References

Neutrophil recruitment and function in health and inflammation

10.1038/nri3399 · 2013 · External reference

Neutrophils and bacterial immune evasion

10.1159/000487756 · 2018 · External reference

How neutrophils shape the immune response: Reassessing their multifaceted role in health and disease

10.3390/ijms242417583 · 2023 · External reference

Control of phagocytosis by microbial pathogens. Frontiers in immunology

10.3389/fimmu.2017.01368 · 2017 · External reference

Neutrophil extracellular traps kill bacteria

10.1126/science.1092385 · 2004 · External reference

Large extracellular vesicle (EV) and neutrophil extracellular trap (NET) interaction captured in vivo during systemic inflammation

10.1038/s41598-024-55081-x · 2024 · External reference

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

10.1038/ncomms7673 · 2015 · External reference

Mouse models of sickle cell disease

10.1016/j.tracli.2008.04.001 · 2008 · External reference

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

10.1001/jama.293.13.1653 · 2005 · External reference

Red blood cell function and dysfunction: Redox regulation, nitric oxide metabolism, anemia

10.1089/ars.2016.6954 · 2017 · External reference

Seminar glucose-6-phosphate dehydrogenase deficiency

10.1016/s0140-6736(08)60073-2 · 2008 · External reference

Mechanisms of hemolysis during sepsis

10.1007/s10753-018-0810-y · 2018 · External reference

Hemolysis at low blood flow rates: In-vitro and in-silico evaluation of a centrifugal blood pump

10.1186/s12967-020-02599-z · 2021 · External reference

Hemolyzed specimens: A major challenge for emergency departments and clinical laboratories

10.3109/10408363.2011.600228 · 2011 · External reference

Cell-free hemoglobin in the pathophysiology of trauma: A scoping review

10.1097/cce.0000000000001052 · 2024 · External reference

Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling

10.1152/ajpcell.00211.2022 · 2023 · External reference

Heme in pathophysiology: A matter of scavenging, metabolism and trafficking across cell membranes

10.3389/fphar.2014.00061 · 2014 · External reference

Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts

10.1016/j.molimm.2011.02.013 · 2011 · External reference

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

10.1182/blood-2013-10-529982 · 2014 · External reference

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1

10.3324/haematol.2015.128777 · 2015 · External reference

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

10.1038/ni.3590 · 2016 · External reference

Hemolysis and immune regulation

10.1097/moh.0000000000000423 · 2018 · External reference

Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation

10.1182/blood-2016-11-751636 · 2017 · External reference

Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease

10.1016/j.bcmd.2019.102399 · 2020 · External reference

Influence of temperature and period of freezing on the generation of hemolysate and blood cell lysate

10.1016/j.clinbiochem.2011.07.015 · 2011 · External reference

Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: An observational study

10.1097/ccm.0b013e3182741a54 · 2013 · External reference

Plasma free hemoglobin is associated with LDH, AST, total bilirubin, reticulocyte count, and the hemolysis score in patients with sickle cell anemia

10.21203/rs.3.rs-4252554/v1 · 2024 · External reference

Hemolysis and plasma free hemoglobin during extracorporeal membrane oxygenation support: From clinical implications to laboratory details

10.1097/mat.0000000000000974 · 2020 · External reference

Free hemoglobin concentration in severe sepsis: Methods of measurement and prediction of outcome

10.1186/cc11425 · 2012 · External reference

Interference studies: Focus on blood cell lysates preparation and testing

2012 · External reference

Systematic assessment of the hemolysis index: Pros and cons

10.1016/bs.acc.2015.05.002 · 2015 · External reference

The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes

10.1016/0003-9861(63)90042-0 · 1963 · External reference

Comparison of indirect cyanmethaemoglobin method and TrueHb haemometer point of care test with direct cyanmethaemoglobin (gold standard) method for strengthening anaemia detection at primary health care level

10.4103/jfmpc.jfmpc_1517_23 · 2024 · External reference

Metabolic pathways involved in formation of spontaneous and lipopolysaccharide‐induced neutrophil extracellular traps (NETs) differ in obesity and systemic inflammation

10.3390/ijms22147718 · 2021 · External reference

NETosis: How vital is it

10.1182/blood-2013-04-457671 · 2013 · External reference

Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread

10.1073/pnas.2536989123 · 2026 · External reference

Serum and serum albumin inhibit in vitro formation of neutrophil extracellular traps (NETs)

10.3389/fimmu.2019.00012 · 2019 · External reference

Itaconate suppresses formation of neutrophil extracellular traps (NETs): Involvement of hypoxia-inducible factor 1α (Hif-1α) and heme oxygenase (HO-1)

10.3389/fimmu.2022.864638 · 2022 · External reference

NETs persisting in vasculature undergo self-renewal with consequences for subsequent infection: A mouse model study

