Research graph
References from HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa. Local targets link to admitted publications; unresolved targets remain external evidence.
Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy
10.3389/fimmu.2019.01965 · 2019 · External reference
Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer
10.1101/gr.209973.116 · 2017 · External reference
Chronic immune activation and accelerated immune aging among HIV-infected adults receiving suppressive antiretroviral therapy for at least 12 years in an African cohort
10.1016/j.heliyon.2024.e31910 · 2024 · External reference
Functional and transcriptional senescence profiles of CD8+ T cells associate with the presence of carotid plaques in people living with HIV
10.1093/infdis/jiag018 · 2026 · External reference
Telomere and ATM dynamics in CD4 T-cell depletion in active and virus-suppressed HIV infections
10.1128/jvi.01061-20 · 2020 · External reference
CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases
10.1038/cddis.2015.414 · 2016 · External reference
The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
10.3389/fragi.2024.1490302 · 2024 · External reference
Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection
10.1007/s13365-024-01223-w · 2024 · External reference
Immune and senescence profiles associated with non-AIDS-defining cancer risk in people with HIV: a case-cohort study
10.3389/fimmu.2025.1707510 · 2025 · External reference
Increased macrophage-specific arterial infiltration relates to noncalcified plaque and systemic immune activation in people with human immunodeficiency virus
10.1093/infdis/jiac301 · 2022 · External reference
Size of HIV-1 reservoir is associated with telomere shortening and immunosenescence in early-treated European children with perinatally acquired HIV-1
10.1002/jia2.25847 · 2021 · External reference
Lower immune senescence of T cell subsets among virologically suppressed Chinese men who have sex with men living with HIV in comparison with those ART naive
10.1186/s12879-025-10511-7 · 2025 · External reference
Senescence-related cytokine levels are associated with HIV-1 serostatus and persistence
10.1097/qad.0000000000004204 · 2025 · External reference
HIV-1 can persist in aged memory CD4+ T lymphocytes with minimal signs of evolution after 8.3 years of effective highly active antiretroviral therapy
10.1097/qai.0b013e318197eb04 · 2009 · External reference
HIV infection and immunosenescence: challenges and intervention strategies
10.1186/s12916-025-04545-6 · 2025 · External reference
Overview of WHO recommendations on HIV and sexually transmitted infection testing, prevention,treatment, care and service delivery In
2025 · External reference
Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses
10.1096/fj.07-9492lsf · 2008 · External reference
Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV-positive individuals
10.1161/circulationaha.118.036232 · 2019 · External reference
Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy
10.1093/cid/ciu051 · 2014 · External reference
Unsuppressed viremia and lower CD4 count associated with faster telomere attrition in African children with perinatal human immunodeficiency virus on long-term antiretroviral therapy. The Journal of Infectious Diseases. jiag060. ISSN
10.1093/infdis/jiag060 · 2026 · External reference
HIV patients stable on ART retain evidence of a high CMV load but changes to Natural Killer cell phenotypes reflect both HIV and CMV
10.1186/s12981-015-0080-9 · 2015 · External reference
Role of thymosin α1 in restoring immune response in immunological nonresponders living with HIV
10.1186/s12879-024-08985-y · 2024 · External reference
Accelerated neuroimmune dysfunction in aged HIV-1-infected humanized mice
10.3390/ph17020149 · 2024 · External reference
Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection
10.1097/qai.0000000000000913 · 2016 · External reference
Proximity of cytomegalovirus-specific CD8(+) T cells to replicative senescence in human immunodeficiency virus-infected individuals
10.3389/fimmu.2018.00201 · 2018 · External reference
Effect of cytomegalovirus co-infection on normalization of selected T-cell subsets in children with perinatally acquired HIV infection treated with combination antiretroviral therapy
10.1371/journal.pone.0120474 · 2015 · External reference
Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key
10.1186/s12981-021-00361-z · 2021 · External reference
Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study
10.1136/bmjopen-2022-067640 · 2023 · External reference
Age-associated expansion of hiv/siv reservoirs in people with hiv and siv-infected macaques
10.1111/acel.70252 · 2025 · External reference
Clinical, virological and immunological subphenotypes in a cohort of early treated hiv-infected children
10.3389/fimmu.2022.875692 · 2022 · External reference
Relationship between CCR5(WT/Δ32) heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection
10.1016/j.cmi.2016.12.020 · 2017 · External reference
Senescence-associated β-galactosidase reveals the abundance of senescent CD8+ T cells in aging humans
