Research graph
References from INPP5K limits PtdIns (4,5)P2 accumulation in CD19 microclusters and restrains CD19 co-receptor membrane proximity and BCR-proximal signaling in B cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Constitutive immune mechanisms: mediators of host defence and immune regulation
10.1038/s41577-020-0391-5 · 2021 · External reference
Inhibitory receptors of the immune system: functions and therapeutic implications
10.1038/cmi.2009.52 · 2009 · External reference
Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations
10.1111/j.1399-0039.2004.00142.x · 2004 · External reference
Aberrant B cell signaling in autoimmune diseases
10.3390/cells11213391 · 2022 · External reference
Defective FcgammaRIIb1 signaling contributes to enhanced calcium response in B cells from patients with systemic lupus erythematosus
10.1006/clim.2001.5104 · 2001 · External reference
Copy number, linkage disequilibrium and disease association in the FCGR locus
10.1093/hmg/ddq216 · 2010 · External reference
CD22: a regulator of innate and adaptive B cell responses and autoimmunity
10.3389/fimmu.2018.02235 · 2018 · External reference
The role of the protein tyrosine phosphatase CD45 in regulation of B lymphocyte activation
10.3109/08830180109045587 · 2001 · External reference
CD72, a negative regulator of B-cell responsiveness
10.1034/j.1600-065x.2000.00608.x · 2000 · External reference
FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications
10.1038/nri2762 · 2010 · External reference
CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels
10.1038/s41423-020-0490-z · 2020 · External reference
PTPN22: setting thresholds for autoimmunity
10.1016/j.smim.2006.03.009 · 2006 · External reference
The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation
10.1016/j.imlet.2005.11.027 · 2006 · External reference
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
10.1084/jem.20021101 · 2003 · External reference
Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction
10.1016/s0952-7915(00)00092-3 · 2000 · External reference
Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus
10.1126/scitranslmed.3009131 · 2014 · External reference
Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
10.1146/annurev.immunol.18.1.393 · 2000 · External reference
CD19 regulates B lymphocyte responses to transmembrane signals
10.1006/smim.1998.9999 · 1998 · External reference
CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
10.1126/science.7684160 · 1993 · External reference
Cd19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification
10.1385/ir:22:2-3:281 · 2000 · External reference
Signaling through CD19 activates vav/mitogen-activated protein kinase pathway and induces formation of a CD19/vav/phosphatidylinositol 3-kinase complex in human B cell precursors
10.1016/s0021-9258(18)31664-8 · 1994 · External reference
Cd19-dependent activation of Akt kinase in B-lymphocytes
10.1074/jbc.m003918200 · 2001 · External reference
Cd19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand
10.1038/ni1547 · 2008 · External reference
CD19: a biomarker for B cell development, lymphoma diagnosis and therapy
10.1186/2162-3619-1-36 · 2012 · External reference
Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
10.1016/1074-7613(95)90157-4 · 1995 · External reference
Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
10.1038/376352a0 · 1995 · External reference
CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes
10.1084/jem.186.11.1923 · 1997 · External reference
CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity
10.4049/jimmunol.157.10.4371 · 1996 · External reference
CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19
10.4049/jimmunol.158.10.4662 · 1997 · External reference
Quantitative genetic variation in CD19 expression correlates with autoimmunity
10.4049/jimmunol.165.11.6635 · 2000 · External reference
Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B lymphocyte development
10.1128/mcb.14.6.3884-3894.1994 · 1994 · External reference
Phosphoinositides: Tiny lipids with giant impact on cell regulation
10.1152/physrev.00028.2012 · 2013 · External reference
Pi4p and PI(4,5)P2 are essential but independent lipid determinants of membrane identity
10.1126/science.1222483 · 2012 · External reference
Live cell imaging of phosphoinositide dynamics with fluorescent protein domains
10.1016/j.bbalip.2006.03.019 · 2006 · External reference
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
10.1038/nature12360 · 2013 · External reference
Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition
10.1038/80930 · 2000 · External reference
The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions
10.4049/jimmunol.0900404 · 2009 · External reference
Ionic protein-lipid interaction at the plasma membrane: what can the charge do
10.1016/j.tibs.2014.01.002 · 2014 · External reference
Regulation of T cell receptor activation by dynamic membrane binding of the CD3ε cytoplasmic tyrosine-based motif
10.1016/j.cell.2008.09.044 · 2008 · External reference
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
10.1073/pnas.1108052108 · 2011 · External reference
Architecture and membrane interactions of the EGF receptor
10.1016/j.cell.2012.12.030 · 2013 · External reference
Conformational coupling across the plasma membrane in activation of the EGF receptor
10.1016/j.cell.2012.12.032 · 2013 · External reference
Acidic phospholipids govern the enhanced activation of IgG-B cell receptor
10.1038/ncomms9552 · 2015 · External reference
Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation
10.1038/s41598-018-23109-8 · 2018 · External reference
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
10.1038/nsmb.3489 · 2017 · External reference
Receptor activation alters inner surface potential during phagocytosis
10.1126/science.1129551 · 2006 · External reference
The inositol 5-phosphatase INPP5K participates in the fine control of ER organization
10.1083/jcb.201802125 · 2018 · External reference
Defective lysosome reformation during autophagy causes skeletal muscle disease
10.1172/jci135124 · 2021 · External reference
Bidirectional interconversion between PtdIns4P and PtdIns(4,5)P2 is required for autophagic lysosome reformation and protection from skeletal muscle disease
10.1080/15548627.2021.1916195 · 2021 · External reference
Inpp5k and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH
10.1093/brain/awab133 · 2021 · External reference
Inositol polyphosphate-5-phosphatase K (Inpp5k) enhances sprouting of corticospinal tract axons after CNS trauma
10.1523/jneurosci.0897-21.2022 · 2022 · External reference
Pi(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesis
10.1126/sciadv.add6911 · 2023 · External reference
Loss of INPP5K attenuates IP3-induced Ca2+ responses in the glioblastoma cell line U-251 MG cells
10.1016/j.bbadva.2023.100105 · 2023 · External reference
Knockdown of INPP5K compromises the differentiation of N2A cells
10.3389/fnmol.2024.1356343 · 2024 · External reference
INPP5K controls the dynamic structure and signaling of wild-type and mutated, leukemia-associated IL-7 receptors
10.1182/blood.2022017819 · 2023 · External reference
Zeiss airyscan: Optimizing usage for fast, gentle, super-resolution imaging
10.1007/978-1-0716-1402-0_5 · 2021 · External reference
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor
10.1016/j.immuni.2009.12.005 · 2010 · External reference
Experimental validation of predicted cancer genes using FRET
10.1088/2050-6120/aab932 · 2018 · External reference
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
10.1126/science.1134389 · 2006 · External reference
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry
10.1042/bj20090884 · 2010 · External reference
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains
10.1002/eji.1830251040 · 1995 · External reference
The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling
10.1083/jcb.202112018 · 2022 · External reference
Antigen-induced oligomerization of the B cell receptor is an early target of FcγRIIB inhibition
10.4049/jimmunol.0902334 · 2010 · External reference
Growth of B cell receptor microclusters is regulated by PIP2 and PIP3 equilibrium and Dock2 recruitment and activation
10.1016/j.celrep.2017.10.117 · 2017 · External reference
Through an ITIM-independent mechanism the FcγRIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19
10.4049/jimmunol.1400101 · 2014 · External reference
Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232
10.1084/jem.20160528 · 2016 · External reference
Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics
10.1038/ni1337 · 2006 · External reference
A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
10.4049/jimmunol.167.5.2469 · 2001 · External reference
Distinct transcriptome architectures underlying lupus establishment and exacerbation
10.1016/j.cell.2022.07.021 · 2022 · External reference
Cd19 regulates src family protein tyrosine kinase activation in B lymphocytes through processive amplification
10.1016/s1074-7613(00)00007-8 · 2000 · External reference
