Research graph
References from Targeting innate immunity in cancer: mechanistic foundations, therapeutic vaccination, and clinical translation. Local targets link to admitted publications; unresolved targets remain external evidence.
Hallmarks of cancer: New dimensions
10.1158/2159-8290.cd-21-1059 · 2022 · External reference
Spatially organized multicellular immune hubs in human colorectal cancer
10.1016/j.cell.2021.08.003 · 2021 · External reference
Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity
10.1038/s43018-025-01039-5 · 2025 · External reference
Intratumoral dendritic cell-CD4(+) T helper cell niches enable CD8(+) T cell differentiation following PD-1 blockade in hepatocellular carcinoma
10.1038/s41591-023-02345-0 · 2023 · External reference
IGSF8 is an innate immune checkpoint and cancer immunotherapy target
10.1016/j.cell.2024.03.039 · 2024 · External reference
IL-15 superagonist NAI in BCG-unresponsive non-muscle-invasive bladder cancer
10.1056/evidoa2200167 · 2023 · External reference
Intratumoral oncolytic herpes virus G47Δ for residual or recurrent glioblastoma: A phase 2 trial
10.1038/s41591-022-01897-x · 2022 · External reference
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
10.1038/s43018-024-00760-x · 2024 · External reference
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
10.1038/s41586-025-09655-y · 2025 · External reference
NK cells mediate clearance of CD8(+) T cell-resistant tumors in response to STING agonists
10.1126/sciimmunol.aaz2738 · 2020 · External reference
CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin's lymphoma
10.1056/nejmoa1807315 · 2018 · External reference
Tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells to activate the NK cell response
10.1016/j.immuni.2018.09.016 · 2018 · External reference
Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections
10.1136/jitc-2022-005518 · 2023 · External reference
DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response
10.1038/s41467-022-34041-x · 2022 · External reference
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
10.1038/s41467-024-44789-z · 2024 · External reference
cDC1 prime and are licensed by CD4(+) T cells to induce anti-tumour immunity
10.1038/s41586-020-2611-3 · 2020 · External reference
A distinct stimulatory cDC1 subpopulation amplifies CD8(+) T cell responses in tumors for protective anti-cancer immunity
10.1016/j.ccell.2023.06.008 · 2023 · External reference
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control
10.1016/j.cell.2018.01.004 · 2018 · External reference
Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer
10.1016/j.cell.2022.02.021 · 2022 · External reference
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
10.1016/j.cell.2023.03.007 · 2023 · External reference
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
10.1126/scitranslmed.abm1375 · 2022 · External reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment
10.1172/jci.insight.150735 · 2021 · External reference
Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
10.1016/j.immuni.2024.04.006 · 2024 · External reference
Spatially segregated macrophage populations predict distinct outcomes in colon cancer
10.1158/2159-8290.cd-23-1300 · 2024 · External reference
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
10.1038/s41556-018-0256-3 · 2019 · External reference
Non-cell-autonomous cancer progression from chromosomal instability
10.1038/s41586-023-06464-z · 2023 · External reference
Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors
10.1038/s41591-020-0856-x · 2020 · External reference
Single-cell and spatial profiling identify three response trajectories to pembrolizumab and radiation therapy in triple negative breast cancer
10.1016/j.ccell.2023.12.012 · 2024 · External reference
Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma
10.1126/scitranslmed.abn6758 · 2023 · External reference
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity
10.1016/j.ccell.2024.10.014 · 2024 · External reference
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma
10.1038/s41586-023-05880-5 · 2023 · External reference
A conserved dendritic-cell regulatory program limits antitumour immunity
10.1038/s41586-020-2134-y · 2020 · External reference
Unleashing type-2 dendritic cells to drive protective antitumor CD4(+) T cell immunity
10.1016/j.cell.2019.02.005 · 2019 · External reference
Overcoming PD-1 blockade resistance with CpG-A toll-like receptor 9 agonist vidutolimod in patients with metastatic melanoma
10.1158/2159-8290.cd-21-0425 · 2021 · External reference
Neoadjuvant vidutolimod and nivolumab in high-risk resectable melanoma: A prospective phase II trial
10.1016/j.ccell.2024.10.007 · 2024 · External reference
Transcriptional and functional analysis of CD1c(+) human dendritic cells identifies a CD163(+) subset priming CD8(+)CD103(+) T cells
10.1016/j.immuni.2020.06.002 · 2020 · External reference
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
10.1038/s43018-023-00668-y · 2024 · External reference
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer
10.1016/j.immuni.2022.10.002 · 2022 · External reference
Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape
10.1126/science.adg1955 · 2024 · External reference
Visualizing synaptic transfer of tumor antigens among dendritic cells
10.1016/j.ccell.2020.05.002 · 2020 · External reference
