Research graph
References from Sterile inflammation in LHON: mitochondrial stress, innate immune signaling, and implications for AAV gene therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Leber hereditary optic neuropathy
10.1136/jmg.39.3.162 · 2002 · External reference
Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines
10.1093/brain/awh258 · 2004 · External reference
Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies
10.1016/j.preteyeres.2010.11.002 · 2011 · External reference
Gene-environment interactions in Leber hereditary optic neuropathy
10.1093/brain/awp158 · 2009 · External reference
Mitochondrial DNA in inflammation and immunity
10.15252/embr.201949799 · 2020 · External reference
Five-year outcomes of Lenadogene Nolparvovec gene therapy in Leber hereditary optic neuropathy
10.1001/jamaophthalmol.2024.5375 · 2025 · External reference
Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy
10.1016/j.celrep.2022.111124 · 2022 · External reference
The energetics of genome complexity
10.1038/nature09486 · 2010 · External reference
Circulating mitochondrial DAMPs cause inflammatory responses to injury
10.1038/nature08780 · 2010 · External reference
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
10.1016/j.immuni.2012.01.009 · 2012 · External reference
Mitochondrial DNA stress primes the antiviral innate immune response
10.1038/nature14156 · 2015 · External reference
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
10.1038/s12276-023-00965-7 · 2023 · External reference
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
10.1016/j.cell.2024.05.017 · 2024 · External reference
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA
10.15252/embj.2020106283 · 2021 · External reference
FBXL4 deficiency increases mitochondrial removal by autophagy
10.15252/emmm.201911659 · 2020 · External reference
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
10.1126/science.aav4011 · 2019 · External reference
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
10.1126/science.aao6047 · 2018 · External reference
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
10.1016/j.immuni.2022.06.007 · 2022 · External reference
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production
10.1016/j.cell.2014.11.036 · 2014 · External reference
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
10.1038/ni.1980 · 2011 · External reference
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
10.1038/nature10992 · 2012 · External reference
Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation
10.1111/acel.13622 · 2022 · External reference
Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy
10.1093/hmg/ddac109 · 2022 · External reference
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis
10.1016/j.jbc.2025.110464 · 2025 · External reference
Establishment of human Leber's hereditary optic neuropathy model using iPSC-derived retinal organoids
10.3389/fncel.2025.1635775 · 2025 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
10.1126/science.1229963 · 2013 · External reference
Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1
10.1128/jvi.00037-14 · 2014 · External reference
Microglial cGAS-STING signaling underlies glaucoma pathogenesis
10.1073/pnas.2409493121 · 2024 · External reference
Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
10.1038/s41419-023-06140-0 · 2023 · External reference
A role for mitochondria in NLRP3 inflammasome activation
10.1038/nature09663 · 2011 · External reference
A Toll-like receptor recognizes bacterial DNA
10.1038/35047123 · 2000 · External reference
Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats
10.1093/cvr/cvv137 · 2015 · External reference
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway
10.1038/s41586-020-2078-2 · 2020 · External reference
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
10.1038/s41586-020-2076-4 · 2020 · External reference
Loss of mitochondrial protease CLPP activates type I IFN responses through the mitochondrial DNA-cGAS-STING signaling axis
10.4049/jimmunol.2001016 · 2021 · External reference
Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity
10.1038/s42255-021-00385-9 · 2021 · External reference
Microglial phagocytosis of live neurons
10.1038/nrn3710 · 2014 · External reference
Complement targets newborn retinal ganglion cells for phagocytic elimination by microglia
10.1523/jneurosci.1854-18.2018 · 2019 · External reference
Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
10.1016/j.preteyeres.2009.07.001 · 2009 · External reference
A histopathologic and morphometric differentiation of nerves in optic nerve hypoplasia and Leber hereditary optic neuropathy
10.1001/archopht.116.7.911 · 1998 · External reference
Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries
10.1084/jem.20160412 · 2017 · External reference
Multiple sclerosis
10.1056/nejmra1401483 · 2018 · External reference
Mitochondrial mutations of Leber's hereditary optic neuropathy: a risk factor for multiple sclerosis
10.1007/s004150070153 · 2000 · External reference
MRI in Leber's hereditary optic neuropathy: the relationship to multiple sclerosis
10.1136/jnnp-2014-308186 · 2015 · External reference
Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation
10.1093/brain/115.4.979 · 1992 · External reference
Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations
10.1212/01.wnl.0000437308.22603.43 · 2013 · External reference
A comprehensive review of Leber hereditary optic neuropathy and its association with multiple sclerosis-like phenotypes known as Harding's disease
10.2147/eb.s470184 · 2024 · External reference
Leber's hereditary optic neuropathy and multiple sclerosis: overlap between mitochondrial disease and neuroinflammation
10.3389/fneur.2025.1538358 · 2025 · External reference
HLA class I genotypes in Leber's hereditary optic neuropathy
10.1016/0022-510x(95)00286-b · 1996 · External reference
HLA class II genotypes in Leber's hereditary optic neuropathy
10.1016/0022-510x(94)90272-0 · 1994 · External reference
HLA-DR15 haplotype and multiple sclerosis: a HuGE review
10.1093/aje/kwk118 · 2007 · External reference
Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein
10.1016/0092-8674(90)90345-f · 1990 · External reference
HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis
10.1016/j.cell.2020.09.054 · 2020 · External reference
HLA-DRB1*15:01 and the MERTK gene interact to selectively influence the profile of MERTK-expressing monocytes in both health and MS
10.1212/nxi.0000000000200190 · 2024 · External reference
TAM receptors regulate multiple features of microglial physiology
10.1038/nature17630 · 2016 · External reference
Phagocytosis and clearance of apoptotic cells is mediated by MER
10.1038/35075603 · 2001 · External reference
Alterations of oligodendrocyte and myelin energy metabolism in multiple sclerosis
10.3390/ijms241612912 · 2023 · External reference
The iron maiden: Oligodendroglial metabolic dysfunction in multiple sclerosis and mitochondrial signaling
10.1016/j.neubiorev.2024.105788 · 2024 · External reference
Review: Mitochondria and disease progression in multiple sclerosis
10.1111/j.1365-2990.2008.00987.x · 2008 · External reference
Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis
10.1038/srep33249 · 2016 · External reference
cGAS-STING-mediated inflammation and neurodegeneration as a strategy for the treatment of neurodegenerative diseases
10.3724/abbs.2023258 · 2024 · External reference
Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration
10.1155/2013/297512 · 2013 · External reference
Endothelial mitochondria in the blood-brain barrier
10.1186/s12987-025-00699-w · 2025 · External reference
The blood-retinal barrier in experimental autoimmune uveoretinitis (EAU): a review
10.3109/02713689208999508 · 1992 · External reference
Multimodal longitudinal optical imaging reveals optic neuritis preceding retinal pathology in experimental autoimmune encephalomyelitis
10.1212/nxi.0000000000200338 · 2025 · External reference
Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier
10.1167/iovs.04-1333 · 2005 · External reference
Randomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy
10.1093/brain/awac421 · 2023 · External reference
Safety of Lenadogene Nolparvovec gene therapy over 5 years in 189 patients with Leber hereditary optic neuropathy
10.1016/j.ajo.2022.11.026 · 2023 · External reference
Immune response and intraocular inflammation in patients with Leber hereditary optic neuropathy treated with intravitreal injection of recombinant adeno-associated virus 2 carrying the ND4 gene: a secondary analysis of a phase 1/2 clinical trial
10.1001/jamaophthalmol.2018.6902 · 2019 · External reference
Safety of intravitreal gene therapy for treatment of subjects with Leber hereditary optic neuropathy due to mutations in the mitochondrial ND4 gene: The REVEAL study
10.1007/s40259-021-00468-9 · 2021 · External reference
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
10.1126/scitranslmed.abd3438 · 2021 · External reference
Overcoming innate immune barriers that impede AAV gene therapy vectors
10.1172/jci143780 · 2021 · External reference
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
10.1172/jci37607 · 2009 · External reference
CpG-depleted adeno-associated virus vectors evade immune detection
10.1172/jci68205 · 2013 · External reference
The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver
10.1182/blood-2010-10-314518 · 2011 · External reference
Ocular inflammatory response to intravitreal injection of adeno-associated virus vector: relative contribution of genome and capsid
10.1089/hum.2019.144 · 2020 · External reference
Systemic and local immune responses to intraocular AAV vector administration in non-human primates
10.1016/j.omtm.2022.01.011 · 2022 · External reference
Immune responses to retinal gene therapy using adeno-associated viral vectors - Implications for treatment success and safety
10.1016/j.preteyeres.2020.100915 · 2021 · External reference
Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates
10.1038/gt.2014.115 · 2015 · External reference
Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors
10.1089/hum.2009.182 · 2010 · External reference
Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses
10.1086/595830 · 2009 · External reference
AAV vector immunogenicity in humans: a long journey to successful gene transfer
