Research graph
References from The ageing microenvironment in sarcopenia: early alterations and targeted therapeutic strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Sarcopenia
10.1136/bmj.c4097 · 2024 · External reference
Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis
10.1002/jcsm.12783 · 2022 · External reference
Prevalence of and risk factors for sarcopenia in community-dwelling people: The Vietnam Osteoporosis Study
10.2139/ssrn.4309650 · 2024 · External reference
Sarcopenia definition, diagnosis and treatment: consensus is growing
10.1093/ageing/afac220 · 2022 · External reference
Diet for the prevention and management of sarcopenia
10.1016/j.metabol.2023.155637 · 2023 · External reference
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies
10.1016/j.mam.2024.101270 · 2024 · External reference
Aging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers
10.1016/j.jare.2025.07.004 · 2026 · External reference
Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets
10.1016/j.mam.2024.101319 · 2024 · External reference
Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5
10.1002/mco2.566 · 2024 · External reference
New insights into the function of the NLRP3 inflammasome in sarcopenia: mechanism and therapeutic strategies
10.1016/j.metabol.2024.155972 · 2024 · External reference
Human skeletal muscle aging atlas
10.1038/s43587-024-00613-3 · 2024 · External reference
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity
10.1016/j.arr.2023.101852 · 2023 · External reference
How acute and chronic exercise regulate muscle atrophic genes to mitigate sarcopenia: A narrative review
10.1007/s40279-025-02383-3 · 2026 · External reference
Metabolic syndrome and sarcopenia
10.3390/nu13103519 · 2021 · External reference
Cellular senescence in sarcopenia: Possible mechanisms and therapeutic potential
10.3389/fcell.2021.793088 · 2021 · External reference
Treating age-related loss of muscle mass and function: Where should we be focusing
10.1113/jp289838 · 2026 · External reference
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
10.1038/s41586-022-05535-x · 2023 · External reference
The immune landscape of murine skeletal muscle regeneration and aging
10.1016/j.celrep.2024.114975 · 2024 · External reference
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration
10.1038/s41467-025-60586-8 · 2025 · External reference
Magnoliae cortex alleviates muscle wasting by modulating M2 macrophages in a cisplatin-induced sarcopenia mouse model
10.3390/ijms22063188 · 2021 · External reference
Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration
10.1002/jcsm.12584 · 2020 · External reference
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations
10.1093/geroni/igac059.2672 · 2022 · External reference
The impact of exercise and protein intake on inflammaging: A meta-analysis and systematic review of randomized controlled trials
10.1093/nutrit/nuae169 · 2025 · External reference
Inflammaging as a target for healthy ageing
10.1093/ageing/afac328 · 2023 · External reference
DAMPs and DAMP-sensing receptors in inflammation and diseases
10.1016/j.immuni.2024.03.002 · 2024 · External reference
Low-magnitude high-frequency vibration attenuates sarcopenia by modulating mitochondrial quality control via inhibiting miR-378
10.1002/jcsm.13740 · 2025 · External reference
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
10.1038/s41590-020-0646-0 · 2020 · External reference
IFNgamma causes mitochondrial dysfunction and oxidative stress in myositis
10.1038/s41467-024-49460-1 · 2024 · External reference
Searching for the link between inflammaging and sarcopenia
10.1016/j.arr.2022.101611 · 2022 · External reference
Muscle wasting in the presence of disease, why is it so variable
10.1111/brv.12489 · 2019 · External reference
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
10.1038/s41467-020-20123-1 · 2021 · External reference
Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia
10.1038/s41467-025-61403-y · 2025 · External reference
Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration
10.1186/s41232-022-00234-6 · 2022 · External reference
Restoring mitochondrial function and muscle satellite cell signaling: Remedies against age-related sarcopenia
10.3390/biom14040415 · 2024 · External reference
Keratocan improves muscle wasting in sarcopenia by promoting skeletal muscle development and fast-twitch fibre synthesis
10.1002/jcsm.13724 · 2025 · External reference
RAGE in the pathophysiology of skeletal muscle
10.1002/jcsm.12350 · 2018 · External reference
Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease
10.1016/j.arr.2022.101682 · 2022 · External reference
Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells
10.1186/s13073-023-01250-y · 2023 · External reference
T lymphocyte depletion ameliorates age-related metabolic impairments in mice
10.1007/s11357-021-00368-4 · 2021 · External reference
Characterizing the skeletal muscle immune microenvironment for sarcopenia: insights from transcriptome analysis and histological validation
10.3389/fimmu.2024.1414387 · 2024 · External reference
Skeletal muscle as potential central link between sarcopenia and immune senescence
10.1016/j.ebiom.2019.10.034 · 2019 · External reference
Structure, function, and immunomodulation of the CD8 co-receptor
10.3389/fimmu.2024.1412513 · 2024 · External reference
Regulatory T cells in skeletal muscle repair and regeneration: recent insights
10.1038/s41419-022-05142-8 · 2022 · External reference
T(reg) cells limit IFN-gamma production to control macrophage accrual and phenotype during skeletal muscle regeneration
10.1073/pnas.1800618115 · 2018 · External reference
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
10.1016/j.cmet.2023.08.010 · 2023 · External reference
IL-17 and IL-17-producing cells in protection versus pathology
10.1038/s41577-022-00746-9 · 2023 · External reference
Regulatory T cells shield muscle mitochondria from interferon-gamma-mediated damage to promote the beneficial effects of exercise
10.1126/sciimmunol.adi5377 · 2023 · External reference
The dynamics of B cell aging in health and disease
10.3389/fimmu.2021.733566 · 2021 · External reference
Cardiac troponin T and autoimmunity in skeletal muscle aging
10.1007/s11357-022-00513-7 · 2022 · External reference
The role of autoantibodies in bridging obesity, aging, and immunosenescence
10.1186/s12979-024-00489-2 · 2024 · External reference
Skeletal muscle disorders: a noncardiac source of cardiac troponin T
10.1161/circulationaha.121.058489 · 2022 · External reference
NF-kappaB in biology and targeted therapy: new insights and translational implications
10.1038/s41392-024-01757-9 · 2024 · External reference
Inflammation: roles in skeletal muscle atrophy
10.3390/antiox11091686 · 2022 · External reference
Inflammaging: the ground for sarcopenia
10.1016/j.exger.2022.111931 · 2022 · External reference
The NLRP3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle
10.1002/jcsm.13062 · 2022 · External reference
Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness
10.1002/jcsm.12339 · 2018 · External reference
Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)
10.1111/acel.14094 · 2024 · External reference
Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy
10.3390/cells9091970 · 2020 · External reference
Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
10.1038/s41556-018-0151-y · 2018 · External reference
Role of Fyn and the interleukin-6-STAT-3-autophagy axis in sarcopenia
10.1016/j.isci.2023.107717 · 2023 · External reference
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
10.1038/s41577-019-0165-0 · 2019 · External reference
Bioengineered 3D skeletal muscle model reveals complement 4b as a cell-autonomous mechanism of impaired regeneration with aging
10.1002/adma.202207443 · 2023 · External reference
Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent accumulation of regulatory T cells
10.1016/j.immuni.2016.01.009 · 2016 · External reference
Experimental models of sarcopenia: bridging molecular mechanism and therapeutic strategy
10.3390/cells9061385 · 2020 · External reference
New insights into molecular changes in skeletal muscle aging and disease: differential alternative splicing and senescence
10.1016/j.mad.2021.111510 · 2021 · External reference
Characterization of cellular senescence in aging skeletal muscle
10.1038/s43587-022-00250-8 · 2022 · External reference
Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function
10.1038/s41467-021-24956-2 · 2021 · External reference
Muscle stem cell aging: identifying ways to induce tissue rejuvenation
10.1016/j.mad.2020.111246 · 2020 · External reference
Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging
10.1111/acel.14299 · 2024 · External reference
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRalpha(+) mesenchymal progenitors
10.1002/jcsm.12770 · 2021 · External reference
Multimodal cell atlas of the ageing human skeletal muscle
10.1038/s41586-024-07348-6 · 2024 · External reference
Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases
10.3389/fimmu.2025.1637191 · 2025 · External reference
Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update
10.3390/cells11152359 · 2022 · External reference
Senescent cells: an emerging target for diseases of ageing
10.1038/nrd.2017.116 · 2017 · External reference
The senescence-associated secretory phenotype and its physiological and pathological implications
10.1038/s41580-024-00727-x · 2024 · External reference
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
10.1038/s41467-020-14734-x · 2020 · External reference
Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis
10.1111/acel.13659 · 2022 · External reference
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
10.18632/aging.204435 · 2022 · External reference
Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3
10.1016/j.celrep.2019.05.095 · 2019 · External reference
Intermittent supplementation with fisetin improves physical function and decreases cellular senescence in skeletal muscle with aging: a comparison to genetic clearance of senescent cells and synthetic senolytic approaches
10.1111/acel.70114 · 2025 · External reference
Contribution of muscle satellite cells to sarcopenia
10.3389/fphys.2022.892749 · 2022 · External reference
Control of satellite cell function in muscle regeneration and its disruption in ageing
10.1038/s41580-021-00421-2 · 2022 · External reference
Metformin restores autophagic flux and mitochondrial function in late passage myoblast to impede age-related muscle loss
10.1016/j.biopha.2024.116981 · 2024 · External reference
Ageing and rejuvenation of tissue stem cells and their niches
10.1038/s41580-022-00510-w · 2023 · External reference
Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states
10.1038/s43587-024-00756-3 · 2024 · External reference
Microenvironment-driven satellite cell regeneration and repair in aging-related sarcopenia: mechanisms and therapeutic frontiers
10.1186/s13287-025-04481-5 · 2025 · External reference
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
10.1016/j.stem.2022.09.002 · 2022 · External reference
The role of oxidative stress-mediated fibro-adipogenic progenitor senescence in skeletal muscle regeneration and repair
10.1186/s13287-025-04242-4 · 2025 · External reference
Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
10.1016/j.celrep.2021.109223 · 2021 · External reference
Autophagy maintains stemness by preventing senescence
10.1038/nature19415 · 2016 · External reference
Orienting muscle stem cells for regeneration in homeostasis, aging, and disease
10.1016/j.stem.2018.10.006 · 2018 · External reference
Perspectives on skeletal muscle stem cells
10.1038/s41467-020-20760-6 · 2021 · External reference
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation
10.1016/j.stem.2021.01.017 · 2021 · External reference
Stem cell aging in the skeletal muscle: the importance of communication
10.1016/j.arr.2021.101528 · 2022 · External reference
Skeletal muscle stem cells in comfort and stress
10.1038/s41536-018-0062-3 · 2018 · External reference
Transcriptional reprogramming of skeletal muscle stem cells by the niche environment
10.1038/s41467-023-36265-x · 2023 · External reference
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease
10.1038/nrm.2016.7 · 2016 · External reference
The effects of muscle cell aging on myogenesis
10.3390/ijms22073721 · 2021 · External reference
The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance
10.1002/jcsm.12653 · 2021 · External reference
Mitochondrial function in muscle stem cell fates
10.3389/fcell.2020.00480 · 2020 · External reference
The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration
10.1016/j.semcdb.2017.11.010 · 2017 · External reference
Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis
10.1016/j.semcdb.2017.11.011 · 2017 · External reference
Foxo3 knockdown mediates decline of Myod1 and Myog reducing myoblast conversion to myotubes
10.3390/cells12172167 · 2023 · External reference
A muscle stem cell support group: Coordinated cellular responses in muscle regeneration
10.1016/j.devcel.2018.06.018 · 2018 · External reference
Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy
10.1038/s41467-018-06068-6 · 2018 · External reference
Single-cell RNA-seq reveals novel interaction between muscle satellite cells and fibro-adipogenic progenitors mediated with FGF7 signalling
10.1002/jcsm.13484 · 2024 · External reference
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion
10.1111/acel.12578 · 2017 · External reference
Advancing single-cell transcriptomic analysis to reveal age-related skeletal muscle changes: A systematic review
10.14336/ad.2025.0701 · 2025 · External reference
