Research graph
References from SLC25 in intestinal inflammation: mechanisms, pathological roles, and therapeutic implications. Local targets link to admitted publications; unresolved targets remain external evidence.
Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease
10.3390/ijms22147618 · 2021 · External reference
The SLC25 carrier family: Important transport proteins in mitochondrial physiology and pathology
10.1152/physiol.00009.2020 · 2020 · External reference
Advances in research on the role of high carbohydrate diet in the process of inflammatory bowel disease (IBD)
10.3389/fimmu.2024.1478374 · 2024 · External reference
Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence
10.1136/gutjnl-2019-319514 · 2020 · External reference
Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase
10.1016/j.immuni.2019.11.009 · 2019 · External reference
SLC25A33-mediated mitochondrial DNA synthesis plays a critical role in the inflammatory response of M1 macrophages by contributing to mitochondrial ROS and VDAC oligomerization
10.7150/ijbs.96563 · 2025 · External reference
Predictive biomarkers for anti-TNF alpha therapy in IBD patients
10.1186/s12967-024-05058-1 · 2024 · External reference
Human mitochondrial ADP/ATP carrier SLC25A4 operates with a ping-pong kinetic mechanism
10.15252/embr.202357127 · 2023 · External reference
Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells
10.1038/onc.2010.146 · 2010 · External reference
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
10.1038/s41467-024-45044-1 · 2024 · External reference
The SLC transporter in nutrient and metabolic sensing, regulation, and drug development
10.1093/jmcb/mjy052 · 2019 · External reference
Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis
10.1038/s41388-018-0492-9 · 2019 · External reference
SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis
10.3748/wjg.v30.i3.252 · 2024 · External reference
The SLC25 mitochondrial carrier family: Structure and mechanism
10.1016/j.tibs.2019.11.001 · 2020 · External reference
Physiological and pathological roles of mitochondrial SLC25 carriers
10.1042/bj20121753 · 2013 · External reference
The mitochondrial transporter family SLC25: Identification, properties and physiopathology
10.1016/j.mam.2012.05.005 · 2013 · External reference
Comprehensive analysis and validation of solute carrier family 25 (SLC25) and its correlation with immune infiltration in pan-cancer
10.21203/rs.3.rs-853235/v1 · 2022 · External reference
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS
10.1038/s41467-022-30126-9 · 2022 · External reference
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8
10.1038/s41419-024-07308-y · 2024 · External reference
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis
10.1038/s41419-022-04692-1 · 2022 · External reference
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
10.1038/nature02056 · 2003 · External reference
Mitochondrial carriers in the cytoplasmic state have a common substrate binding site
10.1073/pnas.0509994103 · 2006 · External reference
The molecular mechanism of transport by the mitochondrial ADP/ATP carrier
10.1016/j.cell.2018.11.025 · 2019 · External reference
Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress
10.1007/s00109-016-1413-4 · 2016 · External reference
Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore
10.1042/bj20011672 · 2002 · External reference
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
10.1073/pnas.95.22.12896 · 1998 · External reference
SLC25A11-mediated reprogramming of mitochondrial redox state and lipid peroxidation confers NRF2-dependent ferroptosis resistance in biliary tract cancer
10.1186/s11658-025-00843-2 · 2026 · External reference
SLC25A39 binds and modulates PRDX1 to suppress ROS-induced necroptosis in hepatocellular carcinoma
10.1016/j.intimp.2026.116246 · 2026 · External reference
Novel insights into SLC25A46-related pathologies in a genetic mouse model
10.1371/journal.pgen.1006656 · 2017 · External reference
The mitochondrial ADP/ATP carrier (SLC25 family): Pathological implications of its dysfunction
10.1016/j.mam.2012.05.006 · 2013 · External reference
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
10.1073/pnas.0610157104 · 2007 · External reference
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
10.1083/jcb.200902153 · 2010 · External reference
TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation
10.1152/ajpgi.00173.2003 · 2004 · External reference
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
10.1126/science.aaf7419 · 2016 · External reference
Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
10.1371/journal.pone.0076918 · 2013 · External reference
SLC25A51 is a mammalian mitochondrial NAD(+) transporter
10.1038/s41586-020-2741-7 · 2020 · External reference
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
10.1038/s41467-020-19871-x · 2020 · External reference
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells
10.1038/s41586-021-04025-w · 2021 · External reference
High-salt-diet (HSD) aggravates the progression of inflammatory bowel disease (IBD) via regulating epithelial necroptosis
10.1186/s43556-023-00135-1 · 2023 · External reference
Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis
10.1038/s41419-020-2299-1 · 2020 · External reference
Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway
10.1016/j.imlet.2020.06.005 · 2020 · External reference
Dietary polyphenols and mitochondrial function: Role in health and disease
10.2174/0929867324666170529101810 · 2019 · External reference
Mitochondrial dysfunction in inflammatory bowel disease
10.3389/fcell.2015.00062 · 2015 · External reference
Mitochondrial control of glycerolipid synthesis by a PEP shuttle
10.64898/2025.12.12.693842 · 2026 · External reference
