Research graph
References from Inflammation-centered neurovascular–immune–metabolic remodeling in ischemic stroke: stage-dependent mechanisms, regulated cell death, and therapeutic translation. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of ischemic stroke, 1990–2021: an analysis of data from the global burden of disease study 2021
10.1016/j.eclinm.2024.102758 · 2024 · External reference
Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s1474-4422(24)00369-7 · 2024 · External reference
Stroke in China: advances in prevention and management on the path to a healthy China
10.1016/s1474-4422(26)00009-8 · 2026 · External reference
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
10.1038/s41392-023-01688-x · 2024 · External reference
Spatiotemporal dynamics of brain pericytes in ischemic stroke
10.1186/s12974-026-03749-8 · 2026 · External reference
NETosis in ischemic stroke: Mechanisms, implications, and therapeutic prospects
10.1016/j.pharmthera.2026.108999 · 2026 · External reference
Immunotherapies for ischemic stroke patients: current status and future directions
10.3390/medsci14010111 · 2026 · External reference
The spatiotemporal dynamic evolution of post-stroke neuroinflammation: energy metabolism mechanisms of acute response and chronic progression
10.3389/fphar.2026.1762764 · 2026 · External reference
Neuroinflammation in stroke-A review of implications for precision immunomodulation
10.1016/j.neuroscience.2026.03.054 · 2026 · External reference
Microglia mitochondrial metabolism in neurological diseases
10.1007/s12035-025-05640-8 · 2026 · External reference
Interplay between lipid metabolism and macrophage dynamics in ischemic stroke: From mechanistic insights to therapeutic strategies
10.1016/j.intimp.2025.115990 · 2026 · External reference
The role of astrocyte metabolic reprogramming in ischemic stroke (Review)
10.3892/ijmm.2025.5490 · 2025 · External reference
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke
10.1038/s41401-024-01405-6 · 2025 · External reference
Mitochondrial dysfunction in cerebrovascular diseases
10.1016/j.molmed.2026.04.002 · 2026 · External reference
Advances in metabolomics of biomarkers for ischemic stroke: From bench to clinic
10.4103/nrr.nrr-d-24-01384 · 2026 · External reference
Exploring NMDAR pathways in ischemic stroke: implications for neurotoxic and neuroprotective mechanisms and therapeutic strategies
10.1007/s00210-025-04357-8 · 2025 · External reference
Molecular mechanisms and targeted intervention strategies of calcium overload in ischemic stroke
10.3390/ijms27052279 · 2026 · External reference
Astrocytic mitochondria transplantation rescues neuron loss and dendritic injuries in acute cerebral ischemic stroke mouse model by flexibly regulating mitochondria dynamics
10.1002/ana.78197 · 2026 · External reference
Cerebral ischemia-reperfusion injury: unraveling the mitophagy-oxidative stress axis for neuroprotective strategies
10.3390/ijms27052448 · 2026 · External reference
Neuronal Nitric Oxide Synthase (nNOS) uncoupling in ischemic stroke: Mechanisms of oxidative/nitrosative stress and opportunities for neuroprotection: A review
10.1016/j.ijbiomac.2025.148589 · 2025 · External reference
Targeting TRPM channels for cerebral ischemia-reperfusion injury
10.1016/j.tips.2024.06.005 · 2024 · External reference
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE
10.1016/j.freeradbiomed.2026.03.054 · 2026 · External reference
NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke
10.1016/j.bbadis.2026.168188 · 2026 · External reference
Immune-mediated blood-brain barrier disruption after ischemic stroke: mechanisms and therapeutic targets
10.3389/fimmu.2025.1716041 · 2025 · External reference
Elevated serum NLRP3 inflammasome level potentially predicts haemorrhagic transformation and unfavourable outcome in acute ischemic stroke patients
10.1080/07853890.2025.2601437 · 2025 · External reference
Serum amyloid A-dependent inflammasome activation and acute injury in a mouse model of experimental stroke
10.3390/ijms27052281 · 2026 · External reference
Perivascular SPP1 drives microglial synaptic engulfment after ischemic stroke
10.1002/cns.70886 · 2026 · External reference
Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke
10.1096/fj.202100471rr · 2021 · External reference
Neutrophil extracellular traps regulate ischemic stroke brain injury
10.1172/jci154225 · 2022 · External reference
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
10.1038/s41467-020-16191-y · 2020 · External reference
Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway
10.1186/s12974-025-03582-5 · 2025 · External reference
Multimodal single-cell transcriptomic and chromatin accessibility profiling reveals monocyte-derived macrophage dynamics following ischemic stroke
10.3390/ijms27083657 · 2026 · External reference
Phagocytosis converts infiltrated monocytes to microglia-like phenotype in experimental brain ischemia
10.1186/s12974-022-02552-5 · 2022 · External reference
Single-cell analyses reveal the dynamic functions of Itgb2+ microglia subclusters at different stages of cerebral ischemia-reperfusion injury in transient middle cerebral occlusion mice model
10.3389/fimmu.2023.1114663 · 2023 · External reference
M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice
10.7150/thno.68895 · 2022 · External reference
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
10.1016/j.immuni.2021.04.022 · 2021 · External reference
Immunomodulation with local, sustained delivery of pituitary adenylate cyclase activating polypeptide results in improved functional recovery in stroke-injured mice
10.1002/adhm.202500765 · 2025 · External reference
M2a macrophages regulate fibrosis and affect the outcome after stroke via PU.1/mTOR pathway in fibroblasts
10.1016/j.neuint.2024.105674 · 2024 · External reference
M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats
10.4103/1673-5374.368299 · 2023 · External reference
Effects of enriched environment on microglia and functional white matter recovery in rats with post stroke cognitive impairment
10.1016/j.neuint.2022.105295 · 2022 · External reference
Cellular communication networks mediated by microglia in ischemic stroke
10.1002/cns.70687 · 2025 · External reference
Dual-functionalized extracellular vesicles promote brain repair and remodeling following ischemic stroke in mice
10.1111/cns.70597 · 2025 · External reference
Characterizing hypoxia-orchestrated post-stroke changes in oligodendrocyte precursor cells for optimized cell therapy
10.1016/j.stemcr.2025.102687 · 2025 · External reference
Endothelial changes at different stages after ischemic stroke contribute to the regulation of immune cell infiltration
10.1111/cns.70456 · 2025 · External reference
Therapeutic potential of astrocyte transdifferentiated neurons
10.4103/nrr.nrr-d-25-00554 · 2026 · External reference
Transcription factor-based gene therapy enables functional repair of rat following chronic ischemic stroke
10.1111/cns.70448 · 2025 · External reference
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
10.1007/s10456-025-09987-3 · 2025 · External reference
Different roles of astrocytes in the blood-brain barrier during the acute and recovery phases of stroke
10.4103/nrr.nrr-d-24-01417 · 2026 · External reference
Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke
10.1177/0271678x17700913 · 2018 · External reference
TAT-PEP alleviated cognitive impairment by alleviating neuronal mitochondria damage and apoptosis after cerebral ischemic reperfusion injury
10.1007/s12035-023-03404-w · 2023 · External reference
Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons
10.1177/0271678x18785567 · 2019 · External reference
N-terminomic changes in neurons during excitotoxicity reveal proteolytic events associated with synaptic dysfunctions and potential targets for neuroprotection
10.1016/j.mcpro.2023.100543 · 2023 · External reference
Preferential synaptic type of GABA-A receptor ligands enhancing neuronal survival and facilitating functional recovery after ischemic stroke
10.1021/acs.jmedchem.4c01578 · 2024 · External reference
Metabolic regulation of synaptic activity
10.1515/revneuro-2017-0090 · 2018 · External reference
Crosstalk of astrocytes and other cells during ischemic stroke
10.3390/life12060910 · 2022 · External reference
Glial cells as therapeutic approaches in brain ischemia-reperfusion injury
10.3390/cells10071639 · 2021 · External reference
Glutamate provides cytoprotective effect for astrocytes against ischemic insult and promotes astrogliosis
2024 · External reference
Metabolic reprogramming in gliocyte post-cerebral ischemia/ reperfusion: From pathophysiology to therapeutic potential
10.2174/1570159x22666240131121032 · 2024 · External reference
Reactive astrocytes release GDNF to promote brain recovery and neuronal survival following ischemic stroke
10.1007/s11064-025-04370-6 · 2025 · External reference
GLAST-CreERT2 mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model
10.1002/glia.23848 · 2020 · External reference
