Research graph
References from Dendritic-cell depletion and dysfunction in sepsis: a compartment- and evidence-aware synthesis. Local targets link to admitted publications; unresolved targets remain external evidence.
The third international consensus definitions for sepsis and septic shock (Sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
Advances in the understanding and treatment of sepsis-induced immunosuppression
10.1038/nrneph.2017.165 · 2018 · External reference
The calm after the storm: Implications of sepsis immunoparalysis on host immunity
10.4049/jimmunol.2300171 · 2023 · External reference
An immune-cell signature of bacterial sepsis
10.1038/s41591-020-0752-4 · 2020 · External reference
Personalized, disease-stage specific, rapid identification of immunosuppression in sepsis
10.3389/fimmu.2024.1430972 · 2024 · External reference
An international observational study validating gene-expression sepsis immune subgroups
10.1186/s13054-025-05319-5 · 2025 · External reference
Immune signatures of sepsis from mild infection to critical illness - a prospective observational study
10.3389/fimmu.2025.1715812 · 2026 · External reference
Decrease in circulating dendritic cells predicts fatal outcome in septic shock
10.1007/s00134-006-0436-7 · 2007 · External reference
Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock
10.1007/s00134-011-2306-1 · 2011 · External reference
Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis
10.1186/cc7969 · 2009 · External reference
Flow cytometric analysis of peripheral blood dendritic cells in patients with severe sepsis
10.1002/cyto.b.20540 · 2011 · External reference
Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis
10.3389/fimmu.2023.1257572 · 2023 · External reference
Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis
10.1186/s13062-026-00836-x · 2026 · External reference
Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis
10.4049/jimmunol.1001147 · 2011 · External reference
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis
10.7150/thno.72760 · 2022 · External reference
Sepsis inflammation impairs the generation of functional dendritic cells by targeting their progenitors
10.3389/fimmu.2021.732612 · 2021 · External reference
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
10.1038/nri3712 · 2014 · External reference
Decoding the heterogeneity of human dendritic cell subsets
10.1016/j.it.2020.10.002 · 2020 · External reference
The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways
10.1182/blood-2007-02-071613 · 2007 · External reference
Transcriptional basis of mouse and human dendritic cell heterogeneity
10.1016/j.cell.2019.09.035 · 2019 · External reference
pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells
10.1126/sciimmunol.add4132 · 2023 · External reference
Distinct ontogenetic lineages dictate cDC2 heterogeneity
10.1038/s41590-024-01745-9 · 2024 · External reference
Phenotypic landscape of immune cells in sepsis: Insights from high-dimensional mass cytometry
10.1021/acsinfecdis.4c00066 · 2024 · External reference
Human blood CD1c+ dendritic cells promote Th1 and Th17 effector function in memory CD4+ T cells
10.3389/fimmu.2017.00971 · 2017 · External reference
SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen
10.1371/journal.pone.0266566 · 2022 · External reference
Adoptive transfer of bone marrow‐derived dendritic cells decreases inhibitory and regulatory T‐cell differentiation and improves survival in murine polymicrobial sepsis
10.1111/imm.12423 · 2015 · External reference
Epigenetic regulation of dendritic cell–derived interleukin-12 facilitates immunosuppression after a severe innate immune response
10.1182/blood-2007-08-106443 · 2008 · External reference
Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/β-catenin pathway
10.1093/burnst/tkad025 · 2024 · External reference
Analysis of circulating plasmacytoid dendritic cells during the course of sepsis
10.1016/j.surg.2015.03.013 · 2015 · External reference
Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients
10.1093/jleuko/qiae003 · 2024 · External reference
Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming
10.3389/fimmu.2023.1140630 · 2023 · External reference
Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells
10.4049/jimmunol.171.2.909 · 2003 · External reference
Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells
10.1128/iai.00238-09 · 2009 · External reference
Innate immune system favors emergency monopoiesis at the expense of DC‐differentiation to control systemic bacterial infection in mice
10.1002/eji.201545530 · 2015 · External reference
Systemic bacterial infections affect dendritic cell development and function
