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References from Single-cell lineage tracing in tumor organoids identifies expansion states depicting the origin and progression of lung adenocarcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
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Is KRAS (G12C) inhibitor monotherapy for non-small cell lung cancer possible? A review of current literature
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Suppression of lung adenocarcinoma progression by Nkx2-1
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Organoids model transcriptional hallmarks of oncogenic KRAS activation in lung epithelial progenitor cells
10.1016/j.stem.2020.07.022 · 2020 · External reference
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform
10.21203/rs.3.rs-1281542/v1 · 2022 · External reference
Lineage tracing
10.1016/j.cell.2012.01.002 · 2012 · External reference
Lineage tracing meets single-cell omics: opportunities and challenges
10.1038/s41576-020-0223-2 · 2020 · External reference
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
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Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis
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Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution
10.1038/s41467-024-51424-4 · 2024 · External reference
Comprehensive molecular profiling of lung adenocarcinoma
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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
10.1038/nm.4333 · 2017 · External reference
KRT8 serves as a novel biomarker for LUAD and promotes metastasis and EMT via NF-κB signaling
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Immunostaining for thyroid transcription factor 1, Napsin A, p40, and cytokeratin 5 aids in differential diagnosis of non-small cell lung carcinoma
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Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq
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The role of ATF3 in the crosstalk between cellular stress response and ferroptosis in tumors
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The transcriptional signature associated with human motile cilia
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Hallmarks of cancer: New dimensions
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Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
10.1038/s41467-020-16164-1 · 2020 · External reference
Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
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Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data
10.1038/s41587-021-01091-3 · 2022 · External reference
Emergence of a high-plasticity cell state during lung cancer evolution
10.1016/j.ccell.2020.06.012 · 2020 · External reference
Critical role for a high-plasticity cell state in lung cancer
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Improved reconstruction of single-cell developmental potential with CytoTRACE 2
10.1038/s41592-025-02857-2 · 2025 · External reference
The epithelial-mesenchymal transition generates cells with properties of stem cells
10.1016/j.cell.2008.03.027 · 2008 · External reference
EMT in cancer
10.1016/j.ccr.2012.11.009 · 2018 · External reference
The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets
10.1038/s43018-021-00282-w · 2021 · External reference
Lung cancer stem cell markers as therapeutic targets: An update on signaling pathways and therapies
10.3389/fonc.2022.873994 · 2022 · External reference
Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells
10.1038/s41419-023-05554-0 · 2023 · External reference
Plexins as regulators of cancer cell proliferation, migration, and invasivity
10.3390/cancers15164046 · 2023 · External reference
Cancer stem cells: landscape, challenges and emerging therapeutic innovations
10.1038/s41392-025-02360-2 · 2025 · External reference
The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation
10.1038/s41576-023-00601-0 · 2023 · External reference
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
10.1186/s12943-023-01744-8 · 2023 · External reference
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
10.1016/j.cell.2016.11.022 · 2016 · External reference
The MYC oncogene - the grand orchestrator of cancer growth and immune evasion
10.1038/s41571-021-00549-2 · 2022 · External reference
CD8(+) T cell differentiation and dysfunction in cancer
10.1038/s41577-021-00574-3 · 2022 · External reference
Functional states of myeloid cells in cancer
10.1016/j.ccell.2023.02.009 · 2023 · External reference
Alveolar type 2 epithelial cell organoids: Focus on culture methods
10.3390/biomedicines11113034 · 2023 · External reference
Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization
10.1016/j.isci.2026.115030 · 2026 · External reference
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state
10.21203/rs.3.rs-2663901/v1 · 2025 · External reference
CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair
10.1038/s41467-024-48632-3 · 2024 · External reference
A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
10.1038/s41467-025-64224-1 · 2025 · External reference
Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury
10.1172/jci.insight.173374 · 2023 · External reference
Resolving the spatial organization of fetal liver hematopoiesis by SeekSpace
10.1186/s13619-025-00234-0 · 2025 · External reference
DSG2+ Cancer stem cells co-located with FAP+ Myofibroblasts in the tumor boundary that determines the efficacy of immunotherapy in non-small cell lung cancer
10.1002/advs.202514543 · 2026 · External reference
Single-cell and spatial transcriptomics reveal POSTN(+) cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer
10.1002/ctm2.1515 · 2023 · External reference
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer
10.1016/j.ccell.2022.10.008 · 2022 · External reference
Lineage tracing on transcriptional landscapes links state to fate during differentiation
10.1126/science.aaw3381 · 2020 · External reference
A subcellular map of the human proteome
10.1126/science.aal3321 · 2017 · External reference
A mass spectrometric-derived cell surface protein atlas
10.1371/journal.pone.0121314 · 2015 · External reference
Dlk1-mediated temporal regulation of notch signaling is required for differentiation of alveolar type II to type I cells during repair
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High-efficiency type II cell-enhanced green fluorescent protein expression facilitates cellular identification, tracking, and isolation
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Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis
10.1016/j.cell.2013.12.039 · 2014 · External reference
Identification of bronchioalveolar stem cells in normal lung and lung cancer
10.1016/j.cell.2005.03.032 · 2005 · External reference
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
10.1038/nature22334 · 2017 · External reference
Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo
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Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells
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Embracing the dropouts in single-cell RNA-seq analysis
10.1038/s41467-020-14976-9 · 2020 · External reference
Validation of noise models for single-cell transcriptomics
10.1038/nmeth.2930 · 2014 · External reference
Comparative analysis of single-cell RNA sequencing methods
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fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
10.1016/j.cels.2018.11.005 · 2019 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
The scverse project provides a computational ecosystem for single-cell omics data analysis
10.1038/s41587-023-01733-8 · 2023 · External reference
UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
10.1101/gr.209601.116 · 2017 · External reference
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts
10.1038/ncomms6871 · 2014 · External reference
Measurement of cancer cell growth heterogeneity through lentiviral barcoding identifies clonal dominance as a characteristic of in vivo tumor engraftment
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Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC
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10.1093/bioinformatics/btac757 · 2023 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
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Extending support for mouse data in the Molecular Signatures Database (MSigDB)
10.1038/s41592-023-02014-7 · 2023 · External reference
UniProt: the universal protein knowledgebase in 2025
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