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References from Dysregulation of the cytotoxic-humoral axis and expansion of regulatory T cells in anti-TIF1γ- positive dermatomyositis. Local targets link to admitted publications; unresolved targets remain external evidence.
Anti-TIF1-γ autoantibodies: warning lights of a tumour autoantigen
10.1093/rheumatology/kez572 · 2020 · External reference
A comprehensive overview on myositis-specific antibodies: new and old biomarkers in idiopathic inflammatory myopathy
10.1007/s12016-015-8510-y · 2017 · External reference
256th ENMC international workshop: myositis specific and associated autoantibodies (MSA-ab): Amsterdam, the Netherlands, 8-10 October 2021
10.1016/j.nmd.2022.05.011 · 2022 · External reference
Dermatomyositis autoantibodies: how can we maximize utility
10.21037/atm-20-5175 · 2021 · External reference
Long-term outcomes of idiopathic inflammatory myopathies: a large-scale longitudinal cohort study
10.1016/j.jaut.2025.103435 · 2025 · External reference
Dermatomyositis and immune-mediated necrotizing myopathies: a window on autoimmunity and cancer
10.3389/fimmu.2017.00992 · 2017 · External reference
239th ENMC International Workshop: classification of dermatomyositis, Amsterdam, the Netherlands, 14–16 December 2018
10.1016/j.nmd.2019.10.005 · 2020 · External reference
International guideline for idiopathic inflammatory myopathy-associated cancer screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
10.1038/s41584-023-01045-w · 2023 · External reference
MDA5 dermatomyositis: unveiling a potentially life-threatening disease
10.3949/ccjm.92a.25018 · 2025 · External reference
Single-cell landscape of peripheral immune response in patients with anti-melanoma differentiation-associated gene 5 dermatomyositis
10.1093/rheumatology/kead597 · 2024 · External reference
Monocyte–macrophage dynamics as key in disparate lung and peripheral immune responses in severe anti-melanoma differentiation-associated gene 5-positive dermatomyositis-related interstitial lung disease
10.1002/ctm2.70226 · 2025 · External reference
Single-cell transcriptomic analysis on multi-subtypes of idiopathic inflammatory myopathy reveals pathological hallmarks associated with stromal stem and immune cells in damaged skeletal muscles
10.1002/art.70185 · 2026 · External reference
A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study
10.3389/fimmu.2024.1436114 · 2024 · External reference
Malignancy in idiopathic inflammatory myopathies: recent insights
10.1007/s12016-025-09080-z · 2025 · External reference
Cancer screening in idiopathic inflammatory myopathies: ten years experience from a single center
10.1016/j.semarthrit.2021.12.008 · 2022 · External reference
Conventional cancer screening versus PET/CT in dermatomyositis/polymyositis
10.1016/j.amjmed.2009.11.012 · 2010 · External reference
Prognostic factors for patients with cancer-associated dermatomyositis: a retrospective, multicenter cohort study of 73 patients
10.1093/rheumatology/keae629 · 2024 · External reference
Clinical features of dermatomyositis patients with anti-TIF1 antibodies: a case based comprehensive review
10.1016/j.autrev.2023.103464 · 2023 · External reference
Human peripheral blood mononuclear cells: a review of recent proteomic applications
10.1002/pmic.202200026 · 2022 · External reference
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications
10.1038/s41467-022-34145-4 · 2022 · External reference
Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis
10.1136/annrheumdis-2020-218661 · 2021 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
T cell receptor (TCR) signaling in health and disease
10.1038/s41392-021-00823-w · 2021 · External reference
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
10.1038/ncomms15081 · 2017 · External reference
Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis
10.1186/s12967-025-06551-x · 2025 · External reference
A blueprint for tumor-infiltrating B cells across human cancers
10.1126/science.adj4857 · 2024 · External reference
Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates
10.7554/elife.83578 · 2023 · External reference
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
10.1038/s41590-024-02059-6 · 2025 · External reference
Single-cell analysis of human PBMCs in healthy and type 2 diabetes populations: dysregulated immune networks in type 2 diabetes unveiled through single-cell profiling
10.3389/fendo.2024.1397661 · 2024 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference
Unraveling the dual role of Pax5: activation and repression in B cell lineage maintenance 9054
10.1093/jimmun/vkaf283.2511 · 2025 · External reference
Impact of Fli1 deletion on B cell populations: a focus on age-associated B cells and transcriptional dynamics
10.1016/j.jdermsci.2024.12.003 · 2025 · External reference
Loss of the FOXP1 transcription factor leads to deregulation of B lymphocyte development and function at multiple stages