Dual roles of astrocyte-derived factors in regulation of blood-brain barrier function after brain damage
10.3390/ijms20030571 · 2019 · External reference
Astrocyte-derived pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke
10.1161/strokeaha.115.012133 · 2016 · External reference
Regulation of blood-brain barrier integrity by brain microvascular endothelial cells in ischemic stroke: A therapeutic opportunity
10.1016/j.ejphar.2025.177553 · 2025 · External reference
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke
10.1186/s12974-020-01780-x · 2020 · External reference
P-glycoprotein aggravates blood brain barrier dysfunction in experimental ischemic stroke by inhibiting endothelial autophagy
10.14336/ad.2022.0225 · 2022 · External reference
Extracellular vesicles maintain blood-brain barrier integrity by the suppression of caveolin-1/CD147/VEGFR2/MMP pathway after ischemic stroke
10.2147/ijn.s444009 · 2024 · External reference
A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia
10.1016/j.redox.2024.103415 · 2024 · External reference
Translational insights into pericyte-mediated regulation of cerebral blood flow: Implications for ischemic stroke
10.1161/strokeaha.125.052018 · 2025 · External reference
Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke
10.3389/fncel.2023.1267785 · 2023 · External reference
Pericytes are required for blood-brain barrier integrity during embryogenesis
10.1038/nature09513 · 2010 · External reference
Microcirculation dysfunction in subacute stroke: The role of delayed capillary pericyte loss
10.14336/ad.2025.0197 · 2025 · External reference
Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo
10.1093/brain/awad401 · 2024 · External reference
Neutrophils obstructing brain capillaries are a major cause of no-reflow in ischemic stroke
10.1016/j.celrep.2020.108260 · 2020 · External reference
PI3Kδ inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-α dependent manner
10.1016/j.expneurol.2024.114728 · 2024 · External reference
Integrin α8-mediated pericyte morphogenesis controls blood-brain barrier integrity
10.1002/advs.202415374 · 2025 · External reference
Rapamycin treatment reduces brain pericyte constriction in ischemic stroke
10.1007/s12975-024-01298-x · 2025 · External reference
Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction
10.1038/s41401-021-00784-4 · 2022 · External reference
Exploring the multi-repair effects of advanced biomimetic rapamycin nanoparticles on cerebral ischemia-reperfusion injury
10.1186/s12951-025-03824-x · 2025 · External reference
Protective effect of brain microvascular endothelial cell-derived exosomes on blood-brain barrier induced by ischemia-reperfusion injury in vivo and in vitro
10.3389/fphar.2025.1548122 · 2025 · External reference
Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane
10.1016/j.biomaterials.2022.121983 · 2023 · External reference
ABI3BP protects against cerebral ischemia-reperfusion injury by preserving blood-brain barrier integrity and activating PI3K/Akt signaling
10.1016/j.bcp.2026.117896 · 2026 · External reference
Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
10.3389/fneur.2013.00032 · 2013 · External reference
Matrix metalloproteinase-9 in hemorrhagic transformation after acute ischemic stroke (Review)
10.3892/mmr.2025.13590 · 2025 · External reference
Crosstalk between oxidative stress and neutrophil response in early ischemic stroke: a comprehensive transcriptome analysis
10.3389/fimmu.2023.1134956 · 2023 · External reference
Multifunctionality of tissue inhibitor of metalloproteinase-1 in central nervous system diseases
10.1016/j.brainresbull.2025.111647 · 2025 · External reference
The role of efferocytosis in ischemic stroke and insights from retinopathy
10.1016/j.tins.2025.06.002 · 2025 · External reference
Single-cell RNA sequencing reveals microglial heterogeneity and functional states after cerebral ischemia-reperfusion injury
10.2147/jir.s539404 · 2025 · External reference
Multicolor fate mapping of microglia reveals polyclonal proliferation, heterogeneity, and cell-cell interactions after ischemic stroke in mice
10.1038/s41467-025-63949-3 · 2025 · External reference
The role of TREM2 after stroke: From mechanisms to therapeutic potential
10.1007/s12035-025-05622-w · 2025 · External reference
TREM2-IGF1 mediated glucometabolic enhancement underlies microglial neuroprotective properties during ischemic stroke
10.1002/advs.202305614 · 2024 · External reference
TREML2 modulates microglial phagocytosis of myelin debris via TLR9 in chronic cerebral ischemia
