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References from Biological roles and clinical translation of low-density neutrophils in rheumatic, autoimmune and inflammatory diseases: paradigm reconstruction and unresolved questions. Local targets link to admitted publications; unresolved targets remain external evidence.
Low-density neutrophils: enigmatic cells in health and disease
10.1155/jimr/3037744 · 2025 · External reference
Low-density granulocytes in systemic autoimmunity and autoinflammation
10.1111/imr.13161 · 2023 · External reference
Low density neutrophils in patients with systemic lupus erythematosus, rheumatoid arthritis, and acute rheumatic fever
10.1002/art.1780291105 · 1986 · External reference
The enigma of low-density granulocytes in humans: complexities in the characterization and function of LDGs during disease
10.3390/pathogens10091091 · 2021 · External reference
Characterizing a low-density neutrophil gene signature in acute and chronic infections and its impact on disease severity
10.1093/jleuko/qiaf027 · 2025 · External reference
Low-density neutrophils in systemic lupus erythematosus
10.1002/art.41395 · 2020 · External reference
Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus
10.1073/pnas.1908576116 · 2019 · External reference
On the origin of low-density neutrophils
10.1002/jlb.5hr0120-459r · 2020 · External reference
Neutrophils as a novel target of modified low-density lipoproteins and an accelerator of cardiovascular diseases
10.3390/ijms21218312 · 2020 · External reference
Neutrophil, quo vadis
10.1189/jlb.3mr0117-015r · 2017 · External reference
Low-density granulocytes in immune-mediated inflammatory diseases
10.1155/2022/1622160 · 2022 · External reference
Roles of neutrophils in autoimmune diseases and cancers
10.3390/ijms26189040 · 2025 · External reference
Role of neutrophils in psoriasis
10.1155/2020/3709749 · 2020 · External reference
Low-density granulocytes in the pathogenesis of inflammatory disease
10.1093/jleuko/qiaf133 · 2025 · External reference
Neutrophils and COVID-19
10.1016/bs.pmbts.2025.02.003 · 2025 · External reference
Advances in the study of low-density neutrophils in rheumatic diseases
10.3389/fimmu.2026.1747583 · 2026 · External reference
The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases
10.1002/mco2.70101 · 2025 · External reference
Neutrophils at the crossroads of innate and adaptive immunity
10.1002/jlb.4mir0220-574rr · 2020 · External reference
Human neutrophils in the saga of cellular heterogeneity: insights and open questions
10.1111/imr.12448 · 2016 · External reference
Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity
10.1007/s00281-013-0375-7 · 2013 · External reference
Neutrophils in the pathogenesis of rheumatic diseases: fueling the fire
10.1007/s12016-020-08816-3 · 2021 · External reference
Neutrophils: need for standardized nomenclature
10.3389/fimmu.2021.602963 · 2021 · External reference
Identification of immunosuppressive neutrophils using multi-omics: why functional testing remains key
10.3389/fimmu.2026.1814355 · 2026 · External reference
Neutrophils in the pathogenesis and manifestations of SLE
10.1038/nrrheum.2011.132 · 2011 · External reference
The role of neutrophils in the pathogenesis of systemic lupus erythematosus
10.1097/bor.0000000000000197 · 2015 · External reference
Neutrophil heterogeneity in sepsis: the role of damage-associated molecular patterns
10.1097/shk.0000000000002019 · 2023 · External reference
Neutrophil dysregulation in the pathogenesis of systemic lupus erythematosus
10.1016/j.rdc.2021.04.002 · 2021 · External reference
NETosis in rheumatic diseases
10.1007/s11926-020-00977-6 · 2021 · External reference
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
10.1038/nm.4027 · 2016 · External reference
Cardiovascular disease in systemic lupus erythematosus: an update
10.1097/bor.0000000000000528 · 2018 · External reference
Cardiovascular disease in systemic lupus erythematosus: a comprehensive update
10.1016/j.jaut.2017.05.008 · 2017 · External reference
Interaction of low-density neutrophils with other immune cells in the mechanism of inflammation
10.1186/s10020-025-01187-5 · 2025 · External reference
Neutrophil: a new player in metastatic cancers
10.3389/fimmu.2020.565165 · 2020 · External reference
Human neutrophils: their role in cancer and relation to myeloid-derived suppressor cells
10.1016/j.smim.2016.03.018 · 2016 · External reference
Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling
10.1189/jlb.5a0116-022r · 2017 · External reference
CD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus
10.1002/ctm2.1150 · 2023 · External reference
Aberrant expansion of CD177(+) neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps
10.1016/j.jaut.2025.103399 · 2025 · External reference
A distinct population of low-density granulocytes with unique features associated with subclinical vascular alterations in systemic lupus erythematosus
10.3389/fimmu.2026.1794775 · 2026 · External reference
Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis
10.1093/rheumatology/kead296 · 2024 · External reference
IL-1beta mediated fibroblast-neutrophil crosstalk promotes inflammatory environment in skin lesions of SLE
10.1016/j.clim.2024.110396 · 2024 · External reference
Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus
10.1136/annrheumdis-2020-218338 · 2021 · External reference
Lupus neutrophils: 'NET' gain in understanding lupus pathogenesis
10.1097/bor.0b013e3283546703 · 2012 · External reference
Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
10.4049/jimmunol.1100450 · 2011 · External reference
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
10.1038/s41467-023-36522-z · 2023 · External reference
Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus
10.1136/annrheumdis-2017-212617 · 2018 · External reference
Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages
10.4049/jimmunol.1202388 · 2013 · External reference
Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus
10.1002/art.21783 · 2006 · External reference
Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome
10.1136/annrheumdis-2019-215781 · 2020 · External reference
Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus
10.1136/annrheumdis-2018-214620 · 2019 · External reference
Neutrophils-important communicators in systemic lupus erythematosus and antiphospholipid syndrome
10.3389/fimmu.2019.02734 · 2019 · External reference
Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2
10.1136/annrheumdis-2013-204837 · 2015 · External reference
Circulating levels of low-density granulocytes and cell-free DNA as predictors of cardiovascular disease and bone deterioration in SLE patients
10.1055/a-2467-6826 · 2025 · External reference
Neutrophils in lupus nephritis
10.1097/bor.0000000000000577 · 2019 · External reference
Neutrophils in rheumatoid arthritis: Breaking immune tolerance and fueling disease
10.1016/j.molmed.2018.12.008 · 2019 · External reference
Low density neutrophils in patients with juvenile idiopathic arthritis
2003 · External reference
Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes
10.1093/rheumatology/kex441 · 2018 · External reference
Expanded population of low-density neutrophils in juvenile idiopathic arthritis
10.3389/fimmu.2023.1229520 · 2023 · External reference
A distinct immature low-density neutrophil population characterizes acute generalized pustular psoriasis
10.1016/j.jid.2022.04.011 · 2022 · External reference
Low-density neutrophils preferentially infiltrate the skin compared to conventional neutrophils in an experimental psoriasis model
10.1093/jimmun/vkag016 · 2026 · External reference
Differences in staining for neutrophil elastase and its controlling inhibitor SLPI reveal heterogeneity among neutrophils in psoriasis
10.1016/j.jid.2019.12.015 · 2020 · External reference
Neutrophil subsets, platelets, and vascular disease in psoriasis
10.1016/j.jacbts.2018.10.008 · 2019 · External reference
Based on gene expression analysis: Low-density neutrophil expression is a characteristic of the fast responders treated with guselkumab for psoriasis
10.3389/fimmu.2022.865875 · 2022 · External reference
Inflammatory myopathies and beyond: The dual role of neutrophils in muscle damage and regeneration
10.3389/fimmu.2023.1113214 · 2023 · External reference
Pathogenic role and clinical significance of neutrophils and neutrophil extracellular traps in idiopathic inflammatory myopathies
10.1007/s10238-024-01384-2 · 2024 · External reference
Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies
10.1172/jci.insight.134189 · 2020 · External reference
Low-density granulocytes and neutrophil extracellular traps as biomarkers of disease activity in adult inflammatory myopathies
10.1097/rhu.0000000000001772 · 2022 · External reference
Abnormally increased low-density granulocytes in peripheral blood mononuclear cells are associated with interstitial lung disease in dermatomyositis
10.1080/14397595.2016.1179861 · 2017 · External reference
Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2
10.1182/blood.2018892752 · 2019 · External reference
Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome
10.1136/annrheumdis-2018-213746 · 2018 · External reference
Low density granulocytes and dysregulated neutrophils driving autoinflammatory manifestations in NEMO deficiency
10.1007/s10875-021-01176-3 · 2022 · External reference
Low density neutrophils are increased in patients with Behcet's disease but do not explain differences in neutrophil function
