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References from Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
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Epidemiology of osteoarthritis
10.1016/j.joca.2021.04.020 · 2022 · External reference
Mitochondrial-ER stress crosstalk in osteoarthritis: From ageing-associated chondrocyte dysfunction to emerging therapeutics
10.1016/j.arr.2026.103252 · 2026 · External reference
Osteoarthritis: Epidemiology, diagnosis, and treatment
10.1002/mco2.70834 · 2026 · External reference
Advances in heterogeneity and classification of osteoarthritis
10.1038/s41413-026-00549-x · 2026 · External reference
Synovitis in osteoarthritis: current understanding with therapeutic implications
10.1186/s13075-017-1229-9 · 2017 · External reference
iMSC-derived extracellular vesicles and their miRNA cargo influence inflammation and oxidative damage in an in vitro osteoarthritis model
10.1038/s41419-026-09033-0 · 2026 · External reference
Skeletal muscle\‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)
10.3892/ijmm.2026.5903 · 2026 · External reference
Systemic implications of osteoarthritis: from local degeneration to systemic metabolic dysregulation
10.1186/s12967-026-08277-w · 2026 · External reference
Mammalian, plant, and gut microbiota-derived extracellular vesicles as emerging therapeutics for bone diseases
10.3389/fbioe.2026.1825617 · 2026 · External reference
Mesenchymal stem cell-derived exosomes and their therapeutic potential for osteoarthritis
10.3390/biology10040285 · 2021 · External reference
Cartilage repair by mesenchymal stem cell-derived exosomes: Preclinical and clinical trial update and perspectives
10.1007/5584_2021_625 · 2021 · External reference
Mesenchymal stem cell therapy in osteoarthritis and rheumatoid arthritis: A systematic review of exosomal microRNAs
10.2147/btt.s571417 · 2025 · External reference
Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage
10.1016/j.joca.2019.01.008 · 2019 · External reference
Current status and future perspectives of research on intra-articular drug delivery systems for osteoarthritis therapy
10.1016/j.actbio.2025.07.057 · 2025 · External reference
Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage
10.1080/10717544.2022.2048130 · 2022 · External reference
Nanomedicines targeting matrix metalloproteinases for osteoarthritis treatment
10.1016/j.ijpharm.2026.127064 · 2026 · External reference
Design strategies of biomaterial-based intra-articular drug delivery system for osteoarthritis therapy
10.1016/j.jconrel.2025.114496 · 2026 · External reference
Proteolysis of the pericellular matrix: Pinpointing the role and involvement of matrix metalloproteinases in early osteoarthritic remodeling
10.1016/j.actbio.2024.05.002 · 2024 · External reference
Smart nanodelivery systems for immunometabolic modulation in osteoarthritis
10.1002/exp2.70185 · 2026 · External reference
Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes
10.1186/ar4679 · 2014 · External reference
MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity
10.1016/j.biomaterials.2017.11.028 · 2018 · External reference
Investigation into the collection and isolation workflows of extracellular vesicles from tears
10.1002/jex2.70158 · 2026 · External reference
Tissue derived extracellular vesicles advance from disease mechanisms to clinical application
10.1186/s11671-026-04785-2 · 2026 · External reference
MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures
10.1007/s10522-026-10468-3 · 2026 · External reference
Systemic health impact of cancer-associated extracellular vesicles and particles
10.1038/s41568-026-00952-w · 2026 · External reference
Extracellular vesicles and particles impact the systemic landscape of cancer
10.15252/embj.2021109288 · 2022 · External reference
Beyond M1/M2: The pivotal role of macrophage metabolic reprogramming in chronic bone disease and targeted intervention
10.3390/ijms27093731 · 2026 · External reference
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
10.1038/ncomms15287 · 2017 · External reference
Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis
10.1186/s13075-024-03398-3 · 2024 · External reference
Comparative analysis of the therapeutic potential of extracellular vesicles secreted by aged and young bone marrow-derived mesenchymal stem cells in osteoarthritis pathogenesis
10.1111/cpr.13776 · 2025 · External reference
Extracellular vesicles from senescent mesenchymal stromal cells are defective and cannot prevent osteoarthritis
10.1186/s12951-024-02509-1 · 2024 · External reference
Hypoxic pretreatment of small extracellular vesicles mediates cartilage repair in osteoarthritis by delivering miR-216a-5p
10.1016/j.actbio.2020.12.034 · 2021 · External reference
Inflammatory fibroblast-like synoviocyte-derived exosomes aggravate osteoarthritis via enhancing macrophage glycolysis
10.1002/advs.202307338 · 2024 · External reference
Adipose mesenchymal stem cells derived exosomes ameliorates KOA cartilage damage and inflammation by activation of PINK1-mediated mitochondrial autophagy
10.21203/rs.3.rs-4554294/v1 · 2025 · External reference
