Research graph
References from Dual roles of DDR1 in stromal remodeling and immune escape: a regulator of the tumor immune microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
New insights on anti-tumor immunity of CD8(+) T cells: cancer stem cells, tumor immune microenvironment and immunotherapy
10.1186/s12967-025-06291-y · 2025 · External reference
The extracellular matrix - immune microenvironment crosstalk in cancer therapy: challenges and opportunities
10.1016/j.matbio.2023.07.003 · 2023 · External reference
The discoidin domain receptor tyrosine kinases are activated by collagen
10.1016/s1097-2765(00)80003-9 · 1997 · External reference
Multifaceted collagen-DDR1 signaling in cancer
10.1016/j.tcb.2023.08.003 · 2024 · External reference
Extracellular matrix and its therapeutic potential for cancer treatment
10.1038/s41392-021-00544-0 · 2021 · External reference
Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers
10.7554/elife.25716 · 2017 · External reference
Discoidin domain receptor functions in physiological and pathological conditions
10.1016/b978-0-12-800180-6.00002-5 · 2014 · External reference
The collagen receptor discoidin domain receptor 1b enhances integrin beta1-mediated cell migration by interacting with talin and promoting Rac1 activation
10.3389/fcell.2022.836797 · 2022 · External reference
Discoidin domain receptor 1 isoform-a (DDR1alpha) promotes migration of leukocytes in three-dimensional collagen lattices
10.1096/fj.01-0359fje · 2001 · External reference
Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B
10.4049/jimmunol.172.4.2332 · 2004 · External reference
DDR1-targeted therapies: current limitations and future potential
10.1016/j.drudis.2024.103975 · 2024 · External reference
Discoidin domain receptors in tumor biology and immunology: progression and challenge
10.3390/biom15060832 · 2025 · External reference
Research progress on the role of DDR1 in cancer and targeted therapy strategy
10.4149/neo_2026_251010n426 · 2026 · External reference
An updated review of discoidin domain receptor 1 (DDR1) modulators (2020-present)
10.1080/13543776.2026.2685624 · 2026 · External reference
Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2
10.1016/j.jmb.2009.10.073 · 2010 · External reference
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
10.1038/s41586-021-04057-2 · 2021 · External reference
DDR1 promotes breast tumor growth by suppressing antitumor immunity
10.3892/or.2019.7338 · 2019 · External reference
Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration
10.18632/aging.205030 · 2023 · External reference
HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated TFAP2A/DDR1 axis
10.1186/s10020-023-00696-5 · 2023 · External reference
A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy
10.1038/s43018-021-00291-9 · 2022 · External reference
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome
10.1038/s41586-022-05169-z · 2022 · External reference
DDR1 drives collagen remodeling and immune exclusion: pan-cancer insights and therapeutic targeting in pancreatic ductal adenocarcinoma
10.3390/ijms26167731 · 2025 · External reference
A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
10.1136/jitc-2023-006720 · 2023 · External reference
Altered Treg infiltration after discoidin domain receptor 1 (DDR1) inhibition and knockout promotes tumor growth in lung adenocarcinoma
10.3390/cancers15245767 · 2023 · External reference
DDR1 associates with TRPV4 in cell-matrix adhesions to enable calcium-regulated myosin activity and collagen compaction
10.1002/jcp.30696 · 2022 · External reference
The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA
10.1242/jcs.046219 · 2009 · External reference
MRIP regulates the myosin IIA activity and DDR1 function to enable collagen tractional remodeling
10.3390/cells9071672 · 2020 · External reference
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1
10.1038/s41388-024-03014-3 · 2024 · External reference
Fibroblast heterogeneity: implications for human disease
10.1172/jci93555 · 2018 · External reference
Cancer-associated fibroblasts functions as multifunctional architects of the tumor stroma and represent emerging therapeutic vulnerabilities
10.1002/advs.202510043 · 2026 · External reference
Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts
10.1016/j.xcrm.2025.102357 · 2025 · External reference
Stiffness regulates extracellular matrix synthesis in fibroblasts by DDR1-TGF-beta/STAT3 mechanotransduction axis
