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References from Traditional Chinese medicine remodels the immune microenvironment of colorectal cancer: mechanisms and therapeutic perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Cancer incidence and mortality in China, 2022
10.1016/j.jncc.2024.01.006 · 2024 · External reference
The immune microenvironment of colorectal cancer
10.1038/s41568-025-00872-1 · 2025 · External reference
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
10.1016/s0140-6736(18)30789-x · 2018 · External reference
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
10.1016/j.cell.2022.12.028 · 2023 · External reference
Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
10.1186/s13020-023-00719-7 · 2023 · External reference
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer
10.1002/med.21989 · 2024 · External reference
Traditional Chinese medicine as a potential barrier-oriented sensitization strategy for immune checkpoint blockade in microsatellite-stable colorectal cancer: from resistance mechanisms to translational validation
10.3389/fimmu.2026.1874066 · 2026 · External reference
Evaluation of CD3 and CD8 T-cell immunohistochemistry for prognostication and prediction of benefit from adjuvant chemotherapy in early-stage colorectal cancer within the QUASAR trial
10.1200/jco.23.02030 · 2024 · External reference
Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer
10.1038/s41421-023-00605-4 · 2023 · External reference
SOX17 enables immune evasion of early colorectal adenomas and cancers
10.1038/s41586-024-07135-3 · 2024 · External reference
Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy
10.1073/pnas.2105323118 · 2021 · External reference
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
10.1038/s41590-020-0728-z · 2020 · External reference
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
10.1038/s41586-022-05593-1 · 2023 · External reference
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
10.1016/j.ccell.2024.07.006 · 2024 · External reference
Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer
10.1007/s00262-024-03887-z · 2024 · External reference
Single-cell analyses define a continuum of cell state and composition changes in the Malignant transformation of polyps to colorectal cancer
10.1038/s41588-022-01088-x · 2022 · External reference
Spatially segregated macrophage populations predict distinct outcomes in colon cancer
10.1158/2159-8290.cd-23-1300 · 2024 · External reference
Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor-associated SPP1 + Macrophages and fibroblasts
10.1158/1078-0432.ccr-22-2041 · 2023 · External reference
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
10.1038/s41591-020-1131-x · 2021 · External reference
DCLK1 suppresses tumor-specific cytotoxic T lymphocyte function through recruitment of MDSCs via the CXCL1-CXCR2 axis
10.1016/j.jcmgh.2022.10.013 · 2023 · External reference
CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis
10.1016/j.ccr.2013.10.009 · 2013 · External reference
Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis
10.1016/j.ebiom.2024.105102 · 2024 · External reference
Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer
10.1172/jci174545 · 2024 · External reference
IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
10.1038/s41467-023-39953-w · 2023 · External reference
Conserved immuno‐collagenic subtypes predict response to immune checkpoint blockade
10.1002/cac2.12538 · 2024 · External reference
Collagen and its roles in the tumor immune microenvironment: structure, function, and therapeutic potential
10.31083/fbl45052 · 2025 · External reference
Spatially organized tumor-stroma boundary determines the efficacy of immunotherapy in colorectal cancer patients
10.1038/s41467-024-54710-3 · 2024 · External reference
Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition
10.1136/jitc-2023-007447 · 2023 · External reference
GPR4 promotes immune exclusion in colon cancer through LOXL2-mediated extracellular matrix remodeling
10.1038/s41467-025-67967-z · 2025 · External reference
Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer
10.1038/s41467-025-66485-2 · 2025 · External reference
Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits
10.1038/s41467-026-74073-1 · 2026 · External reference
Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade
10.1136/jitc-2024-009327 · 2024 · External reference
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
10.1038/s41591-020-0805-8 · 2020 · External reference
PD-1 blockade in mismatch repair–deficient, locally advanced rectal cancer
10.1056/nejmoa2201445 · 2022 · External reference
Neoadjuvant immunotherapy in locally advanced mismatch repair–deficient colon cancer
10.1056/nejmoa2400634 · 2024 · External reference
Nivolumab plus ipilimumab in microsatellite-instability–high metastatic colorectal cancer
10.1056/nejmoa2402141 · 2024 · External reference
Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer
10.1016/j.ccell.2023.04.011 · 2023 · External reference
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
10.1038/s41586-024-07254-x · 2024 · External reference
Tumor-associated macrophages produce PGE2 to promote CD8+ T-cell exhaustion and drive resistance to PD-L1 blockade in microsatellite-stable colorectal cancer
10.1158/0008-5472.can-25-0079 · 2026 · External reference
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis
10.1136/gutjnl-2019-319200 · 2020 · External reference
TIM-3 expression and M2 polarization of macrophages in the TGFβ-activated tumor microenvironment in colorectal cancer
10.3390/cancers15204943 · 2023 · External reference
An integrated tumor, immune and microbiome atlas of colon cancer
10.1038/s41591-023-02324-5 · 2023 · External reference
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver
10.1016/j.ccell.2021.03.004 · 2021 · External reference
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli
10.1038/s41586-020-2080-8 · 2020 · External reference
Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1
10.1080/19490976.2025.2458203 · 2025 · External reference
Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway
10.3389/fimmu.2025.1586146 · 2025 · External reference
Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells
10.1136/gutjnl-2023-330291 · 2023 · External reference
Bifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8+ T cells
10.1136/gutjnl-2025-336025 · 2026 · External reference
Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
10.1016/j.ccell.2025.07.012 · 2025 · External reference
Bile acids produced by gut microbiota activate TGR5 to promote colorectal liver metastasis progression by inducing MDSCs infiltration in liver
10.1016/j.intimp.2025.114829 · 2025 · External reference
Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis
10.1038/s41416-025-03105-2 · 2025 · External reference
Baicalin triggers apoptosis, inhibits migration, and enhances anti‐tumor immunity in colorectal cancer via TLR4/NF‐κB signaling pathway
10.1111/jfbc.13703 · 2022 · External reference
Baicalin suppresses colorectal cancer proliferation and induces M1 polarization of tumor-associated macrophages by promoting proteasomal degradation of HK2
10.3389/fimmu.2026.1812964 · 2026 · External reference
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer
10.1016/j.apsb.2021.06.005 · 2022 · External reference
Quercetin targets BCAT1 to potentiate CD8+ T cell immunity by rewiring branched-chain amino acid metabolism against colorectal cancer metastasis
10.1016/j.phymed.2026.158382 · 2026 · External reference
Icariin modulates the tumor microenvironment in colorectal cancer by targeting M2 macrophage polarization via PI3K/AKT pathway
10.1016/j.bmc.2025.118317 · 2025 · External reference
Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors
10.1016/j.phymed.2024.156224 · 2025 · External reference
Icaritin promotes tumor T‐cell infiltration and induces antitumor immunity in mice
10.1002/eji.201948225 · 2019 · External reference
Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies
10.1016/j.foodchem.2025.143630 · 2025 · External reference
Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
10.1016/j.phrs.2023.107032 · 2024 · External reference
Epimedium and its chemical constituents in cancer treatment: A comprehensive review of traditional applications, antitumor effects, pharmacokinetics, delivery systems, and toxicology
10.1016/j.jep.2025.119738 · 2025 · External reference
Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
10.1136/jitc-2022-004874 · 2022 · External reference
