Research graph
References from Erythrocytes as immunomodulators in trauma: orchestrating clearance pathways, inflammation, and organ injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Immunomodulatory roles of red blood cells
10.1097/moh.0000000000000734 · 2022 · External reference
Blood failure: Traumatic hemorrhage and the interconnections between oxygen debt, endotheliopathy, and coagulopathy
10.15441/ceem.23.127 · 2024 · External reference
Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression
10.3389/fimmu.2024.1416820 · 2024 · External reference
Shedding light on the effects of blood on meniscus tissue: The role of mononuclear leukocytes in mediating meniscus catabolism
10.1016/j.joca.2024.04.022 · 2024 · External reference
Influence of exogenous neuropeptides on the astrocyte response under conditions of continuous and cyclic hypoxia and red blood cell lysate
10.3390/ijms26093953 · 2025 · External reference
Red blood cell transfusion in brain-injured patients: A paradigm shift
10.23736/s0375-9393.25.19417-0 · 2025 · External reference
Liberal versus restrictive transfusion trigger after acute brain injury: More than just higher blood oxygen content
10.1089/neur.2025.0008 · 2025 · External reference
Increased platelet to red blood cell transfusion ratio associated with acute kidney injury in children with life-threatening bleeding
10.1111/trf.17788 · 2024 · External reference
The impact of perioperative blood transfusion on flap survival: A single-center review of limb salvage in the trauma setting
10.1055/a-2483-5207 · 2025 · External reference
Red blood cell-related phenotype-genotype correlations in chronic and acute critical illnesses (traumatic brain injury cohort and COVID-19 cohort)
10.3390/ijms26031239 · 2025 · External reference
Novel concepts in red blood cell clearance
10.1097/moh.0000000000000679 · 2021 · External reference
Smart red blood cell carriers: A nanotechnological approach to cancer drug delivery
10.3390/cimb47090711 · 2025 · External reference
Protein corona reprograms hepatic clearance pathways of biomimetic nanoparticles via ligand masking and differential protein enrichment
10.1002/smll.73301 · 2026 · External reference
Advances in biomimetic nanomaterial delivery systems: Harnessing nature’s inspiration for targeted drug delivery
10.1039/d4tb00565a · 2024 · External reference
Anti-CD47 antibody administration via cisterna magna in proper dosage can reduce perihematomal cell death following intracerebral hemorrhage in rats
10.1016/j.brainresbull.2021.07.003 · 2021 · External reference
Engineered RBCs encapsulating antigen induce multi-modal antigen-specific tolerance and protect against type 1 diabetes
10.3389/fimmu.2022.869669 · 2022 · External reference
Difficult blood typing caused by rouleaux agglutination in patient with acute brain trauma: A case report
10.7754/clin.lab.2023.230317 · 2023 · External reference
Plasmodium impairs antibacterial innate immunity to systemic infections in part through hemozoin-bound bioactive molecules
10.3389/fcimb.2020.00328 · 2020 · External reference
Splenic red pulp macrophages eliminate the liver-resistant streptococcus pneumoniae from the blood circulation of mice
10.1126/sciadv.adq6399 · 2025 · External reference
Redefining the concept of erythrocyte senescence: Is eryptosis fundamentally different from erythrocyte senescence
10.1007/s11357-025-02010-z · 2025 · External reference
Red cell damage during extracorporeal life support
10.1097/mat.0000000000002265 · 2024 · External reference
CD47 promotes, while exposure to apoptotic cells destroys the fusion program of differentiating myoblasts
10.1096/fj.202503809r · 2026 · External reference
Scald injury-induced t cell dysfunction can be mitigated by Gr1 + cell depletion and blockage of CD47/CD172a signaling
10.3389/fimmu.2020.00876 · 2020 · External reference
Immune and metabolic interactions of human erythrocytes: A molecular perspective
10.2174/1871530320666201104115016 · 2021 · External reference
Red blood cell supernatant increases activation and agonist-induced reactivity of blood platelets
10.1016/j.thromres.2020.10.023 · 2020 · External reference
Case report: Successful treatment with anti-C5 monoclonal antibody in a Japanese adolescent who developed thrombotic microangiopathy after autologous bone marrow transplantation for Malignant lymphoma