10.1186/s12950-022-00302-1 · 2022 · External reference
Cardiovascular risk in patients with ankylosing spondylitis
10.3390/jcm13206064 · 2024 · External reference
Card9/neutrophil signalling axis promotes IL-17A-mediated ankylosing spondylitis
10.1136/ard-2022-223146 · 2024 · External reference
A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs
10.4049/jimmunol.0902199 · 2010 · External reference
Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosus
10.1186/ar4681 · 2014 · External reference
Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils
10.1016/j.jaut.2015.01.004 · 2015 · External reference
Dysregulation of U12-type splicing in lupus neutrophils
10.1002/art.70053 · 2026 · External reference
Endotoxaemia in childhood-onset systemic lupus erythematosus induces low-density granulocytes and extracellular traps of innate immune cells
10.1136/lupus-2025-001663 · 2025 · External reference
Extracellular traps in peripheral blood mononuclear cell fraction in childhood-onset systemic lupus erythematosus
10.1038/s41598-024-74705-w · 2024 · External reference
Elevated plasma cfDNA may be associated with active lupus nephritis and partially attributed to abnormal regulation of neutrophil extracellular traps (NETs) in patients with systemic lupus erythematosus
10.2169/internalmedicine.53.2570 · 2014 · External reference
Increased expression of low density granulocytes in juvenile-onset systemic lupus erythematosus patients correlates with disease activity
10.1177/0961203315608959 · 2016 · External reference
Neutrophil and lymphocyte counts are associated with different immunopathological mechanisms in systemic lupus erythematosus
10.1136/lupus-2020-000382 · 2020 · External reference
Low-density granulocytes and neutrophil extracellular trap formation are increased in incomplete systemic lupus erythematosus
10.1093/rheumatology/keae300 · 2025 · External reference
Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
10.1186/s13075-023-03092-w · 2023 · External reference
Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE pregnancies
10.1136/lupus-2020-000463 · 2021 · External reference
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
10.1038/s41467-021-23361-z · 2021 · External reference
Neutrophil extracellular traps in systemic lupus erythematosus: Pathogenic mechanisms, crosstalk with oxidative stress, and antioxidant therapeutic potential
10.3390/antiox15010025 · 2025 · External reference
Recruitment of immature neutrophils in peripheral blood following leukocytapheresis therapy for rheumatoid arthritis
10.1002/jca.20155 · 2007 · External reference
Elevated circulating pro-inflammatory low-density granulocytes in adult-onset Still's disease
10.1093/rheumatology/keaa324 · 2021 · External reference
Elevated granulocyte colony-stimulating factor levels in patients with active phase of adult-onset Still disease
10.3899/jrheum.200617 · 2021 · External reference
The role of neutrophil density in neutrophils-mediated inflammatory response induced by monosodium urate crystals
10.3760/cma.j.cn112138-20191129-00781 · 2020 · External reference
Low density lipoprotein inhibits the physical interaction of phlogistic crystals and inflammatory cells
10.1002/art.1780290309 · 1986 · External reference
Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals
10.1172/jci111380 · 1984 · External reference
Changes in immature granulocyte levels and their association with disease activation following biologic therapy in patients with ankylosing spondylitis
10.1016/j.reumae.2024.11.007 · 2024 · External reference
Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation
10.1016/j.trsl.2016.12.003 · 2017 · External reference
Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19
10.1126/sciadv.ade8272 · 2023 · External reference
Epidermal proliferation and accumulation of polymorphonuclear leukocytes in the psoriatic lesion
10.1159/000248394 · 1989 · External reference
Histopathologic diagnosis of lymphomatous versus inflammatory erythroderma: A morphologic and phenotypic study on 47 skin biopsies
10.1097/dad.0b013e3181cfbfbf · 2010 · External reference
Interleukin-17E, inducible nitric oxide synthase and arginase1 as new biomarkers in the identification of neutrophilic dermatoses
10.1111/ced.14988 · 2022 · External reference
Psoriasis to psoriatic arthritis in terms of complement proteins: A single center experience
10.1097/md.0000000000048114 · 2026 · External reference
Dactylitis is associated with more severe axial joint damage and higher disease activity in axial psoriatic arthritis
10.3899/jrheum.220098 · 2022 · External reference
Serum lipids and lipoproteins in patients with psoriasis
2014 · External reference
Emerging associations between neutrophils, atherosclerosis, and psoriasis
