Research graph
References from Immunometabolic reprogramming in osteoporosis–osteoarthritis comorbidity: from inflammaging to osteochondral unit degeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Osteopontin, a bridge links osteoarthritis and osteoporosis
10.3389/fendo.2022.1012508 · 2022 · External reference
Trend of incidence rate of age-related diseases: results from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database in Korea: a cross- sectional study
10.1186/s12877-023-04578-7 · 2023 · External reference
Denosumab-functionalized nanoparticles target macrophages to mitigate age-related osteoarthritis and osteoporosis
10.1039/d5tb01165e · 2026 · External reference
Targeting osteoporosis-osteoarthritis comorbidity: Multi-omics identification of SON and exploration of therapeutic agents
10.3390/ijms27114905 · 2026 · External reference
Gut microbiota and osteoarthritis: From pathogenesis to novel therapeutic opportunities
10.1142/s0192415x2550003x · 2025 · External reference
Exercise to mend aged-tissue crosstalk in bone targeting osteoporosis & osteoarthritis
10.1016/j.semcdb.2021.08.011 · 2022 · External reference
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
10.1016/j.freeradbiomed.2021.05.003 · 2021 · External reference
Exploring senescence markers as potential drivers of osteoarthritis pain in aging adults
10.1016/j.exger.2025.112950 · 2025 · External reference
Role of the osteochondral unit in the pathogenesis of osteoarthritis: Focus on the potential use of clodronate
10.2174/1573397117666211006094117 · 2022 · External reference
Imaging of bone and joints in vivo: pathological osteoclastogenesis in arthritis
10.1093/intimm/dxab047 · 2021 · External reference
Role of masticatory force in modulating jawbone immunity and bone homeostasis: A review
10.3390/ijms26104478 · 2025 · External reference
Pro-osteogenic and anti-inflammatory synergistic effect of orthosilicic acid, vitamin K2, curcumin, polydatin and quercetin combination in young and senescent bone marrow-derived mesenchymal stromal cells
10.3390/ijms24108820 · 2023 · External reference
Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet
10.1038/s41598-024-82414-7 · 2024 · External reference
Re-thinking the bone remodeling cycle mechanism and the origin of bone loss
10.1016/j.bone.2020.115628 · 2020 · External reference
Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast-osteoblast communication and potential clinical implications
10.7554/elife.95083 · 2024 · External reference
Mechanobiological response of osteocyte TRPV4 base on the piezoelectricity of bone matrix
10.1007/s10439-026-04086-w · 2026 · External reference
Dual-function hydrogel microspheres coordinate immune regulation and osteogenesis coupling to promote femoral regeneration
10.1039/d5tb02399h · 2026 · External reference
Skeletal aging and osteoporosis: Mechanisms and therapeutics
10.3390/ijms22073553 · 2021 · External reference
Perspectives on intrinsic articular cartilage interfaces
10.1016/j.aanat.2026.152799 · 2026 · External reference
Varying development of femoral and tibial subchondral bone tissue and their interaction with articular cartilage during progressing osteoarthritis
10.1007/s00402-020-03480-w · 2020 · External reference
Application of metabolomics in osteoporosis research
10.3389/fendo.2022.993253 · 2022 · External reference
A mechanistic review of chinese medicine polyphenols on bone formation and resorption
10.3389/fphar.2022.1017538 · 2022 · External reference
Immunomodulatory nanomedicine for osteoporosis: Current practices and emerging prospects
10.1016/j.actbio.2024.03.011 · 2024 · External reference
Pathophysiology of bone fragility in type 2 diabetes mellitus
10.1007/s11914-025-00935-0 · 2025 · External reference
The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis
10.1016/j.cytogfr.2020.02.003 · 2020 · External reference
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
10.1172/jci.insight.146728 · 2021 · External reference
Current and emerging bone resorption inhibitors for the treatment of osteoporosis
10.1080/14656566.2025.2451741 · 2025 · External reference
Karanjin counteracts OVX-induced bone loss by dual regulating bone remodeling
10.1016/j.phymed.2025.157099 · 2025 · External reference
Current use of bone turnover markers in the management of osteoporosis
10.1016/j.clinbiochem.2022.09.002 · 2022 · External reference
The role of bone-modifying agents in myeloma bone disease
10.1002/jbm4.10518 · 2021 · External reference
Patterns of misdiagnosis and discordance in detecting osteoporosis: A comparison of dual-energy X-ray absorptiometry and lumbar computed tomography hounsfield units