Tumour-retained activated CCR7(+) dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity
10.1038/s41467-024-44787-1 · 2024 · External reference
Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4(+) T cell response
10.1126/sciimmunol.adq8843 · 2024 · External reference
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination
10.1038/s41591-019-0410-x · 2019 · External reference
Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer
10.1038/s41467-022-34428-w · 2022 · External reference
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade
10.1038/s43018-025-00929-y · 2025 · External reference
Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity
10.1016/j.ccell.2024.06.014 · 2024 · External reference
Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum
10.1016/j.xcrm.2024.101516 · 2024 · External reference
Adjuvant dendritic cell therapy in stage IIIB/C melanoma: The MIND-DC randomized phase III trial
10.1038/s41467-024-45358-0 · 2024 · External reference
Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets
10.1038/s43018-020-00143-y · 2020 · External reference
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial
10.1038/s41591-022-01829-9 · 2022 · External reference
Lymph node and tumor-associated PD-L1(+) macrophages antagonize dendritic cell vaccines by suppressing CD8(+) T cells
10.1016/j.xcrm.2023.101377 · 2024 · External reference
Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice
10.1038/s41467-025-60769-3 · 2025 · External reference
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
10.1038/s41467-022-31218-2 · 2022 · External reference
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
10.1038/s41586-021-03651-8 · 2021 · External reference
Timing and location dictate monocyte fate and their transition to tumor-associated macrophages
10.1126/sciimmunol.adk3981 · 2024 · External reference
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
10.1016/j.cell.2021.01.010 · 2021 · External reference
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers
10.1126/science.ade2292 · 2023 · External reference
Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis
10.1084/jem.20240957 · 2025 · External reference
Spatiotemporal co-dependency between macrophages and exhausted CD8(+) T cells in cancer
10.1016/j.ccell.2022.05.004 · 2022 · External reference
Single-cell and spatial analysis reveal interaction of FAP(+) fibroblasts and SPP1(+) macrophages in colorectal cancer
10.1038/s41467-022-29366-6 · 2022 · External reference
Tumor-associated macrophages restrict CD8(+) T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment
10.1038/s43018-024-00775-4 · 2024 · External reference
Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted
10.1126/scitranslmed.adk1168 · 2024 · External reference
Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells
10.1038/s41467-022-28076-3 · 2022 · External reference
Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination
10.1038/s41467-021-27308-2 · 2021 · External reference
Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial
10.1016/j.xcrm.2023.101307 · 2023 · External reference
Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial
10.1016/s0140-6736(19)30764-0 · 2019 · External reference
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
10.1126/science.aad3018 · 2016 · External reference
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
10.1016/s1470-2045(16)00078-4 · 2016 · External reference
TREM2 modulation remodels the tumor myeloid landscape enhancing anti-PD-1 immunotherapy
10.1016/j.cell.2020.07.013 · 2020 · External reference
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study
10.1016/s1470-2045(21)00584-2 · 2021 · External reference
Neoadjuvant selicrelumab, an agonist CD40 antibody, induces changes in the tumor microenvironment in patients with resectable pancreatic cancer
10.1158/1078-0432.ccr-21-1047 · 2021 · External reference
Combination of the STING agonist MIW815 (ADU-S100) and PD-1 inhibitor spartalizumab in advanced/metastatic solid tumors or lymphomas: an open-label, multicenter, phase ib study
10.1158/1078-0432.ccr-22-2235 · 2023 · External reference
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy
10.1038/s41551-018-0236-8 · 2018 · External reference
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases
10.1016/j.ccell.2023.09.014 · 2023 · External reference
Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
10.1016/j.stem.2024.03.018 · 2024 · External reference
CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial
10.1038/s41591-025-03495-z · 2025 · External reference
Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells
10.1016/j.cell.2018.10.014 · 2018 · External reference
Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity
10.1126/science.aao0505 · 2018 · External reference
NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing
10.1084/jem.20181454 · 2019 · External reference
Efficacy of margetuximab vs trastuzumab in patients with pretreated ERBB2-positive advanced breast cancer: A phase 3 randomized clinical trial
10.1001/jamaoncol.2020.7932 · 2021 · External reference
Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial
10.1038/s41591-025-03640-8 · 2025 · External reference
A pan-cancer single-cell panorama of human natural killer cells
10.1016/j.cell.2023.07.034 · 2023 · External reference
