Research graph
References from Identification of MMP8, DDX24, RNASE2, and EMB as a novel diagnostic gene panel for sepsis: a transcriptome-based modeling study. Local targets link to admitted publications; unresolved targets remain external evidence.
The third international consensus definitions for sepsis and septic shock (Sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2026
10.1097/ccm.0000000000007075 · 2026 · External reference
Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations
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The epidemiology of sepsis in Chinese ICUs: A national cross-sectional survey
10.1097/ccm.0000000000004155 · 2020 · External reference
Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study
10.1186/s13054-021-03883-0 · 2022 · External reference
Effect of delayed antibiotic use on mortality outcomes in patients with sepsis or septic shock: A systematic review and meta-analysis
10.1016/j.intimp.2024.111616 · 2024 · External reference
Novel biomarkers for sepsis: A narrative review
10.1016/j.ejim.2017.09.030 · 2017 · External reference
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians
10.1007/s00134-022-06956-y · 2023 · External reference
Neonatal sepsis: A comprehensive review
10.3390/antibiotics14010006 · 2024 · External reference
Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review
10.1186/s13054-021-03862-5 · 2022 · External reference
American Society for Microbiology evidence-based laboratory medicine practice guidelines to reduce blood culture contamination rates: a systematic review and meta-analysis
10.1128/cmr.00087-24 · 2024 · External reference
Interventions for rapid recognition and treatment of sepsis in the emergency department: a narrative review
10.1016/j.cmi.2020.02.022 · 2021 · External reference
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update
10.1186/s13054-022-04290-9 · 2023 · External reference
Time to blood culture positivity by pathogen and primary service
10.1542/hpeds.2021-005873 · 2021 · External reference
Blood culture-free ultra-rapid antimicrobial susceptibility testing
10.1038/s41586-024-07725-1 · 2024 · External reference
Clinical effectiveness of procalcitonin- or C-reactive protein-guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta-analysis
10.1111/anae.70109 · 2026 · External reference
Sepsis: key insights, future directions, and immediate goals. A review and expert opinion
10.1007/s00134-024-07694-z · 2024 · External reference
Diagnostic performances of procalcitonin and C-reactive protein for sepsis: a systematic review and meta-analysis
10.1097/mej.0000000000001235 · 2025 · External reference
C-reactive protein in adult sepsis: systematic review and meta-analysis
10.1016/j.clinsp.2025.100848 · 2025 · External reference
Comparison of serial pancreatic stone protein, C-reactive protein and procalcitonin for the diagnosis of infection and sepsis in critically ill patients: a multicentre prospective study
10.1186/s12871-026-03883-z · 2026 · External reference
Pentraxin-3, MyD88, GLP-1, and PD-L1: Performance assessment and composite algorithmic analysis for sepsis identification
10.1016/j.jinf.2025.106599 · 2025 · External reference
Development of a gene panel for immune status assessment in sepsis
10.1186/s13613-025-01594-1 · 2025 · External reference
Identification and validation of core biomarkers for sepsis: a comprehensive analysis using bioinformatics and machine learning
10.3389/fimmu.2025.1700704 · 2025 · External reference
Bioinformatic identification and experiment validation revealed that ACTG1 is a promising prognostic signature and therapeutic target for sepsis
10.1093/jleuko/qiad072 · 2023 · External reference
Implications of Ywhah gene expression in the early detection of sepsis
10.1097/shk.0000000000002409 · 2024 · External reference
Immunopathophysiology of human sepsis
10.1016/j.ebiom.2022.104363 · 2022 · External reference
Endothelial dysfunction and neutrophil degranulation as central events in sepsis physiopathology
10.1097/mol.0000000000000107 · 2021 · External reference
Reporting and interpreting decision curve analysis: A guide for investigators
10.1016/j.eururo.2018.08.038 · 2018 · External reference
A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications
10.1186/s12967-023-04499-4 · 2023 · External reference
Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation
10.1038/s41423-020-00581-9 · 2021 · External reference
Immune suppressive activities of low-density neutrophils in sepsis and potential use as a novel biomarker of sepsis-induced immune suppression
10.1038/s41598-025-92417-7 · 2025 · External reference
Low-density neutrophil heterogeneity and spleen tyrosine kinase as therapeutic targets in sepsis
10.1172/jci.insight.201057 · 2026 · External reference
Characterizing a low-density neutrophil gene signature in acute and chronic infections and its impact on disease severity
10.1093/jleuko/qiaf027 · 2025 · External reference
Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study
10.1016/s0140-6736(19)32989-7 · 2020 · External reference
