Research graph
References from Mapping organ-associated autoantigenic landscapes in systemic lupus erythematosus. Local targets link to admitted publications; unresolved targets remain external evidence.
Systemic lupus erythematosus
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Autoimmunity and organ damage in systemic lupus erythematosus
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Anti-DNA antibodies — quintessential biomarkers of SLE
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DNA hydrolyzing autoantibodies
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Cleavage of supercoiled plasmid DNA by autoantibody Fab fragment: Application of the flow linear dichroism technique
10.1073/pnas.92.1.254 · 1995 · External reference
Diagnostics of autoimmune neurodegeneration using fluorescent probing
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Systemic lupus erythematosus and antiphospholipid syndrome: Past, present, future
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Old and new autoantibodies in systemic lupus erythematosus
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Anti-C1q antibodies: A biomarker for diagnosis and management of lupus nephritis. A narrative review
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The autoantibody response to Ro/SSA in cutaneous lupus erythematosus
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Cutaneous involvement in systemic lupus erythematosus: A review for the rheumatologist
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The 2023 ACR/EULAR antiphospholipid syndrome classification criteria
10.1002/art.42624 · 2023 · External reference
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
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Endothelial dysfunction in systemic lupus erythematosus and systemic sclerosis: A common trigger for different microvascular diseases
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Recent insights into the genetic basis of systemic lupus erythematosus
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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
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Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B’-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity
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Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
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Defective B cell tolerance checkpoints in systemic lupus erythematosus
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Type I interferon in the pathogenesis of lupus
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Toll-like receptor signalling in B cells during systemic lupus erythematosus
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The role of defective clearance of apoptotic cells in systemic autoimmunity
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Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus
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Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
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Markers of NETosis in patients with systemic lupus erythematosus and antiphospholipid syndrome
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Exploring the role of neutrophil extracellular traps in systemic lupus erythematosus: A clinical case study and comprehensive review
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Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity
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Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
10.1038/ng.975 · 2011 · External reference
Monogenic lupus due to DNASE1L3 deficiency in a pediatric patient with urticarial rash, hypocomplementemia, pulmonary hemorrhage, and immune-complex glomerulonephritis
10.1016/j.ejmg.2021.104262 · 2021 · External reference
Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme
10.1016/j.cca.2009.06.022 · 2009 · External reference
Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus
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Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
10.1084/jem.20201138 · 2021 · External reference
Interferon pathway in SLE: One key to unlocking the mystery of the disease
10.1136/lupus-2018-000270 · 2019 · External reference
High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus
10.1186/s13075-019-1878-y · 2019 · External reference
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
10.1093/hmg/ddm359 · 2008 · External reference
Association of a functional IRF7 variant with systemic lupus erythematosus
10.1002/art.30193 · 2011 · External reference
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study
10.1016/j.ajhg.2012.02.023 · 2012 · External reference
Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery
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STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
10.1056/nejmoa073003 · 2007 · External reference
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
10.1086/428480 · 2005 · External reference
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
10.1038/ng.79 · 2008 · External reference
The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
10.1172/jci38010 · 2009 · External reference
Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus
10.1038/s41584-026-01365-7 · 2026 · External reference
Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis
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Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus
10.1080/08916930500484849 · 2006 · External reference
High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study
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Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification
10.1136/annrheumdis-2018-214125 · 2019 · External reference
Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis
10.1073/pnas.2519445123 · 2026 · External reference
Characterization of anti-EBNA-1 antibodies and exploration of their molecular mimicry potential in an EBV-infected Sjögren’s syndrome patient
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Evidence for charge-based mimicry in anti dsDNA antibody generation
10.1016/j.jaut.2022.102900 · 2022 · External reference
Epitope spreading in systemic lupus erythematosus: Identification of triggering peptide sequences
10.1002/art.10263 · 2002 · External reference
Development of autoantibodies before the clinical onset of systemic lupus erythematosus
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Recent advances in the diagnosis and management of neuropsychiatric lupus
10.1038/s41584-024-01163-z · 2024 · External reference
Binding of established antinuclear antibodies to neurons depends on tissue fixation and underlying autoantigens
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Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease
10.1002/art.27700 · 2010 · External reference
Association of anti-ribosomal P protein antibodies with neuropsychiatric and other manifestations of systemic lupus erythematosus
10.1007/s10067-008-0921-1 · 2008 · External reference
The clinical significance of antibodies to ribosomal protein P (a-Rib-P) in patients with systemic lupus erythematosus and antiphospholipid syndrome
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Beyond paraneoplastic neurological syndromes: Anti-neuronal antibodies in neuropsychiatric systemic lupus erythematosus
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Clinical significance of the determination of antibodies to the NR2 subunit of glutamate N-methyl-D-aspartate receptors (aNMDAR) in patients with systemic lupus erythematosus and antiphospholipid syndrome
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A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
10.1038/nm1101-1189 · 2001 · External reference
Clinical utility of circulating anti-N-methyl-d-aspartate receptor subunits NR2A/B antibody for the diagnosis of neuropsychiatric syndromes in systemic lupus erythematosus and Sjögren’s syndrome: An updated meta-analysis