Stem cell aging in skeletal muscle regeneration and disease
10.3390/ijms21051830 · 2020 · External reference
Muscle satellite cell cross-talk with a vascular niche maintains quiescence via VEGF and Notch signaling
10.1016/j.stem.2018.09.007 · 2018 · External reference
Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality
10.1038/s41536-024-00353-3 · 2024 · External reference
Cellular senescence: Defining a path forward
10.1016/j.cell.2019.10.005 · 2019 · External reference
Cellular senescence in skeletal muscle: Myogenic and nonmyogenic cell populations, mechanisms, and therapeutic opportunities
10.1152/ajpcell.00876.2025 · 2026 · External reference
Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients
10.1002/jcsm.12885 · 2022 · External reference
A proteomic atlas of senescence-associated secretomes for aging biomarker development
10.2139/ssrn.3380253 · 2020 · External reference
Senescent cell clearance by the immune system: Emerging therapeutic opportunities
10.1016/j.smim.2019.04.003 · 2018 · External reference
Deletion of SA beta-Gal+ cells using senolytics improves muscle regeneration in old mice
10.1111/acel.13528 · 2022 · External reference
An aged immune system drives senescence and ageing of solid organs
10.1038/s41586-021-03547-7 · 2021 · External reference
Cellular senescence in the regenerative niche hampers skeletal muscle repair
10.14336/ad.2024.1501 · 2025 · External reference
Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells
10.1186/s11658-025-00731-9 · 2025 · External reference
Cellular senescence in skeletal muscle aging
10.3803/enm.2025.2816 · 2026 · External reference
Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice
10.1002/jcsm.13526 · 2024 · External reference
Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis
10.1038/s43587-026-01120-3 · 2026 · External reference
Diverse roles of cellular senescence in skeletal muscle inflammation, regeneration, and therapeutics
10.3389/fphar.2021.739510 · 2021 · External reference
Sarcopenia: An overview of emerging therapies and pathophysiological insights in age-related skeletal muscle decline
10.1016/j.bcp.2026.117813 · 2026 · External reference
Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity
10.1111/acel.14386 · 2025 · External reference
Mitochondrial remodeling underlying age-induced skeletal muscle wasting: Let's talk about sex
10.1016/j.freeradbiomed.2024.04.005 · 2024 · External reference
Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence
10.1016/j.cmet.2017.04.021 · 2017 · External reference
Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction
10.1001/jamacardio.2023.0957 · 2023 · External reference
Molecular mechanisms of cancer cachexia-related loss of skeletal muscle mass: Data analysis from preclinical and clinical studies
10.1002/jcsm.13073 · 2023 · External reference
TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
10.1080/15548627.2024.2333717 · 2024 · External reference
Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy
10.1038/s42255-025-01412-9 · 2025 · External reference
Exploring motor unit and neuromuscular junction dysfunction in aging and sarcopenia: Insights from electromyography in systematic review
10.1007/s11357-025-01760-0 · 2025 · External reference
Protein arginine methyltransferase 1 ablation in motor neurons causes mitochondrial dysfunction leading to age-related motor neuron degeneration with muscle loss
10.34133/research.0158 · 2023 · External reference
Neuromuscular impairment at different stages of human sarcopenia
10.1002/jcsm.13531 · 2024 · External reference
Sarcopenia: Aging-related loss of muscle mass and function
10.1152/physrev.00061.2017 · 2019 · External reference
In silico transcriptome-based drug screening identifies celastrol as a multi-species therapeutic agent against aging-related sarcopenia and mitochondrial dysfunction
10.1016/j.jare.2026.01.079 · 2026 · External reference
Prevalence of sarcopenia in patients with chronic kidney disease: A global systematic review and meta-analysis
10.1002/jcsm.13425 · 2024 · External reference
Phenotypic features of cancer cachexia-related loss of skeletal muscle mass and function: Lessons from human and animal studies
10.1002/jcsm.12678 · 2021 · External reference
Association of change in muscle mass assessed by D(3) -creatine dilution with changes in grip strength and walking speed
10.1002/jcsm.12494 · 2020 · External reference
Cell interactome in sarcopenia during aging
10.1002/jcsm.12937 · 2022 · External reference
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia
10.1016/j.arr.2024.102267 · 2024 · External reference
Cellular senescence in ageing: From mechanisms to therapeutic opportunities
10.1038/s41580-020-00314-w · 2021 · External reference
Extracellular matrix: The critical contributor to skeletal muscle regeneration-a comprehensive review
10.1186/s41232-023-00308-z · 2023 · External reference
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
10.1038/nm.4126 · 2016 · External reference
Impact of adipose tissue and lipids on skeletal muscle in sarcopenia
10.1002/jcsm.70000 · 2025 · External reference
An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review
10.1016/j.arr.2023.101883 · 2023 · External reference
Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty
10.1038/s41569-018-0064-2 · 2018 · External reference
Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective
10.1016/j.arr.2024.102587 · 2025 · External reference
The contribution of mitochondria to age-related skeletal muscle wasting: A sex-specific perspective
10.1016/j.lfs.2023.122324 · 2024 · External reference
Lack of vitamin D signalling shifts skeletal muscles towards oxidative metabolism
10.1002/jcsm.13378 · 2024 · External reference
Gut microbiota as a promising therapeutic target for age-related sarcopenia
10.1016/j.arr.2022.101739 · 2022 · External reference
Sedentary behaviour, physical activity, and sarcopenia among older adults in the TSHA: isotemporal substitution model
10.1007/978-3-032-24174-0_19 · 2019 · External reference
Effects of exercise programs in older adults with muscle wasting: A systematic review and meta-analysis: Effects of exercise programs in muscle wasting
10.1016/j.archger.2021.104605 · 2022 · External reference
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
10.1073/pnas.2204750120 · 2023 · External reference
Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification
10.1016/j.freeradbiomed.2024.01.036 · 2024 · External reference
Sarcopenia: revised European consensus on definition and diagnosis
10.1093/ageing/afz046 · 2019 · External reference
Immunometabolism of macrophages regulates skeletal muscle regeneration
10.3389/fcell.2022.948819 · 2022 · External reference
Atom-based 3D-QSAR and DFT analysis of 5-substituted 2-acylaminothiazole derivatives as HIV-1 latency-reversing agents
10.1080/07391102.2022.2112078 · 2023 · External reference
Sarcopenia and cardiovascular diseases
10.1161/circulationaha.123.064071 · 2023 · External reference
Age-stratified associations of sarcopenic obesity with mortality in type 2 diabetes
10.1002/jcsm.70211 · 2026 · External reference
Inflammation in obesity, diabetes, and related disorders
10.1016/j.immuni.2021.12.013 · 2022 · External reference
Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease
10.1016/j.metabol.2023.155676 · 2023 · External reference
Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis
10.1016/j.metabol.2022.155379 · 2023 · External reference
Sarcopenia and sarcopenic obesity and mortality among older people
10.1001/jamanetworkopen.2024.3604 · 2024 · External reference
Cancer cachexia: molecular mechanisms and treatment strategies
10.1186/s13045-023-01454-0 · 2023 · External reference
Kidney function in cachexia and sarcopenia: Facts and numbers
10.1002/jcsm.13260 · 2023 · External reference
Sarcopenia and cardiovascular diseases: A systematic review and meta-analysis
10.1002/jcsm.13221 · 2023 · External reference
The diagnosis and treatment of sarcopenia and sarcopenic obesity
10.3238/arztebl.m2025.0004 · 2025 · External reference
The time course of disuse muscle atrophy of the lower limb in health and disease
10.1002/jcsm.13067 · 2022 · External reference
Single-leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: A systematic review and meta-analysis
10.1002/jcsm.13201 · 2023 · External reference
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
10.1038/s41419-024-06851-y · 2024 · External reference
Sarcopenia phenotype and impaired muscle function in male mice with fast-twitch muscle-specific knockout of the androgen receptor
10.1073/pnas.2218032120 · 2023 · External reference
The Sirt2-Nur77 axis regulates muscle stem cell quiescence and senescence via epigenetic-metabolic synergy
10.1038/s41419-026-08645-w · 2026 · External reference
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
10.1038/s41586-020-2496-1 · 2020 · External reference
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals
10.1038/nature20603 · 2016 · External reference
Three-dimensional chromatin re-organization during muscle stem cell aging
10.1101/2022.09.21.508601 · 2023 · External reference
Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors
10.1016/j.stem.2018.12.014 · 2019 · External reference
Complementing muscle regeneration-fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle
10.1038/s41467-025-60627-2 · 2025 · External reference
Inhibiting uptake of extracellular vesicles derived from senescent bone marrow mesenchymal stem cells by muscle satellite cells attenuates sarcopenia
10.1016/j.jot.2022.06.002 · 2022 · External reference
Methods of muscle atrophy analysis at the single-nucleus level
10.1016/j.mad.2026.112178 · 2026 · External reference
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
10.1126/sciadv.add9984 · 2023 · External reference
Neural cues and genomic clues: NGS insights into neurogenic sarcopenia and muscle atrophy
10.3390/ijms262211185 · 2025 · External reference
Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis
10.1016/j.arr.2020.101185 · 2020 · External reference
Biomarkers for sarcopenia, muscle mass, muscle strength, and physical performance: an umbrella review
10.1186/s12967-025-06575-3 · 2025 · External reference
Immune ageing at single-cell resolution
10.1038/s41577-021-00646-4 · 2022 · External reference
MICU3 regulates mitochondrial Ca(2+)-dependent antioxidant response in skeletal muscle aging
10.1038/s41419-021-04400-5 · 2021 · External reference
Protein kinase ROCK1 activates mitochondrial fission linking to oxidative stress and muscle atrophy
10.1016/j.kint.2025.05.019 · 2025 · External reference
C-terminal agrin fragment as a biomarker for sarcopenia: A systematic review and meta-analysis
10.1002/jcsm.13707 · 2025 · External reference
Sarcopenia in Parkinson's disease: from pathogenesis to interventions
10.1016/j.metabol.2025.156272 · 2025 · External reference
n-3 PUFA dietary lipid replacement normalizes muscle mitochondrial function and oxidative stress through enhanced tissue mitophagy and protects from muscle wasting in experimental kidney disease
10.1016/j.metabol.2022.155242 · 2022 · External reference
Sarcopenia in chronic heart failure: Pathophysiology, clinical consequences, and emerging multimodal therapeutic strategies
10.3390/nu18091431 · 2026 · External reference
Pathophysiological mechanisms leading to muscle loss in chronic kidney disease
10.1038/s41581-021-00498-0 · 2022 · External reference
Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice
10.1007/s10522-020-09867-x · 2020 · External reference
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
10.1038/s41467-021-26095-0 · 2021 · External reference
Skeletal muscle area on CT: Determination of an optimal height scaling power and testing for mortality risk prediction
10.2214/ajr.23.29889 · 2024 · External reference
The link between mitochondrial dysfunction and sarcopenia: An update focusing on the role of pyruvate dehydrogenase kinase 4
10.4093/dmj.2022.0305 · 2023 · External reference
The contributory role of vascular health in age-related anabolic resistance
10.1002/jcsm.12898 · 2022 · External reference
Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
10.1002/jcsm.12901 · 2022 · External reference
Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men
10.1002/jcsm.12137 · 2017 · External reference
Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems
10.1016/j.arr.2023.101966 · 2023 · External reference
Ten-year longitudinal changes in muscle power, force, and velocity in young, middle-aged, and older adults
10.1002/jcsm.13184 · 2023 · External reference
Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease
10.1002/jcsm.13280 · 2023 · External reference
Immunosenescence: molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · 2023 · External reference
Inflammation and aging: signaling pathways and intervention therapies
10.1038/s41392-023-01502-8 · 2023 · External reference
Influence of different modes of exercise training on inflammatory markers in older adults with and without chronic diseases: A systematic review and meta-analysis
10.1016/j.cyto.2023.156303 · 2023 · External reference
Clinical, immunological, and vesicular markers in sarcopenia and presarcopenia
10.31083/fbl42063 · 2025 · External reference
Immunological regulation of skeletal muscle adaptation to exercise
10.1016/j.cmet.2024.04.001 · 2024 · External reference
Dietary protein and amino acid intakes for mitigating sarcopenia in humans
10.1080/10408398.2024.2348549 · 2025 · External reference
Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives
10.1016/j.isci.2026.115024 · 2026 · External reference
Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults
10.1002/jcsm.12922 · 2022 · External reference
A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states
10.1016/j.clnu.2023.08.010 · 2023 · External reference
The effect of leucine supplementation on sarcopenia-related measures in older adults: A systematic review and meta-analysis of 17 randomized controlled trials
10.3389/fnut.2022.929891 · 2022 · External reference
Surveillance and evaluation of vitamin D nutrition and its health impact in Chinese older adults
10.1016/j.tjnut.2025.01.030 · 2025 · External reference
Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
10.1038/s42003-022-04246-3 · 2022 · External reference
Myostatin as a biomarker of muscle wasting and other pathologies-state of the art and knowledge gaps
10.3390/nu12082401 · 2020 · External reference
Inhibiting myostatin expression by the antisense oligonucleotides improves muscle wasting in a chronic kidney disease mouse model
10.3390/ijms26073098 · 2025 · External reference
Myostatin inhibition promotes fast fibre hypertrophy but causes loss of AMP-activated protein kinase signalling and poor exercise tolerance in a model of limb-girdle muscular dystrophy R1/2A
10.1113/jp279943 · 2020 · External reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · 2018 · External reference
The impact of senescence on muscle wasting in chronic kidney disease
10.1002/jcsm.13112 · 2023 · External reference
Targeting ageing with rapamycin and its derivatives in humans: a systematic review
10.1016/s2666-7568(23)00258-1 · 2024 · External reference
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway
10.1016/j.phymed.2023.154906 · 2023 · External reference
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
10.1038/s43587-023-00560-5 · 2024 · External reference
Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
10.1038/s41413-021-00164-y · 2021 · External reference
The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment
10.1038/s41536-022-00204-z · 2022 · External reference
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
10.1038/nm.3464 · 2014 · External reference
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
10.1038/nm.3465 · 2014 · External reference
TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis
10.1002/jcsm.13348 · 2023 · External reference
Wnt4 from the niche controls the mechano-properties and quiescent state of muscle stem cells
10.1016/j.stem.2019.08.007 · 2019 · External reference
TGFbeta signaling curbs cell fusion and muscle regeneration
10.1038/s41467-020-20289-8 · 2021 · External reference
Reduction of senescent fibro-adipogenic progenitors in progeria-aged muscle by senolytics rescues the function of muscle stem cells
10.1002/jcsm.13101 · 2022 · External reference
Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice
10.1038/s41419-023-05843-8 · 2023 · External reference
Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles
10.1038/s43587-021-00143-2 · 2021 · External reference
Muscle quality index improves with resistance exercise training in older adults
10.1016/j.exger.2014.01.027 · 2014 · External reference
Long-term exercise reduces formation of tubular aggregates and promotes maintenance of Ca(2+) entry units in aged muscle
10.3389/fphys.2020.601057 · 2020 · External reference
Leveraging sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification
10.1038/s41746-025-02016-z · 2025 · External reference
Novel metabolic and lipidomic biomarkers of sarcopenia
10.1002/jcsm.13567 · 2024 · External reference
Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages
10.1038/s43587-025-00900-7 · 2025 · External reference
Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan
10.18632/aging.204750 · 2023 · External reference
Association of physical behaviours with sarcopenia in older adults: a systematic review and meta-analysis of observational studies
10.1016/s2666-7568(23)00241-6 · 2024 · External reference
Cellular senescence and senolytics: the path to the clinic
10.1038/s41591-022-01923-y · 2022 · External reference
Cellular senescence: the good, the bad and the unknown
10.1038/s41581-022-00601-z · 2022 · External reference
Pharmacological interventions in human aging
10.1016/j.arr.2024.102213 · 2024 · External reference
Senolytic CAR T cells reverse senescence-associated pathologies
10.1038/s41586-020-2403-9 · 2020 · External reference
Sarcopenia
10.7861/clinmedicine.14-2-183 · 2019 · External reference
The conceptual definition of sarcopenia: Delphi consensus from the Global Leadership Initiative in Sarcopenia (GLIS)
10.1093/ageing/afae052 · 2024 · External reference