10.1016/j.bioadv.2025.214240 · 2025 · External reference
Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices
10.1186/1755-1536-5-3 · 2012 · External reference
The cellular and molecular components involved in pre-metastatic niche formation in colorectal cancer liver metastasis
10.1080/17474124.2021.1848543 · 2021 · External reference
Microenvironment and tumor cell plasticity: an easy way out
10.1016/j.canlet.2013.01.042 · 2013 · External reference
Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction
10.1152/ajpgi.00078.2021 · 2021 · External reference
Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma
10.1038/s41392-021-00563-x · 2021 · External reference
The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair
10.1172/jci10720 · 2001 · External reference
Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src
10.1016/j.carpath.2009.12.006 · 2011 · External reference
DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) axis senses matrix stiffness to promote vascular calcification
10.1161/atvbaha.120.314697 · 2020 · External reference
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
10.1016/j.bioactmat.2022.01.012 · 2022 · External reference
Targeting the tumour vasculature: insights from physiological angiogenesis
10.1038/nrc2868 · 2010 · External reference
Therapeutic targeting of the tumor microenvironment
10.1158/2159-8290.cd-20-1808 · 2021 · External reference
Silencing of discoidin domain receptor-1 (DDR1) concurrently inhibits multiple steps of metastasis cascade in gastric cancer
10.1016/j.tranon.2018.02.003 · 2018 · External reference
Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells
10.1007/s13277-016-5021-2 · 2016 · External reference
Discoidin domain receptor-1 (DDR1) is involved in angiolymphatic invasion in oral cancer
10.3390/cancers12040841 · 2020 · External reference
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis
10.1038/ncb3036 · 2014 · External reference
DDR1 promotes immune evasion in colorectal cancer by orchestrating IL33-mediated M2-like polarization of tumor-associated macrophages
10.1158/2326-6066.cir-25-1073 · 2026 · External reference
Single-cell map of diverse immune phenotypes in the breast tumor microenvironment
10.1016/j.cell.2018.05.060 · 2018 · External reference
Discoidin domain receptor 1 expression in activated T cells is regulated by the ERK MAP kinase signaling pathway
10.1002/jcb.23300 · 2011 · External reference
Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen
10.1016/j.molimm.2010.02.023 · 2010 · External reference
Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway
10.18632/oncotarget.10455 · 2016 · External reference
Human Th17 migration in three-dimensional collagen involves p38 MAPK
10.1002/jcb.25932 · 2017 · External reference
Leukocyte and brain DDR1 hypermethylation is altered in psychosis and is correlated with stress and inflammatory markers
10.2217/epi-2019-0191 · 2020 · External reference
DDR1 is identified as an immunotherapy target for microsatellite stable colon cancer by CRISPR screening
10.1038/s41698-024-00743-2 · 2024 · External reference
DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18
10.1111/cas.15533 · 2022 · External reference
DDR1 drives cervical cancer progression and immune evasion: a bioinformatics analysis with experimental verification
10.1186/s12885-025-15099-4 · 2025 · External reference
Regulation of adaptive immunity by the innate immune system
10.1126/science.1183021 · 2010 · External reference
Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages
10.1016/j.freeradbiomed.2006.10.052 · 2007 · External reference
LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation
10.1124/jpet.111.187328 · 2012 · External reference
Tetrahydroisoquinoline-7-carboxamide derivatives as new selective discoidin domain receptor 1 (DDR1) inhibitors
10.1021/acsmedchemlett.6b00497 · 2017 · External reference
Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice
10.1161/circresaha.107.170662 · 2008 · External reference
Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis
10.1161/circresaha.109.207357 · 2009 · External reference
Macrophage polarization and its role in liver disease
10.3389/fimmu.2021.803037 · 2021 · External reference
Macrophage plasticity, polarization, and function in health and disease
10.1002/jcp.26429 · 2018 · External reference
