutjnl-2023-330155 · 2023 · External reference
Mortality and cancer risk in patients with chronic pancreatitis in Japan: Insights into the importance of surveillance for pancreatic cancer
10.1007/s00535-025-02321-0 · 2025 · External reference
Cancer network pharmacology: Multi-network regulatory mechanisms and future directions
10.1007/s12032-025-02811-4 · 2025 · External reference
Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis
10.1038/s41388-022-02587-1 · 2023 · External reference
EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
10.1016/j.ccell.2023.12.002 · 2024 · External reference
The LAMB3-EGFR signaling pathway mediates synergistic anti-cancer effects of berberine and emodin in pancreatic cancer
10.1016/j.bcp.2024.116509 · 2024 · External reference
Decoding p53 tumor suppression: A crosstalk between genomic stability and epigenetic control
10.1038/s41418-024-01259-9 · 2024 · External reference
Deterministic evolution and stringent selection during preneoplasia
10.1038/s41586-023-06102-8 · 2023 · External reference
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development
10.1038/s42003-025-09465-y · 2026 · External reference
Mechanism of ethyl acetate fraction of Amorphophallus konjac against breast cancer based on network pharmacology, molecular docking and experimental validation
10.1016/j.jep.2025.119648 · 2025 · External reference
Xiaoai Jiedu recipe reduces cell survival and induces apoptosis in hepatocellular carcinoma by stimulating autophagy via the AKT/mTOR pathway
10.1016/j.jep.2024.119135 · 2024 · External reference
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
10.1038/s41580-023-00629-4 · 2023 · External reference
Assessment of the effect of Lasianthera africana on interleukin-6, tumor necrosis factor-alpha and other inflammatory markers in inflamed wistar rats
10.1007/s10787-025-02036-x · 2025 · External reference
The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer
10.3389/fimmu.2022.1093990 · 2023 · External reference
Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion
10.1172/jci162054 · 2023 · External reference
Systemic alterations in type-2 conventional dendritic cells lead to impaired tumor immunity in pancreatic cancer
10.1158/2326-6066.cir-21-0946 · 2023 · External reference
High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment
10.1186/s12967-023-04302-4 · 2023 · External reference
IL-4/STAT6-signaling influences local inflammation and regeneration processes during acute pancreatitis and promotes fibrosis by a direct activation of pancreatic fibroblasts during chronic pancreatitis
10.1002/advs.202515585 · 2026 · External reference