10.4049/immunohorizons.1800079 · 2019 · External reference
Foxp1 is an essential transcriptional regulator of B cell development
10.1038/ni1358 · 2006 · External reference
Human monocyte subsets and phenotypes in major chronic inflammatory diseases
10.3389/fimmu.2019.02035 · 2019 · External reference
Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation
10.1126/scitranslmed.aea9007 · 2025 · External reference
Spatial transcriptomics identifies immune-stromal niches associated with cancer in adult dermatomyositis
10.1038/s41467-026-74871-7 · 2026 · External reference
A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9(+) myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity
10.1038/s41590-026-02502-w · 2026 · External reference
CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes
10.1038/srep34310 · 2016 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Not just an adhesion molecule: LFA-1 contact tunes the T lymphocyte program
10.4049/jimmunol.1700495 · 2017 · External reference
CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells1
10.4049/jimmunol.175.12.7889 · 2005 · External reference
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms
10.1016/j.cellimm.2010.08.014 · 2010 · External reference
PPARd restricts intratumoral Treg function through negatively regulating the CIITA-MHCII axis
10.4049/jimmunol.210.supp.86.03 · 2023 · External reference
PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression
10.1101/2024.12.16.628819 · 2024 · External reference
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia
10.1038/modpathol.2011.164 · 2012 · External reference
Regulatory T cells in autoimmune disease
10.1038/s41590-018-0120-4 · 2018 · External reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · 2008 · External reference
From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
10.1111/nyas.13011 · 2018 · External reference
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
10.1038/nri2889 · 2010 · External reference
Regulatory T cells in the tumour microenvironment
10.1038/s41568-025-00832-9 · 2025 · External reference
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
10.1038/s41584-023-01054-9 · 2024 · External reference
Tumour TIF1 mutations and loss of heterozygosity related to cancer-associated myositis
10.1093/rheumatology/kex413 · 2018 · External reference
Anti-TIF1-γ-positive dermatomyositis: novel biomarkers for cancer risk stratification
10.1007/s00403-025-04511-5 · 2026 · External reference
Characterization of regulatory T cells in patients with dermatomyositis
10.1016/j.jaut.2010.07.006 · 2010 · External reference
TIF1γ regulates stability of regulatory T cells during inflammation
10.1101/2024.05.23.595623 · 2026 · External reference
Association of anti-CCAR1 autoantibodies with decreased cancer risk relative to the general population in patients with anti-transcriptional intermediary factor 1γ-positive dermatomyositis
10.1002/art.42474 · 2023 · External reference
Lymphopenia and autoimmune diseases
10.1186/ar1208 · 2004 · External reference
Peripheral blood lymphocyte subset counts in patients with dermatomyositis: clinical correlations and changes following therapy
10.1097/00005792-200303000-00002 · 2003 · External reference
Dynamic change of lymphocytes associated with short-term prognosis in anti-MDA5-positive dermatomyositis with interstitial lung disease: a multicenter retrospective study
10.1007/s10067-024-07110-3 · 2024 · External reference
Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis
10.1016/j.jaad.2014.12.009 · 2015 · External reference
Effects of long-term cryopreservation of PBMC on recovery of B cell subpopulations
10.1016/j.jim.2021.113081 · 2021 · External reference
Unraveling the diversity and functions of tissue-resident plasma cells
10.1038/s41590-023-01712-w · 2024 · External reference
Immune senescence, immunosenescence and aging
10.3389/fragi.2022.900028 · 2022 · External reference
Causes, consequences, and reversal of immune system aging
10.1172/jci64096 · 2013 · External reference
Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE
10.1038/s41392-023-01350-6 · 2023 · External reference
The genome sequence archive family: toward explosive data growth and diverse data types
10.1016/j.gpb.2021.08.001 · 2021 · External reference
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022
10.1093/nar/gkab951 · 2022 · External reference
Single-cell transcriptome profiling reveals intratumoral heterogeneity and molecular features of ductal carcinoma in situ
10.1158/0008-5472.can-22-0090 · 2022 · External reference
CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics
10.1038/s41596-024-01045-4 · 2025 · External reference
Association of anti-CCAR1 autoantibodies with decreased cancer risk relative to the general population in patients with anti-transcriptional intermediary factor 1γ-positive dermatomyositis
