Research graph
References from Kazachstania pintolopesii accelerates splenic senescence in aged mice via immune cell reprogramming, immunosenescence and amelioration by Astragaloside IV. Local targets link to admitted publications; unresolved targets remain external evidence.
Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice
10.1096/fj.201801381rr · 2019 · External reference
Lack of Hfe and TfR2 in macrophages impairs iron metabolism in the spleen and the bone marrow
10.3390/ijms25179142 · 2024 · External reference
Cross-tissue multicellular coordination and its rewiring in cancer
10.1038/s41586-025-09053-4 · 2025 · External reference
The spleen in local and systemic regulation of immunity
10.1016/j.immuni.2013.10.010 · 2013 · External reference
Structure and function of the spleen
10.1038/nri1669 · 2005 · External reference
An aged immune system drives senescence and ageing of solid organs
10.1038/s41586-021-03547-7 · 2021 · External reference
Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation
10.1038/s43587-025-00981-4 · 2025 · External reference
Impaired ion homeostasis as a possible associate factor in mucopolysaccharidosis pathogenesis: transcriptomic, cellular and animal studies
10.1007/s11011-021-00892-4 · 2022 · External reference
Progressive increases in dietary iron are associated with the emergence of pathologic disturbances of copper homeostasis in growing rats
10.1093/jn/nxx070 · 2018 · External reference
Cross-species comparison illuminates the importance of iron homeostasis for splenic anti-immunosenescence
10.1111/acel.13982 · 2023 · External reference
Lithium enhances ferroptosis sensitivity in melanoma cells and promotes CD8(+) T cell infiltration and differentiation
10.1016/j.freeradbiomed.2024.12.012 · 2025 · External reference
Number and diameter of white pulp of spleen in different age and sex groups of Bangladeshi people
2022 · External reference
Age-related changes in liver, kidney, and spleen stiffness in healthy children measured with acoustic radiation force impulse imaging
10.1016/j.ejrad.2013.01.018 · 2013 · External reference
Xiaohuafuning tang intervenes liver-depression-and-spleen-deficiency syndrome chronic-atrophic-gastritis by reshaping amino acid metabolism through gut microbiota
10.1016/j.phymed.2024.156346 · 2025 · External reference
Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites
10.1016/j.jhazmat.2023.132503 · 2024 · External reference
Evaluation of intrinsic and acquired immune cells infiltration in kidney and spleen of the mice infected with systemic candidiasis and treated with chloroform fraction of Zataria Multiflora Boiss
10.1016/j.micpath.2017.11.032 · 2018 · External reference
Correlation of intestinal bacteria, fungi and dietary nutrient intake in NAFLD patients with spleen deficiency syndrome
10.3389/fcimb.2025.1586212 · 2025 · External reference
Combination of histopathology and FT-Raman spectroscopy for the study of experimental paracoccidioidomycosis in the spleen
10.1111/php.12840 · 2018 · External reference
Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation
10.1136/gutjnl-2019-319101 · 2020 · External reference
A gut-vascular barrier controls the systemic dissemination of bacteria
10.1126/science.aad0135 · 2015 · External reference
Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity
10.1371/journal.ppat.1010873 · 2022 · External reference
Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection
10.1371/journal.pone.0218037 · 2019 · External reference
Intestinal fungal dysbiosis is associated with visceral hypersensitivity in patients with irritable bowel syndrome and rats
10.1053/j.gastro.2017.06.004 · 2017 · External reference
Florfenicol-induced dysbiosis impairs intestinal homeostasis and host immune system in laying hens
10.1186/s40104-025-01186-w · 2025 · External reference
Structure and immunostimulatory activity studies on two novel Flammulina velutipes polysaccharides: revealing potential impacts of -->6)-alpha-D-Glcp(1--> on the TLR-4/MyD88/NF-kappaB pathway
10.1039/d3fo05468c · 2024 · External reference
From birth and throughout life: Fungal microbiota in nutrition and metabolic health
10.1146/annurev-nutr-013120-043659 · 2020 · External reference
Fungi in early-life house dust samples and the development of asthma: A birth cohort study
10.1513/annalsats.202303-187oc · 2023 · External reference
Immune activation of characteristic gut mycobiota Kazachstania pintolopesii on IL-23/IL-17R signaling in ankylosing spondylitis
10.3389/fcimb.2022.1035366 · 2022 · External reference
Kazachstania pintolopesii triggers an immune-endothelial-fibroblast cascade and drives inflammatory arthritis and tissue fibrosis in genetically susceptible hosts