10.3389/fped.2022.908183 · 2022 · External reference
Neurological complications of malaria
10.1007/s11910-022-01214-6 · 2022 · External reference
Influence of blood components on neuroinflammation, blood-brain barrier breakdown, and functional damage after acute subdural hematoma in rats
10.1089/neur.2023.0098 · 2024 · External reference
Prospects for the use of regulators of oxidative stress in the comprehensive treatment of the novel coronavirus disease 2019 (COVID-19) and its complications
10.26355/eurrev_202008_22658 · 2020 · External reference
Cell-free mitochondria are detected in high concentrations in the plasma of orthopedic trauma patients
10.1097/ta.0000000000004483 · 2025 · External reference
Comprehensive proteomics profiling reveals biomarkers of oxidative stress and membrane integrity in red blood cells in acute altitude sickness
10.1021/acsomega.5c05768 · 2025 · External reference
An integrative proteomics metabolomics based strategy reveals the mechanisms involved in wasp sting induced acute kidney injury
10.1016/j.toxicon.2021.11.005 · 2022 · External reference
Macroscopic hematuria-associated severe acute kidney injury triggered by kidney stone formation in a patient with thin basement membrane and no history of microscopic hematuria
10.1007/s13730-024-00942-7 · 2025 · External reference
Macrophages and iron: A special relationship
10.3390/biomedicines9111585 · 2021 · External reference
Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes
10.1172/jci137282 · 2020 · External reference
Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model
10.1038/s41375-023-01903-2 · 2023 · External reference
Aged human stored red blood cell supernatant inhibits macrophage phagocytosis in an HMGB1 dependent manner after trauma in a murine model
10.1097/shk.0000000000000716 · 2017 · External reference
Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes
10.1016/j.isci.2025.114499 · 2026 · External reference
C4d deposits on the surface of RBCs in trauma patients and interferes with their function
10.1097/ccm.0000000000000231 · 2014 · External reference
Trauma patients with type O blood exhibit unique multiomics signature with decreased lectin pathway of complement levels
10.1097/ta.0000000000004367 · 2024 · External reference
Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in precapillary pulmonary arterioles
10.1172/jci.insight.139437 · 2020 · External reference
Direct red blood cell effect on thrombosis is dependent on the interaction of tissue factor and calcium with membrane phosphatidylserine
10.1097/ta.0000000000004340 · 2024 · External reference
Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis
10.1172/jci92077 · 2018 · External reference
Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots
10.1016/j.jtha.2023.05.022 · 2023 · External reference
Platelet, red cell, and endothelial activation and injury during extracorporeal membrane oxygenation
10.1097/mat.0000000000001320 · 2021 · External reference
Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion
10.1016/j.surg.2017.09.028 · 2018 · External reference
Trauma-hemorrhagic shock induces a CD36-dependent RBC endothelial-adhesive phenotype
10.1097/ccm.0000000000000119 · 2014 · External reference
Innate immune responses to trauma
10.1038/s41590-018-0064-8 · 2018 · External reference
Effects of nitrite and far-red light on coagulation
10.1016/j.niox.2020.11.005 · 2021 · External reference
Trauma induces intravascular hemolysis, exacerbated by red blood cell transfusion and associated with disrupted arginine-nitric oxide metabolism
10.1097/shk.0000000000002036 · 2023 · External reference
Emerging pathways in thromboinflammation of sickle cell disease: Novel findings in disease pathogenesis
10.1016/j.rpth.2025.103193 · 2025 · External reference
Shock-driven endotheliopathy in trauma patients is associated with leucocyte derived extracellular vesicles
10.3390/ijms232415990 · 2022 · External reference
Raising the bar on fibrinogen: A retrospective assessment of critical hypofibrinogenemia in severely injured trauma patients
10.1136/tsaco-2022-000937 · 2023 · External reference
Neutrophil membrane nanovesicles alleviate the renal function indicators in acute kidney injury caused by septic rats
10.1007/s12013-024-01664-4 · 2025 · External reference
Epidemiology and outcome of an acute kidney injuries in the polytrauma victims admitted at the apex trauma center in Dubai
