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References from Phosphoregulation of interleukin-1 receptor-associated kinase 1 in inflammatory signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Irak: a kinase associated with the interleukin-1 receptor
10.1126/science.271.5252.1128 · 1996 · External reference
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (Irak) family members
10.1016/s1097-2765(03)00053-4 · 2003 · External reference
Irak-4: a novel member of the Irak family with the properties of an Irak-kinase
10.1073/pnas.082100399 · 2002 · External reference
Irak (Pelle) family member Irak-2 and Myd88 as proximal mediators of Il-1 signaling
10.1126/science.278.5343.1612 · 1997 · External reference
Irak-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (Irak) family
10.1074/jbc.274.27.19403 · 1999 · External reference
Crystal structure of human Irak1
10.1073/pnas.1714386114 · 2017 · External reference
Regulation of innate immune signaling by Irak proteins
10.3389/fimmu.2023.1133354 · 2023 · External reference
Dimeric structure of the pseudokinase Irak3 suggests an allosteric mechanism for negative regulation
10.1016/j.str.2020.11.004 · 2021 · External reference
Myd88: an adapter that recruits Irak to the Il-1 receptor complex
10.1016/s1074-7613(00)80402-1 · 1997 · External reference
Essential role of Irak-4 protein and its kinase activity in toll-like receptor-mediated immune responses but not in Tcr signaling
10.1084/jem.20061523 · 2007 · External reference
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
10.1074/jbc.m309251200 · 2004 · External reference
An oligomeric signaling platform formed by the toll-like receptor signal transducers Myd88 and Irak-4
10.1074/jbc.m109.022392 · 2009 · External reference
Intraperitoneal contrast material improves the Ct detection of peritoneal metastases
10.2214/ajr.157.1.2048534 · 1991 · External reference
Traf6 is a signal transducer for interleukin-1
10.1038/383443a0 · 1996 · External reference
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation
10.1074/jbc.272.34.21540 · 1997 · External reference
Interleukin-1 receptor-associated kinase-1 plays an essential role for toll-like receptor (Tlr)7- and Tlr9-mediated interferon-alpha induction
10.1084/jem.20042372 · 2005 · External reference
Irak1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression
10.1074/jbc.m410369200 · 2004 · External reference
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by Irak1 and Irak4
10.1073/pnas.0900774106 · 2009 · External reference
Spatiotemporal regulation of myd88-irf-7 signalling for robust type-I interferon induction
10.1038/nature03547 · 2005 · External reference
Phosphositeplus, 2014: mutations, ptms and recalibrations
10.1093/nar/gku1267 · 2015 · External reference
Networkin: a resource for exploring cellular phosphorylation networks
10.1093/nar/gkm902 · 2008 · External reference
Kinasephos: a web tool for identifying protein kinase-specific phosphorylation sites
10.1093/nar/gki471 · 2005 · External reference
Unresolved reference
2006 · External reference
Proteomics. Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
Translocation of the interleukin-1 receptor-associated kinase-1 (Irak-1) into the nucleus
10.1016/s0014-5793(00)01759-2 · 2000 · External reference
Irak signalling in cancer
10.1038/bjc.2014.513 · 2015 · External reference
Differential regulation of interleukin-1 receptor associated kinase 1 (Irak1) splice variants
10.1016/j.molimm.2006.03.021 · 2007 · External reference
Irak1: a critical signaling mediator of innate immunity
10.1016/j.cellsig.2007.08.009 · 2008 · External reference
Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase
10.1074/jbc.m205160200 · 2002 · External reference
Effects of Il-1 receptor-associated kinase (Irak) expression on Il-1 signaling are independent of its kinase activity
10.1016/s0014-5793(99)00322-1 · 1999 · External reference
Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappab
10.1042/bj3390227 · 1999 · External reference
Regulation of Irak-4 kinase activity via autophosphorylation within its activation loop
10.1016/j.bbrc.2006.11.068 · 2007 · External reference
Inhibition of interleukin 1 receptor/toll-like receptor signaling through the alternatively spliced, short form of Myd88 is due to its failure to recruit Irak-4
10.1084/jem.20021790 · 2003 · External reference
Il-1-induced Nfkappa B and c-Jun N-terminal kinase (Jnk) activation diverge at Il-1 receptor-associated kinase (Irak)
10.1073/pnas.071054198 · 2001 · External reference
Iraks: key regulatory kinases of innate immunity
10.2174/1568014053005345 · 2005 · External reference
The family of five: Tir-domain-containing adaptors in toll-like receptor signalling
10.1038/nri2079 · 2007 · External reference
Toll-like receptor signalling
10.1038/nri1391 · 2004 · External reference
Helical assembly in the Myd88-Irak4-Irak2 complex in Tlr/Il-1r signalling
10.1038/nature09121 · 2010 · External reference
Irak-mediated translocation of Traf6 and Tab2 in the interleukin-1-induced activation of Nfkappa B
10.1074/jbc.m102262200 · 2001 · External reference
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
10.1074/jbc.m609503200 · 2007 · External reference
Tak1 is a ubiquitin-dependent kinase of Mkk and Ikk
10.1038/35085597 · 2001 · External reference
Ubiquitin signalling in the Nf-kappab pathway
10.1038/ncb0805-758 · 2005 · External reference
Phosphorylation meets ubiquitination: the control of Nf-[kappa]B activity
10.1146/annurev.immunol.18.1.621 · 2000 · External reference
The nuclear factor Nf-kappab pathway in inflammation
10.1101/cshperspect.a001651 · 2009 · External reference
Nf-kappab-dependent induction of microrna Mir-146, an inhibitor targeted to signaling proteins of innate immune responses
10.1073/pnas.0605298103 · 2006 · External reference
Interleukin (Il)-1 receptor-associated kinase (Irak) requirement for optimal induction of multiple Il-1 signaling pathways and Il-6 production
10.1084/jem.187.12.2073 · 1998 · External reference
The interleukin-1 family: back to the future
10.1016/j.immuni.2013.11.010 · 2013 · External reference
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
10.1182/blood-2010-07-273417 · 2011 · External reference
The interleukin-1 receptor/toll-like receptor superfamily: signal transduction during inflammation and host defense
10.1126/stke.2003.171.re3 · 2003 · External reference
Signal transduction pathways activated by the Il-1 receptor/toll-like receptor superfamily
10.1007/978-3-642-59430-4_3 · 2002 · External reference
A noncanonical Irak4-Irak1 pathway counters DNA damage-induced apoptosis independently of Tlr/Il-1r signaling
10.1126/scisignal.adh3449 · 2023 · External reference
The involvement of the interleukin-1 receptor-associated kinases (Iraks) in cellular signaling networks controlling inflammation
10.1016/j.cyto.2007.12.012 · 2008 · External reference
Zc3h12a is an Rnase essential for controlling immune responses by regulating Mrna decay
10.1038/nature07924 · 2009 · External reference
The Ikappab kinase complex regulates the stability of cytokine-encoding Mrna induced by Tlr-Il-1r by controlling degradation of Regnase-1
10.1038/ni.2137 · 2011 · External reference
Viperin interacts with the kinase Irak1 and the E3 ubiquitin ligase Traf6, coupling innate immune signaling to antiviral ribonucleotide synthesis
10.1074/jbc.ra119.007719 · 2019 · External reference
The antiviral enzyme, Viperin, activates protein ubiquitination by the E3 ubiquitin ligase, Traf6
10.1021/jacs.1c01045 · 2021 · External reference
Il-1 receptor-associated kinase signaling and its role in inflammation, cancer progression, and therapy resistance
10.3389/fimmu.2014.00553 · 2014 · External reference
Regulation of Il-1 signaling through control of focal adhesion assembly
10.1096/fj.201700966r · 2018 · External reference