Astragaloside IV inhibits colorectal cancer metastasis by reducing extracellular vesicles release and suppressing M2-type TAMs activation
10.1016/j.heliyon.2024.e31450 · 2024 · External reference
Astragaloside IV alleviates colorectal cancer metastases by regulating RALY / PLD2 axis and inhibiting tumoral exosome biogenesis
10.1002/ptr.70154 · 2026 · External reference
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice
10.1016/j.phymed.2023.155116 · 2023 · External reference
Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo
10.3892/ijo.2017.4183 · 2017 · External reference
Oral microbiota-responsive ZIF nanoplatform via double-layer glycans modified combined with PD-1 inhibitor for treatment of microsatellite-stable colorectal cancer
10.1016/j.mtbio.2025.102565 · 2025 · External reference
Discrimination of the significance of astragalosides in Astragalus radix based on the in vivo exposure levels and pharmacokinetic characteristics of prototype saponins and their metabolites: A strategy for discovering and confirming quality markers
10.1016/j.jep.2026.121415 · 2026 · External reference
Ginsenoside Rg3 in cancer therapy: Pharmacokinetics, molecular mechanisms, and synergistic combinations
10.1142/s0192415x26500552 · 2026 · External reference
Curcumin nanoformulations: Beneficial nanomedicine against cancer
10.1002/ptr.7389 · 2022 · External reference
Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer
10.3389/fphar.2026.1734653 · 2026 · External reference
Curcumin exerts anti-tumor activity in colorectal cancer via gut microbiota-mediated CD8+ T cell tumor infiltration and ferroptosis
10.1039/d4fo04045g · 2025 · External reference
Research on curcumin mediating immunotherapy of colorectal cancer by regulating cancer associated fibroblasts
10.1097/cad.0000000000001659 · 2025 · External reference
Honokiol‐magnolol‐baicalin possesses synergistic anticancer potential and enhances the efficacy of anti‐PD‐1 immunotherapy in colorectal cancer by triggering GSDME‐dependent pyroptosis
10.1002/advs.202417022 · 2025 · External reference
A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability
10.1016/j.isci.2025.112575 · 2025 · External reference
The anticancer application of delivery systems for honokiol and magnolol
10.3390/cancers16122257 · 2024 · External reference
Bufalin inhibits immune escape in metastatic colorectal cancer by regulating M2 macrophage polarization
10.1007/s10495-025-02107-y · 2025 · External reference
Bufalin reverses cancer-associated fibroblast-mediated colorectal cancer metastasis by inhibiting the STAT3 signaling pathway
10.1007/s10495-023-01819-3 · 2023 · External reference
Immediate tumor killing and long-term anti-tumor immunoreaction induced by bufalin-loaded phototherapeutic Janus membrane in CRC postoperative therapy
10.1016/j.mtbio.2026.102824 · 2026 · External reference
Bufalin targets the SRC-3/MIF pathway in chemoresistant cells to regulate M2 macrophage polarization in colorectal cancer
10.1016/j.canlet.2021.05.008 · 2021 · External reference
Mechanism study of bufalin reversal of drug resistance by inhibiting hypoxic colon cancer cell-induced polarization of M2 macrophages
10.1177/15347354251325806 · 2025 · External reference
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy
10.1016/j.phymed.2025.157688 · 2026 · External reference
Integrated pharmacokinetics and multidimensional drug-drug interactions assessment of bufadienolides based on UPLC-QqQ-MS/MS
10.1016/j.jpba.2025.117118 · 2025 · External reference
Efficacy and safety of cinobufacini capsules combined with oxaliplatin-based chemotherapy for advanced colorectal cancer: a human systematic review and meta-analysis
10.3389/fphar.2026.1709044 · 2026 · External reference
The anti-tumor effect and mechanism of triterpenoids in Rhus chinensis Mill. on reversing effector CD8+ T-cells dysfunction by targeting glycolysis pathways in colorectal cancer
10.1177/15347354211017219 · 2021 · External reference
Triterpenoids of Rhus chinensis supressed colorectal cancer progress by enhancing antitumor immunity and CD8 + T cells tumor infiltration
10.1080/01635581.2021.2009523 · 2022 · External reference
Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats
10.1016/j.fct.2018.06.009 · 2018 · External reference
