Research graph
References from Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study
10.1016/s0140-6736(19)32989-7 · 2020 · External reference
Sepsis—pathophysiology and therapeutic concepts
10.3389/fmed.2021.628302 · 2021 · External reference
The third international consensus definitions for sepsis and septic shock (Sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
Sepsis epidemiology, definitions, scoring systems, and diagnostic markers
10.1097/cnq.0000000000000570 · 2025 · External reference
Epidemiology and costs of sepsis in the United States-an analysis based on timing of diagnosis and severity level
10.1097/ccm.0000000000003342 · 2018 · External reference
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
10.1007/s00134-021-06506-y · 2021 · External reference
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
10.1016/s1473-3099(13)70001-x · 2013 · External reference
Detection of early cytokine storm in patients with septic shock after abdominal surgery
10.2478/jtim-2020-0014 · 2020 · External reference
The immunology of sepsis
10.1016/j.immuni.2021.10.012 · 2021 · External reference
Reframing sepsis research through translational integrative models
10.1515/jtim-2026-0017 · 2026 · External reference
NETosis and pyroptosis of immune cells in sepsis
10.1515/jtim-2025-0035 · 2025 · External reference
Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis
10.3389/fimmu.2023.1130214 · 2023 · External reference
Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases
10.1007/s00134-025-08110-w · 2025 · External reference
Parallels between cancer and infectious disease
10.1056/nejmcibr1404664 · 2014 · External reference
Immunometabolic reprogramming in sepsis: mechanisms, clinical endotypes, and therapeutic opportunities
10.3389/fimmu.2026.1731995 · 2026 · External reference
A consensus blood transcriptomic framework for sepsis
10.1038/s41591-025-03964-5 · 2025 · External reference
An integrative model with HLA-DR, CD64, and PD-1 for the diagnostic and prognostic evaluation of sepsis
10.1002/iid3.1138 · 2024 · External reference
Time-dependent variation in immunoparalysis biomarkers among patients with sepsis and critical illness
10.3389/fimmu.2024.1498974 · 2024 · External reference
Fast implementation of DeLong’s algorithm for comparing the areas under correlated receiver operating characteristic curves
10.1109/lsp.2014.2337313 · 2014 · External reference
Sepsis endotypes defined by lymphocyte thresholds and inflammation inform precision immunomodulation
10.1002/mco2.70561 · 2026 · External reference
Unfractionated heparin improves coagulation in sepsis by protecting glycocalyx of endothelia cells through inhibiting heparinase
10.1515/jtim-2025-0094 · 2025 · External reference
Pyroptosis in sepsis: comprehensive analysis of research hotspots and core genes in 2022
10.3389/fmolb.2022.955991 · 2022 · External reference
The role of Gasdermin-D-mediated pryoptosis in organ injury and its therapeutic implications
10.1080/15476278.2023.2177484 · 2023 · External reference
Sepsis and septic shock
10.1056/nejmra2403213 · 2024 · External reference
The holistic view on perfusion monitoring in septic shock
10.1097/mcc.0b013e3283532c08 · 2012 · External reference
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis
10.2478/jtim-2024-0004 · 2024 · External reference
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
10.1007/s00134-007-0934-2 · 2008 · External reference
New-onset septic shock in the ImmunoSep trial
10.1186/s13054-026-05957-3 · 2026 · External reference