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
10.1038/s41590-024-01884-z · 2024 · External reference
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
10.1038/s41586-019-1410-1 · 2019 · External reference
De novo design of potent and selective mimics of IL-2 and IL-15
10.1038/s41586-018-0830-7 · 2019 · External reference
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial
10.1016/s1470-2045(18)30148-7 · 2018 · External reference
Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity
10.1038/s41590-018-0132-0 · 2018 · External reference
Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
10.1038/s41587-022-01626-2 · 2023 · External reference
Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
10.1126/scitranslmed.aaf2341 · 2016 · External reference
Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant
10.1182/blood.2021013972 · 2022 · External reference
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
10.1016/j.stem.2020.05.008 · 2020 · External reference
Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial
10.1016/s0140-6736(24)02462-0 · 2025 · External reference
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19(+) B cell tumors: a phase 1/2 trial
10.1038/s41591-023-02785-8 · 2024 · External reference
Safety and feasibility of 4-1BB co-stimulated CD19-specific CAR-NK cell therapy in refractory/relapsed large B cell lymphoma: a phase 1 trial
10.1038/s43018-025-00940-3 · 2025 · External reference
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
10.1016/j.ccell.2024.07.007 · 2024 · External reference
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression
10.1038/s41590-025-02103-z · 2025 · External reference
Deterministic reprogramming of neutrophils within tumors
10.1126/science.adf6493 · 2024 · External reference
Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment
10.1136/gutjnl-2021-326070 · 2023 · External reference
A neutrophil response linked to tumor control in immunotherapy
10.1016/j.cell.2023.02.032 · 2023 · External reference
Interferon-stimulated neutrophils as a predictor of immunotherapy response
10.1016/j.ccell.2023.12.005 · 2024 · External reference
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis
10.1126/sciimmunol.add5204 · 2023 · External reference
Neutrophil-activating therapy for the treatment of cancer
10.1016/j.ccell.2023.01.002 · 2023 · External reference
CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity
10.1016/j.immuni.2020.03.001 · 2020 · External reference
Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer
10.1084/jem.20190354 · 2020 · External reference
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25
10.1038/s41586-020-2394-6 · 2020 · External reference
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation
10.1016/j.ccell.2023.03.008 · 2023 · External reference
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
10.1016/j.ccell.2025.06.007 · 2025 · External reference
Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models
10.1186/s13046-024-03240-3 · 2024 · External reference
Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment
10.1038/s41416-024-02710-x · 2024 · External reference
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance
10.1038/s41586-023-06696-z · 2023 · External reference
CXCR2 antagonist navarixin in combination with pembrolizumab in select advanced solid tumors: a phase 2 randomized trial
10.1007/s10637-023-01410-2 · 2024 · External reference
A novel peptidylarginine deiminase 4 (PAD4) inhibitor BMS-P5 blocks formation of neutrophil extracellular traps and delays progression of multiple myeloma
10.1158/1535-7163.mct-19-1020 · 2020 · External reference
Localized degradation of neutrophil extracellular traps by photoregulated enzyme delivery for cancer immunotherapy and metastasis suppression
10.1021/acsnano.1c09318 · 2022 · External reference
Cell membrane derived liposomes loaded with DNase I target neutrophil extracellular traps which inhibits colorectal cancer liver metastases
10.1016/j.jconrel.2023.04.013 · 2023 · External reference
Complex I inhibition combined with TLR activation in the breast tumor microenvironment educates cytotoxic neutrophils
10.1126/sciadv.adu5915 · 2025 · External reference
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy
10.1038/s41551-024-01180-z · 2024 · External reference
Neutrophil-mediated delivery of nanocrystal drugs via photoinduced inflammation enhances cancer therapy
10.1021/acsnano.3c02013 · 2023 · External reference
Controlled inflammation drives neutrophil-mediated precision drug delivery in heterogeneous tumors
10.1002/advs.202411307 · 2025 · External reference
Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens
10.1126/sciadv.abj2101 · 2021 · External reference
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
10.1038/ncomms12150 · 2016 · External reference
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
10.1126/sciimmunol.aay6017 · 2020 · External reference
Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors
10.1016/j.xcrm.2023.101380 · 2024 · External reference
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice
10.1084/jem.20201803 · 2021 · External reference
Distinct myeloid-derived suppressor cell populations in human glioblastoma
10.1126/science.abm5214 · 2025 · External reference
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