10.1016/j.ymthe.2019.12.010 · 2020 · External reference
Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells
10.1182/blood-2016-11-751040 · 2017 · External reference
Safety and efficacy of ixoberogene soroparvovec in neovascular age-related macular degeneration in the United States (OPTIC): a prospective, two-year, multicentre phase 1 study
10.1016/j.eclinm.2023.102394 · 2024 · External reference
Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
10.1016/s0140-6736(17)31868-8 · 2017 · External reference
Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study
10.1016/s0140-6736(24)00310-6 · 2024 · External reference
The clinical safety landscape for ocular AAV gene therapies: a systematic review and meta-analysis
10.1016/j.isci.2025.112265 · 2025 · External reference
A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy
10.1093/brain/awr170 · 2011 · External reference
Understanding the molecular basis and pathogenesis of hereditary optic neuropathies: towards improved diagnosis and management
10.1016/s1474-4422(22)00174-0 · 2023 · External reference
The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group
10.1056/nejm199312093292403 · 1993 · External reference
Leber hereditary optic neuropathy: bridging the translational gap
10.1097/icu.0000000000000410 · 2017 · External reference
Leber's hereditary optic neuropathy misdiagnosed as optic neuritis and Lyme disease in a patient with multiple sclerosis
10.1136/bcr-2018-227109 · 2018 · External reference
Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse
10.1093/hmg/ddv045 · 2015 · External reference
Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
10.1155/2015/673090 · 2015 · External reference
Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy
10.3389/fimmu.2022.860070 · 2022 · External reference
Minocycline: far beyond an antibiotic
10.1111/bph.12139 · 2013 · External reference
Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study
10.1167/iovs.11-9413 · 2012 · External reference
Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection
10.1001/archopht.124.4.520 · 2006 · External reference
Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation
10.1016/j.nbd.2007.07.021 · 2007 · External reference
cGAS in action: Expanding roles in immunity and inflammation
10.1126/science.aat8657 · 2019 · External reference
Inflammation in viral vector-mediated ocular gene therapy: A review and report from a workshop hosted by the Foundation Fighting Blindness, 9/2020
10.1167/tvst.10.4.3 · 2021 · External reference
AAV for gene therapy in ocular diseases: Progress and prospects
10.34133/research.0291 · 2023 · External reference
Retinal gene therapy using epiretinal AAV-containing fibrin hydrogel implants
10.1126/sciadv.adv7922 · 2025 · External reference
Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : Preparation for gene therapy clinical trial
10.1001/jamaophthalmol.2013.7971 · 2014 · External reference
Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways
10.1038/cddis.2015.364 · 2015 · External reference
Mitochondrial mutations in ethambutol-induced optic neuropathy
10.3389/fcell.2021.754676 · 2021 · External reference
Linezolid trough concentrations correlate with mitochondrial toxicity-related adverse events in the treatment of chronic extensively drug-resistant tuberculosis
10.1016/j.ebiom.2015.09.051 · 2015 · External reference
Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability
10.1016/j.preteyeres.2013.07.001 · 2013 · External reference
Patient care standards for primary mitochondrial disease: A consensus statement from the Mitochondrial Medicine Society
10.1038/gim.2017.107 · 2017 · External reference
Leber hereditary optic neuropathy: Review of treatment and management
10.3389/fneur.2021.651639 · 2021 · External reference
Ketogenic treatment reduces the percentage of a LHON heteroplasmic mutation and increases mtDNA amount of a LHON homoplasmic mutation
10.1186/s13023-019-1128-z · 2019 · External reference
Nutritional interventions for mitochondrial OXPHOS deficiencies: Mechanisms and model systems
10.1146/annurev-pathol-020117-043644 · 2018 · External reference
Mitochondrial DNA release in innate immune signaling
10.1146/annurev-biochem-032620-104401 · 2023 · External reference
Biomarkers of inflammation detected in Leber hereditary optic neuropathy using phase contrast AOSLO [Conference Abstract
2023 · External reference
LHON-MS - The overlaps in clinical and molecular features of both LHON and MS
10.1016/j.msard.2020.102322 · 2020 · External reference
Evidence for detrimental cross interactions between reactive oxygen and nitrogen species in Leber's hereditary optic neuropathy cells
10.1155/2016/3187560 · 2016 · External reference
Mitophagy activation repairs Leber's hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survival
10.1093/hmg/ddy354 · 2019 · External reference
Contribution of mitochondrial dysfunction combined with NLRP3 inflammasome activation in selected neurodegenerative diseases
10.3390/ph14121221 · 2021 · External reference
Evaluating the evidence for neuroprotective and axonal regenerative activities of different inflammatory cell types after optic nerve injury