Discoidin domain receptor 1 is a potential target correlated with tumor invasion and immune infiltration in gastric cancer
10.3389/fimmu.2022.933165 · 2022 · External reference
DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction
10.1016/j.intimp.2022.109294 · 2022 · External reference
Immune cells within the tumor microenvironment: biological functions and roles in cancer immunotherapy
10.1016/j.canlet.2019.11.009 · 2020 · External reference
Discoidin domain receptor 1: a new class of receptor regulating leukocyte-collagen interaction
10.1385/ir:31:3:219 · 2005 · External reference
NETosis in cancer: a critical analysis of the impact of cancer on neutrophil extracellular trap (NET) release in lung cancer patients vs. mice
10.1007/s00262-019-02474-x · 2020 · External reference
The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis
10.3389/fimmu.2020.01749 · 2020 · External reference
DDR1 promotes LoVo cell proliferation by regulating energy metabolism
10.3724/abbs.2022038 · 2022 · External reference
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
10.1172/jci.insight.146133 · 2021 · External reference
Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer
10.1016/j.intimp.2023.110235 · 2023 · External reference
The hallmarks of cancer metabolism: still emerging
10.1016/j.cmet.2022.01.007 · 2022 · External reference
Fatty acid oxidation: an emerging facet of metabolic transformation in cancer
10.1016/j.canlet.2018.08.006 · 2018 · External reference
DDR1 affects metabolic reprogramming in breast cancer cells by cross-talking to the insulin/IGF system
10.3390/biom11070926 · 2021 · External reference
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma
10.1186/s12967-025-07062-5 · 2025 · External reference
New target DDR1: a "double-edged sword" in solid tumors
10.1016/j.bbcan.2022.188829 · 2023 · External reference
A patent review of discoidin domain receptor 1 (DDR1) modulators (2014-present)
10.1080/13543776.2020.1732925 · 2020 · External reference
A putative role for discoidin domain receptor 1 in cancer chemoresistance
10.1080/19336918.2018.1445954 · 2018 · External reference
Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors
10.1111/cbdd.12863 · 2017 · External reference
Imatinib and nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling
10.1038/srep27378 · 2016 · External reference
Discoidin domain receptor 1 inhibitors: advances and future directions for novel therapeutics with aid of DNA encoded library screens and artificial intelligence
10.2174/1389557523666230125114921 · 2023 · External reference
Discovery of a prominent dual-target DDR1/EGFR inhibitor aimed DDR1/EGFR-positive NSCLC
10.1016/j.bioorg.2024.107500 · 2024 · External reference
Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts
10.1074/jbc.m110.143693 · 2011 · External reference
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization
10.1126/sciadv.abq6152 · 2022 · External reference
The critical role of discoidin domain receptors in the regulation of anti-tumor immune responses
10.1002/ijc.70398 · 2026 · External reference
DDR1 and DDR2 physical interaction leads to signaling interconnection but with possible distinct functions
10.1080/19336918.2018.1460012 · 2018 · External reference
Targeting discoidin domain receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma
10.15252/emmm.201911814 · 2022 · External reference
Ablation of myeloid discoidin domain receptor 2 exacerbates arthritis and high fat diet induced inflammation
10.1016/j.bbrc.2023.01.074 · 2023 · External reference
DDR2/STAT3 positive feedback loop mediates the immunosuppressive microenvironment by upregulating PD-L1 and recruiting MDSCs in oxaliplatin-resistant HCC
10.1016/j.jcmgh.2024.101377 · 2024 · External reference
Targeted DDR1 treatment strategy enhances PD-1 immunotherapy efficacy against gastric cancer
10.1021/acs.jmedchem.5c02505 · 2025 · External reference
Development of antibody-drug conjugates in cancer: overview and prospects
10.1002/cac2.12517 · 2024 · External reference
Strategies and challenges for the next generation of antibody-drug conjugates
10.1038/nrd.2016.268 · 2017 · External reference
Synergistic approach to combating triple-negative breast cancer: DDR1-targeted antibody-drug conjugate combined with pembrolizumab
10.1016/j.jpha.2024.101100 · 2025 · External reference
Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma
10.1002/1878-0261.12520 · 2019 · External reference
