References

What is the status of immunotherapy in thyroid neoplasms

10.3389/fendo.2022.929091 · 2022 · External reference

Metabolic reprogramming in thyroid carcinoma

10.3389/fonc.2018.00082 · 2018 · External reference

Aggressive types of Malignant thyroid neoplasms

10.3390/jcm13206119 · 2024 · External reference

Microsatellite instability occurs in a subset of follicular thyroid cancers

10.1089/thy.2018.0655 · 2019 · External reference

Association between CTLA-4 + 49A > G and - 318C > T single-nucleotide polymorphisms and susceptibility to thyroid neoplasm

10.1007/s12020-018-1663-8 · 2018 · External reference

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1(+) macrophages

10.1038/s41588-025-02380-2 · 2025 · External reference

New insights into the tumor immune microenvironment and immunotherapy of thyroid cancer

10.3389/fimmu.2026.1699500 · 2026 · External reference

Metabolic reprogramming in thyroid cancer

10.3803/enm.2023.1802 · 2024 · External reference

AKT activity is elevated in aggressive thyroid neoplasms where it promotes proliferation and invasion

10.1016/j.yexmp.2017.11.009 · 2017 · External reference

SRCIN1 promotes thyroid carcinoma growth by activating Wnt signaling pathway

10.1038/s41598-025-16674-2 · 2025 · External reference

A spatially resolved transcriptome landscape during thyroid cancer progression

10.1016/j.xcrm.2025.102043 · 2025 · External reference

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer

10.1038/s41419-024-06598-6 · 2024 · External reference

Single-cell transcriptomic analysis revealed the tumor-associated microenvironment of papillary thyroid carcinoma with metastasis

10.21203/rs.3.rs-2721118/v1 · 2025 · External reference

Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches

10.1186/s12967-024-05963-5 · 2024 · External reference

Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer

10.1038/s41598-025-06241-0 · 2025 · External reference

Integrating tumor intraepithelial CD8(+) and stromal FOXP3(+) T-cell densities as an enhanced immune prognostic index in colorectal cancer

10.1016/j.labinv.2025.104213 · 2025 · External reference

Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer

10.3389/fimmu.2024.1293618 · 2024 · External reference

The role of FOXK2-FBXO32 in breast cancer tumorigenesis: Insights into ribosome-associated pathways

10.1111/1759-7714.15482 · 2025 · External reference

Integrative single-cell transcriptome analysis reveals immune suppressive landscape in the anaplastic thyroid cancer

10.1038/s41417-023-00663-6 · 2023 · External reference

Integration of single-cell RNA sequencing and bulk RNA transcriptome sequencing reveals a heterogeneous immune landscape and pivotal cell subpopulations associated with colorectal cancer prognosis

10.3389/fimmu.2023.1184167 · 2023 · External reference

Comparative oncology: cross-sectional single-cell transcriptomic profiling of the tumor microenvironment across seven human cancers

10.3390/cancers17213527 · 2025 · External reference

Fibroblast activation protein (FAP)-mediated promotion of metastasis via the FN1-TGFβ axis and immune suppression in aggressive thyroid cancer

10.1186/s12967-025-07307-3 · 2025 · External reference

Development and validation of a cancer-associated fibroblast-derived lncRNA signature for predicting clinical outcomes in colorectal cancer

10.3389/fimmu.2022.934221 · 2022 · External reference

Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling

10.1016/j.canlet.2024.216985 · 2024 · External reference

Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes

10.1186/s12967-025-06103-3 · 2025 · External reference

Macrophage-induced carboxypeptidase A4 promotes the progression of anaplastic thyroid cancer

10.1089/thy.2023.0427 · 2024 · External reference

ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer

10.1038/s44319-024-00186-7 · 2024 · External reference

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

10.1172/jci.insight.173712 · 2024 · External reference

Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer Malignancy

10.1038/s41419-025-08009-w · 2025 · External reference

THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer

10.1186/s12943-024-02180-y · 2024 · External reference

Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer

10.1038/s41698-025-00924-7 · 2025 · External reference

Pan-cancer single-cell transcriptomic analysis reveals divergent expression of embryonic proangiogenesis gene modules in tumorigenesis

10.1002/cam4.70373 · 2024 · External reference

Targeting tumor hypoxia inhibits aggressive phenotype of dedifferentiated thyroid cancer

10.1210/clinem/dgac548 · 2023 · External reference

Tumor-associated endothelial cells in tumor immune escape and immunotherapy: multifaceted roles and treatment approaches

