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References from Integrated single-cell and bulk tissue analyses reveal distinct macrophage subtypes and a candidate prognostic signature in colorectal cancer: implications for tumor immune characterization. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
10.1007/s10555-023-10158-3 · 2024 · External reference
Exploring immunotherapy in colorectal cancer
10.1186/s13045-022-01294-4 · 2022 · External reference
Diagnosis and treatment of metastatic colorectal cancer: a review
10.1001/jama.2021.6027 · 2021 · External reference
Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer
10.1186/s12951-022-01586-4 · 2022 · External reference
BRD4 regulates PAI-1 expression in tumor-associated macrophages to drive chemoresistance in colorectal cancer
10.1038/s41388-025-03453-6 · 2025 · External reference
Macrophages: targets for next-generation cancer immunotherapy
10.1016/j.ccell.2026.01.020 · 2026 · External reference
Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment
10.3389/fimmu.2020.01731 · 2020 · External reference
Tumor-associated macrophages (TAMs) in colorectal cancer (CRC): from mechanism to therapy and prognosis
10.3390/ijms22168470 · 2021 · External reference
Developing a machine learning-based prognosis and immunotherapeutic response signature in colorectal cancer: insights from ferroptosis, fatty acid dynamics, and the tumor microenvironment
10.3389/fimmu.2024.1416443 · 2024 · External reference
Immune scores in colorectal cancer: where are we
10.1016/j.ejca.2020.08.024 · 2020 · External reference
Targeting tumor-associated macrophages to synergize tumor immunotherapy
10.1038/s41392-021-00484-9 · 2021 · External reference
Visualizing and interpreting cancer genomics data via the Xena platform
10.1038/s41587-020-0546-8 · 2020 · External reference
YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer
10.1038/s41388-023-02794-4 · 2019 · External reference
Identification of key genes for predicting colorectal cancer prognosis by integrated bioinformatics analysis
10.3892/ol.2019.11068 · 2020 · External reference
A 65-gene signature for prognostic prediction in colon adenocarcinoma
10.3892/ijmm.2018.3401 · 2018 · External reference
Identification of a novel macrophage-related prognostic signature in colorectal cancer
10.1038/s41598-024-53207-9 · 2024 · External reference
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer
10.1101/2020.01.10.901579 · 2021 · External reference
Molecular signatures database (MSigDB) 3.0
10.1093/bioinformatics/btr260 · 2011 · External reference
M2 macrophage-related gene signature in chronic rhinosinusitis with nasal polyps
10.3389/fimmu.2022.1047930 · 2022 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes
10.1038/s41596-020-0292-x · 2020 · External reference
Reporting and interpreting decision curve analysis: a guide for investigators
10.1016/j.eururo.2018.08.038 · 2018 · External reference
Identification and verification of immune-related gene prognostic signature based on ssGSEA for osteosarcoma
10.3389/fonc.2020.607622 · 2020 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Brd4 modulates metabolic endotoxemia-induced inflammation by regulating colonic macrophage infiltration in high-fat diet-fed mice
10.1038/s42003-024-07437-2 · 2024 · External reference
Genomics of drug sensitivity in cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
10.1093/nar/gks1111 · 2013 · External reference
Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
10.1016/j.cell.2020.03.048 · 2020 · External reference
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells
10.1186/s12951-025-03690-7 · 2025 · External reference
LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8
10.1161/circresaha.111.241810 · 2011 · External reference
Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation
10.1016/j.bcp.2020.114022 · 2020 · External reference
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
10.1621/nrs.08004 · 2010 · External reference
NR1H3 (LXRα) is associated with pro-inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b-cell lymphoma
10.1002/hon.3050 · 2022 · External reference
Macrophages in colorectal cancer: from normal mucosa to distant metastasis: beyond the M1/M2 paradigm
10.7150/jca.126772 · 2026 · External reference
Tumor-associated macrophages in cancer: from mechanisms to application
10.1186/s43556-025-00396-y · 2025 · External reference