10.1182/blood.2024026643 · 2025 · External reference

Spectrophotometric evaluation of hemolysis in plasma by quantification of free oxyhemoglobin, methemoglobin, and methemalbumin in presence of bilirubin

10.1002/jbio.202000461 · 2021 · External reference

A blue spectral shift of the hemoglobin soret band correlates with the age (time since deposition) of dried bloodstains

10.1371/journal.pone.0012830 · 2010 · External reference

Monoamine-dependent production of reactive oxygen species catalyzed by pseudoperoxidase activity of human hemoglobin

10.1271/bbb.66.1224 · 2002 · External reference

Neutrophil activation by heme: Implications for inflammatory processes

10.1182/blood.v99.11.4160 · 2002 · External reference

Molecular taphonomy of heme: Chemical degradation of hemin under presumed fossilization conditions

10.3390/molecules28134887 · 2023 · External reference

Neutrophil activated by the famous and potent PMA (phorbol myristate acetate)

10.3390/cells11182889 · 2022 · External reference

Neutrophil extracellular traps (NETs) in health and disease

10.1186/s43556-025-00337-9 · 2025 · External reference

The molecular mechanism of neutrophil extracellular traps and its role in bone and joint disease

10.1016/j.heliyon.2023.e22920 · 2023 · External reference

Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: Phospholipase D is dispensable

10.1128/mcb.00869-12 · 2013 · External reference

Red blood cells are dynamic reservoirs of cytokines

10.1038/s41598-018-21387-w · 2018 · External reference

Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases

10.3389/fphar.2012.00077 · 2012 · External reference

Hemolytic transfusion reactions

10.1159/000154811 · 2008 · External reference

Production of anti-ABO blood group antibodies after minor ABO-incompatible bone marrow transplantation in NOD/SCID/gamma(c)(null) mice

10.1111/ctr.12264 · 2013 · External reference

Hemolysis associated with prosthetic heart valves: a review

10.1097/crd.0b013e31819f1a83 · 2009 · External reference

The third international consensus definitions for sepsis and septic shock (sepsis-3)

10.1001/jama.2016.0287 · 2016 · External reference

A central role for free heme in the pathogenesis of severe sepsis

10.1126/scitranslmed.3001118 · 2010 · External reference

Mortality at 180‐days is affected by serum haptoglobin levels in septic patients with high magnitude serum high mobility group box‐1 levels

10.1002/ams2.726 · 2022 · External reference

Hemolysis, hemolytic markers, and mortality in sepsis: a scoping review

10.1186/s40635-025-00786-0 · 2025 · External reference

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

10.1182/blood-2012-11-451229 · 2012 · External reference

Neutrophils in ANCA-associated vasculitis: mechanisms and implications for management

10.3389/fphar.2022.957660 · 2022 · External reference

Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study

10.1186/s13613-024-01251-z · 2024 · External reference

Extracellular histones are major mediators of death in sepsis

10.1038/nm.2053 · 2009 · External reference

The impact of pathogens on sepsis prevalence and outcome

10.3390/pathogens13010089 · 2024 · External reference

Resilience to bacterial infection: difference between species could be due to proteins in serum

10.1086/649557 · 2010 · External reference

Endotoxemia-menace, marker, or mistake

10.1189/jlb.3ru0316-151r · 2016 · External reference

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

10.1038/srep37252 · 2016 · External reference

JNK activation turns on LPS- and Gram-negative bacteria-induced NADPH oxidase-dependent suicidal NETosis

10.1038/s41598-017-03257-z · 2017 · External reference

Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C

10.1016/j.cell.2008.01.042 · 2008 · External reference

Restoring the youth of aged red blood cells and extending their lifespan in circulation by remodelling membrane sialic acid

10.1111/jcmm.12721 · 2016 · External reference

The glycocalyx protects erythrocyte-bound tissue-type plasminogen activator from enzymatic inhibition

10.1124/jpet.106.114405 · 2007 · External reference

Quantitative analysis of hemin-induced neutrophil extracellular trap formation and effects of hydrogen peroxide on this phenomenon

10.1016/j.bbrep.2017.07.009 · 2017 · External reference

Noncanonical roles of caspase-4 and caspase-5 in heme-driven IL-1β release and cell death

10.4049/jimmunol.2000226 · 2021 · External reference

Hemolysis-induced lethality involves inflammasome activation by heme

10.1073/pnas.1405023111 · 2014 · External reference

Induction of NLRP3 inflammasome activation by heme in human endothelial cells

10.1155/2018/4310816 · 2018 · External reference

Transcriptional firing helps to drive NETosis

10.1038/srep41749 · 2017 · External reference

The prolyl isomerase Pin1 controls lipopolysaccharide-induced priming of NADPH oxidase in human neutrophils