10.1097/bsd.0000000000001466 · 2023 · External reference
Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis
10.3389/fmed.2026.1751127 · 2026 · External reference
Osteoarthritis: Mechanisms and therapeutic advances
10.1002/mco2.70290 · 2025 · External reference
Acute synovitis after trauma precedes and is associated with osteoarthritis onset and progression
10.7150/ijbs.39015 · 2020 · External reference
Chondrocyte homeostasis and differentiation: Transcriptional control and signaling in healthy and osteoarthritic conditions
10.3390/life13071460 · 2023 · External reference
Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity
10.7150/thno.96723 · 2024 · External reference
Innate immunity and synovitis: Key players in osteoarthritis progression
10.3390/ijms252212082 · 2024 · External reference
Resistin enhances IL-1β and TNF-α expression in human osteoarthritis synovial fibroblasts by inhibiting miR-149 expression via the MEK and ERK pathways
10.1096/fj.202001071r · 2020 · External reference
Comparison of early-stage changes of osteoarthritis in cartilage and subchondral bone between two different rat models
10.7717/peerj.8934 · 2020 · External reference
Metabolism of subchondral bone tissue in posttraumatic osteoarthrosis in rats
10.1007/s10517-021-05363-5 · 2021 · External reference
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
10.1126/sciadv.abo7868 · 2023 · External reference
Structural relationship between articular cartilage and subchondral bone - A critical frontier in joint homeostasis and osteoarthritis
10.1016/j.aanat.2026.152785 · 2026 · External reference
Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees
10.1093/jbmr/zjae094 · 2024 · External reference
Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
10.1136/annrheumdis-2020-218089 · 2021 · External reference
Early changes in osteochondral tissues in a rabbit model of post-traumatic osteoarthritis
10.1002/jor.25009 · 2021 · External reference
Low bone mass resulting from impaired estrogen signaling in bone increases severity of load-induced osteoarthritis in female mice
10.1016/j.bone.2021.116071 · 2021 · External reference
Uncovering the "riddle of femininity" in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment
10.1016/j.joca.2022.12.009 · 2023 · External reference
Inflammation-mediated aberrant glucose metabolism in subchondral bone induces osteoarthritis
10.1093/stmcls/sxad012 · 2023 · External reference
Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis
10.1152/ajpcell.00039.2023 · 2023 · External reference
Critical requirement of senescence-associated CCN3 expression in CD44-positive stem cells for osteoarthritis progression
10.3390/ijms26199630 · 2025 · External reference
Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice
10.1186/s13075-025-03609-5 · 2025 · External reference
Network rewiring in the aging immune system: From chronic inflammation to age-related pathologies
10.3390/cells15050414 · 2026 · External reference
Cellular senescence and inflammaging in the bone: Pathways, genetics, anti-aging strategies and interventions
10.3390/ijms25137411 · 2024 · External reference
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING
10.1038/s41586-022-04924-6 · 2022 · External reference
eNAMPT is localised to areas of cartilage damage in patients with hip osteoarthritis and promotes cartilage catabolism and inflammation
10.3390/ijms22136719 · 2021 · External reference
Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury
10.1016/j.nbd.2023.106090 · 2023 · External reference
Senescent synovial intimal fibroblasts aggravate osteoarthritis by regulating macrophage polarization and chondrocyte phenotype through ANGPTL4-α5β1 axis
10.1002/advs.202518056 · 2026 · External reference
Immunosenescence, inflammaging, and lung senescence in asthma in the elderly
10.3390/biom12101456 · 2022 · External reference
The roles of the gut microbiota and chronic low-grade inflammation in older adults with frailty
10.3389/fcimb.2021.675414 · 2021 · External reference
Intestinal T cells in aging: Implications for gut barrier integrity and inflammaging
10.1007/s11357-026-02292-x · 2026 · External reference
Gut microbiota and aging: Current understanding and future perspectives
10.1186/s43556-026-00499-0 · 2026 · External reference
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study
10.3164/jcbn.24-93 · 2024 · External reference
Gut microbiota-targeted nutrition for healthy aging: Mechanistic roles of polyphenols and dietary fiber in geroscience