10.1002/art.42474 · ExternalCitation · doi-reference
Single-cell transcriptomic analysis on multi-subtypes of idiopathic inflammatory myopathy reveals pathological hallmarks associated with stromal stem and immune cells in damaged skeletal muscles
10.1002/art.70185 · ExternalCitation · doi-reference
Monocyte–macrophage dynamics as key in disparate lung and peripheral immune responses in severe anti-melanoma differentiation-associated gene 5-positive dermatomyositis-related interstitial lung disease
10.1002/ctm2.70226 · ExternalCitation · doi-reference
Human peripheral blood mononuclear cells: a review of recent proteomic applications
10.1002/pmic.202200026 · ExternalCitation · doi-reference
Anti-TIF1-γ-positive dermatomyositis: novel biomarkers for cancer risk stratification
10.1007/s00403-025-04511-5 · ExternalCitation · doi-reference
Dynamic change of lymphocytes associated with short-term prognosis in anti-MDA5-positive dermatomyositis with interstitial lung disease: a multicenter retrospective study
10.1007/s10067-024-07110-3 · ExternalCitation · doi-reference
A comprehensive overview on myositis-specific antibodies: new and old biomarkers in idiopathic inflammatory myopathy
10.1007/s12016-015-8510-y · ExternalCitation · doi-reference
Malignancy in idiopathic inflammatory myopathies: recent insights
10.1007/s12016-025-09080-z · ExternalCitation · doi-reference
Conventional cancer screening versus PET/CT in dermatomyositis/polymyositis
10.1016/j.amjmed.2009.11.012 · ExternalCitation · doi-reference
Clinical features of dermatomyositis patients with anti-TIF1 antibodies: a case based comprehensive review
10.1016/j.autrev.2023.103464 · ExternalCitation · doi-reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · ExternalCitation · doi-reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · ExternalCitation · doi-reference
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms
10.1016/j.cellimm.2010.08.014 · ExternalCitation · doi-reference
The genome sequence archive family: toward explosive data growth and diverse data types
10.1016/j.gpb.2021.08.001 · ExternalCitation · doi-reference
Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis
10.1016/j.jaad.2014.12.009 · ExternalCitation · doi-reference
Characterization of regulatory T cells in patients with dermatomyositis
10.1016/j.jaut.2010.07.006 · ExternalCitation · doi-reference
Long-term outcomes of idiopathic inflammatory myopathies: a large-scale longitudinal cohort study
10.1016/j.jaut.2025.103435 · ExternalCitation · doi-reference
Impact of Fli1 deletion on B cell populations: a focus on age-associated B cells and transcriptional dynamics
10.1016/j.jdermsci.2024.12.003 · ExternalCitation · doi-reference
Effects of long-term cryopreservation of PBMC on recovery of B cell subpopulations
10.1016/j.jim.2021.113081 · ExternalCitation · doi-reference
239th ENMC International Workshop: classification of dermatomyositis, Amsterdam, the Netherlands, 14–16 December 2018
10.1016/j.nmd.2019.10.005 · ExternalCitation · doi-reference
256th ENMC international workshop: myositis specific and associated autoantibodies (MSA-ab): Amsterdam, the Netherlands, 8-10 October 2021
10.1016/j.nmd.2022.05.011 · ExternalCitation · doi-reference
Cancer screening in idiopathic inflammatory myopathies: ten years experience from a single center
10.1016/j.semarthrit.2021.12.008 · ExternalCitation · doi-reference
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia
10.1038/modpathol.2011.164 · ExternalCitation · doi-reference
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
10.1038/ncomms15081 · ExternalCitation · doi-reference
Foxp1 is an essential transcriptional regulator of B cell development
10.1038/ni1358 · ExternalCitation · doi-reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · ExternalCitation · doi-reference
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
10.1038/nri2889 · ExternalCitation · doi-reference
T cell receptor (TCR) signaling in health and disease
10.1038/s41392-021-00823-w · ExternalCitation · doi-reference
Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE
10.1038/s41392-023-01350-6 · ExternalCitation · doi-reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · ExternalCitation · doi-reference
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications
10.1038/s41467-022-34145-4 · ExternalCitation · doi-reference
Spatial transcriptomics identifies immune-stromal niches associated with cancer in adult dermatomyositis
10.1038/s41467-026-74871-7 · ExternalCitation · doi-reference
Regulatory T cells in the tumour microenvironment
10.1038/s41568-025-00832-9 · ExternalCitation · doi-reference
International guideline for idiopathic inflammatory myopathy-associated cancer screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
10.1038/s41584-023-01045-w · ExternalCitation · doi-reference
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