The challenges of tumor mutational burden as an immunotherapy biomarker
10.1016/j.ccell.2020.10.001 · 2021 · External reference
Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
10.1186/s12885-023-11100-0 · 2023 · External reference
Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis
10.1038/s41467-023-43588-2 · 2023 · External reference
Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma
10.2139/ssrn.3448008 · 2020 · External reference
Bioengineered tumor-derived extracellular vehicles suppressed colorectal cancer liver metastasis and bevacizumab resistance
10.1002/advs.202417714 · 2025 · External reference
Cancer immune evasion, immunoediting and intratumour heterogeneity
10.1038/s41577-024-01111-8 · 2025 · External reference
The emerging roles of eosinophils in immune regulation in health and disease
10.3389/fimmu.2026.1652583 · 2026 · External reference
CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4
10.3390/ijms21218412 · 2020 · External reference
A novel anoikis related gene prognostic model for colorectal cancer based on single cell sequencing and bulk transcriptome analyses
10.1038/s41598-025-15389-8 · 2025 · External reference
Development of a prognostic risk model for colorectal cancer based on microsatellite stability-associated genes
10.1186/s12885-025-14918-y · 2025 · External reference
Construction of prognostic prediction models for colorectal cancer based on ferroptosis-related genes: a multi-dataset and multi-model analysis
10.1177/11795972241293516 · 2024 · External reference
Development of a prognostic prediction model based on damage-associated molecular pattern for colorectal cancer applying bulk RNA-seq analysis
10.1038/s41598-025-10592-z · 2025 · External reference
Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood
10.1038/s41698-024-00689-5 · 2024 · External reference
Machine learning in colorectal cancer prediction and diagnosis: a systematic review of models' performance
10.1016/j.ijmedinf.2025.106170 · 2026 · External reference
Diagnosis and treatment of metastatic colorectal cancer: a review
10.1001/jama.2021.6027 · ExternalCitation · doi-reference
Bioengineered tumor-derived extracellular vehicles suppressed colorectal cancer liver metastasis and bevacizumab resistance
10.1002/advs.202417714 · ExternalCitation · doi-reference
NR1H3 (LXRα) is associated with pro-inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b-cell lymphoma
10.1002/hon.3050 · ExternalCitation · doi-reference
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
10.1007/s10555-023-10158-3 · ExternalCitation · doi-reference
Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation
10.1016/j.bcp.2020.114022 · ExternalCitation · doi-reference
The challenges of tumor mutational burden as an immunotherapy biomarker
10.1016/j.ccell.2020.10.001 · ExternalCitation · doi-reference
Macrophages: targets for next-generation cancer immunotherapy
10.1016/j.ccell.2026.01.020 · ExternalCitation · doi-reference
Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
10.1016/j.cell.2020.03.048 · ExternalCitation · doi-reference
Immune scores in colorectal cancer: where are we
10.1016/j.ejca.2020.08.024 · ExternalCitation · doi-reference
Reporting and interpreting decision curve analysis: a guide for investigators
10.1016/j.eururo.2018.08.038 · ExternalCitation · doi-reference
Machine learning in colorectal cancer prediction and diagnosis: a systematic review of models' performance
10.1016/j.ijmedinf.2025.106170 · ExternalCitation · doi-reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · ExternalCitation · doi-reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · ExternalCitation · doi-reference
YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer
10.1038/s41388-023-02794-4 · ExternalCitation · doi-reference
BRD4 regulates PAI-1 expression in tumor-associated macrophages to drive chemoresistance in colorectal cancer
10.1038/s41388-025-03453-6 · ExternalCitation · doi-reference
Targeting tumor-associated macrophages to synergize tumor immunotherapy
10.1038/s41392-021-00484-9 · ExternalCitation · doi-reference
Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis
10.1038/s41467-023-43588-2 · ExternalCitation · doi-reference
Cancer immune evasion, immunoediting and intratumour heterogeneity
10.1038/s41577-024-01111-8 · ExternalCitation · doi-reference
Visualizing and interpreting cancer genomics data via the Xena platform