10.1186/s40364-025-00883-y · 2025 · External reference

Extracellular matrix stiffness regulates colorectal cancer progression via HSF4

10.1186/s13046-025-03297-8 · 2025 · External reference

Insights into the molecular mechanisms underlying the function of lysyl oxidase like 1 in cancers

10.7717/peerj.19628 · 2025 · External reference

Hypoxia promotes thyroid cancer progression through HIF1α/FGF11 feedback loop

10.1016/j.yexcr.2022.113159 · 2022 · External reference

HIF-1α integrates lipogenic FASN and glycolytic GLUT3 to overcome intratumor oxidative and hypoxic stress for colorectal cancer metastasis

10.21203/rs.3.rs-5868429/v1 · 2026 · External reference

Matrix stiffness-driven cytoskeletal remodeling and tumor progression in anaplastic thyroid cancer via integrin-focal adhesion kinase signaling

10.1038/s41388-025-03674-9 · 2026 · External reference

Nanomedicine delivery systems remodel the immunosuppressive microenvironment of colorectal cancer: synergistic strategies and mechanisms of targeted immune checkpoint inhibitors

10.3389/fimmu.2026.1882956 · 2026 · External reference

Elevated triggering receptor expressed on myeloid cells 2 expression in tumor-associated macrophages suppresses cytotoxic T cell infiltration and facilitates immune escape in colorectal cancer

10.1016/j.jcmgh.2026.101842 · 2026 · External reference

Association of lysyl oxidase expression with clinicopathological features in colorectal adenocarcinomas

10.1007/s00384-025-04852-7 · 2025 · External reference

Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy

10.1186/s12967-024-05199-3 · 2024 · External reference

Role of cytotoxic T cells and PD-1 immune checkpoint pathway in papillary thyroid carcinoma

10.3389/fendo.2022.931647 · 2022 · External reference

PD-L1 expression in colorectal adenocarcinoma is associated with the tumor immune microenvironment and epithelial-mesenchymal transition

10.1093/ajcp/aqac077 · 2022 · External reference

PD-L1 and B7-H3 are effective prognostic factors and potential therapeutic targets for high-risk thyroid cancer

10.1007/s12022-024-09822-3 · 2024 · External reference

PD-L1 expression varies in thyroid cancer types and is associated with decreased progression free survival (PFS) in patients with anaplastic thyroid cancer

10.3390/cancers16213632 · 2024 · External reference

WTAP-induced N(6)-methyladenosine of PD-L1 blocked T-cell-mediated antitumor activity under hypoxia in colorectal cancer

10.1111/cas.16136 · 2024 · External reference

Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer

10.1016/j.xcrm.2026.102786 · 2026 · External reference

Immunohistochemical expression of immune checkpoints; CTLA-4, LAG3, and TIM-3 in cancer cells and tumor-infiltrating lymphocytes (TILs) in colorectal carcinoma

10.1097/pai.0000000000001181 · 2024 · External reference

Targeting T cell exhaustion in colorectal cancer: emerging roles of LAG-3, TIM-3, and TIGIT signaling in overcoming immunotherapy resistance

10.1186/s12964-025-02638-6 · 2026 · External reference

Co-expression of PD-1 with TIGIT or PD-1 with TIM-3 on tumor-infiltrating CD8(+) T cells showed synergistic effects on improved disease-free survival in treatment-naïve CRC patients

10.1016/j.intimp.2023.110207 · 2023 · External reference

Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3

10.1007/s12026-024-09552-y · 2024 · External reference

Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling

10.1007/s00262-025-04187-w · 2025 · External reference

IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth

10.1016/j.biopha.2024.117412 · 2024 · External reference

Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects

10.21203/rs.3.rs-1501746/v1 · 2022 · External reference

IL1R1(+) cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

10.1038/s41467-023-39953-w · 2023 · External reference

Immune and inflammatory cells in thyroid cancer microenvironment

10.3390/ijms20184413 · 2019 · External reference

Immune microenvironment in papillary thyroid carcinoma: roles of immune cells and checkpoints in disease progression and therapeutic implications

10.3389/fimmu.2024.1438235 · 2024 · External reference

Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

10.3389/fimmu.2025.1706496 · 2025 · External reference

miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro

10.1002/cbin.11631 · 2021 · External reference

Integrative single-cell and machine learning analysis identifies an EMT-associated prognostic signature for papillary thyroid cancer

10.1002/cam4.71766 · 2026 · External reference

Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies

10.4251/wjgo.v16.i5.1690 · 2024 · External reference

The effect of l-arginine supplementation and surgical trauma on the frequency of myeloid-derived suppressor cells and T lymphocytes in tumour and blood of colorectal cancer patients

