Research graph
References from Biological barriers underlying the extremely high fatality of symptomatic rabies: neuroinvasion, immune evasion, and blood–brain barrier restriction. Local targets link to admitted publications; unresolved targets remain external evidence.
ICTV virus taxonomy profile: Rhabdoviridae
10.1099/jgv.0.001020 · 2018 · External reference
A call to accelerate an end to human rabies deaths
10.1016/s0140-6736(22)02487-4 · 2022 · External reference
Rabies
10.1001/jama.2022.22254 · 2023 · External reference
Wrangling rabies
10.1038/s41559-022-01802-2 · 2022 · External reference
Heading in the direction of ending human deaths from dog-mediated rabies
10.1016/s1473-3099(24)00506-1 · 2025 · External reference
Rabies - epidemiology, pathogenesis, public health concerns and advances in diagnosis and control: a comprehensive review
10.1080/01652176.2017.1343516 · 2017 · External reference
Rabies, a vaccine preventable disease: Current status, epidemiology, pathogenesis, prevention and control with special reference to India
10.18006/2018.6(1).62.86 · 2018 · External reference
Human rabies: Neuropathogenesis, diagnosis, and management
10.1016/s1474-4422(13)70038-3 · 2013 · External reference
The immune escape strategy of rabies virus and its pathogenicity mechanisms
10.3390/v16111774 · 2024 · External reference
Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates
10.1016/j.celrep.2022.111949 · 2023 · External reference
Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways
10.1128/jvi.79.22.14411-14420.2005 · 2005 · External reference
Inhibition of interferon signaling by rabies virus phosphoprotein P: Activation-dependent binding of STAT1 and STAT2
10.1128/jvi.80.6.2675-2683.2006 · 2006 · External reference
Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous system
10.1128/jvi.79.19.12554-12565.2005 · 2005 · External reference
Human rabies treatment-from palliation to promise
10.3390/v16010160 · 2024 · External reference
Demise of the Milwaukee protocol for rabies
10.1093/cid/ciaf157 · 2025 · External reference
Role of the blood-brain barrier in rabies virus infection and protection
10.1007/s13238-013-3918-8 · 2013 · External reference
Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus
10.1371/journal.ppat.1007189 · 2018 · External reference
Transferrin receptor protein 1 is an entry factor for rabies virus
10.1128/jvi.01612-22 · 2023 · External reference
Lab-attenuated rabies virus facilitates opening of the blood-brain barrier by inducing matrix metallopeptidase 8
10.1128/jvi.01050-22 · 2022 · External reference
Exposure history, post-exposure prophylaxis use, and clinical characteristics of human rabies cases in China, 2006-2012
10.1038/s41598-018-35158-0 · 2018 · External reference
Is the acetylcholine receptor a rabies virus receptor
10.1126/science.7053569 · 1982 · External reference
Rabies virus receptors
10.1080/13550280590900427 · 2005 · External reference
Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus
10.1093/emboj/17.24.7250 · 1998 · External reference
Single-cell transcriptomic classification of rabies-infected cortical neurons
10.1073/pnas.2203677119 · 2022 · External reference
The rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection
10.1128/jvi.02368-06 · 2007 · External reference
Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons
10.1128/jvi.02254-14 · 2014 · External reference
Rabies virus hijacks and accelerates the p75NTR retrograde axonal transport machinery
10.1371/journal.ppat.1004348 · 2014 · External reference
Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin
10.1128/jvi.01648-13 · 2013 · External reference
Real-time imaging of rabies virus entry into living Vero cells
10.1038/srep11753 · 2015 · External reference
Rabies internalizes into primary peripheral neurons via clathrin coated pits and requires fusion at the cell body
10.1371/journal.ppat.1005753 · 2016 · External reference
RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation
10.1128/jvi.00606-24 · 2024 · External reference
Entry of Challenge Virus Standard (CVS) -11 into N2a cells via a clathrin-mediated, cholesterol-, dynamin-, pH-dependent endocytic pathway
10.1186/s12985-019-1186-9 · 2019 · External reference
Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons
10.1371/journal.ppat.1007188 · 2018 · External reference
Establishment of human-induced pluripotent stem cell-derived neurons-a promising in vitro model for a molecular study of rabies virus and host interaction
10.3390/ijms222111986 · 2021 · External reference
The importance of immune evasion in the pathogenesis of rabies virus
10.1292/jvms.16-0092 · 2016 · External reference
Immune evasion by rabies viruses through the maintenance of blood-brain barrier integrity
10.1080/13550280802235924 · 2008 · External reference
Comparative analysis of rabies pathogenic and vaccine strains detection by RIG-I-like receptors
10.1016/j.micinf.2024.105321 · 2024 · External reference
The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling
10.1128/jvi.00989-13 · 2013 · External reference
Nuclear trafficking of the rabies virus interferon antagonist P-protein is regulated by an importin-binding nuclear localization sequence in the C-terminal domain
10.1371/journal.pone.0150477 · 2016 · External reference
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response
10.1128/jvi.02220-09 · 2010 · External reference
Importance of rabies virus nucleoprotein in viral evasion of interferon response in the brain