10.3390/nu18152478 · 2026 · External reference
Drug-mediated disruption of the aging gut microbiota and mucosal immune system
10.3389/fragi.2025.1603847 · 2025 · External reference
Intestinal microbiota, HLA-B27, and spondyloarthritis: Dangerous liaisons
10.1016/j.rdc.2020.01.007 · 2020 · External reference
Gut microbiota and bone aging: Focusing on the gut-X axis modes
10.1016/j.jot.2026.101064 · 2026 · External reference
Short-chain fatty acids in diseases
10.1186/s12964-023-01219-9 · 2023 · External reference
The role of short chain fatty acids in inflammation and body health
10.3390/ijms25137379 · 2024 · External reference
Rebalancing the inflammatory niche in allergic rhinitis
10.1016/j.cca.2025.120776 · 2026 · External reference
A new paradigm in the relationship between melatonin and breast cancer: Gut microbiota identified as a potential regulatory agent
10.3390/cancers13133141 · 2021 · External reference
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
10.1038/s41413-025-00498-x · 2026 · External reference
Post-menopausal osteoporosis and probiotics
10.2174/1389450121666201027124947 · 2021 · External reference
Acidification of drinking water improved tibia mass of broilers through the alterations of intestinal barrier and microbiota
10.5713/ab.21.0455 · 2022 · External reference
Bone-SASP" in skeletal aging
10.1007/s00223-023-01100-4 · 2023 · External reference
Recent advances in senescence-associated secretory phenotype and osteoporosis
10.1016/j.heliyon.2024.e25538 · 2024 · External reference
Cabozantinib, an anti-aging agent, prevents bone loss in estrogen-deficient mice by suppressing senescence-associated secretory phenotype factors
10.3390/ijms26157123 · 2025 · External reference
Aging and the emerging role of cellular senescence in osteoarthritis
10.1016/j.joca.2023.11.018 · 2024 · External reference
Immunosenescence in autoimmune diseases
10.1016/j.autrev.2025.103805 · 2025 · External reference
When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
10.1083/jcb.202212023 · 2023 · External reference
The role of Th/Treg immune cells in osteoarthritis
10.3389/fimmu.2024.1393418 · 2024 · External reference
Senescent CD4(+)CD28(-) T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption during periodontitis
10.3390/ijms23052543 · 2022 · External reference
The interrelationship between diabetes, IL-17 and bone loss
10.1007/s11914-020-00559-6 · 2020 · External reference
Inflammatory and metabolic signaling interfaces of the hypertrophic and senescent chondrocyte phenotypes associated with osteoarthritis
10.3390/ijms242216468 · 2023 · External reference
Osteoblast role in the pathogenesis of rheumatoid arthritis
10.1007/s11033-021-06288-y · 2021 · External reference
Baicalin inhibits IL-1β-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway
10.1186/s13018-023-04483-0 · 2024 · External reference
DAMPs in immunosenescence and cancer
10.1016/j.semcancer.2024.09.005 · 2024 · External reference
Melatonin alleviates osteoarthritis by regulating NADPH oxidase 4-induced ferroptosis and mitigating mitochondrial dysfunction
10.1111/jpi.12992 · 2024 · External reference
ROS signaling cascades: Dual regulations for osteoclast and osteoblast
10.1093/abbs/gmaa098 · 2020 · External reference
The Warburg effect occurs rapidly in stimulated human adult but not umbilical cord blood derived macrophages
10.3389/fimmu.2021.657261 · 2021 · External reference
Understanding the Warburg effect in cancer
10.1101/cshperspect.a041532 · 2025 · External reference
Adenine is an anti-inflammatory metabolite found to be more abundant in M-CSF over GM-CSF-differentiated human macrophages
10.1016/j.imlet.2023.12.003 · 2024 · External reference
The pentose phosphate pathway in cancer: Regulation and therapeutic opportunities
10.1159/000519784 · 2021 · External reference
Skeletal muscle-derived extracellular vesicles transport glycolytic enzymes to mediate muscle-to-bone crosstalk
10.1016/j.cmet.2023.10.013 · 2023 · External reference
Cartilage homeostasis and osteoarthritis
10.3390/ijms23116316 · 2022 · External reference
PRKAR2B-HIF-1α loop promotes aerobic glycolysis and tumour growth in prostate cancer
10.1111/cpr.12918 · 2020 · External reference
HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages
10.1038/s41598-025-95962-3 · 2025 · External reference
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6
10.1186/s12951-023-02264-9 · 2023 · External reference
Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages
10.7150/ijbs.75434 · 2022 · External reference
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production