10.1007/s11883-017-0692-8 · 2017 · External reference
The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats
10.1136/annrheumdis-2012-202218 · 2013 · External reference
Evidence of a causal relationship between body mass index and immune-mediated and inflammatory skin diseases and biomarkers: A Mendelian randomization study
10.2147/ccid.s496066 · 2024 · External reference
Effect of secukinumab on traditional cardiovascular risk factors and inflammatory biomarkers: Post hoc analyses of pooled data across three indications
10.1007/s40744-022-00434-z · 2022 · External reference
In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes
1990 · External reference
Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study
10.1111/j.1365-2133.2012.11168.x · 2012 · External reference
Baricitinib versus placebo or adalimumab in rheumatoid arthritis
10.1056/nejmoa1608345 · 2017 · External reference
Baricitinib in patients with refractory rheumatoid arthritis
10.1056/nejmoa1507247 · 2016 · External reference
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
10.1056/nejmoa1112072 · 2012 · External reference
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
10.1056/nejmoa1109071 · 2012 · External reference
Neutrophils as emerging therapeutic targets
10.1038/s41573-019-0054-z · 2020 · External reference
Interleukin-8: An evolving chemokine
10.1016/j.cyto.2022.155828 · 2022 · External reference
Neutrophil chemoattractant receptors in health and disease: double-edged swords
10.1038/s41423-020-0412-0 · 2020 · External reference
Targeting neutrophil serine proteases in bronchiectasis
10.1183/13993003.01050-2024 · 2025 · External reference
Neutrophil-based drug delivery systems
10.1002/adma.201706245 · 2018 · External reference
Target neutrophil heterogeneity and plasticity in cancer
10.1186/s13045-025-01731-0 · 2025 · External reference
Neutrophils as an emerging therapeutic target and tool for cancer therapy
10.1016/j.lfs.2021.119952 · 2021 · External reference
Neutrophil-based drug delivery systems
10.1002/adma.201706245 · ExternalCitation · doi-reference
Low density lipoprotein inhibits the physical interaction of phlogistic crystals and inflammatory cells
10.1002/art.1780290309 · ExternalCitation · doi-reference
Low density neutrophils in patients with systemic lupus erythematosus, rheumatoid arthritis, and acute rheumatic fever
10.1002/art.1780291105 · ExternalCitation · doi-reference
Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus
10.1002/art.21783 · ExternalCitation · doi-reference
Low-density neutrophils in systemic lupus erythematosus
10.1002/art.41395 · ExternalCitation · doi-reference
Dysregulation of U12-type splicing in lupus neutrophils
10.1002/art.70053 · ExternalCitation · doi-reference
CD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus
10.1002/ctm2.1150 · ExternalCitation · doi-reference
Recruitment of immature neutrophils in peripheral blood following leukocytapheresis therapy for rheumatoid arthritis
10.1002/jca.20155 · ExternalCitation · doi-reference
Neutrophils at the crossroads of innate and adaptive immunity
10.1002/jlb.4mir0220-574rr · ExternalCitation · doi-reference
On the origin of low-density neutrophils
10.1002/jlb.5hr0120-459r · ExternalCitation · doi-reference
The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases
10.1002/mco2.70101 · ExternalCitation · doi-reference
Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity
10.1007/s00281-013-0375-7 · ExternalCitation · doi-reference
Pathogenic role and clinical significance of neutrophils and neutrophil extracellular traps in idiopathic inflammatory myopathies
10.1007/s10238-024-01384-2 · ExternalCitation · doi-reference
Low density granulocytes and dysregulated neutrophils driving autoinflammatory manifestations in NEMO deficiency
10.1007/s10875-021-01176-3 · ExternalCitation · doi-reference
Emerging associations between neutrophils, atherosclerosis, and psoriasis
10.1007/s11883-017-0692-8 · ExternalCitation · doi-reference
NETosis in rheumatic diseases
10.1007/s11926-020-00977-6 · ExternalCitation · doi-reference
Neutrophils in the pathogenesis of rheumatic diseases: fueling the fire
10.1007/s12016-020-08816-3 · ExternalCitation · doi-reference
Effect of secukinumab on traditional cardiovascular risk factors and inflammatory biomarkers: Post hoc analyses of pooled data across three indications
10.1007/s40744-022-00434-z · ExternalCitation · doi-reference
Neutrophils and COVID-19
10.1016/bs.pmbts.2025.02.003 · ExternalCitation · doi-reference
IL-1beta mediated fibroblast-neutrophil crosstalk promotes inflammatory environment in skin lesions of SLE
10.1016/j.clim.2024.110396 · ExternalCitation · doi-reference
Interleukin-8: An evolving chemokine
10.1016/j.cyto.2022.155828 · ExternalCitation · doi-reference