Irak-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing Nox-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes
10.1074/jbc.m109.059501 · 2009 · External reference
The Rock-Ezrin signaling pathway mediates Lps-induced cytokine production in pulmonary alveolar epithelial cells
10.1186/s12964-022-00879-3 · 2022 · External reference
Interleukin-1 receptor-associated kinase 1 in cancer metastasis and therapeutic resistance: Mechanistic insights and translational advances
10.3390/cells13201690 · 2024 · External reference
Interleukin-1 receptor-associated kinase-1 (Irak-1) functionally associates with Pkcepsilon and Vasp in the regulation of macrophage migration
10.1016/j.molimm.2009.12.004 · 2010 · External reference
Isomerase-catalyzed binding of interleukin-1 receptor-associated kinase 1 to the Evh1 domain of vasodilator-stimulated phosphoprotein
10.1021/bi500031e · 2014 · External reference
Protein phosphatase 2a and neutral sphingomyelinase 2 regulate Irak-1 protein ubiquitination and degradation in response to interleukin-1beta
10.1074/jbc.m111.238030 · 2011 · External reference
Protein phosphatase 2a interacts with and directly dephosphorylates Rela
10.1074/jbc.m106103200 · 2001 · External reference
Mechanism of Pp2a-mediated Ikk beta dephosphorylation: A systems biological approach
10.1186/1752-0509-3-71 · 2009 · External reference
Basal protein phosphatase 2a activity restrains cytokine expression: Role for Mapks and Tristetraprolin
10.1038/srep10063 · 2015 · External reference
Interleukin-1 (Il-1) receptor-associated kinase-dependent Il-1-induced signaling complexes phosphorylate Tak1 and Tab2 at the plasma membrane and activate Tak1 in the cytosol
10.1128/mcb.22.20.7158-7167.2002 · 2002 · External reference
Protein phosphatases in Tlr signaling
10.1186/s12964-021-00722-1 · 2021 · External reference
The mechanism of activation of Irak1 and Irak4 by interleukin-1 and toll-like receptor agonists
10.1042/bcj20170097 · 2017 · External reference
Phosphatase Shp-1 promotes Tlr- and Rig-I-activated production of type I interferon by inhibiting the kinase Irak1
10.1038/ni.1604 · 2008 · External reference
Leishmania-induced Irak-1 inactivation is mediated by Shp-1 interacting with an evolutionarily conserved Ktim motif
10.1371/journal.pntd.0000305 · 2008 · External reference
Beta-Trcp-mediated Irak1 degradation releases Tak1-Traf6 from the membrane to the cytosol for Tak1-dependent Nf-Kappab activation
10.1128/mcb.00722-12 · 2012 · External reference
Irak1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (Irak), mediates interleukin-1 signaling and has prolonged stability
10.1074/jbc.m103815200 · 2001 · External reference
A tissue-specific atlas of mouse protein phosphorylation and expression
10.1016/j.cell.2010.12.001 · 2010 · External reference
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
10.1016/j.cell.2006.09.026 · 2006 · External reference
The coming of age of phosphoproteomics--from large data sets to inference of protein functions
10.1074/mcp.r113.032862 · 2013 · External reference
Sequence coverage visualizer: A web application for protein sequence coverage 3d visualization
10.1021/acs.jproteome.2c00358 · 2023 · External reference
Trackviewer: A Bioconductor package for interactive and integrative visualization of multi-omics data
10.1038/s41592-019-0430-y · 2019 · External reference
A phosphoproteomic comparison of B-Rafv600e and Mkk1/2 inhibitors in melanoma cells
10.1074/mcp.m114.047233 · 2015 · External reference
Integrated proteomic analysis of post-translational modifications by serial enrichment
10.1038/nmeth.2518 · 2013 · External reference
Essential role for the prolyl isomerase Pin1 in toll-like receptor signaling and type I interferon-mediated immunity
10.1038/ni.2069 · 2011 · External reference
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
10.1126/scisignal.2000475 · 2010 · External reference