10.1073/pnas.2307904121 · 2024 · External reference
Mitochondrial dysfunction and therapeutic perspectives in osteoporosis
10.3389/fendo.2024.1325317 · 2024 · External reference
Aptamer-functionalized apoptotic vesicles ameliorate osteoarthritis via resuming mitochondria OXPHOS of chondrocytes
10.1126/sciadv.aec1031 · 2026 · External reference
Aminooxyacetic acid hemihydrochloride inhibits osteoclast differentiation and bone resorption by attenuating oxidative phosphorylation
10.3389/fphar.2022.980678 · 2022 · External reference
Novel insights into osteoclast energy metabolism
10.1007/s11914-023-00825-3 · 2023 · External reference
At the heart of mitochondrial quality control: many roads to the top
10.1007/s00018-021-03772-3 · 2021 · External reference
Mitophagy in human health, ageing and disease
10.1038/s42255-023-00930-8 · 2023 · External reference
The pathophysiological role of mitochondrial oxidative stress in rheumatic diseases
10.2147/jir.s534574 · 2025 · External reference
Sparstolonin B suppresses free fatty acid palmitate-induced chondrocyte inflammation and mitigates post-traumatic arthritis in obese mice
10.1111/jcmm.17099 · 2022 · External reference
Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes
10.1016/j.jsbmb.2025.106813 · 2025 · External reference
Benzofuran pyran compound rescues rat and human osteoblast from lipotoxic effect of palmitate by inhibiting lipid biosynthesis and promoting stabilization of RUNX2
10.1016/j.tiv.2020.104872 · 2020 · External reference
Peroxisome functional inhibition alleviates TMJOA cartilage degradation
10.1177/00220345251381299 · 2026 · External reference
Sirtuin 3 deficiency exacerbates age-related periodontal disease
10.1111/jre.12930 · 2021 · External reference
SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury
10.1007/s10565-024-09869-2 · 2024 · External reference
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis
10.1111/acel.13301 · 2021 · External reference
Vitexin alleviates osteoarthritis progression through sirtuin 3-mediated inhibition of chondrocyte ferroptosis and mitochondrial dysfunction
10.1002/ptr.70410 · 2026 · External reference
Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis
10.1038/s41598-020-77892-4 · 2020 · External reference
Lactate dehydrogenase A inhibition prevents RANKL-induced osteoclastogenesis by reducing enhanced glycolysis
10.1016/j.jphs.2023.09.005 · 2023 · External reference
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity
10.1111/febs.70090 · 2025 · External reference
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
10.1136/jitc-2022-004856 · 2022 · External reference
Simulated Galactic Cosmic Rays modify mitochondrial metabolism in osteoclasts, increase osteoclastogenesis and cause trabecular bone loss in mice
10.3390/ijms222111711 · 2021 · External reference
Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion
10.1038/s41401-021-00747-9 · 2022 · External reference
Nox4 expression in osteo-progenitors controls bone development in mice during early life
10.1038/s42003-022-03544-0 · 2022 · External reference
Novel regulatory roles of UCP1 in osteoblasts
10.1016/j.lfs.2021.119427 · 2021 · External reference
Biophysical modulation of the mitochondrial metabolism and redox in bone homeostasis and osteoporosis: How biophysics converts into bioenergetics
10.3390/antiox10091394 · 2021 · External reference
HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation
10.1172/jci.insight.182330 · 2024 · External reference
Dual effects of lipid metabolism on osteoblast function
10.3389/fendo.2020.578194 · 2020 · External reference
sEV-mediated lipid droplets transferred from bone marrow adipocytes promote ferroptosis and impair osteoblast function
10.1016/j.jlr.2024.100657 · 2024 · External reference
Lipid metabolism in ferroptosis
10.1002/adbi.202100396 · 2021 · External reference
Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation
10.1038/s41419-024-06521-z · 2024 · External reference
Oxygen-sensing histone demethylase KDM6A modulates chondrocyte-to-osteoblast transdifferentiation by activating the Wnt/β-catenin pathway
10.3892/ijmm.2026.5874 · 2026 · External reference
Hepatic lipid accumulation and dysregulation associate with enhanced reactive oxygen species and pro-inflammatory cytokine in low-birth-weight goats
10.3390/ani12060766 · 2022 · External reference
Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model
10.1002/jbmr.4413 · 2021 · External reference
Osteal tissue macrophages are involved in endplate osteosclerosis through the OSM-STAT3/YAP1 signaling axis in Modic changes
10.4049/jimmunol.1901001 · 2020 · External reference