Anticancer effect of Salvia plebeia and its active compound by improving T-cell activity via blockade of PD-1/PD-L1 interaction in humanized PD-1 mouse model
10.3389/fimmu.2020.598556 · 2020 · External reference
Marsdenia tenacissima enhances immune response of tumor infiltrating T lymphocytes to colorectal cancer
10.3389/fimmu.2023.1238694 · 2023 · External reference
Sanguisorbae Radix suppresses colorectal tumor growth through PD-1/PD-L1 blockade and synergistic effect with pembrolizumab in a humanized PD-L1-expressing colorectal cancer mouse model
10.3389/fimmu.2021.737076 · 2021 · External reference
Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation
10.1007/s11033-023-09056-2 · 2024 · External reference
Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway
10.1016/j.jep.2024.118854 · 2025 · External reference
Intestinal metabolism of crocin and a pharmacokinetics and pharmacodynamics study in the chronic social defeat stress mouse model
10.3390/ph17070843 · 2024 · External reference
Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade
10.1016/j.jep.2023.116735 · 2023 · External reference
Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis
10.1038/s41401-023-01158-8 · 2024 · External reference
Chinese yam polysaccharide enhances anti-PD-1 immunotherapy in colorectal cancer through alterations in the gut microbiota and metabolites
10.1016/j.ijbiomac.2025.143323 · 2025 · External reference
Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells
10.1016/j.biopha.2022.113399 · 2022 · External reference
Wumei Wan remodels the tumor immune microenvironment via the Ido1-KYN-AHR axis in AOM/DSS-induced colorectal cancer model
10.1016/j.jep.2025.120371 · 2025 · External reference
Early administration of Wumei Wan inhibit myeloid-derived suppressor cells via PI3K/Akt pathway and amino acids metabolism to prevent colitis-associated colorectal cancer
10.1016/j.jep.2024.118260 · 2024 · External reference
Sijunzi decoction enhances sensitivity of colon cancer cells to NK cell destruction by modulating P53 expression
10.1016/j.jep.2024.118115 · 2024 · External reference
The modified Si-Jun-Zi Decoction attenuates colon cancer liver metastasis by increasing macrophage cells
10.1186/s12906-019-2498-4 · 2019 · External reference
Huang-Lian-Jie-Du decoction enhances Capecitabine-Oxaliplatin efficacy via Akkermansia muciniphila and CD8+ T cells in colorectal cancer
10.1016/j.phymed.2025.157233 · 2025 · External reference
Banxia Xiexin Decoction inhibits colitis-associated colorectal cancer development by modulating STAT3 signaling and gut microbiota
10.1016/j.chmed.2024.02.004 · 2025 · External reference
Banxia-xiexin decoction ameliorates colitis-associated colorectal cancer by modulating inflammatory responses and the complement and coagulation cascade pathway
10.2147/jir.s562302 · 2025 · External reference
Effect of a modified Banxia Xiexin decoction plus chemotherapy on stage III; colon cancer
10.19852/j.cnki.jtcm.2019.02.014 · 2019 · External reference
A multicenter, placebo-controlled clinical trial and preliminary experimental study exploring the efficacy of modified Banxia Xiexin Decoction in the treatment of advanced colorectal cancer
10.1016/j.jep.2026.121292 · 2026 · External reference
Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress
10.1016/j.jep.2023.117069 · 2024 · External reference
Tong-Xie-Yao-Fang induces mitophagy in colonic epithelial cells to inhibit colitis-associated colorectal cancer
10.1016/j.jep.2024.118541 · 2024 · External reference
Shenling Baizhu Decoction (SLBZD) may play a synergistic role of tirelizumab in the treatment of colorectal cancer by influencing the imbalance of colon flora and Tumor microenvironment
10.7150/jca.88854 · 2024 · External reference
Neferine-enhanced Shenling Baizhu Tang potentiates anti-PD-1 therapy in colorectal cancer liver metastasis via CYP2E1–PPARα–mediated lipid reprogramming
10.1016/j.phymed.2026.158236 · 2026 · External reference
Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration
10.1186/s12906-015-0649-9 · 2015 · External reference
Effect of Xiaoai Jiedu Decoction Recipe on colon cancer and distribution of Treg cells
10.14148/j.issn.1672-0482.2017.0515 · 2017 · External reference