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
10.1016/j.molcel.2008.07.007 · 2008 · External reference
Proteogenomics connects somatic mutations to signalling in breast cancer
10.1038/nature18003 · 2016 · External reference
Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities
10.1002/ctm2.1179 · 2023 · External reference
Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
10.1016/j.celrep.2014.07.036 · 2014 · External reference
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells
10.1126/scisignal.2001497 · 2011 · External reference
Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation
10.1021/pr100637q · 2010 · External reference
Decreased Nad activates Stat3 and integrin pathways to drive epithelial-mesenchymal transition
10.1074/mcp.ra118.000882 · 2018 · External reference
Toward a comprehensive characterization of a human cancer cell phosphoproteome
10.1021/pr300630k · 2013 · External reference
Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression
10.1074/mcp.m900335-mcp200 · 2010 · External reference
Human Langerhans cells selectively activated via toll-like receptor 2 agonists acquire migratory and Cd4+T cell stimulatory capacity
10.1189/jlb.0807567 · 2008 · External reference
Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels
10.1074/mcp.m113.036392 · 2014 · External reference
Inhibition of interleukin-1beta -induced Nf-Kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of Myd88
10.1074/jbc.m106014200 · 2002 · External reference
The role of pattern-recognition receptors in innate immunity: Update on toll-like receptors
10.1038/ni.1863 · 2010 · External reference
Pattern recognition receptors and inflammation
10.1016/j.cell.2010.01.022 · 2010 · External reference
A polymorphism in the 3'-Utr of interleukin-1 receptor-associated kinase (Irak1), a target gene of Mir-146a, is associated with rheumatoid arthritis susceptibility
10.1016/j.jbspin.2010.05.013 · 2010 · External reference
Identification of Irak1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
10.1073/pnas.0901181106 · 2009 · External reference
Analysis of Tnfaip3, Irak1, and Tlr4 gene polymorphisms in patients with rheumatoid arthritis
10.1002/iid3.70344 · 2026 · External reference
Interleukin-1 receptor associated kinase 1 is a potential therapeutic target of anti-inflammatory therapy for systemic lupus erythematosus
10.1016/j.molimm.2017.03.018 · 2017 · External reference
Tlr2 signaling depletes Irak1 and inhibits induction of type I Ifn by Tlr7/9
10.4049/jimmunol.1102181 · 2012 · External reference
A20 in inflammation and autoimmunity
10.1016/j.it.2013.10.005 · 2014 · External reference
Micrornas, new effectors and regulators of Nf-Kappab
10.1111/j.1600-065x.2011.01089.x · 2012 · External reference
Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes
10.1038/s41375-018-0112-2 · 2018 · External reference
Differential Irak signaling in hematologic Malignancies
10.1016/j.exphem.2013.09.008 · 2013 · External reference
Targeting Irak1 as a therapeutic approach for myelodysplastic syndrome
10.1016/j.ccr.2013.05.006 · 2013 · External reference
Targeting Irak1 in T-cell acute lymphoblastic leukemia
10.18632/oncotarget.4150 · 2015 · External reference
Paralog-specific signaling by Irak1/4 maintains Myd88-independent functions in Mds/Aml
10.1182/blood.2022018718 · 2023 · External reference
Irak1 and Irak4 as emerging therapeutic targets in hematologic Malignancies
10.1097/moh.0000000000000693 · 2022 · External reference
Inhibition of interleukin-1 receptor-associated kinase 1 (Irak1) as a therapeutic strategy
10.18632/oncotarget.26058 · 2018 · External reference
Irak1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
10.1038/ncomms9746 · 2015 · External reference
Targeting an Ikbke cytokine network impairs triple-negative breast cancer growth
10.1172/jci75661 · 2014 · External reference
Tumour-associated macrophages as treatment targets in oncology