10.1158/0008-5472.can-08-1921 · 2009 · External reference
Nitric oxide mediated inhibition of antigen presentation from DCs to CD4(+) T cells in cancer and measurement of STAT1 nitration
10.1038/s41598-017-14970-0 · 2017 · External reference
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
10.1084/jem.20101956 · 2011 · External reference
Impact of surgery-induced myeloid-derived suppressor cells and the NOX2/ROS axis on postoperative survival in human pancreatic cancer
10.1158/2767-9764.crc-23-0447 · 2024 · External reference
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal
10.1038/s41590-020-0666-9 · 2020 · External reference
Monocytic MDSCs exhibit superior immune suppression via adenosine and depletion of adenosine improves efficacy of immunotherapy
10.1126/sciadv.adg3736 · 2023 · External reference
Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer
10.1158/0008-5472.can-09-1882 · 2010 · External reference
c-Rel is a myeloid checkpoint for cancer immunotherapy
10.1038/s43018-020-0061-3 · 2020 · External reference
LXR/ApoE activation restricts innate immune suppression in cancer
10.1016/j.cell.2017.12.026 · 2018 · External reference
Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy
10.1126/scitranslmed.3007974 · 2014 · External reference
Yeast-derived particulate β-glucan treatment subverts the suppression of myeloid-derived suppressor cells (MDSC) by inducing polymorphonuclear MDSC apoptosis and monocytic MDSC differentiation to APC in cancer
10.4049/jimmunol.1501853 · 2016 · External reference
Targeting MDSC differentiation using ATRA: a phase I/II clinical trial combining pembrolizumab and all-trans retinoic acid for metastatic melanoma
10.1158/1078-0432.ccr-22-2495 · 2023 · External reference
Fatty acid transport protein 2 reprograms neutrophils in cancer
10.1038/s41586-019-1118-2 · 2019 · External reference
Entinostat neutralizes myeloid-derived suppressor cells and enhances the antitumor effect of PD-1 inhibition in murine models of lung and renal cell carcinoma
10.1158/1078-0432.ccr-17-0741 · 2017 · External reference
Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice
10.1038/nm.3560 · 2014 · External reference
Selective targeting of myeloid-derived suppressor cells in cancer patients using DS-8273a, an agonistic TRAIL-R2 antibody
10.1158/1078-0432.ccr-16-1784 · 2017 · External reference
A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma
10.1093/noajnl/vdad088 · 2023 · External reference
Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer
10.1007/s00262-013-1396-8 · 2013 · External reference
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine Malignancies
10.1038/s41590-022-01213-2 · 2022 · External reference
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
10.1038/s41586-020-2015-4 · 2020 · External reference
PPARγ drives IL-33-dependent ILC2 pro-tumoral functions
10.1038/s41467-021-22764-2 · 2021 · External reference
Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
10.1016/j.cell.2023.12.015 · 2024 · External reference
Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer
10.1016/j.cell.2021.07.029 · 2021 · External reference
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
10.1038/s41586-024-08426-5 · 2025 · External reference
Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells
10.1126/science.aay5516 · 2020 · External reference
Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer
10.1136/jitc-2019-000316 · 2020 · External reference
A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological Malignancies
10.1016/j.xcrm.2023.100961 · 2023 · External reference
Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial
10.1038/s41467-025-66801-w · 2025 · External reference
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results
10.1038/s41591-023-02363-y · 2023 · External reference
Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer
10.1038/s41423-020-0515-7 · 2021 · External reference
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
10.1038/s41467-019-10676-1 · 2019 · External reference
Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
10.1038/s41467-017-00327-8 · 2017 · External reference
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
10.1038/s41467-020-20600-7 · 2021 · External reference
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18
10.1038/s41467-025-61324-w · 2025 · External reference
Mobilizing antigen-presenting mast cells in anti-PD-1-refractory triple-negative breast cancer: a phase 2 trial
10.1038/s41591-025-03776-7 · 2025 · External reference
Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells
10.1038/ni.3159 · 2015 · External reference
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
10.1038/s41590-019-0321-5 · 2019 · External reference
Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth
10.1126/sciadv.abb5943 · 2021 · External reference
IL-5-producing CD4(+) T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
10.1016/j.ccell.2022.11.014 · 2023 · External reference
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis
10.1016/j.cell.2024.09.016 · 2024 · External reference
Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases
10.1016/j.ccell.2025.01.008 · 2025 · External reference
In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis
10.1172/jci157937 · 2023 · External reference
TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in Malignant glioma: a randomized phase II trial