10.3389/fcimb.2025.1738184 · 2025 · External reference
Fungal commensal promotes intestinal repair via its secreted peptide in mice
10.1038/s41564-025-02233-y · 2026 · External reference
A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection
10.1101/2025.04.30.651489 · 2025 · External reference
The cynomolgus macaque intestinal mycobiome is dominated by the Kazachstania genus and K. pintolopesii species
10.3390/jof8101054 · 2022 · External reference
Fungal symbiont transmitted by free-living mice promotes type 2 immunity
10.1038/s41586-024-08213-2 · 2024 · External reference
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
10.1016/j.cmet.2026.02.010 · 2026 · External reference
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARgamma signaling in mice
10.1016/j.phymed.2023.155116 · 2023 · External reference
Astragaloside IV attenuates fatty acid-induced renal tubular injury in diabetic kidney disease by inhibiting fatty acid transport protein-2
10.1016/j.phymed.2024.155991 · 2024 · External reference
Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy
10.1016/j.jare.2024.10.030 · 2025 · External reference
Astragaloside IV-loaded biomimetic nanoparticles target IkappaBalpha to regulate neutrophil extracellular trap formation for sepsis therapy
10.1186/s12951-025-03260-x · 2025 · External reference
Astragaloside IV, as a potential anticancer agent
10.3389/fphar.2023.1065505 · 2023 · External reference
Pharmacological effects of Astragaloside IV: A review
10.3390/molecules28166118 · 2023 · External reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
fastp 1.0: An ultra-fast all-round tool for FASTQ data quality control and preprocessing
10.1002/imt2.70078 · 2025 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · 2019 · External reference
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
TreeGrafter: Phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations
10.1093/bioinformatics/bty625 · 2019 · External reference
KEGG: Kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4(+) endothelial cells
10.1016/j.cmet.2021.07.015 · 2021 · External reference
Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis
10.1126/sciadv.ado3141 · 2024 · External reference
The dual roles of activating transcription factor 3 (ATF3) in inflammation, apoptosis, ferroptosis, and pathogen infection responses
10.3390/ijms25020824 · 2024 · External reference
Reprogramming of fatty acid metabolism via PPARalpha-orchestrated FADS2 in keratinocytes modulates skin inflammation in psoriasis
10.1002/advs.202417049 · 2025 · External reference
The expanding role of lyso-phosphatidylcholine acyltransferase-3 (LPCAT3), a phospholipid remodeling enzyme, in health and disease
10.1097/mol.0000000000000820 · 2022 · External reference
ACSL6-activated IL-18R1-NF-kappaB promotes IL-18-mediated tumor immune evasion and tumor progression
10.1126/sciadv.adp0719 · 2024 · External reference
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
10.1111/acel.12971 · 2019 · External reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · 2024 · External reference
TSC1 suppresses macrophage necroptosis for the control of infection by fungal pathogen Candida albicans
10.4049/immunohorizons.2000093 · 2021 · External reference
The emerging role of mast cells in response to fungal infection
10.3389/fimmu.2021.688659 · 2021 · External reference
Astragaloside IV attenuates chronic prostatitis by activating Keap1/Nrf2/HO-1 pathway: Suppressing ferroptosis and enhancing antioxidant defense
10.2147/jir.s527722 · 2025 · External reference
Astragalus membranaceus-can it delay cellular aging
10.3390/nu17081299 · 2025 · External reference
Recent advances in Astragaloside IV modulate immune response and skin cells promoting wound healing
10.1177/19373341251381830 · 2026 · External reference
Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects
10.1016/bs.apha.2019.08.002 · 2020 · External reference
Central regulation of stress-evoked peripheral immune responses
10.1038/s41583-023-00729-2 · 2023 · External reference
Microglia require CD4 T cells to complete the fetal-to-adult transition
10.1016/j.cell.2020.06.026 · 2020 · External reference
Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen
10.1038/s41593-023-01561-8 · 2024 · External reference
Astragaloside IV alleviates depression in rats by modulating intestinal microbiota, T-immune balance, and metabolome
10.1021/acs.jafc.3c04063 · 2024 · External reference
Reprogramming of fatty acid metabolism via PPARalpha-orchestrated FADS2 in keratinocytes modulates skin inflammation in psoriasis
10.1002/advs.202417049 · ExternalCitation · doi-reference