Neutrophil subsets, platelets, and vascular disease in psoriasis
10.1016/j.jacbts.2018.10.008 · ExternalCitation · doi-reference
Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils
10.1016/j.jaut.2015.01.004 · ExternalCitation · doi-reference
Cardiovascular disease in systemic lupus erythematosus: a comprehensive update
10.1016/j.jaut.2017.05.008 · ExternalCitation · doi-reference
Aberrant expansion of CD177(+) neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps
10.1016/j.jaut.2025.103399 · ExternalCitation · doi-reference
Differences in staining for neutrophil elastase and its controlling inhibitor SLPI reveal heterogeneity among neutrophils in psoriasis
10.1016/j.jid.2019.12.015 · ExternalCitation · doi-reference
A distinct immature low-density neutrophil population characterizes acute generalized pustular psoriasis
10.1016/j.jid.2022.04.011 · ExternalCitation · doi-reference
Neutrophils as an emerging therapeutic target and tool for cancer therapy
10.1016/j.lfs.2021.119952 · ExternalCitation · doi-reference
Neutrophils in rheumatoid arthritis: Breaking immune tolerance and fueling disease
10.1016/j.molmed.2018.12.008 · ExternalCitation · doi-reference
Neutrophil dysregulation in the pathogenesis of systemic lupus erythematosus
10.1016/j.rdc.2021.04.002 · ExternalCitation · doi-reference
Changes in immature granulocyte levels and their association with disease activation following biologic therapy in patients with ankylosing spondylitis
10.1016/j.reumae.2024.11.007 · ExternalCitation · doi-reference
Human neutrophils: their role in cancer and relation to myeloid-derived suppressor cells
10.1016/j.smim.2016.03.018 · ExternalCitation · doi-reference
Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation
10.1016/j.trsl.2016.12.003 · ExternalCitation · doi-reference
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
10.1038/nm.4027 · ExternalCitation · doi-reference
Neutrophils in the pathogenesis and manifestations of SLE
10.1038/nrrheum.2011.132 · ExternalCitation · doi-reference
Neutrophil chemoattractant receptors in health and disease: double-edged swords
10.1038/s41423-020-0412-0 · ExternalCitation · doi-reference
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
10.1038/s41467-021-23361-z · ExternalCitation · doi-reference
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
10.1038/s41467-023-36522-z · ExternalCitation · doi-reference
Neutrophils as emerging therapeutic targets
10.1038/s41573-019-0054-z · ExternalCitation · doi-reference
Extracellular traps in peripheral blood mononuclear cell fraction in childhood-onset systemic lupus erythematosus
10.1038/s41598-024-74705-w · ExternalCitation · doi-reference
Circulating levels of low-density granulocytes and cell-free DNA as predictors of cardiovascular disease and bone deterioration in SLE patients
10.1055/a-2467-6826 · ExternalCitation · doi-reference
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
10.1056/nejmoa1109071 · ExternalCitation · doi-reference
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
10.1056/nejmoa1112072 · ExternalCitation · doi-reference
Baricitinib in patients with refractory rheumatoid arthritis
10.1056/nejmoa1507247 · ExternalCitation · doi-reference
Baricitinib versus placebo or adalimumab in rheumatoid arthritis
10.1056/nejmoa1608345 · ExternalCitation · doi-reference
Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus
10.1073/pnas.1908576116 · ExternalCitation · doi-reference
Abnormally increased low-density granulocytes in peripheral blood mononuclear cells are associated with interstitial lung disease in dermatomyositis
10.1080/14397595.2016.1179861 · ExternalCitation · doi-reference
Low-density neutrophils preferentially infiltrate the skin compared to conventional neutrophils in an experimental psoriasis model
10.1093/jimmun/vkag016 · ExternalCitation · doi-reference
Characterizing a low-density neutrophil gene signature in acute and chronic infections and its impact on disease severity
10.1093/jleuko/qiaf027 · ExternalCitation · doi-reference
Low-density granulocytes in the pathogenesis of inflammatory disease
10.1093/jleuko/qiaf133 · ExternalCitation · doi-reference
Elevated circulating pro-inflammatory low-density granulocytes in adult-onset Still's disease
10.1093/rheumatology/keaa324 · ExternalCitation · doi-reference
Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis
10.1093/rheumatology/kead296 · ExternalCitation · doi-reference
Low-density granulocytes and neutrophil extracellular trap formation are increased in incomplete systemic lupus erythematosus
10.1093/rheumatology/keae300 · ExternalCitation · doi-reference
Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes
10.1093/rheumatology/kex441 · ExternalCitation · doi-reference