10.1111/acel.13344 · 2021 · External reference
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality
10.1371/journal.ppat.1004078 · 2014 · External reference
Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events
10.1016/j.ebiom.2023.104773 · 2023 · External reference
Predictive value of CD8+ T cell and CD4/CD8 ratio at two years of successful ART in the risk of AIDS and non-AIDS events
10.1016/j.ebiom.2022.104072 · 2022 · External reference
Implications of accumulation of clonally expanded and senescent CD4(+)GNLY(+) T cells in immunological non-responders of HIV-1 infection
10.1080/22221751.2024.2396868 · 2024 · External reference
Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV
10.18632/aging.206353 · 2026 · External reference
Changes in cellular senescence biomarkers across individuals at different stages of HIV infection before and after a year on antiretroviral therapy
10.1093/infdis/jiag133 · 2026 · External reference
Relationship between modern ART regimens and immunosenescence markers in patients with chronic HIV infection
10.20944/preprints202406.1884.v1 · 2024 · External reference
Immunosenescence phenotypes and prognostic significance of CD8 + CD28- T cells in AIDS-related non-Hodgkin lymphoma
10.1080/07853890.2025.2558123 · 2025 · External reference
Inflammescent CX3CR1+CD57+CD8+ T cells are generated and expanded by IL-15
10.1172/jci.insight.132963 · 2020 · External reference
The senescence-associated secretory phenotype and its physiological and pathological implications
10.1038/s41580-024-00727-x · 2024 · External reference
The impact of ageing on monocytes and macrophages
10.1016/j.imlet.2020.12.003 · 2021 · External reference
Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34(+) hematopoietic stem cells from diabetic patients
10.1186/s12933-024-02195-1 · 2024 · External reference
Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
10.18632/aging.204927 · 2023 · External reference
Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging
10.1038/s41420-021-00797-2 · 2021 · External reference
Cytomegalovirus-specific CD8+ T-cell responses are associated with arterial blood pressure in people living with HIV
10.1371/journal.pone.0226182 · 2020 · External reference
Disparate trajectories of cognitive aging among American Indian and Alaskan Native people with and without HIV
10.1037/neu0000950 · 2024 · External reference
Adipose tissue in persons with HIV is enriched for CD4+ T effector memory and T effector memory RA+ cells, which show higher CD69 expression and CD57, CX3CR1, GPR56 co-expression with increasing glucose intolerance
10.3389/fimmu.2019.00408 · 2019 · External reference
Human immunodeficiency virus in an aging population, a complication of success
10.1111/j.1532-5415.2009.02494.x · 2009 · External reference
CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
10.1038/s41514-019-0041-y · 2020 · External reference
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
10.4049/jimmunol.1301721 · 2014 · External reference
CD4+CD28null T lymphocytes resemble CD8+CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients
10.1189/jlb.1a0514-276rr · 2015 · External reference
Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help
10.4049/jimmunol.175.1.112 · 2005 · External reference
Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial
10.1111/tmi.12442 · 2015 · External reference
A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV
10.1371/journal.pone.0238575 · 2020 · External reference
Effects of fish oil on HIV-related inflammation and markers of immunosenescence: A randomized clinical trial
10.1089/acm.2017.0222 · 2018 · External reference
Aging and host responses to severe infection: proteomic analysis of a prospective multicenter cohort from Uganda
10.1097/cce.0000000000001330 · 2025 · External reference
Telomere length in a South African population co-infected with HIV and helminths
10.3390/cimb46070409 · 2024 · External reference
Altered lipid profiles and vaccine induced-humoral responses in children living with HIV on antiretroviral therapy in Tanzania
10.3389/fcimb.2021.721747 · 2021 · External reference
Associations of leucocyte telomere length with cardio-metabolic risk profile in a South African HIV-infected population
10.1097/md.0000000000028642 · 2022 · External reference
Dynamics of CD4 and CD8 T-cell subsets and inflammatory biomarkers during early and chronic HIV infection in mozambican adults
10.3389/fimmu.2017.01925 · 2017 · External reference
Visceral leishmaniasis as an independent cause of high immune activation, T-cell senescence, and lack of immune recovery in virologically suppressed HIV-1-coinfected patients
10.1111/hiv.12206 · 2015 · External reference
T-cell activation, senescence, and exhaustion in asymptomatic HIV/Leishmania infantum co-infection
10.1101/2023.03.06.23286828 · 2023 · External reference
T-cell activation and senescence in asymptomatic HIV/Leishmania infantum co-infection
10.1371/journal.pntd.0012848 · 2025 · External reference
Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils
10.1101/2023.02.25.530027 · 2023 · External reference
T cell senescence by N-glycan branching