10.1007/s10753-025-02397-z · 2025 · External reference
Chemerin 15 enhances microglial phagocytosis to attenuate cerebral ischemia-reperfusion injury through the ChemR23/p38 MAPK pathway
10.1016/j.isci.2025.113396 · 2025 · External reference
Revealing the novel role of purinergic receptor P2X4 in phagocytic uptake after ischemic stroke
10.1161/jaha.124.037148 · 2024 · External reference
HDAC1 dysregulation promotes pro-inflammatory microglial activation and aggravates post-stroke neuroinflammation
10.1080/07853890.2025.2597624 · 2025 · External reference
Orchestrating the frontline: HDAC3-miKO recruits macrophage reinforcements for accelerated myelin debris clearance after stroke
10.7150/thno.103449 · 2025 · External reference
Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation
10.1186/s12974-025-03585-2 · 2025 · External reference
Intercellular communication between peripheral monocytes and central nervous system cells in stroke
10.4103/nrr.nrr-d-25-00738 · 2026 · External reference
NAD+ depletion drives age-related monocyte hyperinflammation after stroke and is reversed by nicotinamide riboside
10.1186/s12974-025-03638-6 · 2025 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion
10.1002/glia.24359 · 2023 · External reference
Oligodendrocyte degeneration and recovery after focal cerebral ischemia
10.1016/j.neuroscience.2010.04.070 · 2010 · External reference
Oligodendrocyte progenitor cell proliferation and fate after white matter stroke in juvenile and adult mice
10.1159/000496200 · 2019 · External reference
Oligodendrocyte precursor cells transplantation protects blood-brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling
10.1038/s41419-019-2206-9 · 2020 · External reference
CD11c+ microglia promote white matter repair after ischemic stroke
10.1038/s41419-023-05689-0 · 2023 · External reference
Role of T lymphocytes and interferon-gamma in ischemic stroke
10.1161/circulationaha.105.593046 · 2006 · External reference
Experimental ischemic stroke induces long-term T cell activation in the brain
10.1177/0271678x18792372 · 2019 · External reference
Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice
10.1016/j.bbi.2021.05.001 · 2021 · External reference
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
10.1038/s41586-018-0824-5 · 2019 · External reference
Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment
10.1186/s12974-024-03206-4 · 2024 · External reference
IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke
10.1007/s11011-013-9413-3 · 2013 · External reference
B cells do not have a major pathophysiologic role in acute ischemic stroke in mice
10.1186/s12974-017-0890-x · 2017 · External reference
B-lymphocyte-mediated delayed cognitive impairment following stroke
10.1523/jneurosci.4098-14.2015 · 2015 · External reference
Natural killer cells are present in Rag1-/- mice and promote tissue damage during the acute phase of ischemic stroke
10.1007/s12975-021-00923-3 · 2022 · External reference
Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke
10.1186/s12974-023-02689-x · 2023 · External reference
Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke
10.1016/j.molimm.2018.08.002 · 2018 · External reference
Danger signals in stroke and their role on microglia activation after ischemia
10.1177/1756286418774254 · 2018 · External reference
Remimazolam alleviates cerebral ischemia-reperfusion injury of rats by inhibiting NF-κB/NLRP3 inflammasome pyroptosis
10.1038/s41598-025-31205-9 · 2025 · External reference
Enterococcus-derived cytolysin exacerbates ischemic stroke by disrupting the blood-brain barrier via NLRP3 activation
10.1186/s12974-025-03590-5 · 2025 · External reference
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway
10.7150/thno.47651 · 2020 · External reference
STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia
10.1038/s41419-024-07208-1 · 2024 · External reference
Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation
10.1080/02699052.2017.1312018 · 2017 · External reference
Assessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients
10.1007/s11239-024-03004-y · 2024 · External reference
Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke
10.1016/j.jocn.2014.05.042 · 2015 · External reference
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice
10.7150/thno.48761 · 2021 · External reference
Astrocyte-derived exosomal miR-378a-5p mitigates cerebral ischemic neuroinflammation by modulating NLRP3-mediated pyroptosis
10.3389/fimmu.2024.1454116 · 2024 · External reference
