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References from Thirty years in, regulatory T cells are ready for medicine. Local targets link to admitted publications; unresolved targets remain external evidence.
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
10.1084/jem.165.2.302 · 1987 · External reference
T cell tolerance by clonal elimination in the thymus
10.1016/0092-8674(87)90568-x · 1987 · External reference
Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance
10.1126/science.1972593 · 1990 · External reference
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
10.4049/jimmunol.155.3.1151 · 1995 · External reference
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
10.1084/jem.184.2.387 · 1996 · External reference
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
10.1084/jem.188.2.287 · 1998 · External reference
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
10.1084/jem.192.2.303 · 2000 · External reference
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
10.4049/jimmunol.160.3.1212 · 1998 · External reference
Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
10.1093/intimm/12.8.1145 · 2000 · External reference
Regulatory T cells: key controllers of immunologic self-tolerance
10.1016/s0092-8674(00)80856-9 · 2000 · External reference
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
10.1038/83784 · 2001 · External reference
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
10.1038/83707 · 2001 · External reference
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
10.1038/ni904 · 2003 · External reference
Control of regulatory T cell development by the transcription factor Foxp3
10.1126/science.1079490 · 2003 · External reference
An essential role for Scurfin in CD4+CD25+ T regulatory cells
10.1038/ni909 · 2003 · External reference
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
10.1038/ni1428 · 2007 · External reference
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
10.1084/jem.20061852 · 2007 · External reference
Stability of the regulatory T cell lineage in vivo
10.1126/science.1191996 · 2010 · External reference
Regulatory T cell lineage specification by the forkhead transcription factor foxp3
10.1016/j.immuni.2005.01.016 · 2005 · External reference
Regulatory T cells and human disease
10.1146/annurev-immunol-042718-041717 · 2020 · External reference
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
10.1038/s41577-024-00994-x · 2024 · External reference
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
10.1038/s41392-025-02326-4 · 2025 · External reference
CTLA-4 control over Foxp3+ regulatory T cell function
10.1126/science.1160062 · 2008 · External reference
Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
10.1126/science.1202947 · 2011 · External reference
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
10.1073/pnas.2023739118 · 2021 · External reference
Confusing signals: recent progress in CTLA-4 biology
10.1016/j.it.2014.12.001 · 2015 · External reference
A function for interleukin 2 in Foxp3-expressing regulatory T cells
10.1038/ni1263 · 2005 · External reference
Interleukin-2 and regulatory T cells in graft-versus-host disease
10.1056/nejmoa1108188 · 2011 · External reference
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
10.1056/nejmoa1105143 · 2011 · External reference
A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease
10.1016/j.jaut.2018.10.017 · 2018 · External reference
Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein
10.1038/s41467-022-31130-9 · 2022 · External reference
Epigenetic control of the foxp3 locus in regulatory T cells
10.1371/journal.pbio.0050038 · 2007 · External reference
DNA methylation controls Foxp3 gene expression
10.1002/eji.200838105 · 2008 · External reference
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage
10.1038/nri2474 · 2009 · External reference
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
10.1038/nature08750 · 2010 · External reference
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
10.1038/ni1437 · 2007 · External reference
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
10.1038/ni.3646 · 2017 · External reference
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping
10.1038/ni.3812 · 2017 · External reference
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance
10.1016/j.immuni.2021.03.020 · 2021 · External reference
Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells
10.1016/j.immuni.2021.04.005 · 2021 · External reference
Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity
10.1084/jem.20202415 · 2021 · External reference
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
10.1016/j.immuni.2025.10.020 · 2025 · External reference
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
10.1016/j.immuni.2012.09.010 · 2012 · External reference
Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells
10.1111/imr.12174 · 2014 · External reference
Regulatory T cell-specific epigenomic region variants are a key determinant of susceptibility to common autoimmune diseases
10.1016/j.immuni.2020.04.006 · 2020 · External reference
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
10.1038/nm.2002 · 2009 · External reference
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
10.1038/nature11132 · 2012 · External reference
Tissue Tregs
10.1146/annurev-immunol-032712-095948 · 2016 · External reference
Principles of regulatory T cell function
10.1016/j.immuni.2023.01.004 · 2023 · External reference
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
10.1016/s2213-8587(13)70113-x · 2013 · External reference
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
10.1126/scitranslmed.3005265 · 2013 · External reference
The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials
10.1038/s41467-024-53384-1 · 2024 · External reference
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
10.1126/scitranslmed.aad4134 · 2015 · External reference
A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes
10.1126/scitranslmed.adn2404 · 2024 · External reference
Next steps in regulatory T cells: Biology and clinical application
10.1016/j.cell.2025.11.035 · 2026 · External reference
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
10.1126/sciimmunol.aba5264 · 2020 · External reference
Cytokine couture: Designer IL2 molecules for the treatment of disease
10.2147/itt.s500229 · 2025 · External reference
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond
10.1016/j.it.2023.04.005 · 2023 · External reference
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
10.1172/jci82771 · 2016 · External reference
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD
10.1172/jci.insight.136185 · 2020 · External reference
Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses
10.1172/jci.insight.160674 · 2022 · External reference
Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus
10.1038/s41467-024-46448-9 · 2024 · External reference
CAR Treg cells mediate linked suppression and infectious tolerance in islet transplantation in mice
10.1126/scitranslmed.adp6519 · 2025 · External reference
Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective
10.1093/immadv/ltad007 · 2023 · External reference
Vitamin C facilitates demethylation of the Foxp3 enhancer in a Tet-dependent manner
10.4049/jimmunol.1502352 · 2016 · External reference
Control of Foxp3 stability through modulation of TET activity
10.1084/jem.20151438 · 2016 · External reference
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
10.1073/pnas.1922600117 · 2020 · External reference
Generating functionally stable and antigen-specific T reg cells from effector T cells for cell therapy of inflammatory diseases
10.1126/scitranslmed.adr6049 · 2025 · External reference
Conversion of pathogenic T cells into functionally stabilized T reg cells for antigen-specific immunosuppression in pemphigus vulgaris
10.1126/scitranslmed.adq9913 · 2025 · External reference
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
10.1126/science.aar3246 · 2018 · External reference
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance
10.1172/jci139991 · 2021 · External reference
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo
2023 · External reference
Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy
10.1101/2025.07.19.665688 · 2025 · External reference
Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models
10.1038/s41467-025-60082-z · 2025 · External reference
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
10.1182/blood-2010-07-293795 · 2011 · External reference
Pharmacokinetics, lineage identity, and trafficking of ex vivo expanded polyclonal regulatory T cells in a prospective randomized clinical trial of kidney transplant recipients with allograft inflammation
10.1016/j.ajt.2025.11.011 · 2026 · External reference
Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota
10.1038/s41586-022-05309-5 · 2022 · External reference
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
10.1038/s41586-022-05089-y · 2022 · External reference
A wave of Thetis cells imparts tolerance to food antigens early in life
10.1126/science.adp0535 · 2025 · External reference
A coordinated cellular network regulates tolerance to food
10.1038/s41586-025-09173-x · 2025 · External reference
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
10.1126/science.aay3638 · 2021 · External reference