10.1038/nrclinonc.2016.217 · 2017 · External reference
Immunity, inflammation, and cancer
10.1016/j.cell.2010.01.025 · 2010 · External reference
Irak1 promotes gastric cancer progression by activating the Pi3k/Akt/Mtor pathway and inducing the M2 polarization of tumor-associated macrophages
10.1097/cm9.0000000000003944 · 2026 · External reference
Mir-146a-5p suppresses M1 polarization of tumor-associated macrophages via IRAK1/NF-kappaB signaling in colorectal polyps
10.1002/ags3.70232 · 2026 · External reference
K63-linked ubiquitination in kinase activation and cancer
10.3389/fonc.2012.00005 · 2012 · External reference
Lys63-linked polyubiquitination of Irak-1 is required for interleukin-1 receptor- and toll-like receptor-mediated Nf-Kappab activation
10.1128/mcb.02098-07 · 2008 · External reference
IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
10.1099/jgv.0.001858 · 2023 · External reference
Modulation of Irak enzymes as a therapeutic strategy against Sars-Cov-2 induced cytokine storm
10.1007/s10238-023-01064-7 · 2023 · External reference
Pacritinib inhibition of Irak1 blocks aberrant Tlr8 signalling by Sars-Cov-2 and Hiv-1-derived Rna
10.1159/000525292 · 2023 · External reference
Unraveling the role of Irak1 in autoimmune rheumatic diseases: Beyond genetic associations
10.1007/s11033-025-10473-8 · 2025 · External reference
Bap1 represses sequential activation of Iraks and Nf-Kappab signaling in pancreatic cancer
10.7150/ijbs.104977 · 2025 · External reference
Recent advances in IRAK1: Pharmacological and therapeutic aspects
10.3390/molecules29102226 · 2024 · External reference
Targeting irak1 for degradation with protacs
10.1021/acsmedchemlett.1c00244 · 2021 · External reference
Pacritinib vs best available therapy, including ruxolitinib, in patients with myelofibrosis: A randomized clinical trial
10.1001/jamaoncol.2017.5818 · 2018 · External reference
Discovery of a selective, covalent Irak1 inhibitor with antiproliferative activity in Myd88 mutated B-cell lymphoma
10.1021/acsmedchemlett.0c00378 · 2020 · External reference
Oncogenically active Myd88 mutations in human lymphoma
10.1038/nature09671 · 2011 · External reference
1,4-Naphthoquinone is a potent inhibitor of Irak1 kinases and the production of inflammatory cytokines in Thp-1 differentiated macrophages
10.1021/acsomega.1c03081 · 2021 · External reference
Role of quinones in toxicology
10.1021/tx9902082 · 2000 · External reference
Inhibition of IRAK1 is an effective therapy for autoimmune hypophysitis in mice
10.3390/ijms232314958 · 2022 · External reference
Thymoquinone: An Irak1 inhibitor with in vivo and in vitro anti-inflammatory activities
10.1038/srep42995 · 2017 · External reference
Mangiferin ameliorates colitis by inhibiting Irak1 phosphorylation in Nf-Kappab and Mapk pathways
10.1016/j.ejphar.2014.06.013 · 2014 · External reference
The dietary flavonoid kaempferol mediates anti-inflammatory responses via the Src, Syk, Irak1, and Irak4 molecular targets
10.1155/2015/904142 · 2015 · External reference
Micrornas: New regulators of immune cell development and function
10.1038/ni.f.209 · 2008 · External reference
Negative regulation of toll-like receptor-mediated signaling by Tollip
10.1074/jbc.m109537200 · 2002 · External reference
The Pellino family: Irak E3 ligases with emerging roles in innate immune signalling
10.1016/j.it.2008.10.001 · 2009 · External reference
Characterization of pellino2, a substrate of irak1 and irak4
10.1016/s0014-5793(03)00697-5 · 2003 · External reference
Socs-1 participates in negative regulation of Lps responses
10.1016/s1074-7613(02)00449-1 · 2002 · External reference
Discovery of highly potent and selective Irak1 degraders to probe scaffolding functions of Irak1 in Abc Dlbcl
10.1021/acs.jmedchem.1c00103 · 2021 · External reference
A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (Irak-1/4) delineates the distinct signaling roles of Irak-1/4 and the Tak1 kinase