10.1016/j.autrev.2016.12.002 · 2017 · External reference
Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus
10.1002/art.23399 · 2008 · External reference
Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression
10.1038/s41590-024-01772-6 · 2024 · External reference
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
10.1016/s1474-4422(08)70224-2 · 2008 · External reference
Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis
10.1038/s41594-024-01387-3 · 2024 · External reference
Role of microtubule-associated proteins in the control of microtubule assembly
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Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus
10.1002/art.20156 · 2004 · External reference
Anti-triosephosphate isomerase antibodies in cerebrospinal fluid are associated with neuropsychiatric lupus
10.1016/j.jneuroim.2006.09.003 · 2006 · External reference
Antibodies to triosephosphate isomerase in patients with neuropsychiatric lupus
10.1016/j.bbrc.2004.07.051 · 2004 · External reference
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases
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Antiganglioside antibodies in cerebrospinal fluid of children with neuropsychiatric lupus erythematosus
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Association of serum neurofilament light chain levels and neuropsychiatric manifestations in systemic lupus erythematosus
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Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study
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EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update
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KDIGO 2024 clinical practice guideline for the management of LUPUS NEPHRITIS
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Biomarkers in Lupus Nephritis: An evidence-based comprehensive review
10.3390/life15101497 · 2025 · External reference
Anti-dsDNA antibodies as a classification criterion and a diagnostic marker for systemic lupus erythematosus: critical remarks
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Utilization of biomarkers in lupus nephritis
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Lupus nephritis biomarkers: A critical review
10.3390/ijms25020805 · 2024 · External reference
Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus
10.1172/jci22820 · 2004 · External reference
Clinical and immunological biomarkers can identify proliferative changes and predict renal flares in lupus nephritis
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Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes
10.1172/jci21075 · 2004 · External reference
Autoantibodies against C1q as a diagnostic measure of lupus nephritis: Systematic review and meta-analysis
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C-reactive protein (CRP) and autoimmune disease: facts and conjectures
10.1080/17402520400001751 · 2004 · External reference
The role of anti-mCRP autoantibodies in lupus nephritis
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Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis
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Prognostic value of anti-CRP antibodies in lupus nephritis in long-term follow-up
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Combination of anti-C1qA08 and anti-mCRP a.a.35-47 antibodies is associated with renal prognosis of patients with lupus nephritis
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Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India
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Autoantibodies targeting Ficolin-2 in systemic lupus erythematosus patients with active nephritis
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Association between the presence of autoantibodies targeting Ficolin-3 and active nephritis in patients with systemic lupus erythematosus
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Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study
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Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies
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Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential
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Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
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Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis
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Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice
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Anti-heparan sulfate antibody and functional loss of glomerular heparan sulfate proteoglycans in lupus nephritis
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Glomerular autoimmune multicomponents of human lupus nephritis in vivo: α-enolase and annexin AI
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Glomerular autoimmune multicomponents of human lupus nephritis in vivo (2): planted antigens
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The extent of tubulointerstitial inflammation is an independent predictor of renal survival in lupus nephritis
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Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis
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Machine learning to quantify in situ humoral selection in human lupus tubulointerstitial inflammation
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The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
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Clinical aspects of cutaneous lupus erythematosus
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Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus
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Bullous systemic lupus erythematosus: a review and update to diagnosis and treatment
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Ro60-roles in RNA processing, inflammation, and rheumatic autoimmune diseases
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TRIM21/Ro52 - roles in innate immunity and autoimmune disease
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The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
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An overview of neonatal lupus with anti-Ro characteristics
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Significance of the anti-Ro (SS-A) antibody in evaluation of patients with cutaneous manifestations of a connective tissue disease
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Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value
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Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
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Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
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Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions
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Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice
10.1172/jci114052 · 1989 · External reference
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block
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The diagnostic benefit of antibodies against ribosomal proteins in systemic lupus erythematosus
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Focus on molecules: galectin-3
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Galectin-3 regulation of wound healing and fibrotic processes: insights for chronic skin wound therapeutics
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The regulation of inflammation by galectin-3
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Galectins in acute and chronic inflammation
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Expression of galectin-3 modulates T-cell growth and apoptosis
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Anti-galectin-3 antibodies induce skin vascular inflammation via promoting local production of IL-1β in systemic lupus erythematosus