10.1038/s41584-023-01054-9 · ExternalCitation · doi-reference
Regulatory T cells in autoimmune disease
10.1038/s41590-018-0120-4 · ExternalCitation · doi-reference
Unraveling the diversity and functions of tissue-resident plasma cells
10.1038/s41590-023-01712-w · ExternalCitation · doi-reference
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
10.1038/s41590-024-02059-6 · ExternalCitation · doi-reference
A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9(+) myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity
10.1038/s41590-026-02502-w · ExternalCitation · doi-reference
CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics
10.1038/s41596-024-01045-4 · ExternalCitation · doi-reference
CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes
10.1038/srep34310 · ExternalCitation · doi-reference
Unraveling the dual role of Pax5: activation and repression in B cell lineage maintenance 9054
10.1093/jimmun/vkaf283.2511 · ExternalCitation · doi-reference
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022
10.1093/nar/gkab951 · ExternalCitation · doi-reference
Single-cell landscape of peripheral immune response in patients with anti-melanoma differentiation-associated gene 5 dermatomyositis
10.1093/rheumatology/kead597 · ExternalCitation · doi-reference
Prognostic factors for patients with cancer-associated dermatomyositis: a retrospective, multicenter cohort study of 73 patients
10.1093/rheumatology/keae629 · ExternalCitation · doi-reference
Tumour TIF1 mutations and loss of heterozygosity related to cancer-associated myositis
10.1093/rheumatology/kex413 · ExternalCitation · doi-reference
Anti-TIF1-γ autoantibodies: warning lights of a tumour autoantigen
10.1093/rheumatology/kez572 · ExternalCitation · doi-reference
Peripheral blood lymphocyte subset counts in patients with dermatomyositis: clinical correlations and changes following therapy
10.1097/00005792-200303000-00002 · ExternalCitation · doi-reference
TIF1γ regulates stability of regulatory T cells during inflammation
10.1101/2024.05.23.595623 · ExternalCitation · doi-reference
PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression
10.1101/2024.12.16.628819 · ExternalCitation · doi-reference
From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
10.1111/nyas.13011 · ExternalCitation · doi-reference
A blueprint for tumor-infiltrating B cells across human cancers
10.1126/science.adj4857 · ExternalCitation · doi-reference
Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation
10.1126/scitranslmed.aea9007 · ExternalCitation · doi-reference
Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis
10.1136/annrheumdis-2020-218661 · ExternalCitation · doi-reference
Single-cell transcriptome profiling reveals intratumoral heterogeneity and molecular features of ductal carcinoma in situ
10.1158/0008-5472.can-22-0090 · ExternalCitation · doi-reference
Causes, consequences, and reversal of immune system aging
10.1172/jci64096 · ExternalCitation · doi-reference
Lymphopenia and autoimmune diseases
10.1186/ar1208 · ExternalCitation · doi-reference
Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis
10.1186/s12967-025-06551-x · ExternalCitation · doi-reference
Dermatomyositis autoantibodies: how can we maximize utility
10.21037/atm-20-5175 · ExternalCitation · doi-reference
Single-cell analysis of human PBMCs in healthy and type 2 diabetes populations: dysregulated immune networks in type 2 diabetes unveiled through single-cell profiling
10.3389/fendo.2024.1397661 · ExternalCitation · doi-reference
Dermatomyositis and immune-mediated necrotizing myopathies: a window on autoimmunity and cancer
10.3389/fimmu.2017.00992 · ExternalCitation · doi-reference
Human monocyte subsets and phenotypes in major chronic inflammatory diseases
10.3389/fimmu.2019.02035 · ExternalCitation · doi-reference
A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study
10.3389/fimmu.2024.1436114 · ExternalCitation · doi-reference
Immune senescence, immunosenescence and aging
10.3389/fragi.2022.900028 · ExternalCitation · doi-reference
MDA5 dermatomyositis: unveiling a potentially life-threatening disease
10.3949/ccjm.92a.25018 · ExternalCitation · doi-reference
Loss of the FOXP1 transcription factor leads to deregulation of B lymphocyte development and function at multiple stages
10.4049/immunohorizons.1800079 · ExternalCitation · doi-reference
Not just an adhesion molecule: LFA-1 contact tunes the T lymphocyte program
10.4049/jimmunol.1700495 · ExternalCitation · doi-reference
CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells1
10.4049/jimmunol.175.12.7889 · ExternalCitation · doi-reference
PPARd restricts intratumoral Treg function through negatively regulating the CIITA-MHCII axis
10.4049/jimmunol.210.supp.86.03 · ExternalCitation · doi-reference
Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates
10.7554/elife.83578 · ExternalCitation · doi-reference