10.4266/acc.2023.00388 · 2023 · External reference
Mitochondrial DNA as a damage-associated molecular pattern in stored blood: Mechanisms of transfusion-induced sterile inflammation
2026 · External reference
Mitochondrial DNA via recipient TLR9 acts as a potent first hit in murine transfusion-related acute lung injury
10.1182/blood.2025028794 · 2025 · External reference
Update on transfusion-related acute lung injury: An overview of its pathogenesis and management
10.3389/fimmu.2023.1175387 · 2023 · External reference
Liberal versus restrictive red blood cell transfusion strategy in acute coronary syndrome and anemia: An updated systematic review and meta-analysis
10.3389/fcvm.2025.1457400 · 2025 · External reference
Factors associated with the progression of traumatic intracranial hematoma during interventional radiology to establish hemostasis of extracranial hemorrhagic injury in severe multiple trauma patients
10.1002/ams2.580 · 2020 · External reference
Arginase I expression and activity in human mononuclear cells after injury
10.1097/00000658-200103000-00014 · 2001 · External reference
A retrospective study of ultramassive transfusion in trauma patients: Is there a value after which additional transfusions are futile
10.1213/ane.0000000000007569 · 2025 · External reference
Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation
10.1016/j.celrep.2022.110847 · 2022 · External reference
Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells
10.1038/s42003-021-02914-4 · 2021 · External reference
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
10.1172/jci137468 · 2021 · External reference
Cell-free hemoglobin in the pathophysiology of trauma: A scoping review
10.1097/cce.0000000000001052 · 2024 · External reference
Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons
10.1073/pnas.2104347118 · 2021 · External reference
Intravenous administration of anti-CD47 antibody augments hematoma clearance, mitigates acute neuropathology, and improves cognitive function in a rat model of penetrating traumatic brain injury
10.1089/neu.2024.0047 · 2024 · External reference
Supra-prophylactic doses of enoxaparin reduces fibrin deposition without exacerbation of intracerebral hemorrhage in a rat model of penetrating traumatic brain injury
10.1089/neu.2023.0060 · 2025 · External reference
Advances in drug delivery systems based on red blood cells and their membrane-derived nanoparticles
10.1021/acsnano.2c11965 · 2023 · External reference
Red blood cells: A potential delivery system
10.1186/s12951-023-02060-5 · 2023 · External reference
Red blood cell membrane-camouflaged prednisolone acetate-loaded PLGA nanoparticles for kidney-targeted drug delivery
10.1016/j.jddst.2023.104693 · 2023 · External reference
RGD peptide modified RBC membrane functionalized biomimetic nanoparticles for thrombolytic therapy
10.1007/s10856-023-06719-1 · 2023 · External reference
Liberal or restrictive transfusion strategy in patients with traumatic brain injury
10.1056/nejmoa2404360 · 2024 · External reference
Efficacy of restrictive versus liberal transfusion strategies in patients with traumatic brain injury: A systematic review and meta-analysis of randomized controlled trials
10.1186/s13613-024-01411-1 · 2024 · External reference
Elevated cell-free hemoglobin: A novel early biomarker following traumatic injury
10.1097/ta.0000000000004543 · 2025 · External reference
Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma
10.3389/fimmu.2024.1390380 · 2024 · External reference
The impact of transfusion kinetics on the inflammatory response following major injury
10.1097/ta.0000000000004399 · 2024 · External reference
Erythrocytes: Member of the immune system that should not be ignored
10.1016/j.critrevonc.2023.104039 · 2023 · External reference
Basic mechanisms of hemolysis-associated thrombo-inflammation and immune dysregulation
10.1161/atvbaha.123.318780 · 2023 · External reference
Immunological impact of the CD71+ RBCs: A potential immune mediator in transfusion
10.1016/j.transci.2023.103721 · 2023 · External reference
The intersection of trauma and immunity: Immune dysfunction following hemorrhage
10.3390/biomedicines12122889 · 2024 · External reference
Residual genetic material in mature red blood cells
10.3390/ijms262110774 · 2025 · External reference