Antibody-drug conjugates targeting DDR1 as a novel strategy for treatment of breast cancer
10.1080/1061186x.2024.2386621 · 2024 · External reference
Advancing targeted protein degradation for cancer therapy
10.1038/s41568-021-00365-x · 2021 · External reference
Targeted degradation of DDR1 by proteolytic targeting chimera reverses immune exclusion for tumor immunotherapy
10.1016/j.ejmech.2025.117750 · 2025 · External reference
Discovery of LLC355 as an autophagy-tethering compound for the degradation of discoidin domain receptor 1
10.1021/acs.jmedchem.4c00162 · 2024 · External reference
Overcoming the tumor collagen barriers: A multistage drug delivery strategy for DDR1-mediated resistant colorectal cancer therapy
10.1002/advs.202402107 · 2024 · External reference
Discoidin domain receptor-driven gene signatures as markers of patient response to anti-PD-L1 immune checkpoint therapy
10.1093/jnci/djac140 · 2022 · External reference
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy
10.1126/sciadv.aav2437 · 2019 · External reference
New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance
10.3389/fonc.2022.956926 · 2022 · External reference
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor
10.1021/cb400430t · 2013 · External reference
Discovery of 4-amino-1H-pyrazolo[3,4-d]pyrimidin derivatives as novel discoidin domain receptor 1 (DDR1) inhibitors
10.1016/j.bmc.2020.115876 · 2021 · External reference
Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma
10.1186/s12885-017-3051-9 · 2017 · External reference
Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors
10.1021/jm301824k · 2013 · External reference
2-Amino-2,3-dihydro-1H-indene-5-carboxamide-based discoidin domain receptor 1 (DDR1) inhibitors: Design, synthesis, and in vivo antipancreatic cancer efficacy
10.1021/acs.jmedchem.9b00365 · 2019 · External reference
Design and optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as selective DDR1 inhibitors
10.1021/acsmedchemlett.9b00495 · 2020 · External reference
Unresolved reference
External reference
Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma
10.1002/1878-0261.12520 · ExternalCitation · doi-reference
Overcoming the tumor collagen barriers: A multistage drug delivery strategy for DDR1-mediated resistant colorectal cancer therapy
10.1002/advs.202402107 · ExternalCitation · doi-reference
Cancer-associated fibroblasts functions as multifunctional architects of the tumor stroma and represent emerging therapeutic vulnerabilities
10.1002/advs.202510043 · ExternalCitation · doi-reference
Development of antibody-drug conjugates in cancer: overview and prospects
10.1002/cac2.12517 · ExternalCitation · doi-reference
The critical role of discoidin domain receptors in the regulation of anti-tumor immune responses
10.1002/ijc.70398 · ExternalCitation · doi-reference
Discoidin domain receptor 1 expression in activated T cells is regulated by the ERK MAP kinase signaling pathway
10.1002/jcb.23300 · ExternalCitation · doi-reference
Human Th17 migration in three-dimensional collagen involves p38 MAPK
10.1002/jcb.25932 · ExternalCitation · doi-reference
Macrophage plasticity, polarization, and function in health and disease
10.1002/jcp.26429 · ExternalCitation · doi-reference
DDR1 associates with TRPV4 in cell-matrix adhesions to enable calcium-regulated myosin activity and collagen compaction
10.1002/jcp.30696 · ExternalCitation · doi-reference
NETosis in cancer: a critical analysis of the impact of cancer on neutrophil extracellular trap (NET) release in lung cancer patients vs. mice
10.1007/s00262-019-02474-x · ExternalCitation · doi-reference
Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells
10.1007/s13277-016-5021-2 · ExternalCitation · doi-reference
Discoidin domain receptor functions in physiological and pathological conditions
10.1016/b978-0-12-800180-6.00002-5 · ExternalCitation · doi-reference
New target DDR1: a "double-edged sword" in solid tumors
10.1016/j.bbcan.2022.188829 · ExternalCitation · doi-reference
Ablation of myeloid discoidin domain receptor 2 exacerbates arthritis and high fat diet induced inflammation
10.1016/j.bbrc.2023.01.074 · ExternalCitation · doi-reference
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
10.1016/j.bioactmat.2022.01.012 · ExternalCitation · doi-reference
Stiffness regulates extracellular matrix synthesis in fibroblasts by DDR1-TGF-beta/STAT3 mechanotransduction axis
