References

Chronic lymphocytic leukemia: 2025 update on the epidemiology, pathogenesis, diagnosis, and therapy

10.1002/ajh.27546 · 2025 · External reference

When and how long to treat chronic lymphocytic leukemia

10.1200/edbk-25-473656 · 2025 · External reference

Chronic lymphocytic leukaemia

10.1038/nrdp.2016.96 · 2017 · External reference

B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor

10.1146/annurev.immunol.21.120601.141018 · 2003 · External reference

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

10.1172/jci23409 · 2005 · External reference

Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells

10.2119/molmed.2011.00360 · 2011 · External reference

Clonal evolution in hematological Malignancies and therapeutic implications

10.1038/leu.2013.248 · 2014 · External reference

Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation

10.1038/leu.2014.158 · 2015 · External reference

Proliferating CLL cells express high levels of CXCR4 and CD5

10.1002/hem3.70064 · 2024 · External reference

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

10.1182/blood-2009-12-257758 · 2010 · External reference

B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities

10.1097/hs9.0000000000000722 · 2022 · External reference

Metabolic reprogramming in the CLL TME; potential for new therapeutic targets

10.1053/j.seminhematol.2024.02.001 · 2024 · External reference

T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production

10.1182/blood-2012-09-457531 · 2013 · External reference

Integrative perspectives on signaling, mechanics, and immune interactions in B-cell Malignancies

10.1002/1873-3468.70180 · 2025 · External reference

Immunomodulation and immune reconstitution in chronic lymphocytic leukemia

10.1053/j.seminhematol.2014.05.006 · 2014 · External reference

Unresolved reference

2020 · External reference

Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: a single institution study of 204 cases

10.1182/blood.v94.2.448.414k13_448_454 · 1999 · External reference

Chronic lymphoid leukemia in young subjects

1987 · External reference

Chronic lymphocytic leukemia in young (</= 55 years) patients: a comprehensive analysis of prognostic factors and outcomes

10.3324/haematol.2013.086066 · 2014 · External reference

Distinct age-related clinical features and risk assessment in Chinese with chronic lymphocytic leukemia

10.3389/fonc.2022.885150 · 2022 · External reference

Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States

10.1186/s12885-017-3176-x · 2017 · External reference

Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model

10.3324/haematol.2014.107326 · 2014 · External reference

Presenting features and prognosis of chronic lymphocytic leukemia in younger adults [see comments

10.1182/blood.v78.6.1545.bloodjournal7861545 · 1991 · External reference

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

10.1182/blood.v97.9.2777 · 2001 · External reference

TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells

10.4049/jimmunol.1403189 · 2015 · External reference

Guidelines for diagnosis, indications for treatment, response assessment and supportive management of chronic lymphocytic leukemia

10.1182/blood-2017-09-806398 · 2018 · External reference

Genomic aberrations and survival in chronic lymphocytic leukemia

10.3324/haematol.10720 · 2000 · External reference

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia

10.1182/blood.v94.6.1840 · 1999 · External reference

CENCAT enables immunometabolic profiling by measuring protein synthesis via bioorthogonal noncanonical amino acid tagging

10.1016/j.crmeth.2024.100883 · 2024 · External reference

Protocol for measuring cellular energetics through noncanonical amino acid tagging in human peripheral blood and murine tissue immune cells

10.1016/j.xpro.2025.104134 · 2025 · External reference

Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate

10.1016/j.ccr.2012.02.014 · 2012 · External reference

Glucose, glycolysis and lymphocyte responses

10.1016/j.molimm.2015.07.034 · 2015 · External reference

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus

10.1136/rmdopen-2024-004567 · 2024 · External reference

Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment

10.1182/blood.2021013990 · 2022 · External reference

IGHV unmutated and mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

10.1182/blood-2012-08-449744 · 2012 · External reference

Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia

10.1182/blood-2018-09-876292 · 2019 · External reference

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

10.1038/s41590-018-0156-5 · 2018 · External reference

Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells

10.4049/jimmunol.1302062 · 2014 · External reference

The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia

10.1182/blood-2010-05-284984 · 2011 · External reference

Treatment of younger patients with chronic lymphocytic leukemia

10.1182/asheducation-2010.1.82 · 2010 · External reference

Comparison of younger versus older B-cell chronic lymphocytic leukemia patients for clinical presentation and prognosis. A retrospective study of 53 cases

10.1111/j.1600-0609.1994.tb00648.x · 1994 · External reference

The metabolic signature of CLL: Enhanced glucose metabolism in a subset of high-risk CLL patients

10.1182/blood.v120.21.1785.1785 · 2012 · External reference

Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling

10.1182/blood-2013-10-532200 · 2015 · External reference

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

10.3324/haematol.2018.203067 · 2019 · External reference

The twilight of immunity: emerging concepts in aging of the immune system

10.1038/s41590-017-0006-x · 2018 · External reference

Hallmarks of aging: An expanding universe

10.1016/j.cell.2022.11.001 · 2023 · External reference

T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease

10.1038/s41375-020-0873-2 · 2020 · External reference

Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Emicro-TCL1 CLL mouse model

10.1182/blood-2015-01-622936 · 2015 · External reference

Control of chronic lymphocytic leukemia development by clonally-expanded CD8(+) T-cells that undergo functional exhaustion in secondary lymphoid tissues

10.1038/s41375-018-0250-6 · 2019 · External reference

Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression

10.1158/1078-0432.ccr-11-2630 · 2012 · External reference

Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target

10.1038/s41467-025-61822-x · 2025 · External reference

mixOmics: An R package for 'omics feature selection and multiple data integration

10.1371/journal.pcbi.1005752 · 2017 · External reference