10.18632/aging.204239 · 2022 · External reference
Tools to quantify and characterize the persistent reservoir in people with HIV-1: focus on non-B subtypes
10.3390/v18010110 · 2026 · External reference
Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure
10.1038/s41579-024-01010-8 · 2024 · External reference
Changes in HIV-1 reservoir dynamics after mpox infection
10.1002/jmv.70690 · 2025 · External reference
Partial recovery of telomere length after long-term virologic suppression in persons with HIV-1
10.1093/ofid/ofae550 · 2024 · External reference
Epigenetic aging biomarkers associated with cognitive impairment in older african american adults with human immunodeficiency virus (HIV)
10.1093/cid/ciab563 · 2021 · External reference
IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection
10.1172/jci.insight.150888 · 2021 · External reference
Impact of aging and HIV infection on serologic response to seasonal influenza vaccination
10.1097/qad.0000000000001774 · 2018 · External reference
HIV-Tat upregulates the expression of senescence biomarkers in CD4(+) T-cells
10.3389/fimmu.2025.1568762 · 2025 · External reference
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes
10.26508/lsa.202503231 · 2025 · External reference
Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape
10.3389/fimmu.2025.1532692 · 2025 · External reference
The interplay between diet and the gut microbiome: implications for health and disease
10.1038/s41579-024-01068-4 · 2024 · External reference
The new orleans alcohol use in HIV study: launching a translational investigation of the interaction of alcohol use with biological and socioenvironmental risk factors for multimorbidity in people living with HIV
10.1111/acer.13980 · 2019 · External reference
HIV latency: should we shock or lock
10.1016/j.it.2016.12.003 · 2017 · External reference
Depicting HIV-1 transcriptional mechanisms: A summary of what we know
10.3390/v12121385 · 2020 · External reference
Block-and-lock strategies to cure HIV infection
10.3390/v12010084 · 2020 · External reference
Activation of human immunodeficiency virus transcription in T cells revisited: NF-kappaB p65 stimulates transcriptional elongation
10.1128/jvi.75.18.8524-8537.2001 · 2001 · External reference
Block and lock HIV cure strategies to control the latent reservoir
10.3389/fcimb.2020.00424 · 2020 · External reference
AP-1 and NF-kappaB synergize to transcriptionally activate latent HIV upon T-cell receptor activation
10.1002/1873-3468.14033 · 2021 · External reference
Transcriptional regulation by calcium, calcineurin, and NFAT
10.1101/gad.1102703 · 2003 · External reference
The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
10.1016/s1074-7613(00)80326-x · 1997 · External reference
CpG methylation controls reactivation of HIV from latency
10.1186/1742-4690-7-s1-o8 · 2009 · External reference
Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
10.1186/s13148-016-0185-6 · 2016 · External reference
HIV latency in isolated patient CD4(+) T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing
10.1126/scitranslmed.aap9927 · 2018 · External reference
Phosphorylation of HIV-1 tat by CDK2 in HIV-1 transcription
10.1186/1742-4690-3-78 · 2006 · External reference
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
10.1016/j.molcel.2005.06.027 · 2005 · External reference
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
10.1073/pnas.0705053104 · 2007 · External reference
In vivo suppression of HIV rebound by didehydro-cortistatin A, a "Block-and-lock" Strategy for HIV-1 treatment
10.1016/j.celrep.2017.09.080 · 2017 · External reference
The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
10.1038/22350 · 1999 · External reference
FACT, a factor that facilitates transcript elongation through nucleosomes
10.1016/s0092-8674(00)80903-4 · 1998 · External reference
Curaxin CBL0100 blocks HIV-1 replication and reactivation through inhibition of viral transcriptional elongation
10.3389/fmicb.2017.02007 · 2017 · External reference
Curaxins: anticancer compounds that simultaneously suppress NF-kappaB and activate p53 by targeting FACT
10.1126/scitranslmed.3002530 · 2011 · External reference
Novel RNA duplex locks HIV-1 in a latent state via chromatin-mediated transcriptional silencing
10.1038/mtna.2015.31 · 2015 · External reference
Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region
10.1074/jbc.m709651200 · 2008 · External reference
RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency
10.1186/s12977-018-0451-0 · 2018 · External reference
Oxidized lipoproteins are associated with markers of inflammation and immune activation in HIV-1 infection
10.1097/qad.0000000000001238 · 2016 · External reference
CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy–naive HIV-infected adults enrolled in Adult Clinical Trials Group studies
10.1093/infdis/jis268 · 2012 · External reference
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits
10.1038/s41588-019-0516-6 · 2019 · External reference
Cellular senescence and other age-related mechanisms in skeletal diseases
10.1038/s41413-025-00448-7 · 2025 · External reference