Metabolic pattern changes of macrophages during cancer development and progression
10.1186/s12967-026-08210-1 · 2026 · External reference
Interactions of B-lymphocytes and bone cells in health and disease
10.1016/j.bone.2021.116296 · 2023 · External reference
Pro-inflammatory immune microenvironment and Thrombospondin-1-positive monocytes as drivers of osteoclastogenesis in postmenopausal osteoporosis
10.1093/jbmr/zjaf083 · 2025 · External reference
Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing
10.3389/fimmu.2023.1264774 · 2023 · External reference
Macrophage polarization: A bridge connecting osteoarthritis and osteoporosis
10.1016/j.bbrc.2026.153322 · 2026 · External reference
New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
10.3389/fimmu.2019.02993 · 2019 · External reference
Research progress in the regulatory role of circRNA-miRNA network in bone remodeling
10.12182/20240360301 · 2024 · External reference
Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications
10.3389/fimmu.2025.1637731 · 2025 · External reference
T helper 17-like regulatory T cells in equine synovial fluid are associated with disease severity of naturally occurring posttraumatic osteoarthritis
10.1177/03635465231153588 · 2023 · External reference
Regulatory T cells in allergic inflammation
10.1016/j.smim.2023.101847 · 2023 · External reference
Potential therapeutic targets beyond cytokines and Janus kinases for autoimmune arthritis
10.1016/j.bcp.2023.115622 · 2023 · External reference
Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions
10.1038/s41584-022-00793-5 · 2022 · External reference
RNA binding proteins in osteoarthritis
10.3389/fcell.2022.954376 · 2022 · External reference
Hypoxic conditions modulate chondrogenesis through the circadian clock: The role of hypoxia-inducible factor-1α
10.3390/cells13060512 · 2024 · External reference
Protective effect of pyrroloquinoline quinone on TNF-α-induced mitochondrial injury in chondrocytes
10.1007/s11596-020-2248-3 · 2021 · External reference
Evodiamine alleviates IL-1β-induced chondrocyte damage by regulating mitochondrial dysfunction via the SIRT1/PGC-1α pathway
10.1007/s10735-025-10640-y · 2025 · External reference
The interplay of p38 MAPK signaling and mitochondrial metabolism, a dynamic target in cancer and pathological contexts
10.1016/j.bcp.2024.116307 · 2024 · External reference
PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function
10.1038/s41413-024-00344-6 · 2024 · External reference
Research progress on the role of chondrocyte mitochondrial homeostasis imbalance in the pathogenesis of osteoarthritis
10.7507/1002-1892.202303006 · 2023 · External reference
Is osteoarthritis a mitochondrial disease? What is the evidence
10.1097/bor.0000000000000855 · 2022 · External reference
Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction
10.7150/ijbs.85585 · 2024 · External reference
The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies
10.1038/s41413-025-00460-x · 2025 · External reference
Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1/M2 balance for osteoarthritis therapy
10.1016/j.jconrel.2025.02.005 · 2025 · External reference
Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions
10.1152/ajpcell.00276.2022 · 2023 · External reference
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming
10.1038/s41423-025-01268-9 · 2025 · External reference
Teriparatide prevented synovial inflammation and cartilage destruction in mice with DMM
10.1080/03008207.2022.2157723 · 2023 · External reference
Multiple roles of ALK3 in osteoarthritis
10.1302/2046-3758.127.bjr-2022-0310.r1 · 2023 · External reference
Axial compressive loading attenuates early osteoarthritis by reducing subchondral bone remodeling
10.1177/03635465231164644 · 2023 · External reference
More severe microdamage and micromechanical alterations: altered subchondral bone remodeling in varus knee osteoarthritis with osteoporosis
10.1007/s00198-025-07652-5 · 2025 · External reference
Subchondral bone remodeling: a therapeutic target for osteoarthritis
10.3389/fcell.2020.607764 · 2020 · External reference
Interplay of lipid metabolism and inflammation in podocyte injury
10.1016/j.metabol.2023.155718 · 2024 · External reference
The interplay between the immune microenvironment and bone aging: from molecular mechanisms to therapeutic interventions
10.1016/j.exger.2025.112974 · 2025 · External reference
Immunoporosis: role of innate immune cells in osteoporosis
10.3389/fimmu.2021.687037 · 2021 · External reference