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Autoantibodies to type VII collagen recognize epitopes in a fibronectin-like region of the noncollagenous (NC1) domain
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Detection of type VII collagen autoantibodies before the onset of bullous systemic lupus erythematosus
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Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen
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Vascular damage in systemic lupus erythematosus
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The double life of a B-1 cell: self-reactivity selects for protective effector functions
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Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development
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Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
10.1186/ar3193 · 2010 · External reference
Decreased levels of autoantibodies against apolipoprotein B-100 antigens are associated with cardiovascular disease in systemic lupus erythematosus
10.1111/cei.12651 · 2015 · External reference
Limited association between antibodies to oxidized low-density lipoprotein and vascular affection in patients with established systemic lupus erythematosus
10.3390/ijms24108987 · 2023 · External reference
Anti-lipoprotein lipase antibodies: a new player in the complex atherosclerotic process in systemic lupus erythematosus
10.1002/art.20630 · 2004 · External reference
Characterization of anti-endothelial cell antibodies in systemic lupus erythematosus (SLE)
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Clinical associations of anti-endothelial cell antibodies in patients with systemic lupus erythematosus
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Presence of complement-fixing anti-endothelial cell antibodies in systemic lupus erythematosus
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Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: the pathogenic and diagnostic implications
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Auto-antibodies to vascular endothelial cadherin in humans: association with autoimmune diseases
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Anti-endothelin receptor type A autoantibodies in systemic lupus erythematosus-associated pulmonary arterial hypertension
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Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2
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Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change
10.1182/blood-2005-05-1943 · 2006 · External reference
Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant
10.1002/1529-0131(200009)43:9<1982::aid-anr9>3.0.co;2-2 · 2000 · External reference
Anti-phosphatidylserine prothrombin antibodies as a predictor of the lupus anticoagulant in an all-comer population
10.1111/jth.15792 · 2022 · External reference
Anti-phosphatidylserine/prothrombin complex antibodies (aPS/PT) increase the risk for thrombosis based on lupus anticoagulant positivity
10.1016/j.clinbiochem.2022.12.007 · 2023 · External reference
Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome
10.1182/blood-2005-07-2636 · 2006 · External reference
Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis
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Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug
10.1182/blood-2009-04-213520 · 2010 · External reference
Annexin A5 in cardiovascular disease and systemic lupus erythematosus
10.1016/j.imbio.2005.10.007 · 2005 · External reference
Annexin A5 and anti-annexin antibodies in patients with systemic lupus erythematosus
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Lupus and the lungs: The assessment and management of pulmonary manifestations of systemic lupus erythematosus
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Pulmonary involvement in systemic lupus erythematosus: A potentially overlooked condition
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Diagnosis and management of lung involvement in systemic lupus erythematosus and Sjögren’s syndrome: a literature review
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Pulmonary complications of systemic lupus erythematosus
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Lupus pleuritis. Clinical features and pleural fluid characteristics with special reference to pleural fluid antinuclear antibodies
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ANA positivity and complement level in pleural fluid are potential diagnostic markers in discriminating lupus pleuritis from pleural effusion of other aetiologies
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Cardiovascular and pulmonary manifestations of systemic lupus erythematosus
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Diffuse alveolar hemorrhage and systemic lupus erythematosus. Clinical presentation, histology, survival, and outcome
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Alveolar hemorrhage in systemic lupus erythematosus: a cohort review
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Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis
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Association between antiphospholipid antibodies and diffuse alveolar haemorrhage risk in systemic lupus erythematosus: a systematic review and meta-analysis
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Association of anti-Ro52 autoantibody with interstitial lung disease in autoimmune diseases: a systematic review and meta-analysis
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Chronic interstitial lung disease associated with systemic lupus erythematosus: A multicentric study of 89 cases
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The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature
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Liver abnormalities in systemic lupus erythematosus: A prospective observational study
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Lupus hepatitis and autoimmune hepatitis (Lupoid hepatitis)
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Lupus hepatitis: an under-recognized disease feature associated with autoantibodies to ribosomal P
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Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells
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Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture
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Liver abnormalities and liver membrane autoantibodies in systemic lupus erythematosus
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Autoantibodies associated with primary biliary cholangitis are common among patients with systemic lupus erythematosus even in the absence of elevated liver enzymes
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Atypical p-ANCA in PSC and AIH: a hint toward a “leaky gut”
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Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus
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Antigen-specific immunotherapies for autoimmune disease
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Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus
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Application of BCMA CAR-T in systemic lupus erythematosus
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BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trial
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Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial
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Switchable targeting of solid tumors by BsCAR T cells
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In vivo CD19 CAR T-cell therapy for refractory systemic lupus erythematosus
10.1056/nejmc2509522 · 2025 · External reference
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