10.3389/fimmu.2019.02567 · 2019 · External reference

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

10.1073/pnas.1414055112 · 2015 · External reference

Stages of NETosis development upon stimulation of neutrophils with activators of different types

10.3390/ijms241512355 · 2023 · External reference

Enhanced induction of heme oxygenase-1 suppresses thrombus formation and affects the protein C system in sepsis

10.1016/j.trsl.2011.10.009 · 2012 · External reference

Carbon monoxide inhibits the expression of proteins associated with intestinal mucosal pyroptosis in a rat model of sepsis induced by cecal ligation and puncture

10.12659/msm.920668 · 2020 · External reference

Hemin induction of HO-1 protects against LPS-induced septic ileus

10.1016/j.jss.2012.07.064 · 2012 · External reference

Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: the role of heme-binding motifs in TLR4 and MD2

10.1111/imm.13708 · 2024 · External reference

Heme on innate immunity and inflammation

10.3389/fphar.2014.00115 · 2014 · External reference

Cargo-laden erythrocyte ghosts target liver mediated by macrophages

10.1016/j.transci.2020.102930 · 2021 · External reference

Red blood cell inspired strategies for drug delivery: emerging concepts and new advances

10.1007/s11095-022-03328-5 · 2022 · External reference

Sialic acid in the regulation of blood cell production, differentiation and turnover

10.1111/imm.13780 · 2024 · External reference

Phosphatidylserine enhances anti-inflammatory effects of reconstituted HDL in macrophages via distinct intracellular pathways

10.1096/fj.201800810r · 2022 · External reference

Liver-to-lung microembolic NETs promote gasdermin D–dependent inflammatory lung injury in sickle cell disease

10.1182/blood.2019000962 · 2020 · External reference

The potential adverse effects of haemolysis

10.2450/2017.0311-16 · 2017 · External reference

Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics

10.1182/blood.2022015596 · 2022 · External reference

Response of neutrophils to extracellular haemoglobin and LTA in human blood system

10.1016/j.ebiom.2015.01.003 · 2015 · External reference

Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on toll-like receptors 2 and 4

10.1128/iai.01320-06 · 2007 · External reference

Hemoglobin increases mortality from bacterial endotoxin

10.1128/iai.65.4.1258-1266.1997 · 1997 · External reference

Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression

10.1021/pr101230y · 2011 · External reference

Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes

10.1172/jci137282 · 2020 · External reference

Neutrophils’ extracellular trap mechanisms: from physiology to pathology

10.3390/ijms232112855 · 2022 · External reference

Delineation of lipopolysaccharide (LPS)-binding sites on hemoglobin: from in silico predictions to biophysical characterization

10.1074/jbc.m111.245472 · 2011 · External reference

Respiratory protein-generated reactive oxygen species as an antimicrobial strategy

10.1038/ni1501 · 2007 · External reference

Lipid A decreases human erythrocytes deformability by increasing intracellular Ca 2+: effects of verapamil, staurosporine and the rho-kinase inhibitor Y-27632

10.3233/ch-2011-1482 · 2011 · External reference

Plasma glutathione reductase activity and prognosis of septic shock

10.1016/j.jss.2015.07.044 · 2016 · External reference

Alterations of red blood cell shape and sialic acid membrane content in septic patients

10.1097/01.ccm.0000079608.00875.14 · 2003 · External reference

The effect of sepsis on the erythrocyte

10.3390/ijms18091932 · 2017 · External reference

Pro-inflammatory actions of heme and other hemoglobin-derived DAMPs

10.3389/fimmu.2020.01323 · 2020 · External reference

Reticulocyte and heinz body staining and enumeration

10.1002/9781119500537.ch23 · 2022 · External reference

Total iron measurement in human serum with a novel smartphone-based assay

10.1109/jtehm.2020.3005308 · 2020 · External reference

Hemichrome binding to band 3: nucleation of Heinz bodies on the erythrocyte membrane

10.1021/bi00322a006 · 1985 · External reference

Acute hemolysis and heme suppress anti-CD40 antibody-induced necro-inflammatory liver disease

10.3389/fimmu.2021.680855 · 2021 · External reference

Bacterial stimulation of Toll-like receptor 4 drives macrophages to hemophagocytose

10.1128/iai.01149-15 · 2015 · External reference

Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis

10.1186/s13054-023-04750-w · 2023 · External reference

Organism type of infection is associated with prognosis in sepsis: an analysis from the MIMIC-IV database

10.1186/s12879-023-08387-6 · 2023 · External reference

Outer membrane lipid secretion and the innate immune response to gram-negative bacteria

10.1128/iai.00920-19 · 2020 · External reference