Elimination of senescent osteocytes by bone-targeting delivery of β-galactose-modified maytansinoid prevents age-related bone loss
10.1002/adhm.202302972 · 2024 · External reference
Roles of metabolic dysregulation in osteoarthritis
10.3389/fcell.2026.1840208 · 2026 · External reference
Anakinra prevents high glucose-mediated potentiation of IL-1β-induced NLRP3 inflammasome activation, small extracellular vesicle release and vascular inflammation
10.1016/j.bcp.2026.118180 · 2026 · External reference
Emerging interactions between mitochondria and NAD(+) metabolism in cardiometabolic diseases
10.1016/j.tem.2024.07.010 · 2025 · External reference
Mitochondrial signaling, the mechanisms of AKI-to-CKD transition and potential treatment targets
10.3390/ijms25031518 · 2024 · External reference
Peptide Szeto-Schiller 31 ameliorates doxorubicin-induced cardiotoxicity by inhibiting the activation of the p38 MAPK signaling pathway
10.3892/ijmm.2021.4896 · 2021 · External reference
Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated mitophagy
10.1039/c9fo02287b · 2020 · External reference
NAD(+) metabolism and its roles in cellular processes during ageing
10.1038/s41580-020-00313-x · 2021 · External reference
Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson's disease
10.1016/j.arr.2020.101107 · 2020 · External reference
NAD(+) and NAFLD - caution, causality and careful optimism
10.1113/jp280908 · 2022 · External reference
NAD precursors, mitochondria targeting compounds and ADP-ribosylation inhibitors in treatment of inflammatory diseases and cancer
10.2174/0929867328666210118152653 · 2021 · External reference
Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis
10.1002/ctm2.70513 · 2025 · External reference
The role of SIRT3 in the osteoporosis
10.3389/fendo.2022.893678 · 2022 · External reference
Nicotinamide adenine dinucleotide supplementation to alleviate heart failure: a mitochondrial dysfunction perspective
10.3390/nu17111855 · 2025 · External reference
Lipid metabolism disorders and osteoarthritis progression: potential intervention with plant active ingredients
10.5312/wjo.v17.i2.113405 · 2026 · External reference
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation
10.1186/s40360-025-00997-x · 2025 · External reference
Peroxisome proliferator-activated receptor α (PPARα)-dependent regulation of fibroblast growth factor 23 (FGF23)
10.1007/s00424-020-02363-8 · 2020 · External reference
MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis
10.1016/j.intimp.2024.112016 · 2024 · External reference
Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation
10.1016/j.phrs.2021.105613 · 2021 · External reference
STING regulates aging-related osteoporosis by mediating the Hk2-Vdac1 mitochondrial axis
10.1016/j.freeradbiomed.2024.09.031 · 2024 · External reference
The role of glycolysis in inflammation
10.1152/ajpcell.00113.2026 · 2026 · External reference
Sports and metabolic bone disease
10.1055/s-0040-1709483 · 2020 · External reference
Lipid metabolism in ferroptosis
10.1002/adbi.202100396 · ExternalCitation · doi-reference
Elimination of senescent osteocytes by bone-targeting delivery of β-galactose-modified maytansinoid prevents age-related bone loss
10.1002/adhm.202302972 · ExternalCitation · doi-reference
Senescent synovial intimal fibroblasts aggravate osteoarthritis by regulating macrophage polarization and chondrocyte phenotype through ANGPTL4-α5β1 axis
10.1002/advs.202518056 · ExternalCitation · doi-reference
Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis
10.1002/ctm2.70513 · ExternalCitation · doi-reference
The role of bone-modifying agents in myeloma bone disease
10.1002/jbm4.10518 · ExternalCitation · doi-reference
Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model
10.1002/jbmr.4413 · ExternalCitation · doi-reference
Early changes in osteochondral tissues in a rabbit model of post-traumatic osteoarthritis
10.1002/jor.25009 · ExternalCitation · doi-reference
Osteoarthritis: Mechanisms and therapeutic advances
10.1002/mco2.70290 · ExternalCitation · doi-reference
Vitexin alleviates osteoarthritis progression through sirtuin 3-mediated inhibition of chondrocyte ferroptosis and mitochondrial dysfunction
10.1002/ptr.70410 · ExternalCitation · doi-reference
At the heart of mitochondrial quality control: many roads to the top
10.1007/s00018-021-03772-3 · ExternalCitation · doi-reference
More severe microdamage and micromechanical alterations: altered subchondral bone remodeling in varus knee osteoarthritis with osteoporosis
10.1007/s00198-025-07652-5 · ExternalCitation · doi-reference
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