The pathophysiology of sepsis and precision-medicine-based immunotherapy
10.1038/s41590-023-01660-5 · 2024 · External reference
The immunology of sepsis
10.1016/j.immuni.2021.10.012 · 2021 · External reference
Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
10.1186/s40779-022-00422-y · 2022 · External reference
Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis
10.1007/s00134-024-07586-2 · 2024 · External reference
Early assessment of leukocyte alterations at diagnosis of septic shock
10.1097/shk.0b013e3181dc0977 · 2010 · External reference
Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy
10.3389/fimmu.2025.1577105 · 2025 · External reference
MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets
10.1016/j.cytogfr.2022.07.007 · 2023 · External reference
Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsis
10.7150/ijbs.92267 · 2024 · External reference
Single-cell transcriptome profiling of sepsis identifies HLA-DR(low)S100A(high) monocytes with immunosuppressive function
10.1186/s40779-023-00462-y · 2023 · External reference
Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis
10.1182/blood.2020009417 · 2021 · External reference
Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-κB signaling pathway in CD4 T cells
10.1016/j.ymthe.2021.12.013 · 2022 · External reference
Heat shock protein 90α reduces CD8(+) T cell exhaustion in acute lung injury induced by lipopolysaccharide
10.1038/s41420-024-02046-8 · 2024 · External reference
Circulating exosomes in sepsis induce PD-1 expression in macrophages and promote Th17 differentiation
10.1097/js9.0000000000003651 · 2026 · External reference
The role of MMP8 in cancer: A systematic review
10.3390/ijms20184506 · 2019 · External reference
Extracellular proteins as potential biomarkers in sepsis-related cerebral injury
10.3389/fimmu.2023.1128476 · 2023 · External reference
Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/beta-catenin pathway
10.1093/burnst/tkad025 · 2024 · External reference
Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study
10.3389/fimmu.2023.1184700 · 2023 · External reference
DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling
10.1371/journal.ppat.1003721 · 2013 · External reference
DExH/D-box helicases at the frontline of intrinsic and innate immunity against viral infections
10.1099/jgv.0.001766 · 2022 · External reference
DDX24 mutation alters NPM1 phase behavior and disrupts nucleolar homeostasis in vascular malformations
10.7150/ijbs.84097 · 2023 · External reference
Anti-apoptotic and anti-oxidative effects of DDX24 through HO-1 transcriptional regulation
10.1096/fj.202500598rr · 2025 · External reference
Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
10.1186/s12950-023-00355-w · 2023 · External reference
Immunomodulatory roles and clinical significance of GZMM and DDX24 in sepsis: a multiomics integrative analysis with experimental validation
10.1155/humu/4951633 · 2026 · External reference
Identification and validation of key genes related to arginine methylation modification in sepsis using transcriptome combined with Mendelian randomization analysis
10.1097/shk.0000000000002741 · 2025 · External reference
Embigin is highly expressed on CD4+ and CD8+ T cells but is dispensable for several T cell effector responses
10.4049/immunohorizons.2300083 · 2024 · External reference
Host defence RNases as antiviral agents against enveloped single stranded RNA viruses
10.1080/21505594.2021.1871823 · 2021 · External reference
Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
10.1007/s00018-022-04229-x · 2022 · External reference
RNASE2 mediates age-associated B cell expansion through monocyte derived IL-10 in patients with systemic lupus erythematosus
10.3389/fimmu.2022.752189 · 2022 · External reference
Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing
10.3389/fimmu.2023.1298041 · 2023 · External reference
Folic acid targeting shared sepsis-osteoporosis pathogenesis: from computational discovery to dynamic binding mechanisms
10.1021/acsomega.5c07505 · 2026 · External reference
Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning
10.3389/fimmu.2022.995974 · 2022 · External reference
A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection
10.3389/fimmu.2023.1257834 · 2023 · External reference
New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation
10.1186/s11658-024-00536-2 · 2024 · External reference
Statistics review 10: further nonparametric methods
10.1186/cc2857 · 2004 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
A travel guide to Cytoscape plugins
10.1038/nmeth.2212 · 2012 · External reference
GeneMANIA update 2018
10.1093/nar/gky311 · 2018 · External reference
On LASSO for predictive regression
10.1016/j.jeconom.2021.02.002 · 2022 · External reference
TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods
10.1136/bmj-2023-078378 · 2024 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
10.1186/s13073-019-0638-6 · 2019 · External reference
Deconvoluting tumor-infiltrating immune cells from RNA-seq data using quanTIseq
10.1016/bs.mie.2019.05.056 · 2020 · External reference