fastp 1.0: An ultra-fast all-round tool for FASTQ data quality control and preprocessing
10.1002/imt2.70078 · ExternalCitation · doi-reference
Impaired ion homeostasis as a possible associate factor in mucopolysaccharidosis pathogenesis: transcriptomic, cellular and animal studies
10.1007/s11011-021-00892-4 · ExternalCitation · doi-reference
Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects
10.1016/bs.apha.2019.08.002 · ExternalCitation · doi-reference
Microglia require CD4 T cells to complete the fetal-to-adult transition
10.1016/j.cell.2020.06.026 · ExternalCitation · doi-reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · ExternalCitation · doi-reference
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4(+) endothelial cells
10.1016/j.cmet.2021.07.015 · ExternalCitation · doi-reference
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
10.1016/j.cmet.2026.02.010 · ExternalCitation · doi-reference
Age-related changes in liver, kidney, and spleen stiffness in healthy children measured with acoustic radiation force impulse imaging
10.1016/j.ejrad.2013.01.018 · ExternalCitation · doi-reference
Lithium enhances ferroptosis sensitivity in melanoma cells and promotes CD8(+) T cell infiltration and differentiation
10.1016/j.freeradbiomed.2024.12.012 · ExternalCitation · doi-reference
The spleen in local and systemic regulation of immunity
10.1016/j.immuni.2013.10.010 · ExternalCitation · doi-reference
Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy
10.1016/j.jare.2024.10.030 · ExternalCitation · doi-reference
Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites
10.1016/j.jhazmat.2023.132503 · ExternalCitation · doi-reference
Evaluation of intrinsic and acquired immune cells infiltration in kidney and spleen of the mice infected with systemic candidiasis and treated with chloroform fraction of Zataria Multiflora Boiss
10.1016/j.micpath.2017.11.032 · ExternalCitation · doi-reference
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARgamma signaling in mice
10.1016/j.phymed.2023.155116 · ExternalCitation · doi-reference
Astragaloside IV attenuates fatty acid-induced renal tubular injury in diabetic kidney disease by inhibiting fatty acid transport protein-2
10.1016/j.phymed.2024.155991 · ExternalCitation · doi-reference
Xiaohuafuning tang intervenes liver-depression-and-spleen-deficiency syndrome chronic-atrophic-gastritis by reshaping amino acid metabolism through gut microbiota
10.1016/j.phymed.2024.156346 · ExternalCitation · doi-reference
Astragaloside IV alleviates depression in rats by modulating intestinal microbiota, T-immune balance, and metabolome
10.1021/acs.jafc.3c04063 · ExternalCitation · doi-reference
Structure and function of the spleen
10.1038/nri1669 · ExternalCitation · doi-reference
Fungal commensal promotes intestinal repair via its secreted peptide in mice
10.1038/s41564-025-02233-y · ExternalCitation · doi-reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · ExternalCitation · doi-reference
Central regulation of stress-evoked peripheral immune responses
10.1038/s41583-023-00729-2 · ExternalCitation · doi-reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · ExternalCitation · doi-reference
An aged immune system drives senescence and ageing of solid organs
10.1038/s41586-021-03547-7 · ExternalCitation · doi-reference
Fungal symbiont transmitted by free-living mice promotes type 2 immunity
10.1038/s41586-024-08213-2 · ExternalCitation · doi-reference
Cross-tissue multicellular coordination and its rewiring in cancer
10.1038/s41586-025-09053-4 · ExternalCitation · doi-reference
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
10.1038/s41587-019-0201-4 · ExternalCitation · doi-reference
Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen
10.1038/s41593-023-01561-8 · ExternalCitation · doi-reference
Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation
10.1038/s43587-025-00981-4 · ExternalCitation · doi-reference
Structure and immunostimulatory activity studies on two novel Flammulina velutipes polysaccharides: revealing potential impacts of -->6)-alpha-D-Glcp(1--> on the TLR-4/MyD88/NF-kappaB pathway
10.1039/d3fo05468c · ExternalCitation · doi-reference
Intestinal fungal dysbiosis is associated with visceral hypersensitivity in patients with irritable bowel syndrome and rats
10.1053/j.gastro.2017.06.004 · ExternalCitation · doi-reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · ExternalCitation · doi-reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · ExternalCitation · doi-reference
TreeGrafter: Phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations
10.1093/bioinformatics/bty625 · ExternalCitation · doi-reference