10.1038/s41467-024-48073-y · 2024 · External reference
Randomized, open-label, phase III study of Tilsotolimod in combination with Ipilimumab versus Ipilimumab alone in patients with advanced refractory melanoma (ILLUMINATE-301)
10.1200/jco.24.00727 · 2025 · External reference
Toll like receptor 7 expressed by Malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells
10.1080/2162402x.2018.1505174 · 2019 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
10.1016/j.immuni.2014.10.017 · 2014 · External reference
An orally available non-nucleotide STING agonist with antitumor activity
10.1126/science.aba6098 · 2020 · External reference
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
10.1038/s41563-022-01251-z · 2022 · External reference
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer
10.1073/pnas.2313693120 · 2023 · External reference
RIG-I activation is critical for responsiveness to checkpoint blockade
10.1126/sciimmunol.aau8943 · 2019 · External reference
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses
10.1084/jem.20190801 · 2019 · External reference
Nanoparticle retinoic acid-inducible gene I agonist for cancer immunotherapy
10.1021/acsnano.3c06225 · 2024 · External reference
Treatment with a retinoic acid-inducible gene I (RIG-I) agonist as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: results from two phase 1 studies
10.1007/s00262-022-03191-8 · 2022 · External reference
Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinoma
10.1136/jitc-2024-009352 · 2025 · External reference
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
10.1038/s41586-020-2071-9 · 2020 · External reference
The AIM2 and NLRP3 inflammasomes trigger IL-1-mediated antitumor effects during radiation
10.1126/sciimmunol.abc6998 · 2021 · External reference
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10.1172/jci133055 · 2020 · External reference
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10.1016/j.immuni.2021.07.002 · 2021 · External reference
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10.1038/s41586-020-2422-6 · 2020 · External reference
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10.1200/jco.23.00980 · 2024 · External reference
The role of the complement system in cancer
10.1172/jci90962 · 2017 · External reference
Modulation of the antitumor immune response by complement
10.1038/ni.1655 · 2008 · External reference
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10.1158/2326-6066.cir-18-0891 · 2019 · External reference
Obstacles to cancer immunotherapy: expression of membrane complement regulatory proteins (mCRPs) in tumors
10.1016/s0161-5890(03)00112-3 · 2003 · External reference
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression
10.4049/jimmunol.1201654 · 2012 · External reference
Compendium of current complement therapeutics
10.1016/j.molimm.2019.07.030 · 2019 · External reference
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10.1038/s41586-026-10353-6 · 2026 · External reference
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10.1038/nature18300 · 2016 · External reference
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10.1016/s0140-6736(23)02268-7 · 2024 · External reference
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10.1038/s41587-024-02420-y · 2025 · External reference
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10.1016/j.annonc.2023.07.006 · 2023 · External reference
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10.1016/j.cell.2020.09.015 · 2020 · External reference
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10.1038/s41586-022-04735-9 · 2022 · External reference
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10.1038/s41591-025-03876-4 · 2025 · External reference
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10.1001/jamaoncol.2022.5370 · 2023 · External reference
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10.1038/s41467-023-39196-9 · 2023 · External reference
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10.1038/s41586-024-08508-4 · 2025 · External reference
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10.1038/s41591-024-02894-y · 2024 · External reference
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10.1038/s41591-022-01937-6 · 2022 · External reference
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10.1038/s41586-025-08758-w · 2025 · External reference
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10.1016/j.ebiom.2020.102922 · 2020 · External reference
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10.1136/jitc-2020-000691 · 2020 · External reference
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10.1159/000533650 · 2024 · External reference
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10.1200/jco.18.02031 · 2019 · External reference
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10.1016/s1470-2045(17)30517-x · 2017 · External reference
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10.1002/cncr.32445 · 2019 · External reference
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10.1001/jamaoncol.2020.7932 · ExternalCitation · doi-reference
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10.1001/jamaoncol.2022.5370 · ExternalCitation · doi-reference
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