10.1016/j.advms.2021.12.005 · 2022 · External reference

ALKBH5 regulates arginase 1 expression in MDSCs and their immunosuppressive activity in tumor-bearing host

10.1016/j.ncrna.2024.03.003 · 2024 · External reference

Cholesterol 25-hydroxylase enhances myeloid-derived suppressor cell (MDSC) immunosuppression via the stimulator of interferon genes (STING)-tank-binding kinase 1 (TBK1)-receptor-interacting protein kinase 3 (RIPK3) pathway in colorectal cancer

10.1002/mco2.70411 · 2025 · External reference

The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis

10.1038/s41598-024-75750-1 · 2024 · External reference

C-C chemokine receptor 4 is a candidate for regulatory T-cell-depletion immunotherapy in differentiated thyroid cancer

10.1016/j.anl.2025.12.004 · 2026 · External reference

Characterizing neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL1β/CXCR2 axis in generation of metastasis-specific neutrophils

10.1158/2767-9764.crc-23-0319 · 2024 · External reference

Caspase-6/gasdermin C-mediated tumor cell pyroptosis promotes colorectal cancer progression through CXCL2-dependent recruitment of myeloid-derived suppressor cells

10.1016/j.iliver.2022.06.002 · 2025 · External reference

Immunometabolic rewiring of dendritic cells to overcome glutamine-driven immune suppression in colorectal cancer

10.1002/advs.202513986 · 2026 · External reference

Emerging role of metabolic reprogramming in the immune microenvironment and immunotherapy of thyroid cancer

10.1016/j.intimp.2024.113702 · 2025 · External reference

Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis

10.1186/s40001-024-01828-1 · 2024 · External reference

Hypoxia facilitates stemness of colon cancer cells via histone lactylation

10.1016/j.bbadis.2025.167993 · 2025 · External reference

VSIG4 promotes tumour-associated macrophage M2 polarization and immune escape in colorectal cancer via fatty acid oxidation pathway

10.1038/ni.3366 · 2025 · External reference

Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives

10.3389/fimmu.2025.1563303 · 2025 · External reference

Lactate-induced CCL8 in tumor-associated macrophages accelerates the progression of colorectal cancer through the CCL8/CCR5/mTORC1 axis

10.3390/cancers15245795 · 2023 · External reference

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

10.21203/rs.3.rs-3150640/v1 · 2024 · External reference

Developing a thyroid cancer differentiation state classification system using deep residual networks and metabolic signature profiling

10.1038/s41746-025-01927-1 · 2025 · External reference

Epacadostat overcomes cetuximab resistance in colorectal cancer by targeting IDO-mediated tryptophan metabolism

10.1111/cas.70057 · 2025 · External reference

ARID5A stabilizes indoleamine 2,3-dioxygenase expression and enhances CAR T cell exhaustion in colorectal cancer

10.1016/j.tranon.2024.101900 · 2024 · External reference

Indoleamine 2,3-dioxygenase immune status as a potential biomarker of radioiodine efficacy for advanced distant metastatic differentiated thyroid cancer

10.3389/fonc.2022.871792 · 2022 · External reference

A Tc1- and Th1-T-lymphocyte-rich tumor microenvironment is a hallmark of MSI colorectal cancer

10.1002/path.6415 · 2025 · External reference

Efficacy of pembrolizumab in microsatellite-stable, tumor mutational burden-high metastatic colorectal cancer: genomic signatures and clinical outcomes

10.1016/j.esmoop.2024.104108 · 2025 · External reference

Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland

10.2340/1651-226x.2024.26452 · 2024 · External reference

A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer

10.1016/j.xcrm.2026.102776 · 2026 · External reference

Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study

10.1002/cjp2.304 · 2023 · External reference

Efficacy and safety of pembrolizumab monotherapy in patients with advanced thyroid cancer in the phase 2 KEYNOTE-158 study

10.1002/cncr.34657 · 2023 · External reference

The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

10.1016/j.celrep.2024.113826 · 2024 · External reference

Genomic landscape and clinical features of advanced thyroid carcinoma: a national database study in Japan

10.1210/clinem/dgae271 · 2024 · External reference

Nivolumab plus ipilimumab in microsatellite-instability-high metastatic colorectal cancer

10.1056/nejmoa2402141 · 2024 · External reference

Myeloid-derived suppressor cells in anaplastic thyroid carcinoma: insights from prospective immune profiling and implications for targeted immunotherapy

10.1136/jcp-2025-210585 · 2026 · External reference

HN1/CEBPB/CCL2 signaling shapes VSIG4(+) tumor-associated macrophages in anaplastic thyroid carcinoma