Progressive increases in dietary iron are associated with the emergence of pathologic disturbances of copper homeostasis in growing rats
10.1093/jn/nxx070 · ExternalCitation · doi-reference
KEGG: Kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · ExternalCitation · doi-reference
Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice
10.1096/fj.201801381rr · ExternalCitation · doi-reference
The expanding role of lyso-phosphatidylcholine acyltransferase-3 (LPCAT3), a phospholipid remodeling enzyme, in health and disease
10.1097/mol.0000000000000820 · ExternalCitation · doi-reference
A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection
10.1101/2025.04.30.651489 · ExternalCitation · doi-reference
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
10.1111/acel.12971 · ExternalCitation · doi-reference
Cross-species comparison illuminates the importance of iron homeostasis for splenic anti-immunosenescence
10.1111/acel.13982 · ExternalCitation · doi-reference
Combination of histopathology and FT-Raman spectroscopy for the study of experimental paracoccidioidomycosis in the spleen
10.1111/php.12840 · ExternalCitation · doi-reference
Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis
10.1126/sciadv.ado3141 · ExternalCitation · doi-reference
ACSL6-activated IL-18R1-NF-kappaB promotes IL-18-mediated tumor immune evasion and tumor progression
10.1126/sciadv.adp0719 · ExternalCitation · doi-reference
A gut-vascular barrier controls the systemic dissemination of bacteria
10.1126/science.aad0135 · ExternalCitation · doi-reference
Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation
10.1136/gutjnl-2019-319101 · ExternalCitation · doi-reference
From birth and throughout life: Fungal microbiota in nutrition and metabolic health
10.1146/annurev-nutr-013120-043659 · ExternalCitation · doi-reference
Recent advances in Astragaloside IV modulate immune response and skin cells promoting wound healing
10.1177/19373341251381830 · ExternalCitation · doi-reference
Astragaloside IV-loaded biomimetic nanoparticles target IkappaBalpha to regulate neutrophil extracellular trap formation for sepsis therapy
10.1186/s12951-025-03260-x · ExternalCitation · doi-reference
Florfenicol-induced dysbiosis impairs intestinal homeostasis and host immune system in laying hens
10.1186/s40104-025-01186-w · ExternalCitation · doi-reference
Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection
10.1371/journal.pone.0218037 · ExternalCitation · doi-reference
Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity
10.1371/journal.ppat.1010873 · ExternalCitation · doi-reference
Fungi in early-life house dust samples and the development of asthma: A birth cohort study
10.1513/annalsats.202303-187oc · ExternalCitation · doi-reference
Astragaloside IV attenuates chronic prostatitis by activating Keap1/Nrf2/HO-1 pathway: Suppressing ferroptosis and enhancing antioxidant defense
10.2147/jir.s527722 · ExternalCitation · doi-reference
Immune activation of characteristic gut mycobiota Kazachstania pintolopesii on IL-23/IL-17R signaling in ankylosing spondylitis
10.3389/fcimb.2022.1035366 · ExternalCitation · doi-reference
Correlation of intestinal bacteria, fungi and dietary nutrient intake in NAFLD patients with spleen deficiency syndrome
10.3389/fcimb.2025.1586212 · ExternalCitation · doi-reference
Kazachstania pintolopesii triggers an immune-endothelial-fibroblast cascade and drives inflammatory arthritis and tissue fibrosis in genetically susceptible hosts
10.3389/fcimb.2025.1738184 · ExternalCitation · doi-reference
The emerging role of mast cells in response to fungal infection
10.3389/fimmu.2021.688659 · ExternalCitation · doi-reference
Astragaloside IV, as a potential anticancer agent
10.3389/fphar.2023.1065505 · ExternalCitation · doi-reference
The dual roles of activating transcription factor 3 (ATF3) in inflammation, apoptosis, ferroptosis, and pathogen infection responses
10.3390/ijms25020824 · ExternalCitation · doi-reference
Lack of Hfe and TfR2 in macrophages impairs iron metabolism in the spleen and the bone marrow
10.3390/ijms25179142 · ExternalCitation · doi-reference
The cynomolgus macaque intestinal mycobiome is dominated by the Kazachstania genus and K. pintolopesii species
10.3390/jof8101054 · ExternalCitation · doi-reference
Pharmacological effects of Astragaloside IV: A review
10.3390/molecules28166118 · ExternalCitation · doi-reference
Astragalus membranaceus-can it delay cellular aging
10.3390/nu17081299 · ExternalCitation · doi-reference
TSC1 suppresses macrophage necroptosis for the control of infection by fungal pathogen Candida albicans
10.4049/immunohorizons.2000093 · ExternalCitation · doi-reference
