Research graph
References from Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease. Local targets link to admitted publications; unresolved targets remain external evidence.
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy
10.1016/j.celrep.2023.112851 · 2023 · External reference
Finerenone with empagliflozin in chronic kidney disease and type 2 diabetes
10.1056/nejmoa2410659 · 2025 · External reference
Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes
10.1056/nejmoa2403347 · 2024 · External reference
Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria
10.1161/circulationaha.123.067584 · 2024 · External reference
A bibliometric study of global trends in diabetic nephropathy and intestinal flora research
10.3389/fmicb.2025.1577703 · 2025 · External reference
Alterations of the gut microbiota in patients with diabetic nephropathy
10.1128/spectrum.00324-22 · 2022 · External reference
Intestinal microbiota and diabetic kidney diseases: the Role of microbiota and derived metabolites inmodulation of renal inflammation and disease progression
10.1016/j.beem.2021.101484 · 2021 · External reference
Gut microbial products valerate and caproate predict renal outcome among the patients with biopsy-confirmed diabetic nephropathy
10.1007/s00592-022-01948-2 · 2022 · External reference
Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1
10.1530/endoabs.110.p314 · 2025 · External reference
Modified huangfeng decoction alleviates diabetic nephropathy by activating autophagy and regulating the gut microbiota
10.1016/j.phymed.2025.156677 · 2025 · External reference
Hong Guo Ginseng Guo (HGGG) protects against kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome and regulating intestinal flora
10.1016/j.phymed.2024.155861 · 2024 · External reference
Identification of renal protective gut microbiome derived-metabolites in diabetic chronic kidney disease: An integrated approach using network pharmacology and molecular docking
10.1016/j.sjbs.2024.104028 · 2024 · External reference
The geneCards suite: from gene data mining to disease genome sequence analyses
10.1002/cpbi.5 · 2016 · External reference
gutMGene v2.0: an updated comprehensive database for target genes of gut microbes and microbial metabolites
10.1093/nar/gkae1002 · 2025 · External reference
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
Relating protein pharmacology by ligand chemistry
10.1038/nbt1284 · 2007 · External reference
ggvenn: draw venn diagram by 'ggplot2'. 0.1.10 ed: CRAN; 2023
2023 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
KEGG for taxonomy-based analysis of pathways and genomes
10.1093/nar/gkac963 · 2023 · External reference
The gene ontology knowledgebase in 2023
10.1093/genetics/iyad031 · 2023 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Defining cell-type specificity at the transcriptional level in human disease
10.1101/gr.155697.113 · 2013 · External reference
Integrated multi-omics approaches to improve classification of chronic kidney disease
10.1038/s41581-020-0286-5 · 2020 · External reference
An atlas of healthy and injured cell states and niches in the human kidney
10.1038/s41586-023-05769-3 · 2023 · External reference
Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis
10.1681/asn.2018090912 · 2019 · External reference
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
10.1038/s41467-022-32972-z · 2022 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · 2017 · External reference
Elucidating the role of gut microbiota metabolites in diabetes by employing network pharmacology
10.1186/s10020-024-01033-0 · 2024 · External reference
ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support
10.1093/nar/gkae236 · 2024 · External reference
PubChem 2023 update
10.1093/nar/gkac956 · 2023 · External reference
PIEZO1-mediated calcium signaling and podocyte injury in diabetic kidney disease
10.1681/asn.0000000634 · 2025 · External reference
The single-cell transcriptomic landscape of early human diabetic nephropathy
10.1073/pnas.1908706116 · 2019 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
10.1093/nar/gkab255 · 2021 · External reference
Gut microbiome studies in CKD: opportunities, pitfalls and therapeutic potential
10.1038/s41581-022-00647-z · 2023 · External reference
Role of the microbiome in gut-heart-kidney cross talk
10.1161/circresaha.123.321763 · 2023 · External reference
The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease
10.1038/s41581-018-0018-2 · 2018 · External reference
Unbiased human kidney tissue proteomics identifies matrix metalloproteinase 7 as a kidney disease biomarker
10.1681/asn.0000000000000141 · 2023 · External reference
Plasma proteins predict kidney function trajectories in type 2 diabetes
10.1210/clinem/dgaf095 · 2025 · External reference
Profibrotic circulating proteins and risk of early progressive renal decline in patients with type 2 diabetes with and without albuminuria
10.2337/figshare.12808433.v1 · 2020 · External reference
Identification and analysis of diverse cell death patterns in diabetic kidney disease using microarray-based transcriptome profiling and single-nucleus RNA sequencing
10.1016/j.compbiomed.2023.107780 · 2024 · External reference
Diagnostic value of TRIM22 in diabetic kidney disease and its mechanism
10.1007/s12020-024-04089-4 · 2025 · External reference
The link between vitamin D status and NF-κB-associated renal dysfunction in experimental diabetes mellitus
10.1016/j.bbagen.2022.130136 · 2022 · External reference
CYP24A1 exacerbated activity during diabetes contributes to kidney tubular apoptosis via caspase-3 increased expression and activation
10.1371/journal.pone.0048652 · 2012 · External reference
Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, inhibits adrenal aldosterone synthesis and renal ERK/EGR1 pathway in the treatment of diabetic kidney disease
10.1016/j.jep.2025.119936 · 2025 · External reference
Increased glucocorticoid metabolism in diabetic kidney disease
10.1371/journal.pone.0269920 · 2022 · External reference