10.1038/s41587-020-0546-8 · ExternalCitation · doi-reference
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes
10.1038/s41596-020-0292-x · ExternalCitation · doi-reference
Identification of a novel macrophage-related prognostic signature in colorectal cancer
10.1038/s41598-024-53207-9 · ExternalCitation · doi-reference
Development of a prognostic prediction model based on damage-associated molecular pattern for colorectal cancer applying bulk RNA-seq analysis
10.1038/s41598-025-10592-z · ExternalCitation · doi-reference
A novel anoikis related gene prognostic model for colorectal cancer based on single cell sequencing and bulk transcriptome analyses
10.1038/s41598-025-15389-8 · ExternalCitation · doi-reference
Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood
10.1038/s41698-024-00689-5 · ExternalCitation · doi-reference
Brd4 modulates metabolic endotoxemia-induced inflammation by regulating colonic macrophage infiltration in high-fat diet-fed mice
10.1038/s42003-024-07437-2 · ExternalCitation · doi-reference
Molecular signatures database (MSigDB) 3.0
10.1093/bioinformatics/btr260 · ExternalCitation · doi-reference
Genomics of drug sensitivity in cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
10.1093/nar/gks1111 · ExternalCitation · doi-reference
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer
10.1101/2020.01.10.901579 · ExternalCitation · doi-reference
LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8
10.1161/circresaha.111.241810 · ExternalCitation · doi-reference
Construction of prognostic prediction models for colorectal cancer based on ferroptosis-related genes: a multi-dataset and multi-model analysis
10.1177/11795972241293516 · ExternalCitation · doi-reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · ExternalCitation · doi-reference
Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
10.1186/s12885-023-11100-0 · ExternalCitation · doi-reference
Development of a prognostic risk model for colorectal cancer based on microsatellite stability-associated genes
10.1186/s12885-025-14918-y · ExternalCitation · doi-reference
Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer
10.1186/s12951-022-01586-4 · ExternalCitation · doi-reference
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells
10.1186/s12951-025-03690-7 · ExternalCitation · doi-reference
Exploring immunotherapy in colorectal cancer
10.1186/s13045-022-01294-4 · ExternalCitation · doi-reference
Tumor-associated macrophages in cancer: from mechanisms to application
10.1186/s43556-025-00396-y · ExternalCitation · doi-reference
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
10.1621/nrs.08004 · ExternalCitation · doi-reference
Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma
10.2139/ssrn.3448008 · ExternalCitation · doi-reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · ExternalCitation · doi-reference
Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment
10.3389/fimmu.2020.01731 · ExternalCitation · doi-reference
M2 macrophage-related gene signature in chronic rhinosinusitis with nasal polyps
10.3389/fimmu.2022.1047930 · ExternalCitation · doi-reference
Developing a machine learning-based prognosis and immunotherapeutic response signature in colorectal cancer: insights from ferroptosis, fatty acid dynamics, and the tumor microenvironment
10.3389/fimmu.2024.1416443 · ExternalCitation · doi-reference
The emerging roles of eosinophils in immune regulation in health and disease
10.3389/fimmu.2026.1652583 · ExternalCitation · doi-reference
Identification and verification of immune-related gene prognostic signature based on ssGSEA for osteosarcoma
10.3389/fonc.2020.607622 · ExternalCitation · doi-reference
CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4
10.3390/ijms21218412 · ExternalCitation · doi-reference
Tumor-associated macrophages (TAMs) in colorectal cancer (CRC): from mechanism to therapy and prognosis
10.3390/ijms22168470 · ExternalCitation · doi-reference
A 65-gene signature for prognostic prediction in colon adenocarcinoma
10.3892/ijmm.2018.3401 · ExternalCitation · doi-reference
Identification of key genes for predicting colorectal cancer prognosis by integrated bioinformatics analysis
10.3892/ol.2019.11068 · ExternalCitation · doi-reference
Macrophages in colorectal cancer: from normal mucosa to distant metastasis: beyond the M1/M2 paradigm
10.7150/jca.126772 · ExternalCitation · doi-reference