10.1016/j.bioadv.2025.214240 · ExternalCitation · doi-reference
Discovery of a prominent dual-target DDR1/EGFR inhibitor aimed DDR1/EGFR-positive NSCLC
10.1016/j.bioorg.2024.107500 · ExternalCitation · doi-reference
Discovery of 4-amino-1H-pyrazolo[3,4-d]pyrimidin derivatives as novel discoidin domain receptor 1 (DDR1) inhibitors
10.1016/j.bmc.2020.115876 · ExternalCitation · doi-reference
Microenvironment and tumor cell plasticity: an easy way out
10.1016/j.canlet.2013.01.042 · ExternalCitation · doi-reference
Fatty acid oxidation: an emerging facet of metabolic transformation in cancer
10.1016/j.canlet.2018.08.006 · ExternalCitation · doi-reference
Immune cells within the tumor microenvironment: biological functions and roles in cancer immunotherapy
10.1016/j.canlet.2019.11.009 · ExternalCitation · doi-reference
Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src
10.1016/j.carpath.2009.12.006 · ExternalCitation · doi-reference
Single-cell map of diverse immune phenotypes in the breast tumor microenvironment
10.1016/j.cell.2018.05.060 · ExternalCitation · doi-reference
The hallmarks of cancer metabolism: still emerging
10.1016/j.cmet.2022.01.007 · ExternalCitation · doi-reference
DDR1-targeted therapies: current limitations and future potential
10.1016/j.drudis.2024.103975 · ExternalCitation · doi-reference
Targeted degradation of DDR1 by proteolytic targeting chimera reverses immune exclusion for tumor immunotherapy
10.1016/j.ejmech.2025.117750 · ExternalCitation · doi-reference
Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages
10.1016/j.freeradbiomed.2006.10.052 · ExternalCitation · doi-reference
DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction
10.1016/j.intimp.2022.109294 · ExternalCitation · doi-reference
Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer
10.1016/j.intimp.2023.110235 · ExternalCitation · doi-reference
DDR2/STAT3 positive feedback loop mediates the immunosuppressive microenvironment by upregulating PD-L1 and recruiting MDSCs in oxaliplatin-resistant HCC
10.1016/j.jcmgh.2024.101377 · ExternalCitation · doi-reference
Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2
10.1016/j.jmb.2009.10.073 · ExternalCitation · doi-reference
Synergistic approach to combating triple-negative breast cancer: DDR1-targeted antibody-drug conjugate combined with pembrolizumab
10.1016/j.jpha.2024.101100 · ExternalCitation · doi-reference
The extracellular matrix - immune microenvironment crosstalk in cancer therapy: challenges and opportunities
10.1016/j.matbio.2023.07.003 · ExternalCitation · doi-reference
Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen
10.1016/j.molimm.2010.02.023 · ExternalCitation · doi-reference
Multifaceted collagen-DDR1 signaling in cancer
10.1016/j.tcb.2023.08.003 · ExternalCitation · doi-reference
Silencing of discoidin domain receptor-1 (DDR1) concurrently inhibits multiple steps of metastasis cascade in gastric cancer
10.1016/j.tranon.2018.02.003 · ExternalCitation · doi-reference
Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts
10.1016/j.xcrm.2025.102357 · ExternalCitation · doi-reference
The discoidin domain receptor tyrosine kinases are activated by collagen
10.1016/s1097-2765(00)80003-9 · ExternalCitation · doi-reference
Discovery of LLC355 as an autophagy-tethering compound for the degradation of discoidin domain receptor 1
10.1021/acs.jmedchem.4c00162 · ExternalCitation · doi-reference
Targeted DDR1 treatment strategy enhances PD-1 immunotherapy efficacy against gastric cancer
10.1021/acs.jmedchem.5c02505 · ExternalCitation · doi-reference
2-Amino-2,3-dihydro-1H-indene-5-carboxamide-based discoidin domain receptor 1 (DDR1) inhibitors: Design, synthesis, and in vivo antipancreatic cancer efficacy
10.1021/acs.jmedchem.9b00365 · ExternalCitation · doi-reference
Tetrahydroisoquinoline-7-carboxamide derivatives as new selective discoidin domain receptor 1 (DDR1) inhibitors
10.1021/acsmedchemlett.6b00497 · ExternalCitation · doi-reference
Design and optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as selective DDR1 inhibitors
10.1021/acsmedchemlett.9b00495 · ExternalCitation · doi-reference
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor
10.1021/cb400430t · ExternalCitation · doi-reference
Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors
10.1021/jm301824k · ExternalCitation · doi-reference
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis
10.1038/ncb3036 · ExternalCitation · doi-reference