10.1016/j.ijmm.2021.151517 · 2021 · External reference
TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis
10.3389/fimmu.2022.945409 · 2022 · External reference
Polymicrobial sepsis diminishes dendritic cell numbers and function directly contributing to impaired primary CD8 T cell responses in vivo
10.4049/jimmunol.1601463 · 2016 · External reference
A novel single cell RNA-seq analysis of non-myeloid circulating cells in late sepsis
10.3389/fimmu.2021.696536 · 2021 · External reference
Immune-cell signatures of persistent inflammation, immunosuppression, and catabolism syndrome after sepsis
10.1016/j.medj.2024.12.003 · 2025 · External reference
The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution
10.1016/j.clim.2024.110175 · 2024 · External reference
Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein
10.1038/s41419-020-2324-4 · 2020 · External reference
Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells
10.1007/s00018-021-03970-z · 2021 · External reference
Toll-like receptor 4 signaling on dendritic cells suppresses polymorphonuclear leukocyte CXCR2 expression and trafficking via interleukin 10 during intra-abdominal sepsis
10.1093/infdis/jiv562 · 2016 · External reference
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
10.1038/nature06663 · 2008 · External reference
Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study
10.5847/wjem.j.1920-8642.2023.041 · 2023 · External reference
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis
10.1126/science.aaa4268 · 2015 · External reference
Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response
10.1182/blood-2005-10-4190 · 2006 · External reference
Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling
10.1111/cpr.13328 · 2022 · External reference
MiR‐146a‐5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7
10.1002/jbt.23151 · 2022 · External reference
PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control
10.1186/s10020-023-00618-5 · 2023 · External reference
RETREG1/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis
10.1080/15548627.2026.2641614 · 2026 · External reference
Nuclear fragile X mental retardation-interacting protein 1-mediated ribophagy regulates immune function of dendritic cells in polymicrobial sepsis
10.1093/burnst/tkaf034 · 2025 · External reference
Suppression of dendritic cell-derived IL-12 by endogenous glucocorticoids is protective in LPS-induced sepsis
10.1371/journal.pbio.1002269 · 2015 · External reference
IL-12 suppression during experimental endotoxin tolerance: Dendritic cell loss and macrophage hyporesponsiveness
10.4049/jimmunol.166.12.7504 · 2001 · External reference
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile
10.2353/ajpath.2006.051155 · 2006 · External reference
Noncanonical dendritic cell differentiation and survival driven by a bacteremic pathogen
10.1189/jlb.0213108 · 2013 · External reference
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells
10.1016/j.immuni.2012.03.027 · 2012 · External reference
The non-canonical Wnt pathway negatively regulates dendritic cell differentiation by inhibiting the expansion of Flt3+ lymphocyte-primed multipotent precursors
10.1038/cmi.2015.39 · 2016 · External reference
Reversal of long-term sepsis-induced immunosuppression by dendritic cells
10.1182/blood-2004-08-3251 · 2005 · External reference
Monocytic HLA-DR expression in intensive care patients: Interest for prognosis and secondary infection prediction
10.1097/ccm.0b013e3181ab858a · 2009 · External reference
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock
10.1007/s00134-010-1962-x · 2010 · External reference
Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis
10.3389/fimmu.2023.1130214 · 2023 · External reference
Construction of an HLA classifier for early diagnosis, prognosis, and recognition of immunosuppression in sepsis by multiple transcriptome datasets
10.3389/fphys.2022.870657 · 2022 · External reference
Systematic analysis of programmed cell death–related genes in sepsis reveals immune heterogeneity and enables patient stratification
10.3389/fcell.2026.1805864 · 2026 · External reference
Contribution of dendritic cell responses to sepsis-induced immunosuppression and to susceptibility to secondary pneumonia
10.3389/fimmu.2018.02590 · 2018 · External reference
Transcriptomic profiles in children with septic shock with or without immunoparalysis
10.3389/fimmu.2021.733834 · 2021 · External reference
Sepsis triggers a late expansion of functionally impaired tissue-vascular inflammatory monocytes during clinical recovery
10.3389/fimmu.2020.00675 · 2020 · External reference