A key role of the mitochondrial citrate carrier (SLC25A1) in TNFalpha- and IFNgamma-triggered inflammation
10.1016/j.bbagrm.2014.07.013 · 2014 · External reference
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
10.1016/j.immuni.2015.02.005 · 2015 · External reference
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
10.1016/j.molcel.2025.08.018 · 2025 · External reference
The mitochondrial citrate carrier: A new player in inflammation
10.1042/bj20111275 · 2011 · External reference
Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport
10.1016/j.molmet.2024.102047 · 2024 · External reference
Liver type 1 innate lymphoid cells undergo apoptosis in murine models of macrophage activation syndrome and are dispensable for disease
10.1002/eji.202451043 · 2024 · External reference
Welcome to the family: Identification of the NAD(+) transporter of animal mitochondria as member of the solute carrier family SLC25
10.3390/biom11060880 · 2021 · External reference
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
10.1038/nature09973 · 2011 · External reference
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
10.1016/j.immuni.2012.10.020 · 2013 · External reference
Intestinal absorption of water-soluble vitamins in health and disease
10.1042/bj20110326 · 2011 · External reference
Mitochondrial dysfunction in sepsis
10.1042/bss0660149 · 2003 · External reference
The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters
10.1074/jbc.m114.610808 · 2014 · External reference
Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity
10.1038/s42255-021-00385-9 · 2021 · External reference
Colonocyte metabolism shapes the gut microbiota
10.1126/science.aat9076 · 2018 · External reference
Microbiota-activated PPAR-gamma signaling inhibits dysbiotic Enterobacteriaceae expansion
10.1126/science.aam9949 · 2017 · External reference
The treatment-naive microbiome in new-onset Crohn's disease
10.1016/j.chom.2014.02.005 · 2014 · External reference
The human uncoupling proteins 5 and 6 (UCP5/SLC25A14 and UCP6/SLC25A30) transport sulfur oxyanions, phosphate and dicarboxylates
10.1016/j.bbabio.2019.07.010 · 2019 · External reference
The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
10.7717/peerj.3849 · 2017 · External reference
A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis
10.7554/elife.94187.3 · 2024 · External reference
Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response
10.1016/j.gendis.2022.05.039 · 2023 · External reference
Xianglian pill alleviates ulcerative colitis by inhibiting M1 macrophage polarization via modulation of energy metabolite itaconate
10.1016/j.phymed.2024.156179 · 2024 · External reference
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Ebeta-cells exposed to glucose versus fatty acids
10.1371/journal.pone.0082364 · 2013 · External reference
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
10.1016/j.chom.2025.09.009 · 2025 · External reference
Mitoferrin is essential for erythroid iron assimilation
10.1038/nature04512 · 2006 · External reference
Characterization of a nucleus located mollusc mitoferrin and its response to OsHV-1 infection
10.1016/j.bbagen.2018.10.014 · 2019 · External reference
Diseases caused by mutations in mitochondrial carrier genes SLC25: A review
10.3390/biom10040655 · 2020 · External reference
The role of mitochondria-related proteins in inflammation and autoimmune diseases: A causal analysis using Mendelian randomization and colocalization
10.1007/s13755-025-00358-2 · 2025 · External reference
Targeting SLC25A33 suppresses vascular smooth muscle cell proliferation and migration by reducing cytosolic mtDNA levels: Implications for occlusive vascular diseases
10.4093/dmj.2024.0632 · 2026 · External reference
The mitochondrial citrate carrier (CIC) is present and regulates insulin secretion by human male gamete
10.1210/en.2011-1562 · 2012 · External reference
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma
10.1084/jem.20041948 · 2005 · External reference
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
10.1038/nm.4345 · 2017 · External reference
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
10.1016/j.cell.2006.11.013 · 2006 · External reference
Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory
2022 · External reference
Mechanism of Shenling Baizhu Powder in alleviation of ulcerative colitis in mice based on high-throughput transcriptome sequencing
2022 · External reference
Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response
10.1038/srep39299 · 2016 · External reference
Wumei Wan attenuates angiogenesis and inflammation by modulating RAGE signaling pathway in IBD: Network pharmacology analysis and experimental evidence
10.1016/j.phymed.2023.154658 · 2023 · External reference
Bioinspired and biomimetic strategies for inflammatory bowel disease therapy
10.1039/d3tb02995f · 2024 · External reference
Yeast-inspired orally-administered nanocomposite scavenges oxidative stress and restores gut immune homeostasis for inflammatory bowel disease treatment
10.1021/acsnano.4c18099 · 2025 · External reference
Targeting lipophilic cations to mitochondria
10.1016/j.bbabio.2008.03.029 · 2008 · External reference
Cytotoxicity of mitochondria-targeted resveratrol derivatives: Interactions with respiratory chain complexes and ATP synthase
10.1016/j.bbabio.2014.06.010 · 2014 · External reference
Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis
10.1016/j.mtbio.2024.100965 · 2024 · External reference
Epithelial NAD(+) depletion drives mitochondrial dysfunction and contributes to intestinal inflammation
10.3389/fimmu.2023.1231700 · 2023 · External reference
Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
2002 · External reference
Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice
10.1152/ajpgi.00312.2011 · 2012 · External reference