IL17A mediates glycolysis-dependent primary angiogenesis and exacerbates ischemic stroke injury
10.1007/s12035-025-05387-2 · 2025 · External reference
The role of TNF-α in ischemic stroke
10.3390/ijms27031424 · 2026 · External reference
Targeted inhibition of microglial C5aR1 by PMX205 mitigates post-ischemic stroke neuroinflammation and promotes functional recovery
10.1016/j.brainresbull.2026.111873 · 2026 · External reference
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke
10.1007/s10565-026-10177-0 · 2026 · External reference
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation
10.1084/jem.20021098 · 2003 · External reference
Central nervous system injury-induced immune deficiency syndrome
10.1038/nrn1765 · 2005 · External reference
Immunodepression, infections, and functional outcome in ischemic stroke
10.1161/strokeaha.122.038867 · 2022 · External reference
Translocation and dissemination of commensal bacteria in post-stroke infection
10.1038/nm.4194 · 2016 · External reference
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells
10.1038/nm.4068 · 2016 · External reference
Microbiota dysbiosis controls the neuroinflammatory response after stroke
10.1523/jneurosci.1114-16.2016 · 2016 · External reference
Distinct commensal bacterial signature in the gut is associated with acute and long-term protection from ischemic stroke
10.1161/strokeaha.120.029262 · 2020 · External reference
Stroke affects intestinal immune cell trafficking to the central nervous system
10.1016/j.bbi.2021.05.008 · 2021 · External reference
Immune cell infiltration into the brain after ischemic stroke in humans compared to mice and rats: a systematic review and meta-analysis
10.1007/s12975-021-00887-4 · 2021 · External reference
The Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) protocol: novel method for evaluating human stroke
10.1136/neurintsurg-2018-014118 · 2019 · External reference
Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy
10.1177/0271678x211028496 · 2022 · External reference
Platelet activation and chemokine release are related to local neutrophil-dominant inflammation during hyperacute human stroke
10.1007/s12975-021-00938-w · 2022 · External reference
Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke
10.1177/0271678x221078617 · 2022 · External reference
Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity
10.1186/s12974-021-02157-4 · 2021 · External reference
Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain
10.1016/j.expneurol.2025.115550 · 2026 · External reference
Spatial myeloid landscape of large artery atherosclerotic and cardioembolic thrombi retrieved by mechanical thrombectomy
10.1096/fj.202501658rr · 2025 · External reference
Association between thrombus composition and etiology in patients with acute ischemic stroke treated by thrombectomy
10.1161/strokeaha.124.047092 · 2025 · External reference
Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy
10.1177/0271678x251327944 · 2026 · External reference
A NETs-centric multi-omics framework prioritizes PGLYRP1 and MMP9 as subtype-associated thromboinflammatory biomarker candidates and putative therapeutic hypotheses in ischemic stroke
10.1016/j.nbd.2026.107422 · 2026 · External reference
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
10.1126/science.abf7844 · 2021 · External reference
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
10.1038/s41593-022-01029-1 · 2022 · External reference
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
10.1186/s12974-023-02980-x · 2023 · External reference
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
10.1016/j.cell.2025.06.045 · 2025 · External reference
Nociceptive neurons promote myeloid-derived suppressor cell mobilization to alleviate post-stroke neuroinflammation
10.7150/thno.119474 · 2025 · External reference
Single-cell omics and flow cytometry identify distinct immune states of dural and brain-infiltrating IL-17-producing γδ T cells after experimental stroke
10.1186/s12974-026-03794-3 · 2026 · External reference
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
10.1084/jem.20221983 · 2024 · External reference
Meningeal lymphatic-associated brain swelling in acute stroke
10.1371/journal.pone.0342643 · 2026 · External reference
CCN1 is a therapeutic target for reperfused ischemic brain injury
10.1007/s12975-024-01279-0 · 2025 · External reference
Meningeal lymphatics drives macrophage clearance via CCL2-CCR2 axis after cerebral ischemia
10.3390/cimb48030259 · 2026 · External reference
Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice
10.1038/s41467-025-56847-1 · 2025 · External reference
Microglial heterogeneity in the ischemic stroke mouse brain of both sexes
10.1186/s13073-024-01368-7 · 2024 · External reference
TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke
10.1016/j.neurot.2025.e00745 · 2025 · External reference
The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke
10.1161/strokeaha.111.629337 · 2012 · External reference
Spatiotemporal double-edged sword of macrophages: Temporal regulation of neuroinflammation and neurorepair in ischemic stroke
10.1155/jimr/1172895 · 2026 · External reference
Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery
10.1038/s41467-025-58254-y · 2025 · External reference
Endothelial cells temporally orchestrate lymphocyte dynamics and functional outcomes after ischemic stroke
10.1186/s12987-026-00794-6 · 2026 · External reference
Lactylation at the crossroads of metabolism and epigenetics in neuroinflammation
10.3389/fimmu.2026.1784112 · 2026 · External reference
Oligodendroglia metabolically support axons and contribute to neurodegeneration
10.1038/nature11314 · 2012 · External reference
Assessment of phase-dependent alterations in cortical glycolytic and mitochondrial metabolism following ischemic stroke
10.1080/17590914.2025.2488935 · 2025 · External reference
The role of lactate and lactylation in ischemic stroke
10.1016/j.intimp.2025.115502 · 2025 · External reference
Lactate modulates microglial inflammatory responses through HIF-1α-mediated CCL7 signaling after cerebral ischemia in mice
10.1016/j.intimp.2024.113801 · 2025 · External reference
Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke
10.1016/j.nbd.2025.107061 · 2025 · External reference
Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion
10.1038/s42003-024-07425-6 · 2024 · External reference
Lactate and lactylation modifications in neurological disorders
10.4103/nrr.nrr-d-24-01344 · 2026 · External reference
Mitophagy is activated in brain damage induced by cerebral ischemia and reperfusion via the PINK1/Parkin/p62 signalling pathway
10.1016/j.brainresbull.2018.06.018 · 2018 · External reference
Targeting neuronal mitophagy in ischemic stroke: an update
10.1093/burnst/tkad018 · 2023 · External reference
Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke
10.1038/jcbfm.2015.123 · 2015 · External reference
Rational application of β-hydroxybutyrate attenuates ischemic stroke by suppressing oxidative stress and mitochondrial-dependent apoptosis via activation of the Erk/CREB/eNOS pathway
10.1021/acschemneuro.1c00046 · 2021 · External reference
The role of phospholipids in mitochondrial dynamics and associated diseases
10.31083/fbl27634 · 2025 · External reference
Lipid metabolism, microglia, and stroke
10.4103/nrr.nrr-d-24-01523 · 2026 · External reference
Exploring novel roles of lipid droplets and lipid metabolism in regulating inflammation and blood-brain barrier function in neurological diseases
10.3389/fnins.2025.1603292 · 2025 · External reference
Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion
10.14814/phy2.16118 · 2024 · External reference
Targeting foam cell formation to improve recovery from ischemic stroke
10.1016/j.nbd.2023.106130 · 2023 · External reference
AXL promotes ischemic myelin repair through alleviating myelin debris deposition and lipid droplets accumulation
10.1002/advs.202517825 · 2026 · External reference
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism
10.1038/s41401-025-01505-x · 2025 · External reference
Lipid paradox in statin-naïve acute ischemic stroke but not hemorrhagic stroke
10.3389/fneur.2018.00541 · 2018 · External reference
Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis
10.1212/01.wnl.0000252799.64165.d5 · 2007 · External reference
Cholesterol levels and risk of hemorrhagic transformation after acute ischemic stroke
10.1159/000329315 · 2011 · External reference
High-dose atorvastatin after stroke or transient ischemic attack
10.1056/nejmoa061894 · 2006 · External reference
Excitotoxic storms of ischemic stroke: a non-neuronal perspective
10.1007/s12035-024-04184-7 · 2024 · External reference
Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia
10.3389/fphar.2025.1576884 · 2025 · External reference
The ADMA-NO-NOX2 axis and its association with leptomeningeal collateral impairment in acute ischemic stroke
10.1038/s41598-025-30283-z · 2025 · External reference
New insights into tryptophan metabolism in ischemic stroke: a promising therapeutic target
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