10.1111/1348-0421.12058 · 2013 · External reference
The matrix protein of rabies virus binds to RelAp43 to modulate NF-kappaB-dependent gene expression related to innate immunity
10.1038/srep39420 · 2016 · External reference
RelAp43, a member of the NF-kappaB family involved in innate immune response against Lyssavirus infection
10.1371/journal.ppat.1003060 · 2012 · External reference
The ectodomain of rabies virus glycoprotein determines dendritic cell activation
10.1016/j.antiviral.2017.01.022 · 2017 · External reference
The roles of rabies virus structural proteins in immune evasion and implications for vaccine development
10.1139/cjm-2024-0023 · 2024 · External reference
Effect of inhibition of Toll-like receptor 3 signaling on pathogenesis of rabies virus in mouse model
10.1016/j.actatropica.2022.106589 · 2022 · External reference
Inhibition of MEK-ERK1/2-MAP kinase signalling pathway reduces rabies virus induced pathologies in mouse model
10.1016/j.micpath.2017.09.044 · 2017 · External reference
Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-α, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse model
10.1007/s11262-015-1265-y · 2016 · External reference
Rabies virus uniquely reprograms the transcriptome of human monocyte-derived macrophages
10.3389/fcimb.2023.1013842 · 2023 · External reference
A comparative analysis of the dendritic cell response upon exposure to different rabies virus strains
10.1371/journal.pntd.0012994 · 2025 · External reference
mAb therapy controls CNS-resident lyssavirus infection via a CD4 T cell-dependent mechanism
10.15252/emmm.202216394 · 2023 · External reference
Structure and function of the blood-brain barrier
10.1016/j.nbd.2009.07.030 · 2010 · External reference
Blood-brain barrier: From physiology to disease and back
10.1152/physrev.00050.2017 · 2019 · External reference
The blood-brain barrier: structure, regulation, and drug delivery
10.1038/s41392-023-01481-w · 2023 · External reference
Failure to open the blood-brain barrier and deliver immune effectors to central nervous system tissues leads to the lethal outcome of silver-haired bat rabies virus infection
10.1128/jvi.01964-06 · 2007 · External reference
Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrier
10.1128/jvi.00710-07 · 2007 · External reference
Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines/cytokines induced by rabies virus infection
10.1128/jvi.03149-13 · 2014 · External reference
Expression of neuronal CXCL10 induced by rabies virus infection initiates infiltration of inflammatory cells, production of chemokines and cytokines, and enhancement of blood-brain barrier permeability
10.1128/jvi.02154-14 · 2015 · External reference
Lab-attenuated rabies virus causes abortive infection and induces cytokine expression in astrocytes by activating mitochondrial antiviral-signaling protein signaling pathway
10.3389/fimmu.2017.02011 · 2018 · External reference
Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice
10.1016/j.antiviral.2014.07.013 · 2014 · External reference
Receptor-mediated transcytosis for brain delivery of therapeutics: receptor classes and criteria
10.3389/fddev.2024.1360302 · 2024 · External reference
Targeting the transferrin receptor for brain drug delivery
10.1016/j.pneurobio.2019.101665 · 2019 · External reference
A SynB1-conjugated antibody cocktail crosses the blood-brain barrier to produce a therapeutic effect on rabies
10.1073/pnas.2516465122 · 2025 · External reference
Neuronal apoptosis does not play an important role in human rabies encephalitis
10.1080/13550280802216502 · 2008 · External reference
Structural abnormalities in neurons are sufficient to explain the clinical disease and fatal outcome of experimental rabies in yellow fluorescent protein-expressing transgenic mice
10.1128/jvi.01677-07 · 2008 · External reference
A spatial and cellular distribution of rabies virus infection in the mouse brain revealed by fMOST and single-cell RNA sequencing
10.1002/ctm2.700 · 2022 · External reference
Neuroimmunology of rabies: New insights into an ancient disease
10.1002/jmv.29042 · 2023 · External reference
Street rabies virus causes dendritic injury and F-actin depolymerization in the hippocampus
10.1099/vir.0.047480-0 · 2013 · External reference
Overexpression of MAP2 and NF-H associated with dendritic pathology in the spinal cord of mice infected with rabies virus
10.3390/v10030112 · 2018 · External reference
Early transcriptional changes in rabies virus-infected neurons and their impact on neuronal functions
10.3389/fmicb.2021.730892 · 2021 · External reference
Rabies virus infection of primary neuronal cultures and adult mice: failure to demonstrate evidence of excitotoxicity
10.1128/jvi.01272-06 · 2006 · External reference
Rabies virus infection causes pyroptosis of neuronal cells
10.3390/ijms25115616 · 2024 · External reference
A one medicine mission for an effective rabies therapy
10.3389/fvets.2022.867382 · 2022 · External reference
A phase 2b, randomized, double blinded comparison of the safety and efficacy of the monoclonal antibody mixture SYN023 and human rabies immune globulin in patients exposed to rabies
10.1016/j.vaccine.2024.05.066 · 2024 · External reference
Kinetics of blood-brain barrier transport of monoclonal antibodies targeting the insulin receptor and the transferrin receptor
10.3390/ph15010003 · 2022 · External reference
New treatments to rabies virus infections
10.1016/j.antiviral.2026.106380 · 2026 · External reference