TRPC6 effects on albumin permeation, nephrin shedding, and apoptosis in podocytes: Role of calcineurin and metalloproteases
10.14814/phy2.70614 · 2025 · External reference
Tubular injury triggers podocyte dysfunction by β-catenin-driven release of MMP-7
10.1172/jci.insight.122399 · 2019 · External reference
Tensile stress promotes the chondrogenic ability of condylar cartilage stem/progenitor cells in the temporomandibular joint via the Piezo1-Ca(2+)-Prkca pathway
10.1186/s13287-025-04439-7 · 2025 · External reference
Cathepsin K deficiency prevented kidney damage and dysfunction in response to 5/6 nephrectomy injury in mice with or without chronic stress
10.1161/hypertensionaha.122.19137 · 2022 · External reference
Mild stretch activates cPLA2 in alveolar type II epithelial cells independently through the MEK/ERK and PI3K pathways
10.1016/j.bbalip.2010.12.007 · 2011 · External reference
Protective mechanisms of resveratrol derivatives against TNF-α-induced inflammatory responses in rat mesangial cells
10.1016/j.cyto.2018.10.008 · 2019 · External reference
Mesangial cell regeneration from exogenous stromal progenitor by utilizing embryonic kidney
10.1016/j.bbrc.2019.10.080 · 2019 · External reference
PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease
10.1172/jci.insight.137298 · 2020 · External reference
Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21
10.1111/bph.16101 · 2023 · External reference
MMP7 damages the integrity of the renal tubule epithelium by activating MMP2/9 during ischemia-reperfusion injury
10.1007/s10735-020-09914-4 · 2020 · External reference
Mechanism of fluid reabsorption in kidney proximal tubule: Interplay between lateral Na(+)/K(+)-ATPase and AQP1 and SGLT1 mediated water fluxes
10.1111/apha.70242 · 2026 · External reference
Interaction of vitamin D with peptide hormones with emphasis on parathyroid hormone, FGF23, and the renin-angiotensin-aldosterone system
10.3390/nu14235186 · 2022 · External reference
Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3
10.1152/ajprenal.00464.2014 · 2015 · External reference
Renal tubular acidosis and osteopetrosis with carbonic anhydrase II deficiency: Pathogenesis of impaired acidification
10.1007/s004670050354 · 1997 · External reference
Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1
10.1096/fj.04-2820fje · 2005 · External reference
Hypertrophy in the distal convoluted tubule of an 11β-hydroxysteroid dehydrogenase type 2 knockout model
10.1681/asn.2013060634 · 2015 · External reference
Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7
10.4081/ejh.2025.4178 · 2025 · External reference
CYP24A1 affected macrophage polarization through degradation of vitamin D as a candidate biomarker for ovarian cancer prognosis
10.1016/j.intimp.2024.112575 · 2024 · External reference
IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression
10.1172/jci184721 · 2025 · External reference
Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer
10.1038/s41418-019-0312-y · 2019 · External reference
Pathogenic role of mast cells in the development of diabetic nephropathy: A study of patients at different stages of the disease
10.1007/s00125-011-2391-2 · 2012 · External reference
Impact of mast cell chymase on renal disease progression
10.2174/157340212800505007 · 2012 · External reference
Integrated multi-omics analysis unveils microbiota-metabolite-host interactions and novel biomarkers for early diabetic kidney disease diagnosis
10.3389/fimmu.2026.1781013 · 2026 · External reference
Modulatory effect of caffeic acid in alleviating diabetes and associated complications
10.4239/wjd.v14.i2.62 · 2023 · External reference
Metabolomics study of cadmium-induced diabetic nephropathy and protective effect of caffeic acid phenethyl ester using UPLC-Q-TOF-MS combined with pattern recognition
10.1016/j.etap.2017.06.021 · 2017 · External reference
Caffeic acid attenuates diabetic kidney disease via modulation of autophagy in a high-fat diet/streptozotocin-induced diabetic rat
10.1038/s41598-017-02320-z · 2017 · External reference
Chlorogenic acid alleviates renal fibrosis by reducing lipid accumulation in diabetic kidney disease through suppressing the Notch1 and Stat3 signaling pathway
10.1080/0886022x.2024.2371988 · 2024 · External reference
The role of chalcones in suppression of NF-κB-mediated inflammation and cancer
10.1016/j.intimp.2010.12.006 · 2011 · External reference
Urine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes
10.1016/j.jdiacomp.2015.08.024 · 2015 · External reference
Matrix metalloproteinase-7 in urinary extracellular vesicles identifies rapid disease progression in autosomal dominant polycystic kidney disease
10.1681/asn.0000000000000277 · 2024 · External reference
Early short-term platelet-derived growth factor inhibition prevents the development of chronic allograft nephropathy in experimental rat kidney transplantation
10.1016/j.transproceed.2006.10.083 · 2006 · External reference
Structure-based optimization and biological evaluation of potent and selective MMP-7 inhibitors for kidney fibrosis
10.1021/acs.jmedchem.3c01166 · 2023 · External reference
Effect of acetazolamide on obesity-induced glomerular hyperfiltration: A randomized controlled trial
10.1371/journal.pone.0137163 · 2015 · External reference
Bioavailability of naringenin chalcone in humans after ingestion of cherry tomatoes
10.1024/0300-9831/a000574 · 2020 · External reference
Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
10.1016/j.phrs.2021.105759 · 2021 · External reference
Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia: A systematic review and meta-analysis
10.1097/md.0000000000035353 · 2023 · External reference
Urinary metabolomics of phenolic compounds reveals biomarkers of type-2 diabetes within the PREDIMED trial
10.1016/j.biopha.2023.114703 · 2023 · External reference
Caffeic acid and cyclen-based hydrogel for synergistic antibacterial therapy
10.1021/acsami.4c09037 · 2024 · External reference
Efficacy, safety, and mechanism of Huangkui Capsules in treating chronic kidney disease: Meta-analysis and integrative bioinformatics
2023 · External reference