A comparative study on the effect of exosomes secreted by mesenchymal stem cells derived from adipose and bone marrow tissues in the treatment of osteoarthritis-induced mouse model
10.1155/2021/9688138 · 2021 · External reference
Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis
10.1016/j.mtbio.2023.100813 · 2023 · External reference
Stem cell and cell-free strategies for osteoarthritis: Toward durable regenerative therapies
10.1155/sci/6699734 · 2026 · External reference
Mechanosensitive miRNAs in cartilage and subchondral bone remodeling: Emerging targets for osteoarthritis therapy
10.2147/jir.s529149 · 2025 · External reference
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression
10.1038/s41467-025-59861-5 · 2025 · External reference
Enhanced exosome biomanufacturing, precision isolation, and advanced engineering: toward mechanistic regulation and biomaterial integration for osteoarthritis therapy
10.1186/s12951-026-04710-w · 2026 · External reference
Spatial distribution of extracellular vesicles, autofluorescence and CD9 positivity around chondrocytes in the superficial layer of articular cartilage
10.1002/jev2.70183 · 2025 · External reference
Advancing osteoarthritis treatment: The therapeutic potential of mesenchymal stem cell-derived exosomes and biomaterial integration
10.3390/biomedicines12112478 · 2024 · External reference
Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis
10.1038/s41598-017-01905-y · 2017 · External reference
Identification of exosomal mRNA, lncRNA and circRNA signatures in an osteoarthritis synovial fluid-exosomal study
10.1016/j.yexcr.2021.112881 · 2022 · External reference
Therapeutic extracellular vesicles from synovial fibroblast-primed MSCs for osteoarthritis treatment
10.1002/adhm.71406 · 2026 · External reference
Synovial fibroblast extracellular vesicles induce inflammation via delivering miR-21-5p in osteoarthritis
10.3390/cells14070519 · 2025 · External reference
M2-sEVs-based immunotherapy for alleviation of osteoarthritis-related pain by regulating synovial macrophage NGF expression via the NOTCH pathway
10.1080/17435889.2026.2623975 · 2026 · External reference
NsPEFs-enriched ADSCs-EVs alleviate osteoarthritis via RSPO3-mediated dual pro-chondrogenic and pro-M2 macrophage properties
10.1016/j.bioactmat.2026.01.006 · 2026 · External reference
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
10.1038/s41413-025-00502-4 · 2026 · External reference
Exosomes in aging and age-related disorders: mechanisms, therapeutic potentials, and challenges
10.1186/s12967-025-07379-1 · 2025 · External reference
Hybrid extracellular vesicles drive irreversible mitochondria damage and TCA metabolite deficiency-related chondrocyte senescence
10.1016/j.xinn.2025.101247 · 2026 · External reference
Cellular senescence in skeletal diseases: a bibliometric analysis from 2007 to 2024
10.1016/j.exger.2025.112857 · 2025 · External reference
Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8
10.1111/jcmm.13808 · 2018 · External reference
Extracellular vesicles in bone aging: therapeutic strategies and applications
10.20517/evcna.2025.58 · 2025 · External reference
Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging
10.1007/s10787-025-02001-8 · 2025 · External reference
Exosomes in Osteoarthritis: Emerging Roles in Pathogenesis, Diagnosis, and Therapeutic Potential
10.2174/0113816128412201251125100451 · 2026 · External reference
Platelet-Derived Components for Skin and Bone Aging and Age-Associated Pathologies: Mechanisms, Bioengineering Strategies, and Clinical Translation
10.3390/molecules31050867 · 2026 · External reference
Extracellular vesicles from human adipose-derived stem cells relieve pain and inflammation in a rat model of knee osteoarthritis
10.1186/s13287-026-04932-7 · 2026 · External reference
Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression
10.3390/ijms241713414 · 2023 · External reference
FTO-overexpressing extracellular vesicles from BM-MSCs reverse cellular senescence and aging to ameliorate osteoarthritis by modulating METTL3/YTHDF2-mediated RNA m6A modifications
10.1016/j.ijbiomac.2024.134600 · 2024 · External reference
Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap
10.1002/jex2.70131 · 2026 · External reference
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis
10.18632/aging.202506 · 2021 · External reference
The Infrapatellar Fat Pad in Osteoarthritis: From Pathophysiology to a Novel Therapeutic Target
10.3390/ijms27052369 · 2026 · External reference
Functional Assessment of Genetically Modified Infrapatellar Fat Pad Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles (EVs): Potential Implications for Inflammation/Pain Reversal in Osteoarthritis
10.3390/cells14241952 · 2025 · External reference
Apoptotic extracellular vesicles act as master regulators of the bone healing niche
10.1186/s12951-026-04351-z · 2026 · External reference
Decoding the therapeutic potential of extracellular vesicles in osteoarthritis: from biomolecular composition to clinical translation
10.1097/js9.0000000000003219 · 2025 · External reference
Apoptotic extracellular vesicles: unveiling mechanisms, diverse functions, and biomedical implications
