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References from Mechanisms of therapeutic antibodies immunogenicity: infliximab oligomeric aggregates increase T-cell response and uptake by dendritic cells involving mannose-sensitive receptor CD206. Local targets link to admitted publications; unresolved targets remain external evidence.
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Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity
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10.3389/fimmu.2020.00725 · 2020 · External reference
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Unresolved reference
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Subvisible particles in solutions of Remicade in intravenous saline activate immune system pathways in in vitro human cell systems
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The immunogenicity of antibody aggregates in a novel transgenic mouse model
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Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro
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Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics
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Infliximab aggregates produced in severe and mild elevated temperature stress conditions induce an extended specific CD4 T-cell response
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Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity
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Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms
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Development of a FRET-based assay for analysis of mAbs internalization and processing by dendritic cells in preclinical immunogenicity risk assessment
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10.1146/annurev-immunol-061020-053707 · 2021 · External reference
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals
10.1111/imr.13407 · 2024 · External reference
Antigen-presenting cell internalization is key for understanding and evaluating therapeutic antibodies’ immunogenicity
10.3389/fimmu.2025.1617395 · 2025 · External reference
Monoclonal antibody N-glycosylation profiling using capillary electrophoresis – Mass spectrometry: Assessment and method validation
10.1016/j.talanta.2017.09.083 · 2018 · External reference
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206
10.1016/j.jbc.2021.100368 · 2021 · External reference
C-type lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell adhesion molecules turned to pathogen recognition receptors
10.3390/biology10010001 · 2020 · External reference
Aggregation of protein therapeutics enhances their immunogenicity: Causes and mitigation strategies
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Immunogenicity risk assessment of spontaneously occurring therapeutic monoclonal antibody aggregates
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Evaluation of in vitro assays to assess the modulation of dendritic cells functions by therapeutic antibodies and aggregates
10.3389/fimmu.2019.00601 · 2019 · External reference
Effects of protein aggregates: An immunologic perspective
10.1208/aapsj080359 · 2006 · External reference
Impact of stress on the immunogenic potential of adalimumab
10.1016/j.xphs.2022.12.027 · 2023 · External reference
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10.3390/pharmaceutics14020325 · 2022 · External reference
Ultraviolet laser‐induced cross‐linking in peptides
10.1002/rcm.6610 · 2013 · External reference
Characterization of 30 therapeutic antibodies and related products by size exclusion chromatography: Feasibility assessment for future mass spectrometry hyphenation
10.1016/j.jchromb.2017.09.027 · 2017 · External reference
Microparticles and nanoparticles delivered in intravenous saline and in an intravenous solution of a therapeutic antibody product
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Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice
10.4161/mabs.22066 · 2012 · External reference
Classification and characterization of therapeutic antibody aggregates
10.1074/jbc.m110.160457 · 2011 · External reference
Quantitative analysis of the CD4+ T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay
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Quantitative analysis of the CD4 T‐cell repertoire specific to therapeutic antibodies in healthy donors
10.1096/fj.10-173872 · 2011 · External reference
Secukinumab demonstrates significantly lower immunogenicity potential compared to Ixekizumab
10.1007/s13555-018-0220-y · 2018 · External reference
A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
10.1038/s41591-019-0568-2 · 2019 · External reference
Antibodies internalization mechanisms by dendritic cells and their role in therapeutic antibody immunogenicity
10.1002/eji.202250340 · 2024 · External reference
Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics
10.3389/fimmu.2024.1406804 · 2024 · External reference
Fucosylation and sialylation of Fc-fragment of anti-tumour necrosis factor alpha antibodies do not influence their immunogenicity in monocyte-derived dendritic cells
10.1093/ecco-jcc/jjab038 · 2021 · External reference
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Cellular uptake mechanisms and endosomal trafficking of supercharged proteins
10.1016/j.chembiol.2012.06.014 · 2012 · External reference
A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes
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Do signalling endosomes play a role in T cell activation
10.1111/febs.12427 · 2013 · External reference
Stories from the dendritic cell guardhouse
10.3389/fimmu.2019.02880 · 2019 · External reference
The ins and outs of MHC class II-mediated antigen processing and presentation
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Sequence-dependent internalization of aggregating peptides
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Fcγ receptor-dependent internalization and off-target cytotoxicity of antibody-drug conjugate aggregates
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Decoding the mannose receptor-mAb interaction: The importance of high-mannose N-glycans and glycan-pairing
10.1080/19420862.2024.2400414 · 2024 · External reference
Glycosylation profile and biological activity of Remicade® compared with Flixabi® and Remsima®
10.1080/19420862.2017.1337620 · 2017 · External reference
Transmembrane TNF-dependent uptake of anti-TNF antibodies
10.1080/19420862.2017.1304869 · 2017 · External reference
Crucial role for immune complexes but not FcRn in immunization against anti–TNF-α antibodies after a single injection in mice
10.4049/jimmunol.1601246 · 2017 · External reference
Infliximab–tumor necrosis factor complexes elicit formation of anti-drug antibodies
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Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments
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Antigen processing and presentation mechanisms in myeloid cells
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A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
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HIV-1 viremia prevents the establishment of interleukin 2–producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
10.1084/jem.20031598 · 2003 · External reference
Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo
10.1002/eji.200737578 · 2008 · External reference
Aggregate formation and antibody stability in infusion bags: The impact of manual and robotic compounding of monoclonal antibodies
10.1016/j.xphs.2023.10.015 · 2024 · External reference
Stability of infliximab solutions in different temperature and dilution conditions
10.1016/j.jpba.2017.12.012 · 2018 · External reference
Single-cell RNA counting at allele and isoform resolution using Smart-seq3
10.1038/s41587-020-0497-0 · 2020 · External reference
Antigen receptor repertoire profiling from RNA-seq data
10.1038/nbt.3979 · 2017 · External reference
MiXCR: software for comprehensive adaptive immunity profiling
10.1038/nmeth.3364 · 2015 · External reference
NIH Image to ImageJ: 25 years of image analysis
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