The role of neutrophils in the pathogenesis of systemic lupus erythematosus
10.1097/bor.0000000000000197 · ExternalCitation · doi-reference
Cardiovascular disease in systemic lupus erythematosus: an update
10.1097/bor.0000000000000528 · ExternalCitation · doi-reference
Neutrophils in lupus nephritis
10.1097/bor.0000000000000577 · ExternalCitation · doi-reference
Lupus neutrophils: 'NET' gain in understanding lupus pathogenesis
10.1097/bor.0b013e3283546703 · ExternalCitation · doi-reference
Histopathologic diagnosis of lymphomatous versus inflammatory erythroderma: A morphologic and phenotypic study on 47 skin biopsies
10.1097/dad.0b013e3181cfbfbf · ExternalCitation · doi-reference
Psoriasis to psoriatic arthritis in terms of complement proteins: A single center experience
10.1097/md.0000000000048114 · ExternalCitation · doi-reference
Low-density granulocytes and neutrophil extracellular traps as biomarkers of disease activity in adult inflammatory myopathies
10.1097/rhu.0000000000001772 · ExternalCitation · doi-reference
Neutrophil heterogeneity in sepsis: the role of damage-associated molecular patterns
10.1097/shk.0000000000002019 · ExternalCitation · doi-reference
Interleukin-17E, inducible nitric oxide synthase and arginase1 as new biomarkers in the identification of neutrophilic dermatoses
10.1111/ced.14988 · ExternalCitation · doi-reference
Human neutrophils in the saga of cellular heterogeneity: insights and open questions
10.1111/imr.12448 · ExternalCitation · doi-reference
Low-density granulocytes in systemic autoimmunity and autoinflammation
10.1111/imr.13161 · ExternalCitation · doi-reference
Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study
10.1111/j.1365-2133.2012.11168.x · ExternalCitation · doi-reference
Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19
10.1126/sciadv.ade8272 · ExternalCitation · doi-reference
The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats
10.1136/annrheumdis-2012-202218 · ExternalCitation · doi-reference
Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2
10.1136/annrheumdis-2013-204837 · ExternalCitation · doi-reference
Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus
10.1136/annrheumdis-2017-212617 · ExternalCitation · doi-reference
Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome
10.1136/annrheumdis-2018-213746 · ExternalCitation · doi-reference
Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus
10.1136/annrheumdis-2018-214620 · ExternalCitation · doi-reference
Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome
10.1136/annrheumdis-2019-215781 · ExternalCitation · doi-reference
Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus
10.1136/annrheumdis-2020-218338 · ExternalCitation · doi-reference
Card9/neutrophil signalling axis promotes IL-17A-mediated ankylosing spondylitis
10.1136/ard-2022-223146 · ExternalCitation · doi-reference
Neutrophil and lymphocyte counts are associated with different immunopathological mechanisms in systemic lupus erythematosus
10.1136/lupus-2020-000382 · ExternalCitation · doi-reference
Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE pregnancies
10.1136/lupus-2020-000463 · ExternalCitation · doi-reference
Endotoxaemia in childhood-onset systemic lupus erythematosus induces low-density granulocytes and extracellular traps of innate immune cells
10.1136/lupus-2025-001663 · ExternalCitation · doi-reference
Role of neutrophils in psoriasis
10.1155/2020/3709749 · ExternalCitation · doi-reference
Low-density granulocytes in immune-mediated inflammatory diseases
10.1155/2022/1622160 · ExternalCitation · doi-reference
Low-density neutrophils: enigmatic cells in health and disease
10.1155/jimr/3037744 · ExternalCitation · doi-reference
Epidermal proliferation and accumulation of polymorphonuclear leukocytes in the psoriatic lesion
10.1159/000248394 · ExternalCitation · doi-reference
Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies
10.1172/jci.insight.134189 · ExternalCitation · doi-reference
Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals
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Target neutrophil heterogeneity and plasticity in cancer
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Neutrophil, quo vadis
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Expanded population of low-density neutrophils in juvenile idiopathic arthritis
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Roles of neutrophils in autoimmune diseases and cancers
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The role of neutrophil density in neutrophils-mediated inflammatory response induced by monosodium urate crystals
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Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
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