10.1016/j.bbadis.2026.168303 · 2026 · External reference

Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

10.1038/s43018-023-00691-z · 2024 · External reference

IL2RA(+)VSIG4(+) tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer

10.1016/j.bbadis.2022.166591 · 2023 · External reference

Tumor-associated macrophages as a potential therapeutic target in thyroid cancers

10.1007/s00262-023-03549-6 · 2023 · External reference

USP15 facilitates colorectal cancer immune evasion through SMYD3/CCL2-dependent myeloid-derived suppressor cell recruitment

10.1158/2326-6066.cir-24-1194 · 2025 · External reference

The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

10.1038/s41590-024-02068-5 · 2025 · External reference

Vascular normalization was associated with colorectal tumor regression upon anti-PD-L1 combinational therapy

10.1155/2023/5867047 · 2023 · External reference

Efficacy and safety of fruquintinib combined with immunotherapy in later-line treatment of metastatic colorectal cancer

10.3892/ol.2025.15287 · 2025 · External reference

Targeting CSF1R in myeloid-derived suppressor cells: insights into its immunomodulatory functions in colorectal cancer and therapeutic implications

10.1186/s12951-024-02584-4 · 2024 · External reference

CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer

10.1016/j.phrs.2024.107126 · 2024 · External reference

Lipopolysaccharide induces resistance to CAR-T cell therapy of colorectal cancer cells through TGF-β-mediated stemness enhancement

10.1021/acs.molpharmaceut.4c00264 · 2025 · External reference

Hypoxia promotes Malignant progression of colorectal cancer by inducing POSTN(+) cancer-associated fibroblast formation

10.1002/mc.23882 · 2025 · External reference

Enhanced efficacy of dual chimeric antigen receptor-T cells targeting programmed death-ligand 1 and cancer-associated fibroblasts in colorectal cancer in vitro

10.25259/cytojournal_245_2024 · 2025 · External reference

DNTGF-βR armored CAR-T cell therapy against tumors from bench to bedside

10.1186/s12967-023-04829-6 · 2024 · External reference

Tumor-infiltrating T lymphocytes recognize thyroid-specific proteins and neo-antigens in follicular cell-derived thyroid cancers

10.1210/clinem/dgaf639 · 2026 · External reference

Dynamics of the Γδtcr repertoires during the dedifferentiation process and pilot implications for immunotherapy of thyroid cancer

10.1002/advs.202306364 · 2024 · External reference

Tumor-infiltrating immune cell landscapes in the lymph node metastasis of papillary thyroid cancer

10.3390/curroncol30030200 · 2023 · External reference

Immunotherapy in initial treatment of anaplastic thyroid cancer: evaluation of overall survival in a national cancer database study

10.1177/10507256251372191 · 2025 · External reference

Dendritic cell vaccination in medullary thyroid carcinoma

10.1158/1078-0432.ccr-03-0698 · 2004 · External reference

Dendritic cell vaccine therapy for colorectal cancer

10.1016/j.phrs.2020.105374 · 2021 · External reference

Tubeimuside I improves the efficacy of a therapeutic Fusobacterium nucleatum dendritic cell-based vaccine against colorectal cancer

10.3389/fimmu.2023.1154818 · 2023 · External reference

Case report: a multi-peptide vaccine targeting individual somatic mutations induces tumor infiltration of neoantigen-specific T cells in a patient with metastatic colorectal cancer

10.3390/vaccines13090960 · 2025 · External reference

Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication

10.1016/j.biopha.2023.115659 · 2023 · External reference

Metformin reprograms tryptophan metabolism to stimulate CD8+ T-cell function in colorectal cancer

10.1158/0008-5472.can-22-3042 · 2023 · External reference

Neutrophil diversity is associated with T-cell immunity and clinical relevance in patients with thyroid cancer

10.1038/s41420-024-01970-z · 2024 · External reference

Metabolic reprogramming and immunosenescence in colorectal cancer: mechanisms and therapeutic implications

10.3389/fcell.2025.1662464 · 2025 · External reference

Preclinical evaluation of novel tyrosine-kinase inhibitors in medullary thyroid cancer

10.3390/cancers14184442 · 2022 · External reference

Immunomodulatory effects of lenvatinib in patients with advanced thyroid cancer

10.1007/s00262-025-04241-7 · 2025 · External reference

A multicenter, open-label, randomized, phase II study of cediranib with or without lenalidomide in iodine 131-refractory differentiated thyroid cancer

10.1016/j.annonc.2023.05.002 · 2023 · External reference