Xiaoai jiedu prescription-containing serum enhances lethal effect of NK cells on colon cancer cells
10.13422/j.cnki.syfjx.20220822 · 2022 · External reference
Integrated gut microbiota and metabolome analysis reveals the mechanism of Xiaoai Jiedu recipe in ameliorating colorectal cancer
10.3389/fonc.2023.1184786 · 2023 · External reference
Xianlian Jiedu Decoction alleviates colorectal cancer by regulating metabolic profiles, intestinal microbiota and metabolites
10.1016/j.phymed.2024.155385 · 2024 · External reference
Identification of significant modules and targets of xian-lian-jie-du decoction based on the analysis of transcriptomics, proteomics and single-cell transcriptomics in colorectal tumor
10.2147/jir.s344861 · 2022 · External reference
Mechanism of xianlian jiedu prescription targeting NETs formation to inhibit liver metastasis in colorectal cancer
10.13422/j.cnki.syfjx.20252128 · 2025 · External reference
Xian-Lian-Jie-Du Decoction suppresses colorectal cancer liver metastasis by inhibiting Plaur/Hbegf/EGFR-mediated actin cytoskeleton remodeling
10.1016/j.phymed.2026.158482 · 2026 · External reference
Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells
10.1016/j.apsb.2025.05.013 · 2025 · External reference
Shen-Bai-Jie-Du decoction suppresses the progression of colorectal adenoma to carcinoma through regulating gut microbiota and short-chain fatty acids
10.1186/s13020-024-01019-4 · 2024 · External reference
Jianpi Jiedu decoction suppresses colorectal cancer growth by inhibiting M2 polarization of TAMs through the tryptophan metabolism-AhR pathway
10.1016/j.intimp.2024.112610 · 2024 · External reference
Jianpi Jiedu Recipe inhibits colorectal cancer liver metastasis via regulating ITGBL1-rich extracellular vesicles mediated activation of cancer-associated fibroblasts
10.1016/j.phymed.2022.154082 · 2022 · External reference
Jianpi Jiedu formula modulates glutamine metabolism to inhibit colorectal cancer liver metastasis
10.1016/j.phymed.2025.157680 · 2026 · External reference
The JPJDF has synergistic effect with fluoropyrimidine in the maintenance therapy for metastatic colorectal cancer
10.2174/1574892815666200717141205 · 2020 · External reference
Effects of Qizhen Decoction on the intestinal bacterial abundance and its composition in colitis associated cancer mice
2018 · External reference
Mechanism of Qizhen decoction-mediated maturation of DC cells to activate the IL-12/JAK2/STAT4 pathway to sensitise PD-1 inhibitors in the treatment of colorectal cancer
10.1016/j.jep.2023.117399 · 2024 · External reference
Effects of Jiedu Sangen Decoction on inhibiting invasion and metastasis of colon cancer based on Cancer-associated fibroblasts Sirt1-NF-κB pathway
2015 · External reference
Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development
10.1016/j.phymed.2025.156795 · 2025 · External reference
ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function
10.18632/aging.204111 · 2022 · External reference
Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1 antibody efficacy via immunometabolic remodeling in colorectal cancer
10.1016/j.phymed.2025.157312 · 2025 · External reference
Huaier overcomes tumor-induced immunosuppression in colorectal cancer by activating MHC I and CD8+ T cells
10.1016/j.phymed.2025.157157 · 2025 · External reference
Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder
10.1016/j.chmed.2025.04.001 · 2025 · External reference
Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL-4R mediated macrophage polarization
10.1016/j.jep.2025.119511 · 2025 · External reference
TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond
10.1007/s10555-024-10226-2 · 2025 · External reference
Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract
10.1038/ni.3580 · 2016 · External reference
TRIM29 promotes DNA virus infections by inhibiting innate immune response
10.1038/s41467-017-00101-w · 2017 · External reference
TRIM29 negatively regulates the type I IFN production in response to RNA virus
10.4049/jimmunol.1701569 · 2018 · External reference
Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice
10.1038/s41467-024-44745-x · 2024 · External reference
TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways
10.1016/j.mucimm.2024.10.004 · 2025 · External reference