10.1074/jbc.ra119.011857 · 2020 · External reference
Discovery of novel, potent, and selective Irak1 inhibitors as potential therapeutics for hepatocellular carcinoma
10.1021/acs.jmedchem.5c02988 · 2026 · External reference
Emerging interleukin-1 receptor-associated kinase 4 (Irak4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer
10.1016/j.apsb.2024.09.008 · 2024 · External reference
R289, a dual Irak 1/4 inhibitor, in patients with relapsed/refractory (R/R) lower-risk myelodysplastic syndrome (Lr-Mds): Initial results from a phase 1b study
10.1182/blood-2024-206096 · 2024 · External reference
Irak1/4/Pan-Flt3 kinase inhibitors with reduced Herg block as treatments for acute myeloid leukemia
10.1021/acsmedchemlett.5c00147 · 2025 · External reference
Targeting Il-1/Irak1/4 signaling in acute myeloid leukemia stem cells following treatment and relapse
10.1038/s41375-025-02816-y · 2026 · External reference
Kme-0584, a highly potent Irak1/Irak4/Panflt3 inhibitor, is a promising clinical candidate for hypomethylating agent plus venetoclax resistant Aml/Mds patients
10.1182/blood-2023-189899 · 2023 · External reference
Widening the bottleneck of phosphoproteomics: Evolving strategies for phosphopeptide enrichment
10.1002/mas.21636 · 2021 · External reference
Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells
10.1074/mcp.m112.017863 · 2012 · External reference
Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography
10.1074/mcp.m400077-mcp200 · 2005 · External reference
Why phosphoproteomics is still a challenge
10.1039/c5mb00024f · 2015 · External reference
Status of large-scale analysis of post-translational modifications by mass spectrometry
10.1074/mcp.o113.034181 · 2013 · External reference
Irak1 and Irak4 promote phosphorylation, ubiquitination, and degradation of Myd88 adaptor-like (Mal)
10.1074/jbc.m109.098137 · 2010 · External reference
Emerging precision drug delivery systems for controlled activation of the cgas-sting pathway in cancer, infection, and autoimmune disorders
10.1016/j.intimp.2025.116052 · 2026 · External reference
Benzimidazole derived non-cdn sting agonists: Mechanisms, sar evolution, and therapeutic potential - a comprehensive review
10.1016/j.bioorg.2026.109704 · 2026 · External reference
Neighboring phosphoser-pro motifs in the Undefined domain of Irak1 impart bivalent advantage for Pin1 binding
10.1111/febs.13943 · 2016 · External reference
Inhibition of Irak1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies
10.1172/jci75821 · 2015 · External reference
Essential role for Tirap in activation of the signalling cascade shared by Tlr2 and Tlr4
10.1038/nature01182 · 2002 · External reference
Mal (Myd88-adapter-like) is required for Toll-like receptor-4 signal transduction
10.1038/35092578 · 2001 · External reference
Tirap: An adapter molecule in the Toll signaling pathway
10.1038/ni0901-835 · 2001 · External reference
Shared principles in Nf-kappab signaling
10.1016/j.cell.2008.01.020 · 2008 · External reference
Ubiquitin-mediated activation of tak1 and ikk
10.1038/sj.onc.1210413 · 2007 · External reference
Quantifying ubiquitin signaling
10.1016/j.molcel.2015.02.020 · 2015 · External reference
De-ubiquitination and ubiquitin ligase domains of A20 downregulate Nf-kappab signalling
10.1038/nature02794 · 2004 · External reference
Regulation of type I interferon responses
10.1038/nri3581 · 2014 · External reference
The Jak-Stat pathway at twenty
10.1016/j.immuni.2012.03.013 · 2012 · External reference
A20-binding inhibitor of Nf-kappab activation 1 is a physiologic inhibitor of Nf-kappab: A molecular switch for inflammation and autoimmunity
10.1002/art.39245 · 2015 · External reference
Sigirr, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
10.1038/ni968 · 2003 · External reference
Irak-M is a negative regulator of Toll-like receptor signaling
10.1016/s0092-8674(02)00827-9 · 2002 · External reference