10.1007/s10495-026-02295-1 · 2026 · External reference
Bibliometric and LDA analysis of extracellular vesicles in osteoarthritis
10.1038/s41413-025-00484-3 · 2025 · External reference
Exosomal Interventions in Bone and Osteochondral Repair: Mechanisms and Outcomes
10.3390/ijms262211172 · 2025 · External reference
Mesenchymal stem cells and extracellular vesicles for knee osteoarthritis: clinical application, mechanism exploration and prospect
10.1186/s13287-025-04783-8 · 2025 · External reference
The crosstalk among macrophages, chondrocytes and mesenchymal stem cells in osteoarthritis: the role of extracellular vesicles
10.1186/s13287-025-04659-x · 2025 · External reference
Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis
10.1038/s41598-017-15376-8 · 2017 · External reference
Macrophage: A Potential Target on Cartilage Regeneration
10.3389/fimmu.2020.00111 · 2020 · External reference
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression
10.1002/ccs3.70008 · 2025 · External reference
Extracellular vesicles in osteoarthritis: mechanisms, therapeutic potential, and diagnostic applications
10.3389/fimmu.2025.1595095 · 2025 · External reference
BMSC-derived exosomal miR-27a-3p ameliorates osteoarthritis via dual regulation of chondrocyte protection and macrophage M1 polarization through TXNIP/NLRP3 signaling
10.1016/j.abb.2026.110902 · 2026 · External reference
New mesenchymal stem/stromal cell-based strategies for osteoarthritis treatment: targeting macrophage-mediated inflammation to restore joint homeostasis
10.1007/s00109-025-02547-8 · 2025 · External reference
Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis
10.21037/atm-22-3912 · 2022 · External reference
BMP-7 modified exosomes derived from synovial mesenchymal stem cells attenuate osteoarthritis by M2 polarization of macrophages
10.1016/j.heliyon.2023.e19934 · 2023 · External reference
The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan
10.1016/j.arr.2025.102823 · 2025 · External reference
Biomaterial Strategies in Osteoarthritis: New Insights Bridging Aging Phenotypes and Hypoxic Microenvironment Pathology
10.1002/adhm.202501570 · 2025 · External reference
Progress in antisenescence biomaterials for improved osteoarthritis therapy
10.1016/j.actbio.2025.08.044 · 2025 · External reference
Immunoregulatory orchestrations in osteoarthritis and mesenchymal stromal cells for therapy
10.1016/j.jot.2025.08.009 · 2025 · External reference
Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis
10.1002/advs.202413759 · 2025 · External reference
Circulating Metabolites Treat Human TMJ-OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis
10.2139/ssrn.5391649 · 2026 · External reference
Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges
10.1002/wnan.70031 · 2025 · External reference
Targeting osteoarthritis with small extracellular vesicle therapy: potential and perspectives
10.3389/fbioe.2025.1570526 · 2025 · External reference
Regulatory Challenges and Opportunities for Cell-Derived Extracellular Vesicles in Pharmaceutical Development: A European and Global Perspective
10.1002/jev2.70332 · 2026 · External reference
Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model
10.1186/s13287-024-03632-4 · 2024 · External reference
Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19
10.1016/j.jot.2020.03.005 · 2021 · External reference
Mechanical loading primes MSC-derived exosomes to promote cartilage repair
10.1016/j.bioactmat.2026.06.023 · 2026 · External reference
Chondroprotective effects of bone marrow mesenchymal stem cell-derived exosomes in osteoarthritis
10.1007/s10863-023-09991-6 · 2024 · External reference
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis
10.1016/j.bcp.2022.115343 · 2022 · External reference
Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2
10.1016/j.intimp.2023.110315 · 2023 · External reference
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
10.7150/thno.17133 · 2017 · External reference
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis
10.1016/j.biomaterials.2019.03.022 · 2019 · External reference
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage
10.1186/s13287-022-03005-9 · 2022 · External reference
Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
10.1186/s12951-024-03088-x · 2025 · External reference
Therapeutic efficacy of extracellular vesicles from hiPSC-derived MSCs in serum-containing and xeno-free media for osteoarthritis treatment
10.1186/s13287-025-04890-6 · 2026 · External reference
M2 macrophage-derived extracellular vesicles encapsulated in hyaluronic acid alleviate osteoarthritis by modulating macrophage polarization
10.1021/acsbiomaterials.3c01833 · 2024 · External reference
Exosomes and small extracellular vesicles as an alternative to mesenchymal stromal cell therapy in knee osteoarthritis: From biological rationale to clinical evidence
10.3390/ijms27093737 · 2026 · External reference
Functional nucleic acid hydrogels: Paving the way for next-generation bone and cartilage regeneration
10.1016/j.mtbio.2025.102708 · 2026 · External reference
MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis
10.1080/15384101.2018.1526603 · 2018 · External reference
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis
10.1080/15384101.2021.2019411 · 2022 · External reference
Bio-nanoparticles loaded with synovial-derived exosomes ameliorate osteoarthritis progression by modifying the oxidative microenvironment
10.1186/s12951-024-02538-w · 2024 · External reference
Mitochondrial transplantation for osteoarthritis: From molecular mechanisms to clinical translation
10.3389/fimmu.2026.1716906 · 2026 · External reference
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNA
10.1016/j.bioactmat.2025.11.046 · 2026 · External reference
ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis
10.1016/j.phrs.2024.107474 · 2024 · External reference
Autophagic LC3(+) calcified extracellular vesicles initiate cartilage calcification in osteoarthritis
10.1126/sciadv.abn1556 · 2022 · External reference
Extracellular vesicles and autophagy in osteoarthritis
10.1155/2016/2428915 · 2016 · External reference
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in osteoarthritis
10.1186/s12951-023-02086-9 · 2023 · External reference
Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism
10.1186/s13287-025-04412-4 · 2025 · External reference
A synergistic strategy involving reverse-adaptation and engineered MSC exosomes against ferroptosis in osteoarthritis
10.1016/j.biomaterials.2026.124024 · 2026 · External reference
Mapping the landscape of mesenchymal stem cell-derived extracellular vesicles: From bench to bedside
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Bridging osteoimmunology and regenerative therapy: The role of MSCs and extracellular vesicles
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Engineered exosome biomedical technologies for precision diagnosis and therapy in orthopedic diseases
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Research landscape of nanomaterials in osteoarthritis: A bibliometric and knowledge mapping analysis
10.1177/19373368261419658 · 2026 · External reference
Current status and future prospects of nanocarrier-mediated miRNA delivery for osteoarthritis therapy
10.3389/fmed.2025.1728944 · 2025 · External reference
Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration
10.1016/j.jconrel.2024.04.009 · 2024 · External reference
Chondrocyte-targeted delivery system of sortase A-engineered extracellular vesicles silencing MMP13 for osteoarthritis therapy
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Mechanisms and therapeutic potential of stem cell-derived extracellular vesicles as nanocarriers in musculoskeletal disorders
10.1002/biot.70172 · 2026 · External reference
Reversing the surface charge of MSC-derived small extracellular vesicles by ϵPL-PEG-DSPE for enhanced osteoarthritis treatment
10.1002/jev2.12160 · 2021 · External reference
Cartilage-targeting exosomes for delivery of receptor antagonist of interleukin-1 in osteoarthritis treatment
10.1016/j.joca.2025.02.785 · 2025 · External reference
Chondrocyte-targeted microRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy
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Interfacing extracellular vesicles with bioengineered materials for regenerative medicine
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Functional extracellular vesicles for regenerative medicine
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Biodistribution of therapeutic extracellular vesicles
10.20517/evcna.2023.12 · 2023 · External reference
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Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro
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Engineered MSC-exosomes delivering miRNAs for respiratory disease diagnostics and therapy: Opportunities and challenges
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Endocytosis of extracellular vesicles and release of their cargo from endosomes
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Endosomal escape of nucleic acids from extracellular vesicles mediates functional therapeutic delivery
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CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
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Equine osteoarthritis modifies fatty acid signatures in synovial fluid and its extracellular vesicles
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Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers
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OA foundations - experimental models of osteoarthritis
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The utility of animal models in understanding osteoarthritis (OA) pathogenesis - an update on the impact of genetically modified mice
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Immune system-related plasma pathogenic extracellular vesicle subpopulations predict osteoarthritis progression
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Macrophage membrane-coated nanoparticles in inflammatory diseases: from bioinspired design to translational potential
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