10.1007/s12035-024-04679-3 · 2025 · External reference
A histopathologic and morphometric differentiation of nerves in optic nerve hypoplasia and Leber hereditary optic neuropathy
10.1001/archopht.116.7.911 · ExternalCitation · doi-reference
Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection
10.1001/archopht.124.4.520 · ExternalCitation · doi-reference
Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : Preparation for gene therapy clinical trial
10.1001/jamaophthalmol.2013.7971 · ExternalCitation · doi-reference
Immune response and intraocular inflammation in patients with Leber hereditary optic neuropathy treated with intravitreal injection of recombinant adeno-associated virus 2 carrying the ND4 gene: a secondary analysis of a phase 1/2 clinical trial
10.1001/jamaophthalmol.2018.6902 · ExternalCitation · doi-reference
Five-year outcomes of Lenadogene Nolparvovec gene therapy in Leber hereditary optic neuropathy
10.1001/jamaophthalmol.2024.5375 · ExternalCitation · doi-reference
Mitochondrial mutations of Leber's hereditary optic neuropathy: a risk factor for multiple sclerosis
10.1007/s004150070153 · ExternalCitation · doi-reference
Evaluating the evidence for neuroprotective and axonal regenerative activities of different inflammatory cell types after optic nerve injury
10.1007/s12035-024-04679-3 · ExternalCitation · doi-reference
Safety of intravitreal gene therapy for treatment of subjects with Leber hereditary optic neuropathy due to mutations in the mitochondrial ND4 gene: The REVEAL study
10.1007/s40259-021-00468-9 · ExternalCitation · doi-reference
HLA class II genotypes in Leber's hereditary optic neuropathy
10.1016/0022-510x(94)90272-0 · ExternalCitation · doi-reference
HLA class I genotypes in Leber's hereditary optic neuropathy
10.1016/0022-510x(95)00286-b · ExternalCitation · doi-reference
Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein
10.1016/0092-8674(90)90345-f · ExternalCitation · doi-reference
Safety of Lenadogene Nolparvovec gene therapy over 5 years in 189 patients with Leber hereditary optic neuropathy
10.1016/j.ajo.2022.11.026 · ExternalCitation · doi-reference
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production
10.1016/j.cell.2014.11.036 · ExternalCitation · doi-reference
HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis
10.1016/j.cell.2020.09.054 · ExternalCitation · doi-reference
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
10.1016/j.cell.2024.05.017 · ExternalCitation · doi-reference
Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy
10.1016/j.celrep.2022.111124 · ExternalCitation · doi-reference
Linezolid trough concentrations correlate with mitochondrial toxicity-related adverse events in the treatment of chronic extensively drug-resistant tuberculosis
10.1016/j.ebiom.2015.09.051 · ExternalCitation · doi-reference
Safety and efficacy of ixoberogene soroparvovec in neovascular age-related macular degeneration in the United States (OPTIC): a prospective, two-year, multicentre phase 1 study
10.1016/j.eclinm.2023.102394 · ExternalCitation · doi-reference
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
10.1016/j.immuni.2012.01.009 · ExternalCitation · doi-reference
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
10.1016/j.immuni.2022.06.007 · ExternalCitation · doi-reference
The clinical safety landscape for ocular AAV gene therapies: a systematic review and meta-analysis
10.1016/j.isci.2025.112265 · ExternalCitation · doi-reference
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis
10.1016/j.jbc.2025.110464 · ExternalCitation · doi-reference
LHON-MS - The overlaps in clinical and molecular features of both LHON and MS
10.1016/j.msard.2020.102322 · ExternalCitation · doi-reference
Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation
10.1016/j.nbd.2007.07.021 · ExternalCitation · doi-reference
The iron maiden: Oligodendroglial metabolic dysfunction in multiple sclerosis and mitochondrial signaling
10.1016/j.neubiorev.2024.105788 · ExternalCitation · doi-reference
Systemic and local immune responses to intraocular AAV vector administration in non-human primates
10.1016/j.omtm.2022.01.011 · ExternalCitation · doi-reference
Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
10.1016/j.preteyeres.2009.07.001 · ExternalCitation · doi-reference
Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies
10.1016/j.preteyeres.2010.11.002 · ExternalCitation · doi-reference
Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability
10.1016/j.preteyeres.2013.07.001 · ExternalCitation · doi-reference
Immune responses to retinal gene therapy using adeno-associated viral vectors - Implications for treatment success and safety
10.1016/j.preteyeres.2020.100915 · ExternalCitation · doi-reference
AAV vector immunogenicity in humans: a long journey to successful gene transfer
10.1016/j.ymthe.2019.12.010 · ExternalCitation · doi-reference
Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
10.1016/s0140-6736(17)31868-8 · ExternalCitation · doi-reference
Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study
10.1016/s0140-6736(24)00310-6 · ExternalCitation · doi-reference