Targeting the tumour vasculature: insights from physiological angiogenesis
10.1038/nrc2868 · ExternalCitation · doi-reference
Strategies and challenges for the next generation of antibody-drug conjugates
10.1038/nrd.2016.268 · ExternalCitation · doi-reference
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1
10.1038/s41388-024-03014-3 · ExternalCitation · doi-reference
Extracellular matrix and its therapeutic potential for cancer treatment
10.1038/s41392-021-00544-0 · ExternalCitation · doi-reference
Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma
10.1038/s41392-021-00563-x · ExternalCitation · doi-reference
Advancing targeted protein degradation for cancer therapy
10.1038/s41568-021-00365-x · ExternalCitation · doi-reference
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
10.1038/s41586-021-04057-2 · ExternalCitation · doi-reference
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome
10.1038/s41586-022-05169-z · ExternalCitation · doi-reference
DDR1 is identified as an immunotherapy target for microsatellite stable colon cancer by CRISPR screening
10.1038/s41698-024-00743-2 · ExternalCitation · doi-reference
A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy
10.1038/s43018-021-00291-9 · ExternalCitation · doi-reference
Imatinib and nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling
10.1038/srep27378 · ExternalCitation · doi-reference
Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts
10.1074/jbc.m110.143693 · ExternalCitation · doi-reference
Antibody-drug conjugates targeting DDR1 as a novel strategy for treatment of breast cancer
10.1080/1061186x.2024.2386621 · ExternalCitation · doi-reference
A patent review of discoidin domain receptor 1 (DDR1) modulators (2014-present)
10.1080/13543776.2020.1732925 · ExternalCitation · doi-reference
An updated review of discoidin domain receptor 1 (DDR1) modulators (2020-present)
10.1080/13543776.2026.2685624 · ExternalCitation · doi-reference
The cellular and molecular components involved in pre-metastatic niche formation in colorectal cancer liver metastasis
10.1080/17474124.2021.1848543 · ExternalCitation · doi-reference
A putative role for discoidin domain receptor 1 in cancer chemoresistance
10.1080/19336918.2018.1445954 · ExternalCitation · doi-reference
DDR1 and DDR2 physical interaction leads to signaling interconnection but with possible distinct functions
10.1080/19336918.2018.1460012 · ExternalCitation · doi-reference
Discoidin domain receptor-driven gene signatures as markers of patient response to anti-PD-L1 immune checkpoint therapy
10.1093/jnci/djac140 · ExternalCitation · doi-reference
Discoidin domain receptor 1 isoform-a (DDR1alpha) promotes migration of leukocytes in three-dimensional collagen lattices
10.1096/fj.01-0359fje · ExternalCitation · doi-reference
DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18
10.1111/cas.15533 · ExternalCitation · doi-reference
Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors
10.1111/cbdd.12863 · ExternalCitation · doi-reference
LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation
10.1124/jpet.111.187328 · ExternalCitation · doi-reference
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy
10.1126/sciadv.aav2437 · ExternalCitation · doi-reference
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization
10.1126/sciadv.abq6152 · ExternalCitation · doi-reference
Regulation of adaptive immunity by the innate immune system
10.1126/science.1183021 · ExternalCitation · doi-reference
A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
10.1136/jitc-2023-006720 · ExternalCitation · doi-reference
Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction
10.1152/ajpgi.00078.2021 · ExternalCitation · doi-reference
Therapeutic targeting of the tumor microenvironment
10.1158/2159-8290.cd-20-1808 · ExternalCitation · doi-reference
DDR1 promotes immune evasion in colorectal cancer by orchestrating IL33-mediated M2-like polarization of tumor-associated macrophages
10.1158/2326-6066.cir-25-1073 · ExternalCitation · doi-reference
DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) axis senses matrix stiffness to promote vascular calcification
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Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice
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Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis
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DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
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The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair
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Fibroblast heterogeneity: implications for human disease
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Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices
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HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated TFAP2A/DDR1 axis
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Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma
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DDR1 drives cervical cancer progression and immune evasion: a bioinformatics analysis with experimental verification
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New insights on anti-tumor immunity of CD8(+) T cells: cancer stem cells, tumor immune microenvironment and immunotherapy
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Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma
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The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA
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Discoidin domain receptor 1: a new class of receptor regulating leukocyte-collagen interaction
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Targeting discoidin domain receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma
10.15252/emmm.201911814 · ExternalCitation · doi-reference
Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration
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Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway
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Discoidin domain receptor 1 inhibitors: advances and future directions for novel therapeutics with aid of DNA encoded library screens and artificial intelligence
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Leukocyte and brain DDR1 hypermethylation is altered in psychosis and is correlated with stress and inflammatory markers
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The collagen receptor discoidin domain receptor 1b enhances integrin beta1-mediated cell migration by interacting with talin and promoting Rac1 activation
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The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis
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Macrophage polarization and its role in liver disease
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Discoidin domain receptor 1 is a potential target correlated with tumor invasion and immune infiltration in gastric cancer
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New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance
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DDR1 affects metabolic reprogramming in breast cancer cells by cross-talking to the insulin/IGF system
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Discoidin domain receptors in tumor biology and immunology: progression and challenge
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Discoidin domain receptor-1 (DDR1) is involved in angiolymphatic invasion in oral cancer
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Altered Treg infiltration after discoidin domain receptor 1 (DDR1) inhibition and knockout promotes tumor growth in lung adenocarcinoma
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MRIP regulates the myosin IIA activity and DDR1 function to enable collagen tractional remodeling
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DDR1 drives collagen remodeling and immune exclusion: pan-cancer insights and therapeutic targeting in pancreatic ductal adenocarcinoma
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DDR1 promotes LoVo cell proliferation by regulating energy metabolism
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DDR1 promotes breast tumor growth by suppressing antitumor immunity
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Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B
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Research progress on the role of DDR1 in cancer and targeted therapy strategy
10.4149/neo_2026_251010n426 · ExternalCitation · doi-reference
Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers
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