Understanding the molecular basis and pathogenesis of hereditary optic neuropathies: towards improved diagnosis and management
10.1016/s1474-4422(22)00174-0 · ExternalCitation · doi-reference
A Toll-like receptor recognizes bacterial DNA
10.1038/35047123 · ExternalCitation · doi-reference
Phagocytosis and clearance of apoptotic cells is mediated by MER
10.1038/35075603 · ExternalCitation · doi-reference
Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways
10.1038/cddis.2015.364 · ExternalCitation · doi-reference
Patient care standards for primary mitochondrial disease: A consensus statement from the Mitochondrial Medicine Society
10.1038/gim.2017.107 · ExternalCitation · doi-reference
Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates
10.1038/gt.2014.115 · ExternalCitation · doi-reference
Circulating mitochondrial DAMPs cause inflammatory responses to injury
10.1038/nature08780 · ExternalCitation · doi-reference
The energetics of genome complexity
10.1038/nature09486 · ExternalCitation · doi-reference
A role for mitochondria in NLRP3 inflammasome activation
10.1038/nature09663 · ExternalCitation · doi-reference
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
10.1038/nature10992 · ExternalCitation · doi-reference
Mitochondrial DNA stress primes the antiviral innate immune response
10.1038/nature14156 · ExternalCitation · doi-reference
TAM receptors regulate multiple features of microglial physiology
10.1038/nature17630 · ExternalCitation · doi-reference
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
10.1038/ni.1980 · ExternalCitation · doi-reference
Microglial phagocytosis of live neurons
10.1038/nrn3710 · ExternalCitation · doi-reference
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
10.1038/s12276-023-00965-7 · ExternalCitation · doi-reference
Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
10.1038/s41419-023-06140-0 · ExternalCitation · doi-reference
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
10.1038/s41586-020-2076-4 · ExternalCitation · doi-reference
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway
10.1038/s41586-020-2078-2 · ExternalCitation · doi-reference
Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity
10.1038/s42255-021-00385-9 · ExternalCitation · doi-reference
Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis
10.1038/srep33249 · ExternalCitation · doi-reference
The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group
10.1056/nejm199312093292403 · ExternalCitation · doi-reference
Multiple sclerosis
10.1056/nejmra1401483 · ExternalCitation · doi-reference
Microglial cGAS-STING signaling underlies glaucoma pathogenesis
10.1073/pnas.2409493121 · ExternalCitation · doi-reference
Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries
10.1084/jem.20160412 · ExternalCitation · doi-reference
Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses
10.1086/595830 · ExternalCitation · doi-reference
Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors
10.1089/hum.2009.182 · ExternalCitation · doi-reference
Ocular inflammatory response to intravitreal injection of adeno-associated virus vector: relative contribution of genome and capsid
10.1089/hum.2019.144 · ExternalCitation · doi-reference
HLA-DR15 haplotype and multiple sclerosis: a HuGE review
10.1093/aje/kwk118 · ExternalCitation · doi-reference
Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation
10.1093/brain/115.4.979 · ExternalCitation · doi-reference
Randomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy
10.1093/brain/awac421 · ExternalCitation · doi-reference
Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines
10.1093/brain/awh258 · ExternalCitation · doi-reference
Gene-environment interactions in Leber hereditary optic neuropathy
10.1093/brain/awp158 · ExternalCitation · doi-reference
A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy
10.1093/brain/awr170 · ExternalCitation · doi-reference
Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats
10.1093/cvr/cvv137 · ExternalCitation · doi-reference
Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy
10.1093/hmg/ddac109 · ExternalCitation · doi-reference
Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse
10.1093/hmg/ddv045 · ExternalCitation · doi-reference
Mitophagy activation repairs Leber's hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survival
10.1093/hmg/ddy354 · ExternalCitation · doi-reference
Leber hereditary optic neuropathy: bridging the translational gap
10.1097/icu.0000000000000410 · ExternalCitation · doi-reference
Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation
10.1111/acel.13622 · ExternalCitation · doi-reference
Minocycline: far beyond an antibiotic
10.1111/bph.12139 · ExternalCitation · doi-reference
Review: Mitochondria and disease progression in multiple sclerosis
10.1111/j.1365-2990.2008.00987.x · ExternalCitation · doi-reference
Retinal gene therapy using epiretinal AAV-containing fibrin hydrogel implants
10.1126/sciadv.adv7922 · ExternalCitation · doi-reference
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
10.1126/science.1229963 · ExternalCitation · doi-reference
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